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Article ; Online: Patterns of tumour transcriptional variability.

Ng, Raymond W S / Shaffer, Sydney M

2023 Volume 618, Issue 7965, Page(s) 464–465

MeSH term(s)	Humans ; Neoplasms ; Transcriptome
Language	English
Publishing date	2023-05-31
Publishing country	England
Document type	News
ZDB-ID	120714-3
ISSN	1476-4687 ; 0028-0836
ISSN (online)	1476-4687
ISSN	0028-0836
DOI	10.1038/d41586-023-01744-0
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Zs.A 26: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Effects of mirror therapy with electrical stimulation for upper limb recovery in people with stroke: a systematic review and meta-analysis.

Pan, Hong / Liu, Tai Wa / Ng, Shamay S M / Chen, Pei Ming / Chung, Raymond C K / Lam, Stefanie S L / Li, Carol S K / Chan, Charles C C / Lai, Charles W K / Ng, Winnie W L / Tang, Maria W S / Hui, Elsie / Woo, Jean

Disability and rehabilitation

2024 , Page(s) 1–16

Abstract: Purpose: To provide updated evidence about the effects of MT with ES for recovering upper extremities motor function in people with stroke.: Methods: Systematic review and meta-analysis were completed. Methodological quality was assessed using the ... ...

Abstract	Purpose: To provide updated evidence about the effects of MT with ES for recovering upper extremities motor function in people with stroke. Methods: Systematic review and meta-analysis were completed. Methodological quality was assessed using the version 2 of the Cochrane risk-of-bias tool. The GRADE approach was employed to assess the certainty of evidence. Results: A total of 16 trials with 773 participants were included in this review. The results demonstrated that MT with ES was more effective than sham (standardized mean difference [SMD], 1.89 [1.52-2.26]) and ES alone (SMD, 0.42 [0.11-0.73]) with low quality of evidence, or MT alone (SMD, 0.47[0.04-0.89]) with low quality of evidence for improving upper extremity motor control assessed using Fugl-Meyer Assessment. MT with ES had significant improvement of (MD, 6.47 [1.92-11.01]) the upper extremity gross gripping function assessed using the Action Research Arm Test compared with MT alone with low quality of evidence. MT combined with ES was more effective than sham group (SMD, 1.17 [0.42-1.93) for improving the ability to perform activities of daily living with low quality of evidence assessed using Motor Activity Log. Conclusion: MT with ES may be effective in improving upper limb motor recovery in people with stroke.
Language	English
Publishing date	2024-02-09
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1104775-6
ISSN	1464-5165 ; 0963-8288
ISSN (online)	1464-5165
ISSN	0963-8288
DOI	10.1080/09638288.2024.2310757
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Article: Botulinum toxin A injection for post-stroke upper limb spasticity and rehabilitation practices from centers across Asian countries.

Rosales, Raymond L / Chia, Nicholas V C / Kumthornthip, Witsanu / Goh, Khean Jin / Mak, Choon Soon / Kong, Keng He / Ng, Yee Sien / Chou, Li Wei / Flordelis, M Jeanne / Do, Thuy / Maisonobe, Pascal / Li, Leonard S W / Suputtitada, Areerat

Frontiers in neurology

2024 Volume 15, Page(s) 1335365

Abstract: Purpose: Describe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings.: Methods: Subgroup analysis of a prospective, observational study (NCT01020500) of adult ... ...

Abstract	Purpose: Describe real-life practice and outcomes in the management of post-stroke upper limb spasticity with botulinum toxin A (BoNT-A) in Asian settings. Methods: Subgroup analysis of a prospective, observational study (NCT01020500) of adult patients (≥18 years) with post-stroke upper limb spasticity presenting for routine spasticity management, including treatment with BoNT-A. The primary outcome was goal attainment as assessed using goal-attainment scaling (GAS). Patients baseline clinical characteristics and BoNT-A injection parameters are also described. Results: Overall, 51 patients from Asia were enrolled. Rates of comorbid cognitive and emotional problems were relatively low. Patients tended to have more severe distal limb spasticity and to prioritize active over passive function goals. Most (94.1%) patients in the subgroup were treated with abobotulinumtoxinA. For these patients, the median total dose was 500 units, and the most frequently injected muscles were the biceps brachii (83.3%), flexor carpi radialis (72.9%), and flexor digitorum profundus (66.7%). Overall, 74.5% achieved their primary goal and the mean GAS T score after one treatment cycle was 56.0 ± 13.0, with a change from baseline of 20.9 ± 14.3 ( Conclusion: In the Asian treatment setting, BoNT-A demonstrated a clinically significant effect on goal attainment for the real-life management of upper limb spasticity following stroke.
Language	English
Publishing date	2024-04-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564214-5
ISSN	1664-2295
ISSN	1664-2295
DOI	10.3389/fneur.2024.1335365
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Article: Addressing the risk and management of cardiometabolic complications in prostate cancer patients on androgen deprivation therapy and androgen receptor axis-targeted therapy: consensus statements from the Hong Kong Urological Association and the Hong Kong Society of Uro-Oncology.

Poon, Darren M C / Tan, Guang-Ming / Chan, Kuen / Chan, Marco T Y / Chan, Tim-Wai / Kan, Raymond W M / Lam, Martin H C / Leung, Clarence L H / Wong, Kenneth C W / Kam, Kevin K H / Ng, Chi-Fai / Chiu, Peter K F

Frontiers in oncology

2024 Volume 14, Page(s) 1345322

Abstract: Background: Androgen deprivation therapy (ADT) is the foundational treatment for metastatic prostate cancer (PCa). Androgen receptor (AR) axis-targeted therapies are a new standard of care for advanced PCa. Although these agents have significantly ... ...

Abstract	Background: Androgen deprivation therapy (ADT) is the foundational treatment for metastatic prostate cancer (PCa). Androgen receptor (AR) axis-targeted therapies are a new standard of care for advanced PCa. Although these agents have significantly improved patient survival, the suppression of testosterone is associated with an increased risk of cardiometabolic syndrome. This highlights the urgency of multidisciplinary efforts to address the cardiometabolic risk of anticancer treatment in men with PCa. Methods: Two professional organizations invited five urologists, five clinical oncologists, and two cardiologists to form a consensus panel. They reviewed the relevant literature obtained by searching PubMed for the publication period from April 2013 to April 2023, to address three discussion areas: (i) baseline assessment and screening for risk factors in PCa patients before the initiation of ADT and AR axis-targeted therapies; (ii) follow-up and management of cardiometabolic complications; and (iii) selection of ADT agents among high-risk patients. The panel convened four meetings to discuss and draft consensus statements using a modified Delphi method. Each drafted statement was anonymously voted on by every panelist. Results: The panel reached a consensus on 18 statements based on recent evidence and expert insights. Conclusion: These consensus statements serve as a practical recommendation for clinicians in Hong Kong, and possibly the Asia-Pacific region, in the management of cardiometabolic toxicities of ADT or AR axis-targeted therapies in men with PCa.
Language	English
Publishing date	2024-01-31
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2649216-7
ISSN	2234-943X
ISSN	2234-943X
DOI	10.3389/fonc.2024.1345322
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Article ; Online: Surgical Treatment of Single-Level Lumbar Stenosis Is Associated with Lower 2-Year Mortality and Total Cost Compared with Nonsurgical Treatment: A Risk-Adjusted, Paired Analysis.

Hwang, Raymond W / Briggs, Catherine M / Greenwald, Scott D / Manberg, Paul J / Chamoun, Nassib G / Tromanhauser, Scott G

The Journal of bone and joint surgery. American volume

2023 Volume 105, Issue 3, Page(s) 214–222

Abstract: Background: Spine surgery has demonstrated cost-effectiveness in reducing pain and restoring function, but the impact of spine surgery relative to nonsurgical care on longer-term outcomes has been less well described. Our objective was to compare single- ...

Abstract	Background: Spine surgery has demonstrated cost-effectiveness in reducing pain and restoring function, but the impact of spine surgery relative to nonsurgical care on longer-term outcomes has been less well described. Our objective was to compare single-level surgical treatment for lumbar stenosis, with or without spondylolisthesis, and nonsurgical treatment with respect to patient mortality, resource utilization, and health-care payments over the first 2 years following initial treatment. Methods: A retrospective review of the Medicare National Database Fee for Service Files from 2011 to 2017 was performed. A 2-year prediction of mortality risk (risk stratification index, RSI) was used as a measure of patient baseline health. Patients (88%) were matched by RSI and demographics. Mortality, spine-related health-care utilization, and 2-year total Medicare payments for patients undergoing surgical treatment were compared with matched patients undergoing nonsurgical treatment. Results: We identified 61,534 patients with stenosis alone and 83,813 with stenosis and spondylolisthesis. Surgical treatment was associated with 28% lower 2-year mortality compared with matched patients undergoing nonsurgical treatment. Total Medicare payments were significantly lower for patients with stenosis alone undergoing laminectomy alone and for patients with stenosis and spondylolisthesis undergoing laminectomy with or without fusion compared with patients undergoing nonsurgical treatment. There was no significant difference in mortality when fusion or laminectomy was compared with combined fusion and laminectomy. However, laminectomy alone was associated with significantly lower 2-year payments when treating stenosis with or without spondylolisthesis. Conclusions: Surgical treatment for stenosis with or without spondylolisthesis within the Medicare population was associated with significantly lower mortality and total medical payments at 2 years compared with nonsurgical treatment, although residual confounding could have contributed to these findings. Level of evidence: Therapeutic Level III. See Instructions for Authors for a complete description of levels of evidence.
MeSH term(s)	Humans ; Aged ; United States ; Constriction, Pathologic ; Spondylolisthesis/surgery ; Spondylolisthesis/complications ; Spinal Stenosis/surgery ; Spinal Stenosis/complications ; Spinal Fusion ; Lumbar Vertebrae/surgery ; Treatment Outcome ; Medicare ; Laminectomy ; Decompression, Surgical
Language	English
Publishing date	2023-01-12
Publishing country	United States
Document type	Journal Article
ZDB-ID	220625-0
ISSN	1535-1386 ; 0021-9355
ISSN (online)	1535-1386
ISSN	0021-9355
DOI	10.2106/JBJS.22.00181
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Book ; Online: A cross-corpus study on speech emotion recognition

Milner, Rosanna / Jalal, Md Asif / Ng, Raymond W. M. / Hain, Thomas

2022

Abstract: For speech emotion datasets, it has been difficult to acquire large quantities of reliable data and acted emotions may be over the top compared to less expressive emotions displayed in everyday life. Lately, larger datasets with natural emotions have ... ...

Abstract	For speech emotion datasets, it has been difficult to acquire large quantities of reliable data and acted emotions may be over the top compared to less expressive emotions displayed in everyday life. Lately, larger datasets with natural emotions have been created. Instead of ignoring smaller, acted datasets, this study investigates whether information learnt from acted emotions is useful for detecting natural emotions. Cross-corpus research has mostly considered cross-lingual and even cross-age datasets, and difficulties arise from different methods of annotating emotions causing a drop in performance. To be consistent, four adult English datasets covering acted, elicited and natural emotions are considered. A state-of-the-art model is proposed to accurately investigate the degradation of performance. The system involves a bi-directional LSTM with an attention mechanism to classify emotions across datasets. Experiments study the effects of training models in a cross-corpus and multi-domain fashion and results show the transfer of information is not successful. Out-of-domain models, followed by adapting to the missing dataset, and domain adversarial training (DAT) are shown to be more suitable to generalising to emotions across datasets. This shows positive information transfer from acted datasets to those with more natural emotions and the benefits from training on different corpora. Comment: ASRU 2019
Keywords	Computer Science - Computation and Language ; Computer Science - Sound ; Electrical Engineering and Systems Science - Audio and Speech Processing
Subject code	006
Publishing date	2022-07-05
Publishing country	us
Document type	Book ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: The role of spermatozoa-zona pellucida interaction in selecting fertilization-competent spermatozoa in humans.

Leung, Erica T Y / Lee, Brayden K M / Lee, Cheuk-Lun / Tian, Xinyi / Lam, Kevin K W / Li, Raymond H W / Ng, Ernest H Y / Yeung, William S B / Ou, Jian-Ping / Chiu, Philip C N

Frontiers in endocrinology

2023 Volume 14, Page(s) 1135973

Abstract: Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of reduced fertilization rates in ... ...

Abstract	Human fertilization begins when a capacitated spermatozoon binds to the zona pellucida (ZP) surrounding a mature oocyte. Defective spermatozoa-ZP interaction contributes to male infertility and is a leading cause of reduced fertilization rates in assisted reproduction treatments (ARTs). Human ejaculate contains millions of spermatozoa with varying degrees of fertilization potential and genetic quality, of which only thousands of motile spermatozoa can bind to the ZP at the fertilization site. This observation suggests that human ZP selectively interacts with competitively superior spermatozoa characterized by high fertilizing capability and genetic integrity. However, direct evidence for ZP-mediated sperm selection process is lacking. This study aims to demonstrate that spermatozoa-ZP interaction represents a crucial step in selecting fertilization-competent spermatozoa in humans. ZP-bound and unbound spermatozoa were respectively collected by a spermatozoa-ZP coincubation assay. The time-course data demonstrated that ZP interacted with a small proportion of motile spermatozoa. Heat shock 70 kDa protein 2 (HSPA2) and sperm acrosome associated 3 (SPACA 3) are two protein markers associated with the sperm ZP-binding ability. Immunofluorescent staining indicated that the ZP-bound spermatozoa had significantly higher expression levels of HSPA2 and SPACA3 than the unbound spermatozoa. ZP-bound spermatozoa had a significantly higher level of normal morphology, DNA integrity, chromatin integrity, protamination and global methylation when compared to the unbound spermatozoa. The results validated the possibility of applying spermatozoa-ZP interaction to select fertilization-competent spermatozoa in ART. This highly selective interaction might also provide diagnostic information regarding the fertilization potential and genetic qualities of spermatozoa independent of those derived from the standard semen analysis.
MeSH term(s)	Humans ; Male ; Zona Pellucida/metabolism ; Sperm-Ovum Interactions ; Semen/metabolism ; Spermatozoa/metabolism ; Fertilization
Language	English
Publishing date	2023-03-20
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2592084-4
ISSN	1664-2392
ISSN	1664-2392
DOI	10.3389/fendo.2023.1135973
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Article ; Online: Fertility restoration in mice with chemotherapy induced ovarian failure using differentiated iPSCs.

Elias, Kevin M / Ng, Nicholas W / Dam, Kh U / Milne, Ankrish / Disler, Emily R / Gockley, Alison / Holub, Nicole / Seshan, Maya L / Church, George M / Ginsburg, Elizabeth S / Anchan, Raymond M

EBioMedicine

2023 Volume 94, Page(s) 104715

Abstract: Background: Treatment options for premature ovarian insufficiency (POI) are limited to hormone replacement and donor oocytes. A novel induced pluripotent stem cell (iPSC) transplant paradigm in a mouse model has potential translational applications for ... ...

Abstract	Background: Treatment options for premature ovarian insufficiency (POI) are limited to hormone replacement and donor oocytes. A novel induced pluripotent stem cell (iPSC) transplant paradigm in a mouse model has potential translational applications for management of POI. Methods: Mouse ovarian granulosa cell derived-iPSCS were labelled with green fluorescent protein (GFP) reporter and differentiated in vitro into oocytes. Differentiated cells were assayed for estradiol and progesterone secretion by enzyme-linked immunosorbent assays. After Fluorescence-Activated Cell Sorting (FACS) for the cell surface marker anti-Mullerian hormone receptor (AMHR2), enriched populations of differentiated cells were surgically transplanted into ovaries of mice that had POI secondary to gonadotoxic pre-treatment with alkylating agents. A total of 100 mice were used in these studies in five separate experiments with 56 animals receiving orthotopic ovarian injections of either FACS sorted or unsorted differentiated iPSCSs and the remaining animals receiving sham injections of PBS diluent. Following transplantation surgery, mice were stimulated with gonadotropins inducing oocyte development and underwent oocyte retrieval. Nine transplanted mice were cross bred with wild-type mice to assess fertility. Lineage tracing of resultant oocytes, F1 (30 pups), and F2 (42 pups) litters was interrogated by GFP expression and validation by short tandem repeat (STR) lineage tracing. Findings: [1] iPSCs differentiate into functional oocytes and steroidogenic ovarian cells which [2] express an ovarian (GJA1) and germ cell (ZP1) markers. [3] Endocrine function and fertility were restored in mice pretreated with gonadotoxic alkylating agents via orthotopic transplantation of differentiated iPSCS, thus generating viable, fertile mouse pups. Interpretation: iPSC-derived ovarian tissue can reverse endocrine and reproductive sequelae of POI. Funding: Center for Infertility and Reproductive Surgery Research Award, Siezen Foundation award (RMA). Reproductive Scientist Development Program, Marriott Foundation, Saltonstall Foundation, Brigham Ovarian Cancer Research Fund (K.E).
MeSH term(s)	Humans ; Female ; Mice ; Animals ; Induced Pluripotent Stem Cells ; Primary Ovarian Insufficiency/chemically induced ; Primary Ovarian Insufficiency/therapy ; Fertility ; Antineoplastic Agents/adverse effects ; Alkylating Agents/adverse effects ; Alkylating Agents/metabolism
Chemical Substances	Antineoplastic Agents ; Alkylating Agents
Language	English
Publishing date	2023-07-21
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2851331-9
ISSN	2352-3964
ISSN (online)	2352-3964
DOI	10.1016/j.ebiom.2023.104715
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Article ; Online: Translation and validation of the Traditional Chinese version of the COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (Version 2).

Chan, Dorothy N S / Choi, Kai Chow / Ng, Marques S N / Xing, Weijie / Law, Bernard M H / Ho, Pui Shan / Au, Cecilia / Chan, Mandy / Tong, Man / Ling, Wai Man / Chan, Maggie / Mak, Suzanne S S / Chan, Raymond J / So, Winnie K W

Health and quality of life outcomes

2021 Volume 19, Issue 1, Page(s) 17

Abstract: Background: Cancer patients often experience severe financial distress due to the high cost of their treatment, and strategies are needed to objectively measure this financial distress. The COmprehensive Score for financial Toxicity-Functional ... ...

Abstract	Background: Cancer patients often experience severe financial distress due to the high cost of their treatment, and strategies are needed to objectively measure this financial distress. The COmprehensive Score for financial Toxicity-Functional Assessment of Chronic Illness Therapy (COST-FACIT) is one instrument used to measure such financial distress. This study aimed to translate the COST-FACIT (Version 2) [COST-FACIT-v2] instrument into traditional Chinese (COST-FACIT-v2 [TC]) and evaluate its psychometric properties. Methods: The Functional Assessment of Chronic Illness Therapy (FACIT) translation method was adopted. The translated version was reviewed by an expert panel and by 20 cancer patients for content validity and face validity, respectively, and 640 cancer patients, recruited from three oncology departments, completed the translated scale. Its reliability was evaluated in terms of internal consistency and test-retest reliability. Confirmatory factor analysis has been used to evaluate the one- and two-factor structures of the instrument reported in the literature. The convergent validity was examined by the correlation with health-related quality of life (HRQoL) and psychological distress. Known-group validity was examined by the difference in the COST-FACIT-v2 (TC) total mean score between groups with different income levels and frequency of health care service use. Results: The COST-FACIT-v2 (TC) showed good content and face validity and demonstrated high internal consistency (Cronbach's alpha, 0.86) and acceptable test-retest reliability (intraclass correlation coefficient, 0.71). Confirmatory factor analysis showed that the one- and two-factor structures of the instrument that have been reported in the literature could not be satisfactorily fitted to the data. Psychological distress correlated significantly with the COST-FACIT-v2 (TC) score (r = 0.47; p < 0.001). HRQOL showed a weak to moderate negative correlation with the COST-FACIT-v2 (TC) score (r = - 0.23 to - 0.46; p < 0.001). Significant differences were seen among the COST-FACIT-v2 (TC) scores obtained in groups of different income level and frequency of health care service use. Conclusions: The COST-FACIT-v2 (TC) showed some desirable psychometric properties to support its validity and reliability for assessing cancer patients' level of financial toxicity.
MeSH term(s)	Adult ; Aged ; Asian Continental Ancestry Group ; Chronic Disease/economics ; Chronic Disease/therapy ; Cost of Illness ; Factor Analysis, Statistical ; Female ; Humans ; Male ; Middle Aged ; Neoplasms/economics ; Psychometrics/instrumentation ; Reproducibility of Results ; Socioeconomic Factors ; Surveys and Questionnaires ; Translations
Language	English
Publishing date	2021-01-08
Publishing country	England
Document type	Journal Article
ISSN	1477-7525
ISSN (online)	1477-7525
DOI	10.1186/s12955-020-01646-z
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Article: Application of Artificial Intelligence for Nasopharyngeal Carcinoma Management - A Systematic Review.

Ng, Wai Tong / But, Barton / Choi, Horace C W / de Bree, Remco / Lee, Anne W M / Lee, Victor H F / López, Fernando / Mäkitie, Antti A / Rodrigo, Juan P / Saba, Nabil F / Tsang, Raymond K Y / Ferlito, Alfio

Cancer management and research

2022 Volume 14, Page(s) 339–366

Abstract: Introduction: Nasopharyngeal carcinoma (NPC) is endemic to Eastern and South-Eastern Asia, and, in 2020, 77% of global cases were diagnosed in these regions. Apart from its distinct epidemiology, the natural behavior, treatment, and prognosis are ... ...

Abstract	Introduction: Nasopharyngeal carcinoma (NPC) is endemic to Eastern and South-Eastern Asia, and, in 2020, 77% of global cases were diagnosed in these regions. Apart from its distinct epidemiology, the natural behavior, treatment, and prognosis are different from other head and neck cancers. With the growing trend of artificial intelligence (AI), especially deep learning (DL), in head and neck cancer care, we sought to explore the unique clinical application and implementation direction of AI in the management of NPC. Methods: The search protocol was performed to collect publications using AI, machine learning (ML) and DL in NPC management from PubMed, Scopus and Embase. The articles were filtered using inclusion and exclusion criteria, and the quality of the papers was assessed. Data were extracted from the finalized articles. Results: A total of 78 articles were reviewed after removing duplicates and papers that did not meet the inclusion and exclusion criteria. After quality assessment, 60 papers were included in the current study. There were four main types of applications, which were auto-contouring, diagnosis, prognosis, and miscellaneous applications (especially on radiotherapy planning). The different forms of convolutional neural networks (CNNs) accounted for the majority of DL algorithms used, while the artificial neural network (ANN) was the most frequent ML model implemented. Conclusion: There is an overall positive impact identified from AI implementation in the management of NPC. With improving AI algorithms, we envisage AI will be available as a routine application in a clinical setting soon.
Language	English
Publishing date	2022-01-26
Publishing country	New Zealand
Document type	Journal Article ; Review
ZDB-ID	2508013-1
ISSN	1179-1322
ISSN	1179-1322
DOI	10.2147/CMAR.S341583
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