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Book ; Online ; E-Book: Utilities and industrial history

Wilson, John F. / Toms, Steven / Jones, Ian G.

(Routledge Focus on Industrial History)

2022

Abstract: This shortform book presents key peer-reviewed research selected by expert series editors and contextualised by new analysis on the industrial history of delivering utilities. With contributions on the strengths and weaknesses of the creation of ... ...

Author's details	edited by John F. Wilson, Steven Toms and Ian G. Jones
Series title	Routledge Focus on Industrial History
Abstract	"This shortform book presents key peer-reviewed research selected by expert series editors and contextualised by new analysis on the industrial history of delivering utilities. With contributions on the strengths and weaknesses of the creation of electricity networks, the organisation and performance of Britain's nationalised gas industry, and the environmental impact of delivering water and removing waste water, this volume provides an array of fascinating insights into industrial history. Of interest to business and economic historians, this shortform book also provides analysis and illustrative case-studies that will be valuable reading across the social sciences"--
Keywords	Electric utilities ; Gas industry
Subject code	363.60973
Language	English
Size	1 online resource (115 pages)
Publisher	Routledge, Taylor & Francis Group
Publishing place	London, UK ; New York, NY
Document type	Book ; Online ; E-Book
Remark	Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
ISBN	1-00-333150-5 ; 1-003-33150-5 ; 1-000-77457-0 ; 1-03-236350-9 ; 978-1-00-333150-6 ; 978-1-003-33150-6 ; 978-1-000-77457-3 ; 978-1-03-236350-9
Database	ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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Article ; Online: Realising the potential of correlates of protection for vaccine development, licensure and use: short summary.

King, Deborah F / Groves, Helen / Weller, Charlie / Jones, Ian / Cramer, Jakob P / Gilbert, Peter B / Goldblatt, David / Gruber, Marion F / Kampmann, Beate / Maïga, Diadié / Pasetti, Marcela F / Plotkin, Stanley A / Precioso, Alexander / Wassie, Liya / Wittke, Frederick / Kaslow, David C

NPJ vaccines

2024 Volume 9, Issue 1, Page(s) 82

Language	English
Publishing date	2024-04-29
Publishing country	England
Document type	Journal Article
ISSN	2059-0105
ISSN (online)	2059-0105
DOI	10.1038/s41541-024-00872-6
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Article ; Online: Key subphenotypes of bipolar disorder are differentially associated with polygenic liabilities for bipolar disorder, schizophrenia, and major depressive disorder.

Song, Jie / Jonsson, Lina / Lu, Yi / Bergen, Sarah E / Karlsson, Robert / Smedler, Erik / Gordon-Smith, Katherine / Jones, Ian / Jones, Lisa / Craddock, Nick / Sullivan, Patrick F / Lichtenstein, Paul / Di Florio, Arianna / Landén, Mikael

Molecular psychiatry

2024

Abstract: Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It remains unclear how subphenotypes associate with genetic loadings of BD and related psychiatric disorders. We investigated associations between the subphenotypes ... ...

Abstract	Bipolar disorder (BD) features heterogenous clinical presentation and course of illness. It remains unclear how subphenotypes associate with genetic loadings of BD and related psychiatric disorders. We investigated associations between the subphenotypes and polygenic risk scores (PRS) for BD, schizophrenia, and major depressive disorder (MDD) in two BD cohorts from Sweden (N = 5180) and the UK (N = 2577). Participants were assessed through interviews and medical records for inter-episode remission, psychotic features during mood episodes, global assessment of functioning (GAF, function and symptom burden dimensions), and comorbid anxiety disorders. Meta-analyses based on both cohorts showed that inter-episode remission and GAF-function were positively correlated with BD-PRS but negatively correlated with schizophrenia-PRS (SCZ-PRS) and MDD-PRS. Moreover, BD-PRS was negatively, and MDD-PRS positively, associated with the risk of comorbid anxiety disorders. Finally, SCZ-PRS was positively associated with psychotic symptoms during mood episodes. Assuming a higher PRS of certain psychiatric disorders in cases with a positive family history, we further tested the associations between subphenotypes in index BD people and occurrence of BD, schizophrenia, or MDD in their relatives using Swedish national registries. BD patients with a relative diagnosed with BD had: (1) higher GAF and lower risk of comorbid anxiety than those with a relative diagnosed with schizophrenia or MDD, (2) lower risk of psychotic symptoms than those with a relative diagnosed with schizophrenia. Our findings shed light on the genetic underpinnings of the heterogeneity in clinical manifestations and course of illness in BD, which ultimately provide insights for developing personalized approaches to the diagnosis and treatment.
Language	English
Publishing date	2024-02-14
Publishing country	England
Document type	Journal Article
ZDB-ID	1330655-8
ISSN	1476-5578 ; 1359-4184
ISSN (online)	1476-5578
ISSN	1359-4184
DOI	10.1038/s41380-024-02448-1
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Article ; Online: Calculated and Empirical Values of Vibronic Transition Dipole Moments of Reactive Chemical Intermediates for Determination of Concentrations.

Jones, Ian W / Bersson, Jonathan S / Liu, Jinjun / Sharma, Ketan / Vasilyev, Oleg A / Miller, Terry A / Stanton, John F

The journal of physical chemistry. A

2023 Volume 127, Issue 21, Page(s) 4670–4681

Abstract: Absorption spectroscopy has long been known as a technique for making molecular concentration measurements and has received enhanced visibility in recent years with the advent of new techniques, like cavity ring-down spectroscopy, that have increased its ...

Abstract	Absorption spectroscopy has long been known as a technique for making molecular concentration measurements and has received enhanced visibility in recent years with the advent of new techniques, like cavity ring-down spectroscopy, that have increased its sensitivity. To apply the method, it is necessary to have a known molecular absorption cross section for the species of interest, which typically is obtained by measurements of a standard sample of known concentration. However, this method fails if the species is highly reactive, and indirect means for attaining the cross section must be employed. The HO
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article
ISSN	1520-5215
ISSN (online)	1520-5215
DOI	10.1021/acs.jpca.3c01584
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Article ; Online: Robotic colorectal surgery in the emergent diverticulitis setting: is it safe? A review of large national database.

Curfman, Karleigh R / Jones, Ian F / Conner, Jeffrey R / Neighorn, Christopher C / Wilson, Ryan K / Rashidi, Laila

International journal of colorectal disease

2023 Volume 38, Issue 1, Page(s) 142

Abstract: Background: As robotic colorectal surgery continues to advance in conjunction with improved recovery protocols, we began implementing robotic surgery (RS) as an option for emergent diverticulitis surgery. Our hospital system utilizes the Da Vinci Xi ... ...

Abstract	Background: As robotic colorectal surgery continues to advance in conjunction with improved recovery protocols, we began implementing robotic surgery (RS) as an option for emergent diverticulitis surgery. Our hospital system utilizes the Da Vinci Xi system, and staff are required to undergo training, making emergent colorectal surgery a feasible option. However, it is essential to determine the safety with reproducibility of our experiences. Methods: A de-identified retrospective review was performed of Intuitive's national database which obtained data from 262 facilities from January 2018 through December 2021. This identified over 22,000 emergent colorectal surgeries. Of those, over 2500 were performed for diverticulitis in which 126 were RS, 446 laparoscopic surgery (LS), and 1952 open surgery (OS). Clinical outcome metrics including conversion rates, anastomotic leaks, intensive care unit (ICU) admissions, length of stay, mortality, and readmissions were obtained. The cohort was defined by patients who were seen in the emergency department (ED) with diverticulitis and proceeded to have a sigmoid colectomy within 24 h of ED arrival. Results: RS was associated with increased operating time (RS 262, LS 207, OS 182 min), but data has shown many benefits of emergent RS compared to OS. We identified significant decreases in ICU admission rates (OS 19.0%, RS 9.5%, p = 0.01) and anastomotic leak rates (OS 4.4%, RS 0.8%, p = 0.04), with borderline improvement in overall length of stay (OS 9.9, RS 8.9 days, p = 0.05). When compared with LS, RS showed many comparable results. However, RS witnessed a statistically significant improvement in anastomotic leak rates (LS 4.5%, RS 0.8%, p = 0.04). Importantly, there was a striking difference in conversion rates to OS. LS converted over 28.7% of cases to OS, whereas RS only converted 7.9%, p = 0.000005. Conclusion: Given these findings, RS is another MIS tool that could be a safe and feasible option for the acute management of emergent diverticulitis.
MeSH term(s)	Humans ; Robotic Surgical Procedures/adverse effects ; Anastomotic Leak ; Colorectal Surgery ; Reproducibility of Results ; Diverticulitis/surgery
Language	English
Publishing date	2023-05-25
Publishing country	Germany
Document type	Review ; Journal Article
ZDB-ID	84975-3
ISSN	1432-1262 ; 0179-1958
ISSN (online)	1432-1262
ISSN	0179-1958
DOI	10.1007/s00384-023-04436-3
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Article ; Online: How can the findings of the EMAX trial on long-acting bronchodilation in chronic obstructive pulmonary disease be applied in the primary care setting?

Kerwin, Edward M / Jones, Paul W / Bjermer, Leif H / Maltais, François / Boucot, Isabelle H / Naya, Ian P / Lipson, David A / Compton, Chris / Tombs, Lee / Vogelmeier, Claus F

Chronic respiratory disease

2023 Volume 20, Page(s) 14799731231202257

Abstract: This review addresses outstanding questions regarding initial pharmacological management of chronic obstructive pulmonary disease (COPD). Optimizing initial treatment improves clinical outcomes in symptomatic patients, including those with low ... ...

Abstract	This review addresses outstanding questions regarding initial pharmacological management of chronic obstructive pulmonary disease (COPD). Optimizing initial treatment improves clinical outcomes in symptomatic patients, including those with low exacerbation risk. Long-acting muscarinic antagonist/long-acting β
MeSH term(s)	Humans ; Administration, Inhalation ; Adrenergic beta-2 Receptor Agonists/therapeutic use ; Bronchodilator Agents/therapeutic use ; Primary Health Care ; Pulmonary Disease, Chronic Obstructive ; Clinical Trials as Topic
Chemical Substances	Adrenergic beta-2 Receptor Agonists ; Bronchodilator Agents
Language	English
Publishing date	2023-10-06
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2211488-9
ISSN	1479-9731 ; 1479-9723
ISSN (online)	1479-9731
ISSN	1479-9723
DOI	10.1177/14799731231202257
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Article ; Online: Complex Polyheterocycles and the Stereochemical Reassignment of Pileamartine A via Aza-Heck Triggered Aryl C-H Functionalization Cascades.

Jones, Benjamin T / García-Cárceles, Javier / Caiger, Lewis / Hazelden, Ian R / Lewis, Richard J / Langer, Thomas / Bower, John F

Journal of the American Chemical Society

2021 Volume 143, Issue 38, Page(s) 15593–15598

Abstract: Structurally complex benzo- and spiro-fused N-polyheterocycles can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions. The method ... ...

Abstract	Structurally complex benzo- and spiro-fused N-polyheterocycles can be accessed via intramolecular Pd(0)-catalyzed alkene 1,2-aminoarylation reactions. The method uses
Language	English
Publishing date	2021-09-21
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3155-0
ISSN	1520-5126 ; 0002-7863
ISSN (online)	1520-5126
ISSN	0002-7863
DOI	10.1021/jacs.1c08615
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Article ; Online: A National Map of NCI-Designated Cancer Center Catchment Areas on the 50th Anniversary of the Cancer Centers Program.

DelNero, Peter F / Buller, Ian D / Jones, Rena R / Tatalovich, Zaria / Vanderpool, Robin C / Ciolino, Henry P / Croyle, Robert T

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology

2022 Volume 31, Issue 5, Page(s) 965–971

Abstract: Background: In 1971, the National Cancer Act created a process to recognize the leadership, facilities, and research efforts at cancer centers throughout the United States. Toward this goal, each NCI-designated cancer center defines and describes a ... ...

Abstract	Background: In 1971, the National Cancer Act created a process to recognize the leadership, facilities, and research efforts at cancer centers throughout the United States. Toward this goal, each NCI-designated cancer center defines and describes a catchment area to which they tailor specific scientific and community engagement activities. Methods: The geographically defined catchment areas of 63 NCI-designated comprehensive and clinical cancer centers are collated and presented visually. In addition, the NCI-designated cancer center catchment areas are geographically linked with publicly available data sources to aggregate sociodemographic and epidemiologic characteristics across the NCI Cancer Centers Program. Results: The national map portrays the size, shape, and locations for 63 catchment areas of the 71 NCI-designated cancer centers. The findings illustrate the geographic extent of the NCI Cancer Centers Program during the 50th anniversary of the National Cancer Act. Conclusions: NCI-designated cancer centers occupy a prominent role in the cancer control ecosystem and continue to perform research to address the burden of cancer among their local communities. The strength of the NCI Cancer Centers Program is partly defined by the scope, quality, and impact of community outreach and engagement activities in the catchment areas. Impact: The collation and geographic presentation of the distinct, but complementary, NCI-designated cancer center catchment areas are intended to support future research and community outreach activities among NCI-designated cancer centers. See related commentary by Vadaparampil and Tiro, p. 952.
MeSH term(s)	Anniversaries and Special Events ; Catchment Area, Health ; Ecosystem ; Humans ; National Cancer Institute (U.S.) ; Neoplasms/prevention & control ; Neoplasms/therapy ; United States/epidemiology
Language	English
Publishing date	2022-01-31
Publishing country	United States
Document type	Research Support, N.I.H., Intramural ; Journal Article ; Comment
ZDB-ID	1153420-5
ISSN	1538-7755 ; 1055-9965
ISSN (online)	1538-7755
ISSN	1055-9965
DOI	10.1158/1055-9965.EPI-21-1230
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Article: Assessing the validity of a self-reported clinical diagnosis of schizophrenia.

Woolway, Grace E / Legge, Sophie E / Lynham, Amy / Smart, Sophie E / Hubbard, Leon / Daniel, Ellie R / Pardiñas, Antonio F / Escott-Price, Valentina / O'Donovan, Michael C / Owen, Michael J / Jones, Ian R / Walters, James Tr

medRxiv : the preprint server for health sciences

2023

Abstract: Background: Diagnoses in psychiatric research can be derived from various sources. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia.: Methods: The study included 3,029 clinically ascertained participants with ... ...

Abstract	Background: Diagnoses in psychiatric research can be derived from various sources. This study assesses the validity of a self-reported clinical diagnosis of schizophrenia. Methods: The study included 3,029 clinically ascertained participants with schizophrenia or psychotic disorders diagnosed by self-report and/or research interview and 1,453 UK Biobank participants with self-report and/or medical record diagnosis of schizophrenia or schizoaffective disorder depressed-type (SA-D). We assessed positive predictive values (PPV) of self-reported clinical diagnoses against research interview and medical record diagnoses. We compared polygenic risk scores (PRS) and phenotypes across diagnostic groups, and compared the variance explained by schizophrenia PRS to samples in the Psychiatric Genomics Consortium (PGC). Results: In the clinically ascertained sample, the PPV of self-reported schizophrenia to a research diagnosis of schizophrenia was 0.70, which increased to 0.81 when benchmarked against schizophrenia or SA-D. In UK Biobank, the PPV of self-reported schizophrenia to a medical record diagnosis was 0.74. Compared to self-report participants, those with a research diagnosis were younger and more likely to have a high school qualification (clinically ascertained sample) and those with a medical record diagnosis were less likely to be employed or have a high school qualification (UK Biobank). Schizophrenia PRS did not differ between participants that had a diagnosis from self-report, research diagnosis or medical record diagnosis. Polygenic liability r Conclusions: Self-report measures of schizophrenia are justified in research to maximise sample size and representativeness, although within sample validation of diagnoses is recommended.
Language	English
Publishing date	2023-12-08
Publishing country	United States
Document type	Preprint
DOI	10.1101/2023.12.06.23299622
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Article ; Online: Developing a patient decision aid for Achilles tendon rupture management: a mixed-methods study.

Gan, Jan F L / McKay, Marnee J / Jones, Caitlin M P / Harris, Ian A / McCaffery, Kirsten / Thompson, Rachel / Hoffmann, Tammy C / Adie, Sam / Maher, Christopher G / Zadro, Joshua R

BMJ open

2023 Volume 13, Issue 6, Page(s) e072553

Abstract: Objective: To develop and user-test a patient decision aid portraying the benefits and harms of non-surgical management and surgery for Achilles tendon ruptures.: Design: Mixed methods.: Setting: A draft decision aid was developed using guidance ... ...

Abstract	Objective: To develop and user-test a patient decision aid portraying the benefits and harms of non-surgical management and surgery for Achilles tendon ruptures. Design: Mixed methods. Setting: A draft decision aid was developed using guidance from a multidisciplinary steering group and existing patient decision aids. Participants were recruited through social media. Participants: People who have previously sustained an Achilles tendon rupture and health professionals who manage these patients. Primary and secondary outcomes: Semi-structured interviews and questionnaires were used to gather feedback on the decision aid from health professionals and patients who had previously suffered an Achilles tendon rupture. The feedback was used to redraft the decision aid and assess acceptability. An iterative cycle of interviews, redrafting according to feedback and further interviews was used. Interviews were analysed using reflexive thematic analysis. Questionnaire data were analysed descriptively. Results: We interviewed 18 health professionals (13 physiotherapists, 3 orthopaedic surgeons, 1 chiropractor, 1 sports medicine physician) and 15 patients who had suffered an Achilles tendon rupture (median time since rupture was 12 months). Most health professionals and patients rated the aid's acceptability as good-excellent. Interviews showcased agreement among health professionals and patients on most aspects of the decision aid: introduction, treatment options, comparing benefits and harms, questions to ask health professionals and formatting. However, health professionals had differing views on details about Achilles tendon retraction distance, factors that modify the risk of harms, treatment protocols and evidence on benefits and harms. Conclusion: Our patient decision aid is an acceptable tool to both patients and health professionals, and our study highlights the views of key stakeholders on important information to consider when developing a patient decision aid for Achilles tendon rupture management. A randomised controlled trial evaluating the impact of this tool on the decision-making of people considering Achilles tendon surgery is warranted.
MeSH term(s)	Humans ; Achilles Tendon/surgery ; Physicians ; Ankle Injuries ; Physical Therapists ; Tendon Injuries/surgery ; Decision Support Techniques
Language	English
Publishing date	2023-06-14
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2599832-8
ISSN	2044-6055 ; 2044-6055
ISSN (online)	2044-6055
ISSN	2044-6055
DOI	10.1136/bmjopen-2023-072553
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