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Article ; Online: Heteromeric complexes of aldo-keto reductase auxiliary K

Nystoriak, Matthew A / Zhang, Deqing / Jagatheesan, Ganapathy / Bhatnagar, Aruni

2017 Volume 276, Page(s) 210–217

Abstract: Redox-sensitive potassium channels consisting of the voltage-gated K ...

Abstract	Redox-sensitive potassium channels consisting of the voltage-gated K
MeSH term(s)	Aldo-Keto Reductases/chemistry ; Aldo-Keto Reductases/genetics ; Aldo-Keto Reductases/metabolism ; Animals ; Coronary Vessels/metabolism ; Coronary Vessels/pathology ; Isoenzymes/chemistry ; Isoenzymes/metabolism ; Kv1.5 Potassium Channel/metabolism ; Male ; Mice ; Mice, Inbred C57BL ; Mice, Knockout ; Microscopy, Confocal ; Myocytes, Cardiac/metabolism ; Myocytes, Cardiac/pathology ; Protein Subunits/chemistry ; Protein Subunits/genetics ; Protein Subunits/metabolism ; RNA, Messenger/metabolism ; Sarcolemma/metabolism
Chemical Substances	Isoenzymes ; Kv1.5 Potassium Channel ; Protein Subunits ; RNA, Messenger ; Aldo-Keto Reductases (EC 1.1.1.-)
Language	English
Publishing date	2017-03-22
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	218799-1
ISSN	1872-7786 ; 0009-2797
ISSN (online)	1872-7786
ISSN	0009-2797
DOI	10.1016/j.cbi.2017.03.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: History and Evolution of Radiosurgery in India: A Historical Vignette.

Ganapathy, Krishnan

Neurology India

2023 Volume 71, Issue 4, Page(s) 837–838

MeSH term(s)	Humans ; Radiosurgery ; Neurosurgery ; India
Language	English
Publishing date	2023-08-28
Publishing country	India
Document type	Journal Article
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.383808
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Article ; Online: The Learning Curve.

Ganapathy, Krishnan

Neurology India

2023 Volume 71, Issue 3, Page(s) 639

MeSH term(s)	Humans ; Learning Curve ; Retrospective Studies ; Postoperative Complications
Language	English
Publishing date	2023-06-16
Publishing country	India
Document type	Journal Article
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.378680
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Article ; Online: Science and Art of Reviewing Papers to Maintain Standards in Academia.

Ganapathy, Krishnan

Neurology India

2022 Volume 69, Issue 6, Page(s) 1547–1550

Abstract: This review article highlights the necessity and importance of peer review of articles submitted to journals. Publication in a peer reviewed, good impact indexed journal is an indirect endorsement of the article contents. The editor and the readership ... ...

Abstract	This review article highlights the necessity and importance of peer review of articles submitted to journals. Publication in a peer reviewed, good impact indexed journal is an indirect endorsement of the article contents. The editor and the readership depend on the integrity and total involvement of reviewers. What is expected of the reviewer and the authors is discussed. Reviewers need to be sensitive to authors' reactions. Authors should also respond, not react or be hypersensitive.
MeSH term(s)	Humans ; Peer Review
Language	English
Publishing date	2022-01-03
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.333463
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Article ; Online: Infectious Bronchitis Virus Infection of Chicken: The Essential Role of Mucosal Immunity.

Ganapathy, Kannan

Avian diseases

2022 Volume 65, Issue 4, Page(s) 619–623

Abstract: Infection with either virulent or vaccine strains of infectious bronchitis virus (IBV) elicits a complex interaction of nonspecific, innate, mucosal, cellular, and humoral immunity, thereby mounting an optimal defensive response in chickens. Through this ...

Abstract	Infection with either virulent or vaccine strains of infectious bronchitis virus (IBV) elicits a complex interaction of nonspecific, innate, mucosal, cellular, and humoral immunity, thereby mounting an optimal defensive response in chickens. Through this process, mucosal immunity plays an essential role in preventing infection and clearing the virus. It also assists in the development of longer lasting local immunity against IBV, mainly in the respiratory tract but also in the oviduct and gastrointestinal mucosal linings. The head-associated lymphoid tissues, particularly the Harderian gland, have an important role in the synthesis of immunoglobulin A (IgA). Levels of this immunoglobulin in lachrymal fluid often reflect the degree of protection against IBV challenge. Beyond the head, the importance of mucosal immunity has predominantly been studied in the trachea. Though IgA has been the major focus of IBV mucosal immunity investigations, the role of mucosa-associated nonspecific, innate, and cellular immune responses may also be significant. Ciliary movements and nonspecific substances in the mucosa, such as mucins and peptides, assist in the entrapment and removal of living and nonliving antigens. Mucosa-associated innate immune responses determine cascades of downstream cellular and humoral immunity against IBV. Cellular immunity, particularly involving CD4+, CD8+, and other T-cell subsets, have been studied in mucosa-associated sites, especially the trachea. The strength of cellular immunity at mucosal sites has been associated with protection against IBV. Recently, the evaluation of mucosal immunity has shifted from traditional methods to quantitative assays of mRNA transcription of immune genes. This and other molecular-based approaches will likely boost our understanding of chicken mucosal immunity against virulent and vaccine strains of IBV. It has been well accepted that mucosal immunity plays an important role in pathogenicity, vaccinal immunity, and protection conferred against virulent IBV.
MeSH term(s)	Animals ; Chickens ; Coronavirus Infections/veterinary ; Immunity, Mucosal ; Infectious bronchitis virus ; Poultry Diseases ; Vaccines, Attenuated ; Viral Vaccines
Chemical Substances	Vaccines, Attenuated ; Viral Vaccines
Language	English
Publishing date	2022-01-23
Publishing country	United States
Document type	Journal Article
ZDB-ID	40871-2
ISSN	1938-4351 ; 0005-2086
ISSN (online)	1938-4351
ISSN	0005-2086
DOI	10.1637/aviandiseases-D-21-00100
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Article ; Online: Pros and Cons on Use of Live Viral Vaccines in Commercial Chicken Flocks.

Ganapathy, Kannan / Parthiban, Sivamurthy

Avian diseases

2024 Volume 67, Issue 4, Page(s) 410–420

Abstract: The poultry industry is the largest source of meat and eggs for the growing human population worldwide. Key concerns in poultry farming are nutrition, management, flock health, and biosecurity measures. As part of the flock health, use of live viral ... ...

Abstract	The poultry industry is the largest source of meat and eggs for the growing human population worldwide. Key concerns in poultry farming are nutrition, management, flock health, and biosecurity measures. As part of the flock health, use of live viral vaccines plays a vital role in the prevention of economically important and common viral diseases. This includes diseases and production losses caused by Newcastle disease virus, infectious bronchitis virus, infectious laryngotracheitis virus, infectious bursal disease virus, Marek's disease virus, chicken infectious anemia virus, avian encephalomyelitis virus, fowlpox virus, and avian metapneumovirus. These viruses cause direct and indirect harms, such as financial losses worth millions of dollars, loss of protein sources, and threats to animal welfare. Flock losses vary by type of poultry, age of affected animals, co-infections, immune status, and environmental factors. Losses in broiler birds can consist of high mortality, poor body weight gain, high feed conversion ratio, and increased carcass condemnation. In commercial layers and breeder flocks, losses include higher than normal mortality rate, poor flock uniformity, drops in egg production and quality, poor hatchability, and poor day-old-chick quality. Despite the emergence of technology-based vaccines, such as inactivated, subunit, vector-based, DNA or RNA, and others, the attenuated live vaccines remain as important as before. Live vaccines are preferred in the global veterinary vaccine market, accounting for 24.3% of the global market share in 2022. The remaining 75% includes inactivated, DNA, subunit, conjugate, recombinant, and toxoid vaccines. The main reason for this is that live vaccines can induce innate, mucosal, cellular, and humoral immunities by single or multiple applications. Some live vaccine combinations provide higher and broader protection against several diseases or strains of viruses. This review aimed to explore insights on the pros and cons of attenuated live vaccines commonly used against major viral infections of the global chicken industry, and the future road map for improvement.
MeSH term(s)	Humans ; Animals ; Chickens ; Viral Vaccines ; Poultry Diseases/prevention & control ; Vaccines, Attenuated ; DNA
Chemical Substances	Viral Vaccines ; Vaccines, Attenuated ; DNA (9007-49-2)
Language	English
Publishing date	2024-02-05
Publishing country	United States
Document type	Review ; Journal Article
ZDB-ID	40871-2
ISSN	1938-4351 ; 0005-2086
ISSN (online)	1938-4351
ISSN	0005-2086
DOI	10.1637/aviandiseases-D-23-99998
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Article ; Online: Good Death in Neurological Practice.

Ganapathy, Krishnan

Neurology India

2021 Volume 69, Issue 4, Page(s) 792–796

Abstract: Background: Clinicians in neurological practice, particularly surgeons, encounter more deaths than most other specialists.: Objective: This communication reviews the literature on "good death" and extrapolates the observations and inferences to ... ...

Abstract	Background: Clinicians in neurological practice, particularly surgeons, encounter more deaths than most other specialists. Objective: This communication reviews the literature on "good death" and extrapolates the observations and inferences to neurological practice. Changes in approaches to "good death" in the COVID-19 era (coronavirus disease 2019) are also discussed. Materials and methods: The author, over a 40-year period, has come across 2,500 deaths in a government, trust, and corporate hospital in Chennai, India. Retrospectively, the author questions if, in spite of his conservatism and obsession with quality of life, he should have taken proactive measures to also ensure a good quality of death. Results and conclusion: In the background of the lessons learned in a metro, across various socioeconomic groups and with varied access to technology, the author concludes that ensuring "good death" should also fall within the domain of neurologic practice.
MeSH term(s)	COVID-19 ; Humans ; India ; Male ; Quality of Life ; Retrospective Studies ; SARS-CoV-2
Language	English
Publishing date	2021-09-10
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.325314
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Telemedicine: An Integral Part of Clinical Neurosciences.

Ganapathy, Krishnan

Neurology India

2021 Volume 69, Issue 2, Page(s) 352–353

MeSH term(s)	Ambulatory Care ; Humans ; Neurosciences ; Neurosurgery ; Pandemics ; Telemedicine
Language	English
Publishing date	2021-04-27
Publishing country	India
Document type	Journal Article ; Comment
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.314545
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Article ; Online: Telemedicine and Neurological Practice in the COVID-19 Era.

Ganapathy, Krishnan

Neurology India

2020 Volume 68, Issue 3, Page(s) 555–559

Abstract: Background: The COVID-19 pandemic has within months turned the world upside down. With personal distancing and shortage of personal protective equipment, face-to-face health care encounters are increasingly becoming problematic. Neurological ... ...

Abstract	Background: The COVID-19 pandemic has within months turned the world upside down. With personal distancing and shortage of personal protective equipment, face-to-face health care encounters are increasingly becoming problematic. Neurological manifestations are also being observed in clinical presentations. Objective: Worldwide most countries, the World Health Organization (WHO) and Centre for Disease Control (USA) have recommended use of Telemedicine during the current pandemic.With acute shortage of neurologists and neurosurgeons and their lopsided distribution, it becomes more difficult to provide neurological care to those who need it the most, particularly with travel restrictions. The author has since 2002 been advocating use of Telemedicine in Neurosciences. Materials and methods: This article reviews the increasing deployment of Telemedicine in neurological practice in the last few years, particularly the radical exponential use in the last few months due to COVID-19. Conclusions: With possible reduction in face-to-face consultations, remote evaluation may become mainstream. Webinars will play an increasing role. CME's and resident training will become more and more digital. The world will never be the same again. It is imperative that we accept and start deploying the "New Normal".
MeSH term(s)	Betacoronavirus ; COVID-19 ; Coronavirus Infections/epidemiology ; Humans ; Mobile Applications ; Neurology/education ; Neurology/methods ; Pandemics ; Pneumonia, Viral/epidemiology ; SARS-CoV-2 ; Telemedicine/methods ; Telephone ; Telerehabilitation ; Videoconferencing
Keywords	covid19
Language	English
Publishing date	2020-07-08
Publishing country	India
Document type	Journal Article ; Review
ZDB-ID	415522-1
ISSN	1998-4022 ; 0028-3886
ISSN (online)	1998-4022
ISSN	0028-3886
DOI	10.4103/0028-3886.288994
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Article: Effect of Self-Directed Learning Module and Assessment on Learning of National Health Programme by Medical Undergraduates - A Mixed Methods Evaluation.

Rajalakshmi, M / Ganapathy, Kalaiselvan

Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine

2023 Volume 48, Issue 3, Page(s) 465–470

Abstract: Background: Competency-based medical education (CBME) curriculum in India has introduced many new concepts like a foundation course, early clinical exposure, and self-directed learning (SDL). Sometimes SDL simply means self-study. Self-directed learning ...

Abstract	Background: Competency-based medical education (CBME) curriculum in India has introduced many new concepts like a foundation course, early clinical exposure, and self-directed learning (SDL). Sometimes SDL simply means self-study. Self-directed learning as defined by Knowles is a process in which individuals take the initiative with or without the help of others in diagnosing their learning needs, setting their own learning goals, identifying appropriate learning resources, and selecting appropriate learning strategies. SDL is seen as a prerequisite for life-long learners, especially medical graduates. We found poor uptake of SDL sessions in terms of learning and attendance by students. To develop and assess the effect of the SDL module in Community Medicine for Phase -3 MBBS students. Materials and methods: The study design was a program development and evaluation design. The program development consists of free listing and Nominal Group Technique (NGT). The evaluation design consists of a formative assessment, an end-of-module assessment, and feedback from undergraduate students, postgraduates, and faculties. Data collection procedure: SDL module was developed, agreed and implemented among undergraduates of Phase - 3 MBBS students. Results: Free listing was conducted among undergraduate students who had completed the phase 3 MBBS examination and Nominal Group Technique was conducted among the faculties (n = 7) and Postgraduates of the Department of Community Medicine (n = 2) to explore the appropriate topics for SDL in Community Medicine. The topic with the highest ranking and which was finalized for preparation of the SDL module was "National Health Programme". Three fourth 118 (75%) of the students scored ≥50% at the end of the module assessment. Manual content analysis for the feedback was categorized into three themes such as facilitating factors, challenges, and solutions. Conclusions: Effective implementation and assessment of SDL sessions are one of the new concepts in the CBME curriculum.
Language	English
Publishing date	2023-05-30
Publishing country	India
Document type	Journal Article
ZDB-ID	2085330-0
ISSN	1998-3581 ; 0970-0218
ISSN (online)	1998-3581
ISSN	0970-0218
DOI	10.4103/ijcm.ijcm_520_22
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