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Article ; Online: Nrf-2-dependent antioxidant and anti-inflammatory effects underlie the protective effect of esculeoside A against retinal damage in streptozotocin-induced diabetic rats.

Alsabaani, Nasser A / Amawi, Kawther / Eleawa, Samy M / Nabeel Ibrahim, Wisam / Aldhaban, Walid / Alaraj, Ahmad Mohammad / Alkhalaf, Badr / Sami, Waqas / Alshaikhli, Hisham / Alkhateeb, Mahmoud A

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie

2024 Volume 173, Page(s) 116461

Abstract: Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy is not well-investigated and was the core objective of this study. In addition, we tested if ... ...

Abstract	Esculeoside A (ESA) is a tomato-derived glycoside with antioxidant and anti-inflammatory properties. The protective effect of ESA against diabetic retinopathy is not well-investigated and was the core objective of this study. In addition, we tested if such protection involves the activation of Nrf2 signaling. Type 1 diabetes mellitus (T1DM) was induced in adult Wistar male rats by an intraperitoneal injection of streptozotocin (65 mg/kg). Non-diabetic and T1DM rats were divided into two subgroup groups given either the vehicle or ESA (100 mg)/kg. An additional T1DM group was given ESA (100 mg/kg) and an Nrf2 inhibitor (2 mg/kg) (n=8 rats/group). Treatments continued for 12 weeks. In this study, according to the histological features, ESA improved the structure of ganglionic cells and increased the number of cells of the inner nuclear and plexiform layers in the retinas of T1DM rats. Concomitantly, it reduced the retina levels of malondialdehyde (lipid peroxides), vascular endothelial growth factor, interleukin-6, tumor necrosis factor-α, Bax, and caspase-3. In the retinas of the control and diabetic rats, ESA boosted the levels of total glutathione, superoxide dismutase, heme-oxygenase-1, and Bcl2, reduced the mRNA levels of REDD1, and enhanced cytoplasmic and nuclear levels of Nrf2. However, ESA failed to alter the mRNA levels of Nrf2 and keap1, protein levels of keap1, plasma glucose, plasma insulin, serum triglycerides, cholesterol, and LDL-c in both the control and T1DM rats. In conclusion, ESA alleviates retinopathy in T1DM rats by suppressing REDD1-associated degradation and inhibiting the Nrf2/antioxidant axis.
MeSH term(s)	Rats ; Male ; Animals ; Antioxidants/metabolism ; Rats, Wistar ; Kelch-Like ECH-Associated Protein 1/metabolism ; Streptozocin/pharmacology ; Diabetes Mellitus, Experimental/complications ; Diabetes Mellitus, Experimental/drug therapy ; Diabetes Mellitus, Experimental/chemically induced ; Diabetes Mellitus, Type 1/complications ; Diabetes Mellitus, Type 1/drug therapy ; Vascular Endothelial Growth Factor A/metabolism ; NF-E2-Related Factor 2/metabolism ; Diabetic Retinopathy/drug therapy ; Diabetic Retinopathy/prevention & control ; Diabetic Retinopathy/metabolism ; RNA, Messenger/metabolism ; Oxidative Stress ; Sapogenins
Chemical Substances	Antioxidants ; Kelch-Like ECH-Associated Protein 1 ; Streptozocin (5W494URQ81) ; Vascular Endothelial Growth Factor A ; NF-E2-Related Factor 2 ; esculeoside A ; RNA, Messenger ; Sapogenins
Language	English
Publishing date	2024-03-18
Publishing country	France
Document type	Journal Article
ZDB-ID	392415-4
ISSN	1950-6007 ; 0753-3322 ; 0300-0893
ISSN (online)	1950-6007
ISSN	0753-3322 ; 0300-0893
DOI	10.1016/j.biopha.2024.116461
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Article ; Online: Investigation of physical properties and carbon dioxide solubility in tetramethylammonium bromide and tetraethylammonium bromide ionic liquids solutions.

Rather, Sami-Ullah / Sulaimon, Aliyu Adebayo / Shariff, Azmi M / Qasim, Ali / Bamufleh, Hisham Saeed / Alhumade, Hesham Abdulhamed / Saeed, Usman / Al-Alayah, Walid

Chemosphere

2023 Volume 337, Page(s) 139290

Abstract: Carbon dioxide is a major greenhouse gas that is responsible for global warming and renders harmful effects on the atmosphere. The unconstrained release of ... ...

Abstract	Carbon dioxide is a major greenhouse gas that is responsible for global warming and renders harmful effects on the atmosphere. The unconstrained release of CO
MeSH term(s)	Animals ; Ionic Liquids ; Carbon Dioxide ; Tetraethylammonium ; Solubility ; Moles
Chemical Substances	Ionic Liquids ; Carbon Dioxide (142M471B3J) ; tetramethylammonium (H0W55235FC) ; Tetraethylammonium (66-40-0) ; triethylammonium bicarbonate (15715-58-9)
Language	English
Publishing date	2023-06-20
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139290
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Article ; Online: Corrigendum to 'Prediction of carbon-dioxide activity coefficient for solubility in ionic liquids using multi-non-linear regression analysis', Chemosphere, 311, (2023), 1-10, 137102.

Rather, Sami-Ullah / Shariff, Azmi M / Sulaimon, Aliyu Adebayo / Bamufleh, Hisham S / Qasim, Ali / Khan, Muhammad Saad / Alhumade, Hesham / Saeed, Usman / Alalayah, Walid M

Chemosphere

2023 Volume 315, Page(s) 137721

Language	English
Publishing date	2023-01-10
Publishing country	England
Document type	Published Erratum
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137721
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Article ; Online: Thirteen years' survival after glioblastoma.

Sami Walid, M

Southern medical journal

2010 Volume 103, Issue 6, Page(s) 590–591

MeSH term(s)	Aged ; Biopsy ; Brain Neoplasms/diagnosis ; Brain Neoplasms/pathology ; Diagnosis, Differential ; Female ; Frontal Lobe/pathology ; Glioblastoma/diagnosis ; Glioblastoma/pathology ; Humans ; Necrosis ; Neoplasm Recurrence, Local/diagnosis ; Neoplasm Recurrence, Local/pathology ; Prognosis ; Survivors ; Temporal Lobe/pathology
Language	English
Publishing date	2010-06
Publishing country	United States
Document type	Comment ; Letter
ZDB-ID	185329-6
ISSN	1541-8243 ; 0038-4348
ISSN (online)	1541-8243
ISSN	0038-4348
DOI	10.1097/SMJ.0b013e3181d743fb
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Article: Impact of body mass index on semen parameters and reproductive hormones among men undergoing microsurgical subinguinal varicocelectomy.

Mahdi, Mohammed / Majzoub, Ahmad / Elbardisi, Haitham / Arafa, Mohamed / Khalafalla, Kareim / Al Said, Sami / El Ansari, Walid

Arab journal of urology

2023 Volume 21, Issue 3, Page(s) 190–197

Abstract: ... included. Patients were grouped into: Group A (kg/m: Results: Patients' mean age was 35.87 ± 8.17 years ...

Abstract	Background: Few studies assessed the relationships between BMI and post varicocelectomy semen quality and fertility potential and they reported inconsistent findings. Objective: To assess the association of BMI with semen parameters and reproductive hormones before and after microsurgical varicocelectomy. Materials and methods: Retrospective chart review in a tertiary infertility center. Of 1170 patients with clinical varicocele during the study period (8 years), 813 patients were eligible and included. Patients were grouped into: Group A (kg/m Results: Patients' mean age was 35.87 ± 8.17 years. Higher-grade varicocele was significantly more prevalent in the lower BMI groups. BMI was significantly negatively correlated with preoperative sperm concentration, total motility progressive motility and total motile sperm count. Pre-operatively, sperm concentration, total motility, progressive motility and total motile sperm count showed significant differences between BMI groups, where higher BMI (Groups C and D) exhibited the poorest semen parameters. Postoperatively, all groups showed significant improvement in sperm concentration compared with pre-operative values. However, total and progressive motility were significantly improved in Groups A, B and C, while in Group D (highest BMI), total motility improved clinically but not statistically, progressive motility did not display improvement, and total motile sperm count was significantly improved only in Groups B and C. Postoperatively, mean improvements in semen parameters across the BMI groups were not significantly different, except for morphology, which improved significantly more in the less obese patients. Conclusion: For infertile patients with clinical varicocele undergoing micro-surgical varicocelectomy, BMI appears not to impact the improvements across most of the semen parameters and hormones. The procedure might improve the fertility potential.
Language	English
Publishing date	2023-05-09
Publishing country	United States
Document type	Journal Article
ZDB-ID	2631788-6
ISSN	2090-598X
ISSN	2090-598X
DOI	10.1080/2090598X.2023.2206336
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Article ; Online: Research is needed into the role of preoperative HbA1c screening in cost control.

Walid, M Sami

Journal of hospital medicine

2010 Volume 5, Issue 6, Page(s) E8

MeSH term(s)	Cost-Benefit Analysis ; Diabetes Complications/prevention & control ; Diabetes Mellitus/blood ; Diabetes Mellitus/diagnosis ; Diabetes Mellitus/economics ; Glycated Hemoglobin A/analysis ; Humans ; Postoperative Complications/prevention & control ; Preoperative Care/methods
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2010-07
Publishing country	United States
Document type	Letter
ZDB-ID	2233783-0
ISSN	1553-5606 ; 1553-5592
ISSN (online)	1553-5606
ISSN	1553-5592
DOI	10.1002/jhm.685
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Zs.A 6276: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MO 542: Show issues

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Article ; Online: Biocomposite Coatings Delay Senescence in Stored Diospyros kaki Fruits by Regulating Antioxidant Defence Mechanism and Delaying Cell Wall Degradation

Saleem, Muhammad Shahzad / Ejaz, Shaghef / Mosa, Walid F. A. / ʻAlī, Sājid / Sardar, Hasan / Ali, Muhammad Moaaz / Ullah, Sami / Ali, Hayssam M. / Lisek, Anna / Anjum, Muhammad Akbar

Horticulturae. 2023 Mar. 07, v. 9, no. 3

2023

Abstract: Climacteric rise in the rate of respiration and ethylene production in harvested persimmon (Diospyros kaki) fruits leads to early onset of fruit tissue senescence. Therefore, this study was carried out to maintain the quality of stored persimmons by ... ...

Abstract	Climacteric rise in the rate of respiration and ethylene production in harvested persimmon (Diospyros kaki) fruits leads to early onset of fruit tissue senescence. Therefore, this study was carried out to maintain the quality of stored persimmons by using edible coatings. For this purpose, Aloe vera gel was combined with food hydrocolloids, gum arabic or tragacanth gum, and applied on persimmon fruits that were stored for 20 days at 20 ± 1 °C and 80–85% RH. Biocomposite coatings, compared to control, remarkably reduced weight loss, decay incidence, respiration rate, ethylene production, electrolyte leakage, malondialdehyde, H₂O₂ and superoxide anion content in stored fruits. The use of composite coatings inhibited colour change by reducing the accumulation of total carotenoids, maintained higher antioxidative enzymes activity and suppressed the activity of cell wall degrading enzymes, resultantly preserving cell wall components. Composite coated fruits exhibited the least change in biochemical attributes and higher sensory scores in comparison with non-coated fruits at the end of the storage period. In conclusion, Aloe vera gel/gum arabic was the most effective coating treatment before storing persimmons.
Keywords	Aloe vera ; Diospyros kaki ; antioxidant activity ; biocomposites ; carotenoids ; cell respiration ; cell walls ; climacteric fruits ; color ; electrolyte leakage ; ethylene production ; gels ; gum arabic ; gum tragacanth ; hydrocolloids ; malondialdehyde ; persimmons ; storage time ; superoxide anion ; weight loss
Language	English
Dates of publication	2023-0307
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article ; Online
ZDB-ID	2813983-5
ISSN	2311-7524
ISSN	2311-7524
DOI	10.3390/horticulturae9030351
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Investigation of physical properties and carbon dioxide solubility in tetramethylammonium bromide and tetraethylammonium bromide ionic liquids solutions

Rather, Sami-ullah / Sulaimon, Aliyu Adebayo / Shariff, Azmi M. / Qāsim ʻAlī Nīshāpūrī / Bamufleh, Hisham Saeed / Alhumade, Hesham Abdulhamed / Saeed, Usman / Al-Alayah, Walid

Chemosphere. 2023 Oct., v. 337 p.139290-

2023

Abstract: Carbon dioxide is a major greenhouse gas that is responsible for global warming and renders harmful effects on the atmosphere. The unconstrained release of CO₂ into the atmosphere should be prevented and various techniques have been developed in this ... ...

Abstract	Carbon dioxide is a major greenhouse gas that is responsible for global warming and renders harmful effects on the atmosphere. The unconstrained release of CO₂ into the atmosphere should be prevented and various techniques have been developed in this regard to capture CO₂ using different solvents and other compounds. Ionic liquids are a suitable candidate to capture CO₂ due to their better solubility behaviour. In this work, two ionic liquids namely tetramethylammonium bromide (TMAB) and tetraethylammonium bromide (TEAB) are employed experimentally to capture CO₂ and investigate their solubility behaviour. The study is performed at the temperature values of 303 K, 313 K, and 323 K and the pressure values of 5, 10, 15, and 20 bar equivalent to 0.5, 1.0, 1.5, and 2.0 MPa respectively. The concentrations of both ionic liquid solutions are 2.5 wt%, 5.0 wt%, and 10.0 wt%. The solubility results are considered in terms of mol fraction which is the ratio of moles of CO₂ captured per moles of ionic liquid. The density and viscosity values are also determined for both compounds at respective conditions. COSMO-RS is used to generate the sigma profile, sigma surface, and Henry's constant of the ions involved in the study. CO₂ is found to be soluble in both ionic liquids, but TEAB showed better solubility behaviour as compared to TMAB. The solubility of CO₂ is found to be increasing with the increase in pressure while it decreases with the increase in temperature.
Keywords	carbon dioxide ; greenhouse gases ; ionic liquids ; solubility ; temperature ; tetraethylammonium compounds ; tetramethylammonium compounds ; viscosity ; CO2 solubility ; Density ; Tetramethylammonium bromide ; Tetraethylammonium bromide
Language	English
Dates of publication	2023-10
Publishing place	Elsevier Ltd
Document type	Article ; Online
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2023.139290
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Article ; Online: Prediction of carbon-dioxide activity coefficient for solubility in ionic liquids using multi-non-linear regression analysis.

Rather, Sami-Ullah / Shariff, Azmi M / Sulaimon, Aliyu Adebayo / Bamufleh, Hisham S / Qasim, Ali / Saad Khan, Muhammad / Alhumade, Hesham / Saeed, Usman / M Alalayah, Walid

Chemosphere

2022 Volume 311, Issue Pt 2, Page(s) 137102

Abstract: Activity coefficient values offer insight into the intermolecular interactions between the solute and the solvent and the deviation from the ideal behavior. ... ...

Abstract	Activity coefficient values offer insight into the intermolecular interactions between the solute and the solvent and the deviation from the ideal behavior. CO
Language	English
Publishing date	2022-11-02
Publishing country	England
Document type	Journal Article
ZDB-ID	120089-6
ISSN	1879-1298 ; 0045-6535 ; 0366-7111
ISSN (online)	1879-1298
ISSN	0045-6535 ; 0366-7111
DOI	10.1016/j.chemosphere.2022.137102
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Article ; Online: Schistosoma mansoni and soil-transmitted helminths among schoolchildren in An-Nadirah District, Ibb Governorate, Yemen after a decade of preventive chemotherapy.

Al-Murisi, Walid M S / Al-Mekhlafi, Abdulsalam M / Mahdy, Mohammed A K / Al-Haidari, Sami Ahmed / Annuzaili, Dhekra A / Thabit, Ahmed Ali Qaid

PloS one

2022 Volume 17, Issue 8, Page(s) e0273503

Abstract: The Ministry of Public Health in Yemen continues the implementation of school and community-based preventive chemotherapy with praziquantel and albendazole for the control and elimination of schistosomiasis and soil-transmitted helminths (STH). The ... ...

Abstract	The Ministry of Public Health in Yemen continues the implementation of school and community-based preventive chemotherapy with praziquantel and albendazole for the control and elimination of schistosomiasis and soil-transmitted helminths (STH). The latest remapping to update the distribution of schistosomiasis and STH was conducted seven years ago. This study aimed to estimate the prevalence, intensity and associated risk factors of Schistosoma mansoni and STH among schoolchildren in An-Nadirah District, Ibb Governorate, Yemen. A cross-sectional study was carried out among schoolchildren aged 6-15 years in four selected schools. Biological, demographic, socioeconomic and environmental data were collected using a pre-tested questionnaire. S. mansoni and STH eggs were detected and counted by the microscopic examination of Kato-Katz fecal smears. Out of 417 schoolchildren, 17.0% were infected with at least one intestinal helminth. Prevalence of S. mansoni and STH were 6.5% and 9.1%, respectively. The most prevalent parasite among STH was Ascaris lumbricoides (8.4%). Unemployed fathers (Adjusted Odds Ratio (AOR) = 3.2; 95% Confidence interval (CI): 1.23, 8.52; P = 0.018), eating exposed food (AOR: 2.9; 95%CI = 1.24, 6.89; P = 0.014), not washing hands before eating and after defecation (AOR: 4.8; 95%CI = 1.77, 12.81; P = 0.002), and schools located close to water stream (AOR: 22.1; 95%CI = 5.12, 95.46; P <0.001) were independent risk factors of ascariasis. Swimming in ponds/stream (AOR: 3.9; 95%CI = 1.63, 9.55; P = 0.002), and schools close to the stream (AOR: 24.7; 95%CI = 3.05, 200.07; P = 0.003) were independent risk factors of intestinal schistosomiasis. The present study does not indicate a reduction in the prevalence of intestinal schistosomiasis in this rural area since the latest remapping conducted in 2014, although ascariasis was reduced by half. The prevalence of the two parasites was highly focal in areas close to the valley, suggesting a significant role of the stream in sustaining and accelerating the parasitic infection. Children practicing swimming and having poor hygienic practices were at high exposure to S. mansoni and A. lumbricoides, respectively. Water, Sanitation and Hygiene intervention, school-based health education, and snail control, in addition to mass drug administration, will help in the interruption of transmission of schistosomiasis and STH.
MeSH term(s)	Animals ; Ascariasis/epidemiology ; Child ; Cross-Sectional Studies ; Feces/parasitology ; Helminthiasis/drug therapy ; Helminthiasis/epidemiology ; Helminthiasis/prevention & control ; Helminths ; Humans ; Prevalence ; Schistosoma mansoni ; Schistosomiasis/epidemiology ; Schistosomiasis mansoni/drug therapy ; Schistosomiasis mansoni/epidemiology ; Schistosomiasis mansoni/prevention & control ; Soil/parasitology ; Water ; Yemen/epidemiology
Chemical Substances	Soil ; Water (059QF0KO0R)
Language	English
Publishing date	2022-08-25
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2267670-3
ISSN	1932-6203 ; 1932-6203
ISSN (online)	1932-6203
ISSN	1932-6203
DOI	10.1371/journal.pone.0273503
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