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  1. Article: The Use of Human Tissues for Research: What Investigators Need to Know.

    Bledsoe, Marianna J / Grizzle, William E

    Alternatives to laboratory animals : ATLA

    2022  Volume 50, Issue 4, Page(s) 265–274

    Abstract: While laboratory animals are necessary for some aspects of the development of scientific and biomedical advances, including those of precision medicine, the use of human tissues is necessary in order to explore the findings and ensure that they are ... ...

    Abstract While laboratory animals are necessary for some aspects of the development of scientific and biomedical advances, including those of precision medicine, the use of human tissues is necessary in order to explore the findings and ensure that they are relevant to human systems. Many sources of human tissues exist, but researchers - particularly those making the transition from animal to human systems - may not be aware of how best to find quality sources of human tissues or how best to use them in their research. In this article, we discuss the advantages of using human tissues in research. In addition, we highlight some of the major advances made possible through the use of human tissue, and describe how human tissue is collected for research. We discuss the various types of bioresources that make human tissue available, and advise on how investigators can find and use appropriate bioresources to support their research - with the hope that this information will help facilitate the transition from research on animals to research using human tissues, as rapidly as is practicable.
    MeSH term(s) Animals ; Biological Specimen Banks ; Biomedical Research ; Humans
    Language English
    Publishing date 2022-07-08
    Publishing country England
    Document type Journal Article
    ZDB-ID 605800-0
    ISSN 0261-1929
    ISSN 0261-1929
    DOI 10.1177/02611929221107933
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3391: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  2. Book: Translational pathology of early cancer

    Srivastava, Sudhir / Grizzle, William E.

    (Cancer biomarkers ; 9,1/6)

    2011  

    Author's details guest ed.: Sudhir Srivastava and William E. Grizzle
    Series title Cancer biomarkers ; 9,1/6
    Collection
    Language English
    Size 552 S. : Ill., graph. Darst.
    Publisher IOS Press
    Publishing place Amsterdam
    Publishing country Netherlands
    Document type Book
    HBZ-ID HT017085691
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    Zs A 6127 -9- verfügbar in Königswinter Königswinter

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  3. Article ; Online: Issues in the Use of Human Tissues to Support Precision Medicine.

    Grizzle, William E

    Journal of health care for the poor and underserved

    2019  Volume 30, Issue 4S, Page(s) 66–78

    Abstract: Precision medicine is an approach in which the characteristics of patients as well as their diseases are used to identify optimal therapy; it links researchers, patients, health care providers, and clinical laboratories. In precision medicine, specific ... ...

    Abstract Precision medicine is an approach in which the characteristics of patients as well as their diseases are used to identify optimal therapy; it links researchers, patients, health care providers, and clinical laboratories. In precision medicine, specific molecular characteristics of an untreatable cancer can be targeted by specific molecular-based therapy. Access to high-quality human tissues is necessary to determine many characteristics of patients and their diseases (such as targetable molecules). There are ethical issues in using human tissues in precision medicine, including informed consent and confidentiality, optimal utilization, quality of tissues, and minimization of bias. When human tissues are obtained for patient therapy, the bioresource should be a component certified by Clinical Laboratory Improvement Amendments. For precision medicine to benefit medically underserved populations requires extensive focused research, planning, and resources, some of which are currently unavailable at rural and other sites where care is provided to underserved populations.
    MeSH term(s) Confidentiality/standards ; Humans ; Informed Consent/standards ; Medically Underserved Area ; Minority Groups ; Neoplasms/pathology ; Precision Medicine/ethics ; Precision Medicine/methods ; Precision Medicine/standards ; Rural Population ; Tissue Banks/ethics ; Tissue Banks/organization & administration ; Tissue Banks/standards
    Language English
    Publishing date 2019-11-14
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 1142637-8
    ISSN 1548-6869 ; 1049-2089
    ISSN (online) 1548-6869
    ISSN 1049-2089
    DOI 10.1353/hpu.2019.0117
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3605: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 493: Show issues

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  4. Article ; Online: Metrics for the Evaluation of Bioresources: Tell Us the Whole Story.

    Bledsoe, Marianna J / Watson, Peter H / Grizzle, William E

    Biopreservation and biobanking

    2023  Volume 21, Issue 3, Page(s) 223–224

    Language English
    Publishing date 2023-06-20
    Publishing country United States
    Document type Editorial
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2023.29123.editorial
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Biobank: What's in a Name?

    Watson, Peter H / Hewitt, Robert E / Catchpoole, Daniel R / Grizzle, William E

    Biopreservation and biobanking

    2019  Volume 17, Issue 3, Page(s) 204–208

    MeSH term(s) Biological Specimen Banks ; Biomedical Research ; Specimen Handling ; Terminology as Topic
    Language English
    Publishing date 2019-06-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2019.29053.mjb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Missed Opportunities and Lost Lives: Consequences of Some Proposed Changes to Regulations on Research with Human Tissues--Letter.

    Grizzle, William E

    Clinical cancer research : an official journal of the American Association for Cancer Research

    2015  Volume 21, Issue 23, Page(s) 5404–5405

    MeSH term(s) Ethics, Research ; Humans ; Research/legislation & jurisprudence ; Specimen Handling ; Tissue Banks/ethics ; Tissue Banks/legislation & jurisprudence
    Language English
    Publishing date 2015-12-01
    Publishing country United States
    Document type Letter
    ZDB-ID 1225457-5
    ISSN 1557-3265 ; 1078-0432
    ISSN (online) 1557-3265
    ISSN 1078-0432
    DOI 10.1158/1078-0432.CCR-15-2513
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4223: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article ; Online: Biospecimen Utilization: A Critical Challenge in Global Bioresource/Biobanking Operations.

    Bledsoe, Marianna J / Grizzle, William E

    Biopreservation and biobanking

    2019  Volume 17, Issue 3, Page(s) 201–203

    MeSH term(s) Biological Specimen Banks ; Humans ; Internationality ; Procedures and Techniques Utilization ; Specimen Handling
    Language English
    Publishing date 2019-06-13
    Publishing country United States
    Document type Introductory Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2019.29054.mjb
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Commentary on Improving Biospecimen Utilization by Classic Biobanks: Identifying Past and Minimizing Future Mistakes.

    Grizzle, William E / Sexton, Katherine C

    Biopreservation and biobanking

    2018  Volume 17, Issue 3, Page(s) 243–247

    Abstract: Many classic biobanks collect more human tissues than they distribute, leading to increased inventories, unnecessary storage, increased expenses, and reduced chargeback income. This situation is a result of biobanks operating without well-defined goals, ... ...

    Abstract Many classic biobanks collect more human tissues than they distribute, leading to increased inventories, unnecessary storage, increased expenses, and reduced chargeback income. This situation is a result of biobanks operating without well-defined goals, having incorrect views of the potential number of investigators who will utilize specimens, and collection of biospecimens without adequately considering the need for specific tissues by investigators. These deficiencies frequently lead to unrealistic plans for biospecimen utilization and biobanks that are larger than necessary. For example, tissue collections usually are not periodically compared with biospecimen distribution and modified accordingly. An ethical issue has arisen as to the acceptability of consenting patients for the use of their tissues in research without a realistic planned approach to distribution of the biospecimens and their ultimate utilization in supporting biomedical research. These issues and how to minimize them are discussed in this commentary focused on how classic biobanks can improve utilization of their biospecimens.
    MeSH term(s) Biological Specimen Banks ; Biomedical Research ; Facilities and Services Utilization ; Humans
    Language English
    Publishing date 2018-12-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2593993-2
    ISSN 1947-5543 ; 1947-5535
    ISSN (online) 1947-5543
    ISSN 1947-5535
    DOI 10.1089/bio.2018.0080
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Hallmarks and Determinants of Oncogenic Translation Revealed by Ribosome Profiling in Models of Breast Cancer.

    Vaklavas, Christos / Blume, Scott W / Grizzle, William E

    Translational oncology

    2020  Volume 13, Issue 2, Page(s) 452–470

    Abstract: Gene expression is extensively and dynamically modulated at the level of translation. How cancer cells prioritize the translation of certain mRNAs over others from a pool of competing mRNAs remains an open question. Here, we analyze translation in cell ... ...

    Abstract Gene expression is extensively and dynamically modulated at the level of translation. How cancer cells prioritize the translation of certain mRNAs over others from a pool of competing mRNAs remains an open question. Here, we analyze translation in cell line models of breast cancer and normal mammary tissue by ribosome profiling. We identify key recurrent themes of oncogenic translation: higher ribosome occupancy, greater variance of translational efficiencies, and preferential translation of transcriptional regulators and signaling proteins in malignant cells as compared with their nonmalignant counterpart. We survey for candidate RNA interacting proteins that could associate with the 5'untranslated regions of the transcripts preferentially translated in breast tumour cells. We identify SRSF1, a prototypic splicing factor, to have a pervasive direct and indirect impact on translation. In a representative estrogen receptor-positive and estrogen receptor-negative cell line, we find that protein synthesis relies heavily on SRSF1. SRSF1 is predominantly intranuclear. Under certain conditions, SRSF1 translocates from the nucleus to the cytoplasm where it associates with MYC and CDK1 mRNAs and upregulates their internal ribosome entry site-mediated translation. Our results point to a synergy between splicing and translation and unveil how certain RNA-binding proteins modulate the translational landscape in breast cancer.
    Language English
    Publishing date 2020-01-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2443840-6
    ISSN 1936-5233 ; 1936-5233 ; 1944-7124
    ISSN (online) 1936-5233
    ISSN 1936-5233 ; 1944-7124
    DOI 10.1016/j.tranon.2019.12.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Intraoperative Imaging in Hepatopancreatobiliary Surgery.

    Husarova, Tereza / MacCuaig, William M / Dennahy, Isabel S / Sanderson, Emma J / Edil, Barish H / Jain, Ajay / Bonds, Morgan M / McNally, Molly W / Menclova, Katerina / Pudil, Jiri / Zaruba, Pavel / Pohnan, Radek / Henson, Christina E / Grizzle, William E / McNally, Lacey R

    Cancers

    2023  Volume 15, Issue 14

    Abstract: Hepatopancreatobiliary surgery belongs to one of the most complex fields of general surgery. An intricate and vital anatomy is accompanied by difficult distinctions of tumors from fibrosis and inflammation; the identification of precise tumor margins; or ...

    Abstract Hepatopancreatobiliary surgery belongs to one of the most complex fields of general surgery. An intricate and vital anatomy is accompanied by difficult distinctions of tumors from fibrosis and inflammation; the identification of precise tumor margins; or small, even disappearing, lesions on currently available imaging. The routine implementation of ultrasound use shifted the possibilities in the operating room, yet more precision is necessary to achieve negative resection margins. Modalities utilizing fluorescent-compatible dyes have proven their role in hepatopancreatobiliary surgery, although this is not yet a routine practice, as there are many limitations. Modalities, such as photoacoustic imaging or 3D holograms, are emerging but are mostly limited to preclinical settings. There is a need to identify and develop an ideal contrast agent capable of differentiating between malignant and benign tissue and to report on the prognostic benefits of implemented intraoperative imaging in order to navigate clinical translation. This review focuses on existing and developing imaging modalities for intraoperative use, tailored to the needs of hepatopancreatobiliary cancers. We will also cover the application of these imaging techniques to theranostics to achieve combined diagnostic and therapeutic potential.
    Language English
    Publishing date 2023-07-20
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2527080-1
    ISSN 2072-6694
    ISSN 2072-6694
    DOI 10.3390/cancers15143694
    Database MEDical Literature Analysis and Retrieval System OnLINE

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