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Article ; Online: Evaluating the ASTHMAXcel Mobile Application Regarding Asthma Knowledge and Clinical Outcomes.

Hsia, Brian C / Wu, Sammy / Mowrey, Wenzhu B / Jariwala, Sunit P

2020 Volume 65, Issue 8, Page(s) 1112–1119

Abstract: Background: We sought to longitudinally assess the efficacy of the patient-facing ASTHMAXcel mobile application in improving asthma knowledge and outcomes in adults with asthma.: Methods: ASTHMAXcel is a novel smartphone application consistent with ... ...

Abstract	Background: We sought to longitudinally assess the efficacy of the patient-facing ASTHMAXcel mobile application in improving asthma knowledge and outcomes in adults with asthma. Methods: ASTHMAXcel is a novel smartphone application consistent with the National Asthma Education and Prevention Program, Global Initiative for Asthma, and British Thoracic Society/Scottish Intercollegiate Guidelines Network guidelines. The intervention was provided for 1-time use at baseline only. The Asthma Knowledge Questionnaire (AKQ), the Asthma Control Test (ACT), and the mini-Asthma Quality of Life Questionnaire (mini-AQLQ) were administered at baseline and at 2, 4, and 6 months thereafter. Rates of asthma-related emergency department visits, hospitalizations, and prednisone use were also evaluated. Results: ACT scores increased significantly at 2, 4, and 6 months (mean scores: 15.1 vs 16.9, Conclusions: ASTHMAXcel contributes to improved asthma knowledge and outcomes and to decreased health care utilization. ASTHMAXcel is an inexpensive, scalable aid for out-patient asthma management.
MeSH term(s)	Asthma/drug therapy ; Hospitalization ; Humans ; Mobile Applications ; Quality of Life ; Surveys and Questionnaires
Language	English
Publishing date	2020-06-02
Publishing country	United States
Document type	Evaluation Study ; Journal Article
ZDB-ID	603252-7
ISSN	1943-3654 ; 0098-9142 ; 0020-1324
ISSN (online)	1943-3654
ISSN	0098-9142 ; 0020-1324
DOI	10.4187/respcare.07550
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Article ; Online: Long Interspersed Nuclear Element-1 Analytes in Extracellular Vesicles as Tools for Molecular Diagnostics of Non-Small Cell Lung Cancer.

Bowers, Emma C / Cavalcante, Alexandre M / Nguyen, Kimberly / Li, Can / Wang, Yingshan / El-Zein, Randa / Chen, Shu-Hsia / Kim, Min P / McKay, Brian S / Ramos, Kenneth S

International journal of molecular sciences

2024 Volume 25, Issue 2

Abstract: Aberrant expression of the oncogenic retrotransposon LINE-1 is a hallmark of various cancer types, including non-small cell lung cancers (NSCLCs). Here, we present proof-of-principle evidence that LINE-1 analytes in extracellular vesicles (EVs) serve as ... ...

Abstract	Aberrant expression of the oncogenic retrotransposon LINE-1 is a hallmark of various cancer types, including non-small cell lung cancers (NSCLCs). Here, we present proof-of-principle evidence that LINE-1 analytes in extracellular vesicles (EVs) serve as tools for molecular diagnostics of NSCLC, with LINE-1 status in tumor cells and tissues mirroring the LINE-1 mRNA and ORF1p cargos of EVs from lung cancer cell culture conditioned media or human plasma. The levels of LINE-1 analytes in plasma EVs from ostensibly healthy individuals were higher in females than males. While the profiles of LINE-1 mRNA and ORF1p in African Americans compared to Hispanics were not significantly different, African Americans showed slightly higher ORF1p content, and 2-3 times greater ranges of LINE-1 values compared to Hispanics. Whole plasma ORF1p levels correlated with EV ORF1p levels, indicating that most of the circulating LINE-1 protein is contained within EVs. EV LINE-1 mRNA levels were elevated in patients with advanced cancer stages and in select patients with squamous cell carcinoma and metastatic tumors compared to adenocarcinomas. The observed EV LINE-1 mRNA profiles paralleled the patterns of ORF1p expression in NSCLC tissue sections suggesting that LINE-1 analytes in plasma EVs may serve to monitor the activity of LINE-1 retroelements in lung cancer.
MeSH term(s)	Female ; Male ; Humans ; Carcinoma, Non-Small-Cell Lung/diagnosis ; Carcinoma, Non-Small-Cell Lung/genetics ; Lung Neoplasms/diagnosis ; Lung Neoplasms/genetics ; Pathology, Molecular ; Retroelements ; Extracellular Vesicles/genetics ; RNA, Messenger/genetics
Chemical Substances	Retroelements ; RNA, Messenger
Language	English
Publishing date	2024-01-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2019364-6
ISSN	1422-0067 ; 1422-0067 ; 1661-6596
ISSN (online)	1422-0067
ISSN	1422-0067 ; 1661-6596
DOI	10.3390/ijms25021169
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Article ; Online: Vitamin D Oral Replacement in Children With Obesity Related Asthma: VDORA1 Randomized Clinical Trial.

Clinical pharmacology and therapeutics

2023 Volume 115, Issue 2, Page(s) 231–238

Abstract: ... target serum level, but 50-72.7% of participants in cohorts A-C achieved the target serum level. In part ...

Abstract	Children with asthma and obesity are more likely to have lower vitamin D levels, but the optimal replacement dose is unknown in this population. The objective of this study is identifying a vitamin D dose in children with obesity-related asthma that safely achieves serum vitamin D levels of ≥ 40 ng/mL. This prospective multisite randomized controlled trial recruited children/adolescents with asthma and body mass index ≥ 85% for age/sex. Part 1 (dose finding), evaluated 4 oral vitamin D regimens for 16 weeks to identify a replacement dose that achieved serum vitamin D levels ≥ 40 ng/mL. Part 2 compared the replacement dose calculated from part 1 (50,000 IU loading dose with 8,000 IU daily) to standard of care (SOC) for 16 weeks to identify the proportion of children achieving target serum 25(OH)D level. Part 1 included 48 randomized participants. Part 2 included 64 participants. In Part 1, no SOC participants achieved target serum level, but 50-72.7% of participants in cohorts A-C achieved the target serum level. In part 2, 78.6% of replacement dose participants achieved target serum level compared with none in the SOC arm. No related serious adverse events were reported. This trial confirmed a 50,000 IU loading dose plus 8,000 IU daily oral vitamin D as safe and effective in increasing serum 25(OH)D levels in children/adolescents with overweight/obesity to levels ≥ 40 ng/mL. Given the critical role of vitamin D in many conditions complicating childhood obesity, these data close a critical gap in our understanding of vitamin D dosing in children.
MeSH term(s)	Adolescent ; Child ; Humans ; Vitamin D ; Cholecalciferol/adverse effects ; Prospective Studies ; Vitamin D Deficiency/diagnosis ; Vitamin D Deficiency/drug therapy ; Pediatric Obesity/complications ; Pediatric Obesity/drug therapy ; Pediatric Obesity/chemically induced ; Vitamins ; Asthma/drug therapy ; Dietary Supplements
Chemical Substances	Vitamin D (1406-16-2) ; Cholecalciferol (1C6V77QF41) ; Vitamins
Language	English
Publishing date	2023-11-28
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	123793-7
ISSN	1532-6535 ; 0009-9236
ISSN (online)	1532-6535
ISSN	0009-9236
DOI	10.1002/cpt.3086
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Article ; Online: Validation of American Society of Echocardiography Guideline-Recommended Parameters of Right Ventricular Dysfunction Using Artificial Intelligence Compared With Cardiac Magnetic Resonance Imaging.

Hsia, Brian C / Lai, Ashton / Singh, Supreet / Samtani, Rajeev / Bienstock, Solomon / Liao, Steve / Stern, Eric / LaRocca, Gina / Sanz, Javier / Lerakis, Stamatios / Croft, Lori / Carrasso, Shemy / Rosenmann, David / DeMaria, Anthony / Stone, Gregg W / Goldman, Martin E

Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography

2023 Volume 36, Issue 9, Page(s) 967–977

Abstract: Background: Right ventricular (RV) function is important in the evaluation of cardiac function, but its assessment using standard transthoracic echocardiography (TTE) remains challenging. Cardiac magnetic resonance imaging (CMR) is considered the gold ... ...

Abstract	Background: Right ventricular (RV) function is important in the evaluation of cardiac function, but its assessment using standard transthoracic echocardiography (TTE) remains challenging. Cardiac magnetic resonance imaging (CMR) is considered the gold standard. The American Society of Echocardiography recommends surrogate measures of RV function and RV ejection fraction (RVEF) by TTE, including fractional area change (FAC), free wall strain (FWS), and tricuspid annular planar systolic excursion (TAPSE), but they require technical expertise in acquisition and quantification. Methods: The aim of this study was to evaluate the sensitivity, specificity, and positive and negative predictive values of FAC, FWS, and TAPSE derived using a rapid, novel artificial intelligence (AI) software (LVivoRV) from a single-plane transthoracic echocardiographic apical four-chamber, RV-focused view without ultrasound-enhancing agents for detecting abnormal RV function compared with CMR-derived RVEF. RV dysfunction was defined as RVEF < 50% and RVEF < 40% on CMR. Results: TTE and CMR were performed within a median of 10 days (interquartile range, 2-32 days) of each other in 225 consecutive patients without interval procedural or pharmacologic intervention. The sensitivity and negative predictive value to detect CMR-defined RV dysfunction when all three AI-derived parameters (FAC, FWS, and TAPSE) were abnormal were 91% and 96%, while those of expert physician reads were 91% and 97%. Specificity and positive predictive value were lower (50% and 32%) compared with expert physician-read echocardiograms (82% and 56%). Conclusions: AI-derived measurements of FAC, FWS, and TAPSE had excellent sensitivity and negative predictive value for ruling out significant RV dysfunction (CMR RVEF < 40%), comparable with that of expert physician readers, but lower specificity. Thus AI, using American Society of Echocardiography guidelines, may serve as a useful screening tool for rapid bedside assessment to exclude significant RV dysfunction.
MeSH term(s)	Humans ; Ventricular Dysfunction, Right/diagnostic imaging ; Artificial Intelligence ; Magnetic Resonance Imaging, Cine/methods ; Echocardiography ; Magnetic Resonance Imaging ; Stroke Volume ; Ventricular Function, Right
Language	English
Publishing date	2023-06-17
Publishing country	United States
Document type	Journal Article
ZDB-ID	1035622-8
ISSN	1097-6795 ; 0894-7317
ISSN (online)	1097-6795
ISSN	0894-7317
DOI	10.1016/j.echo.2023.05.015
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Article ; Online: Blueprinting extendable nanomaterials with standardized protein blocks.

Huddy, Timothy F / Hsia, Yang / Kibler, Ryan D / Xu, Jinwei / Bethel, Neville / Nagarajan, Deepesh / Redler, Rachel / Leung, Philip J Y / Weidle, Connor / Courbet, Alexis / Yang, Erin C / Bera, Asim K / Coudray, Nicolas / Calise, S John / Davila-Hernandez, Fatima A / Han, Hannah L / Carr, Kenneth D / Li, Zhe / McHugh, Ryan /

Reggiano, Gabriella / Kang, Alex / Sankaran, Banumathi / Dickinson, Miles S / Coventry, Brian / Brunette, T J / Liu, Yulai / Dauparas, Justas / Borst, Andrew J / Ekiert, Damian / Kollman, Justin M / Bhabha, Gira / Baker, David

Nature

2024 Volume 627, Issue 8005, Page(s) 898–904

Abstract: A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in ... ...

Abstract	A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies, in comparison, has been much more complex, largely owing to the irregular shapes of protein structures
MeSH term(s)	Crystallography, X-Ray ; Nanostructures/chemistry ; Proteins/chemistry ; Proteins/metabolism ; Microscopy, Electron ; Reproducibility of Results
Chemical Substances	Proteins
Language	English
Publishing date	2024-03-13
Publishing country	England
Document type	Journal Article
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/s41586-024-07188-4
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Article ; Online: Developing and evaluating ASTHMAXcel adventures: A novel gamified mobile application for pediatric patients with asthma.

Hsia, Brian C / Singh, Anjani K / Njeze, Obumneme / Cosar, Emine / Mowrey, Wenzhu B / Feldman, Jonathan / Reznik, Marina / Jariwala, Sunit P

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology

2020 Volume 125, Issue 5, Page(s) 581–588

Abstract: Background: The ASTHMAXcel mobile application has been linked to favorable outcomes among adult patients with asthma.: Objective: To assess the impact of ASTHMAXcel Adventures, a gamified, guideline-based, pediatric version on asthma control, ... ...

Abstract	Background: The ASTHMAXcel mobile application has been linked to favorable outcomes among adult patients with asthma. Objective: To assess the impact of ASTHMAXcel Adventures, a gamified, guideline-based, pediatric version on asthma control, knowledge, health care utilization, and patient satisfaction. Methods: Pediatric patients with asthma received the ASTHMAXcel Adventures mobile intervention on-site only at baseline (visit 1), 4 months (visit 2), and 6 months (visit 3). The asthma control test, asthma illness representation scale-self-administered, pediatric asthma impact survey, and Client Satisfaction Questionnaire-8 were used to assess asthma control, knowledge, and patient satisfaction. Patients reported the number of asthma-related emergency department (ED) visits, hospitalizations, and oral prednisone use. Results: A total of 39 patients completed the study. The proportion of controlled asthma increased from visit 1 to visits 2 and 3 (30.8% vs 53.9%, P = .04; 30.8% vs 59.0%, P = .02), and largely seen in boys. The mean asthma illness representation scale-self-administered scores increased from baseline pre- to postintervention, with sustained improvements at visits 2 and 3 (3.55 vs 3.76, P < .001; 3.55 vs 3.80, P = .001; 3.55 vs 3.99, P < .001). The pediatric asthma impact survey scores improved from baseline to visits 2 and 3 (43.33 vs 34.08, P < .001; 43.33 vs 31.74, P < .001). ED visits and prednisone use significantly decreased from baseline to visits 2 and 3 (ED: 0.46 vs 0.13, P = .03; 0.46 vs 0.02, P = .02; prednisone use, 0.49 vs 0.13, P = .02; 0.49 vs 0.03, P = .003. Satisfaction was high with mean client satisfaction questionnaire score of approximately 30 (out of 32) at all visits. Conclusion: ASTHMAXcel Adventures improved asthma control, knowledge, and quality of life, and reduced ED visits and prednisone use with high satisfaction scores.
MeSH term(s)	Adolescent ; Asthma/therapy ; Child ; Emergency Service, Hospital/statistics & numerical data ; Female ; Health Knowledge, Attitudes, Practice ; Hospitalization/statistics & numerical data ; Humans ; Male ; Mobile Applications ; Patient Acceptance of Health Care/statistics & numerical data ; Patient Satisfaction ; Prednisone/administration & dosage ; Prospective Studies ; Quality of Life ; Self Care ; Video Games
Chemical Substances	Prednisone (VB0R961HZT)
Keywords	covid19
Language	English
Publishing date	2020-07-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1228189-x
ISSN	1534-4436 ; 0003-4738 ; 1081-1206
ISSN (online)	1534-4436
ISSN	0003-4738 ; 1081-1206
DOI	10.1016/j.anai.2020.07.018
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Article ; Online: Recombinant human lecithin-cholesterol acyltransferase in patients with atherosclerosis: phase 2a primary results and phase 2b design.

Bonaca, Marc P / George, Richard T / Morrow, David A / Bergmark, Brian A / Park, Jeong-Gun / Abuhatzira, Liron / Vavere, Andrea L / Karathanasis, Sotirios K / Jin, ChaoYu / She, Dewei / Hirshberg, Boaz / Hsia, Judy / Sabatine, Marc S

European heart journal. Cardiovascular pharmacotherapy

2021 Volume 8, Issue 3, Page(s) 243–252

Abstract: ... area under the curve (AUC) from 0 to 96 h post dose 3 (AUC 0-96 h) for HDL-C, HDL cholesteryl ester (HDL-CE), and total ... were randomized. MEDI6012 significantly increased AUC 0-96 h for HDL-C, HDL-CE and CE in a graded ... fashion with increasing doses. Relative to placebo, MEDI6012 increased HDL-C at Day 19 by 66% (95% CI 33 ...

Abstract	Aims: Reverse cholesterol transport (RCT) removes cholesterol and stabilizes vulnerable plaques. In addition, high-density lipoprotein (HDL) may be cardioprotective in acute myocardial infarction (MI). Lecithin-cholesterol acyltransferase (LCAT) may enhance RCT. The objective of this study was to investigate the pharmacokinetics, pharmacodynamics, and safety of multiple ascending doses of recombinant human LCAT (MEDI6012) to inform a Phase 2b programme. Methods and results: This was a randomized, blinded, placebo-controlled, dose-escalation Phase 2a study of MEDI6012. Patients were randomized into one of four cohorts (40, 120, 300 mg IV weekly ×3 doses, or 300 mg IV-push, 150 mg at 48 h and 100 mg at 7 days). All cohorts were planned to randomize 6:2 (MEDI6012 vs. placebo). The primary endpoints were baseline-adjusted area under the curve (AUC) from 0 to 96 h post dose 3 (AUC 0-96 h) for HDL-C, HDL cholesteryl ester (HDL-CE), and total cholesteryl ester (CE). The primary safety endpoints were treatment-emergent adverse events. A total of 32 patients were randomized. MEDI6012 significantly increased AUC 0-96 h for HDL-C, HDL-CE and CE in a graded fashion with increasing doses. Relative to placebo, MEDI6012 increased HDL-C at Day 19 by 66% (95% CI 33-99, P = 0.014) with 120 mg and 144% (95% CI 108-181, P < 0.001) with 300 mg. An IV-push increased HDL-C by 40.8% at 30 min. Overall adverse events were similar between groups with no severe, life-threatening/fatal adverse events, or neutralizing antibodies. Conclusions: Multiple ascending doses of MEDI6012 were safe and well tolerated and significantly increased HDL-C, HDL-CE and CE in a dose-related manner. These data support the ongoing Phase 2b programme investigating MEDI6012 in ST-elevation MI.
MeSH term(s)	Atherosclerosis ; Cholesterol ; Humans ; Lecithins/adverse effects ; Lipoproteins, HDL/adverse effects ; Phosphatidylcholine-Sterol O-Acyltransferase/adverse effects ; Sterol O-Acyltransferase
Chemical Substances	Lecithins ; Lipoproteins, HDL ; Cholesterol (97C5T2UQ7J) ; Sterol O-Acyltransferase (EC 2.3.1.26) ; Phosphatidylcholine-Sterol O-Acyltransferase (EC 2.3.1.43)
Language	English
Publishing date	2021-01-22
Publishing country	England
Document type	Clinical Trial, Phase II ; Journal Article ; Randomized Controlled Trial ; Research Support, Non-U.S. Gov't
ZDB-ID	2808613-2
ISSN	2055-6845 ; 2055-6837
ISSN (online)	2055-6845
ISSN	2055-6837
DOI	10.1093/ehjcvp/pvab001
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Article: Blueprinting expandable nanomaterials with standardized protein building blocks.

Huddy, Timothy F / Hsia, Yang / Kibler, Ryan D / Xu, Jinwei / Bethel, Neville / Nagarajan, Deepesh / Redler, Rachel / Leung, Philip J Y / Courbet, Alexis / Yang, Erin C / Bera, Asim K / Coudray, Nicolas / Calise, S John / Davila-Hernandez, Fatima A / Weidle, Connor / Han, Hannah L / Li, Zhe / McHugh, Ryan / Reggiano, Gabriella /

Kang, Alex / Sankaran, Banumathi / Dickinson, Miles S / Coventry, Brian / Brunette, T J / Liu, Yulai / Dauparas, Justas / Borst, Andrew J / Ekiert, Damian / Kollman, Justin M / Bhabha, Gira / Baker, David

bioRxiv : the preprint server for biology

2023

Abstract	A wooden house frame consists of many different lumber pieces, but because of the regularity of these building blocks, the structure can be designed using straightforward geometrical principles. The design of multicomponent protein assemblies in comparison has been much more complex, largely due to the irregular shapes of protein structures
Language	English
Publishing date	2023-06-09
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.06.09.544258
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Article ; Online: Determining the optimal duration for premature ventricular contraction monitoring.

Hsia, Brian C / Greige, Nicolas / Patel, Shreyans K / Clark, Rachel M / Ferrick, Kevin J / Fisher, John D / Gross, Jay / Di Biase, Luigi / Krumerman, Andrew

Heart rhythm

2020 Volume 17, Issue 12, Page(s) 2119–2125

Abstract: Background: Premature ventricular contractions (VPC) have hour-to-hour and day-to-day variation. High VPC burden correlates with cardiomyopathy.: Objective: To determine the optimal duration for ambulatory electrocardiogram monitoring for accurate ... ...

Abstract	Background: Premature ventricular contractions (VPC) have hour-to-hour and day-to-day variation. High VPC burden correlates with cardiomyopathy. Objective: To determine the optimal duration for ambulatory electrocardiogram monitoring for accurate assessment of VPC burden. Methods: Our group performed a retrospective analysis on patch monitors used for any indication with overall VPC burden ≥5.0% between February 1, 2016, and February 1, 2020. We generated cumulative daily VPC averages for each day of wear and performed linear regression analysis between each cumulative daily average and overall burden. Patients were divided into groups based on low or high VPC frequency, and the analysis was repeated. Split-sample validation was used to internally validate the overall prediction model. Results: A total of 116 patches representing 107 patients (mean age: 64.5; female: 48%) were analyzed. Mean overall VPC burden was 13.4% ± 7.5% (range: 5.0%-42.0%). Day 1 R Conclusion: Mobile telemetry for a period of ∼7 days accurately reflects overall VPC burden. Measurement of VPC burden for only 24-48 hours may not accurately reflect total burden. Monitoring for 2 weeks or longer adds little additional VPC information.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Electrocardiography, Ambulatory/methods ; Female ; Follow-Up Studies ; Heart Rate/physiology ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Contraction/physiology ; Retrospective Studies ; Time Factors ; Ventricular Function, Left/physiology ; Ventricular Premature Complexes/diagnosis ; Ventricular Premature Complexes/physiopathology
Language	English
Publishing date	2020-07-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2229357-7
ISSN	1556-3871 ; 1547-5271
ISSN (online)	1556-3871
ISSN	1547-5271
DOI	10.1016/j.hrthm.2020.07.013
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Article ; Online: QT prolongation in a diverse, urban population of COVID-19 patients treated with hydroxychloroquine, chloroquine, or azithromycin.

Hsia, Brian C / Greige, Nicolas / Quiroz, Jose A / Khokhar, Ahmed S / Daily, Johanna / Di Biase, Luigi / Ferrick, Kevin J / Fisher, John D / Krumerman, Andrew

Journal of interventional cardiac electrophysiology : an international journal of arrhythmias and pacing

2020 Volume 59, Issue 2, Page(s) 337–345

Abstract: Purpose: Hydroxychloroquine, chloroquine, and azithromycin have been used for treatment of COVID-19, but may cause QT prolongation. Minority populations are disproportionately impacted by COVID-19. This study evaluates the risk of QT prolongation and ... ...

Abstract	Purpose: Hydroxychloroquine, chloroquine, and azithromycin have been used for treatment of COVID-19, but may cause QT prolongation. Minority populations are disproportionately impacted by COVID-19. This study evaluates the risk of QT prolongation and subsequent outcomes after administration of these medications in largely underrepresented minority COVID-19 patients. Methods: We conducted an observational study on hospitalized COVID-19 patients in the Montefiore Health System (Bronx, NY). We examined electrocardiograms (ECG) pre/post-medication initiation to evaluate QTc, HR, QRS duration, and presence of other arrhythmias. Results: One hundred five patients (mean age 67 years; 44.8% F) were analyzed. The median time from the first dose of any treatment to post-medication ECG was 2 days (IQR: 1-3). QTc in men increased from baseline (440 vs 455 ms, p < 0.001), as well as in women (438 vs 463 ms, p < 0.001). The proportion of patients with QT prolongation increased significantly (14.3% vs 34.3%, p < 0.001) even when adjusted for electrolyte abnormalities. The number of patients whose QTc > 500 ms was significantly increased after treatment (16.2% vs. 4.8%, p < 0.01). Patients with either QTc > 500 ms or an increase of 60 ms had a higher frequency of death (47.6% vs. 22.6%, p = 0.02) with an odds ratio of 3.1 (95% CI: 1.1-8.7). Adjusting for race/ethnicity yielded no significant associations. Conclusions: Hydroxychloroquine, chloroquine, and/or azithromycin were associated with QTc prolongation but did not result in fatal arrhythmias. Our findings suggest that any harm is unlikely to outweigh potential benefits of treatment. Careful risk-benefit analyses for individual patients should guide the use of these medications. Randomized control trials are necessary to evaluate their efficacies.
MeSH term(s)	Age Distribution ; Aged ; Aged, 80 and over ; Antimalarials/administration & dosage ; Antimalarials/adverse effects ; Azithromycin/administration & dosage ; Azithromycin/adverse effects ; COVID-19 ; Chloroquine/administration & dosage ; Chloroquine/adverse effects ; Coronavirus Infections/diagnosis ; Coronavirus Infections/drug therapy ; Coronavirus Infections/epidemiology ; Electrocardiography/methods ; Female ; Follow-Up Studies ; Hospitalization/statistics & numerical data ; Humans ; Hydroxychloroquine/administration & dosage ; Hydroxychloroquine/adverse effects ; Incidence ; Long QT Syndrome/chemically induced ; Long QT Syndrome/diagnostic imaging ; Long QT Syndrome/drug therapy ; Long QT Syndrome/epidemiology ; Male ; Middle Aged ; Pandemics/prevention & control ; Pandemics/statistics & numerical data ; Pneumonia, Viral/diagnosis ; Pneumonia, Viral/drug therapy ; Pneumonia, Viral/epidemiology ; Risk Assessment ; Sex Distribution ; Urban Population
Chemical Substances	Antimalarials ; Hydroxychloroquine (4QWG6N8QKH) ; Azithromycin (83905-01-5) ; Chloroquine (886U3H6UFF)
Keywords	covid19
Language	English
Publishing date	2020-07-11
Publishing country	Netherlands
Document type	Journal Article ; Observational Study
ZDB-ID	1329179-8
ISSN	1572-8595 ; 1383-875X
ISSN (online)	1572-8595
ISSN	1383-875X
DOI	10.1007/s10840-020-00822-x
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