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  1. Article ; Online: Should authors of overviews of systematic reviews invite the authors of the systematic reviews they analyzed to re-evaluate or validate their methodological analysis?

    Faggion, Clovis Mariano / Nagendrababu, Venkateshbabu / Dummer, Paul M H

    Journal of clinical epidemiology

    2023  Volume 158, Page(s) 177–178

    MeSH term(s) Humans ; Systematic Reviews as Topic ; Evidence-Based Medicine ; Research Design
    Language English
    Publishing date 2023-03-28
    Publishing country United States
    Document type Letter
    ZDB-ID 639306-8
    ISSN 1878-5921 ; 0895-4356
    ISSN (online) 1878-5921
    ISSN 0895-4356
    DOI 10.1016/j.jclinepi.2023.03.021
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Review of patient-reported outcomes (PROs) and non-PROs in randomized controlled trials addressing head/neck cancers.

    Gode, Michelle / Faggion, Clovis Mariano

    Cancer medicine

    2024  Volume 13, Issue 8, Page(s) e7036

    Abstract: Background: To assess the frequency of patient-reported outcomes (PROs) and non-PROs in randomized controlled trials (RCTs) addressing head/neck cancers.: Methods: We included RCTs about interventions to treat head/neck cancers. PubMed was searched ... ...

    Abstract Background: To assess the frequency of patient-reported outcomes (PROs) and non-PROs in randomized controlled trials (RCTs) addressing head/neck cancers.
    Methods: We included RCTs about interventions to treat head/neck cancers. PubMed was searched on September 16, 2022 and included studies published during three periods (2000-2002, 2010-2012, and 2020-2022). Data on types of outcomes and instruments to measure them were extracted and organized into PROs and non-PROs, and temporal trends for reporting outcomes were determined.
    Results: There was a reduction in the frequency of non-PROs (40% to 22%) and an increase in PROs (5% to 19%) over 20 years. The frequency of reporting both non-PROs and PROs seemed to be stable over the same period (55% to 58%). A great variety of instruments to measure PROs and non-PROs was identified.
    Conclusions: There has been a growth in the types of PROs in more recent years, and they were more frequently reported in RCTs. However, head/neck cancer trials with a combination of PROs and non-PROs were the most prevalent.
    MeSH term(s) Patient Reported Outcome Measures ; Humans ; Head and Neck Neoplasms/therapy ; Randomized Controlled Trials as Topic ; Quality of Life
    Language English
    Publishing date 2024-04-22
    Publishing country United States
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2659751-2
    ISSN 2045-7634 ; 2045-7634
    ISSN (online) 2045-7634
    ISSN 2045-7634
    DOI 10.1002/cam4.7036
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Methodological quality of systematic reviews in dentistry including animal studies: a cross-sectional study.

    Menne, Max C / Su, Naichuan / Faggion, Clovis M

    Irish veterinary journal

    2023  Volume 76, Issue 1, Page(s) 33

    Abstract: Background: The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall confidence in ... ...

    Abstract Background: The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall confidence in the results of those systematic reviews.
    Material & methods: PubMed, Web of Science and Scopus were searched for systematic reviews including animal studies in dentistry published later than January 2010 until 18th of July 2022. Overall confidence in the results was assessed using a modified version of the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) checklist. Checklist items were rated as yes, partial yes, no and not applicable. Linear regression analysis was used to investigate associations between systematic review characteristics and the overall adherence to the AMSTAR-2 checklist. The overall confidence in the results was calculated based on the number of critical and non-critical weaknesses presented in the AMSTAR-2 items and rated as high, moderate, low and critical low.
    Results: Of initially 951 retrieved systematic reviews, 190 were included in the study. The overall confidence in the results was low in 43 (22.6%) and critically low in 133 (70.0%) systematic reviews. While some AMSTAR-2 items were regularly reported (e.g. conflict of interest, selection in duplicate), others were not (e.g.
    Funding: n = 1; 0.5%). Multivariable linear regression analysis showed that the adherence scores of AMSTAR-2 was significantly associated with publication year, journal impact factor (IF), topic, and the use of tools to assess risk of bias (RoB) of the systematic reviews.
    Conclusion: Although the methodological quality of dental systematic reviews of animal models improved over the years, it is still suboptimal. The overall confidence in the results was mostly low or critically low. Systematic reviews, which were published later, published in a journal with a higher IF, focused on non-surgery topics, and used at least one tool to assess RoB correlated with greater adherence to the AMSTAR-2 guidelines.
    Language English
    Publishing date 2023-12-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 2571182-9
    ISSN 2046-0481 ; 2046-0481
    ISSN (online) 2046-0481
    ISSN 2046-0481
    DOI 10.1186/s13620-023-00261-w
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Methodological quality of systematic reviews in dentistry including animal studies

    Max C. Menne / Naichuan Su / Clovis M. Faggion

    Irish Veterinary Journal, Vol 76, Iss 1, Pp 1-

    a cross-sectional study

    2023  Volume 13

    Abstract: Abstract Background The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall ... ...

    Abstract Abstract Background The overall confidence in the results of systematic reviews including animal models can be heterogeneous. We assessed the methodological quality of systematic reviews including animal models in dentistry as well as the overall confidence in the results of those systematic reviews. Material & methods PubMed, Web of Science and Scopus were searched for systematic reviews including animal studies in dentistry published later than January 2010 until 18th of July 2022. Overall confidence in the results was assessed using a modified version of the A MeaSurement Tool to Assess systematic Reviews (AMSTAR-2) checklist. Checklist items were rated as yes, partial yes, no and not applicable. Linear regression analysis was used to investigate associations between systematic review characteristics and the overall adherence to the AMSTAR-2 checklist. The overall confidence in the results was calculated based on the number of critical and non-critical weaknesses presented in the AMSTAR-2 items and rated as high, moderate, low and critical low. Results Of initially 951 retrieved systematic reviews, 190 were included in the study. The overall confidence in the results was low in 43 (22.6%) and critically low in 133 (70.0%) systematic reviews. While some AMSTAR-2 items were regularly reported (e.g. conflict of interest, selection in duplicate), others were not (e.g. funding: n = 1; 0.5%). Multivariable linear regression analysis showed that the adherence scores of AMSTAR-2 was significantly associated with publication year, journal impact factor (IF), topic, and the use of tools to assess risk of bias (RoB) of the systematic reviews. Conclusion Although the methodological quality of dental systematic reviews of animal models improved over the years, it is still suboptimal. The overall confidence in the results was mostly low or critically low. Systematic reviews, which were published later, published in a journal with a higher IF, focused on non-surgery topics, and used at least one tool to assess RoB ...
    Keywords Systematic reviews ; Methods ; Methodological study ; Animal study ; Preclinical study ; AMSTAR-2 ; Veterinary medicine ; SF600-1100
    Language English
    Publishing date 2023-12-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article ; Online: Are researchers paying too much for attending dental meetings?

    Faggion, Clovis M / Giannakopoulos, Nikolaos N

    British dental journal

    2019  Volume 226, Issue 12, Page(s) 927–929

    Abstract: Dental meetings are important venues for sharing knowledge and experiences among researchers and clinicians. The costs for participating in such events, however, are high and have increased over the years. This opinion paper discusses the fairness of ... ...

    Abstract Dental meetings are important venues for sharing knowledge and experiences among researchers and clinicians. The costs for participating in such events, however, are high and have increased over the years. This opinion paper discusses the fairness of such a policy, with high costs for researchers presenting their findings, as well as some suggestions to reduce the economic burden of participants actively involved in presenting their research findings.
    MeSH term(s) Attitude ; Congresses as Topic ; Humans
    Language English
    Publishing date 2019-06-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 218090-x
    ISSN 1476-5373 ; 0007-0610
    ISSN (online) 1476-5373
    ISSN 0007-0610
    DOI 10.1038/s41415-019-0421-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Reporting quality of abstracts of randomized controlled trials related to implant dentistry.

    Menne, Max C / Pandis, Nikolaos / Faggion, Clovis M

    Journal of periodontology

    2021  , Page(s) 73–82

    Abstract: Background: Abstracts of scientific articles should be accurate and detailed in summarizing the information in the full-text because they are the first article section the reader examines. This study assessed the reporting quality of randomized ... ...

    Abstract Background: Abstracts of scientific articles should be accurate and detailed in summarizing the information in the full-text because they are the first article section the reader examines. This study assessed the reporting quality of randomized controlled trials (RCTs) abstracts related to implant dentistry and examined associations between reporting quality and study characteristics.
    Methods: On the 17
    Results: Four-hundred and thirty four of the 678 retrieved abstracts were eligible for inclusion. The mean OCS and OCS% were 6,23 (standard deviation [SD] = 1.56) or 41.5% (SD = 10.4), respectively. Items most frequently reported included the title (n = 434; 100%), intended intervention (n = 425; 98%) and conclusions (n = 430; 99%). Participant allocation, blinding, and trial registration were rarely completely reported with frequencies of 2%, 3% and 4%, respectively. We found that number of authors, continent, type of RCT, number of centers, report of ethical approval, funding, structure and length of the abstract were associated with better abstract reporting.
    Conclusion: The reporting quality of abstracts in RCTs related to implant dentistry is suboptimal. Journals should start to incorporate and endorse the use of the CONSORT-A guidelines in their instructions to authors to enhance reporting quality. This article is protected by copyright. All rights reserved.
    Language English
    Publishing date 2021-09-13
    Publishing country United States
    Document type Journal Article
    ZDB-ID 390921-9
    ISSN 1943-3670 ; 0022-3492 ; 1049-8885 ; 0095-960X
    ISSN (online) 1943-3670
    ISSN 0022-3492 ; 1049-8885 ; 0095-960X
    DOI 10.1002/JPER.21-0396
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Meta-research publications in dentistry: a review.

    Faggion, Clovis M / Listl, Stefan / Smits, Kirsten P J

    European journal of oral sciences

    2021  Volume 129, Issue 1, Page(s) e12748

    Abstract: The present scoping review has the objective of providing an overview of meta-research in dentistry. A search of the PubMed database was performed for the period 11 October 2014 to 10 October 2019. Study selection and data extraction were performed ... ...

    Abstract The present scoping review has the objective of providing an overview of meta-research in dentistry. A search of the PubMed database was performed for the period 11 October 2014 to 10 October 2019. Study selection and data extraction were performed independently by one author; prior to this, a random sample of 10% of the retrieved titles and abstracts were independently screened by two authors, achieving agreement of >80% on eligibility for initial inclusion, corresponding to good agreement. The following information was extracted from the full text of each article: meta-research area of interest; study design; type of studies evaluated in the meta-research; type of methodology used in assessment of the primary research; conflicts of interest reported; sponsorships reported; dental discipline; journal of publication; country of the first author; number of citations; and impact factor. A total of 7800 documents were initially retrieved. After analysis of the title/abstract and the full text of each article, and a snowballing procedure, 155 meta-research studies were identified and included. The 'methods' and 'reporting' meta-research areas were the most prevalent, with 73 (47%) and 61 (40%) studies, respectively. General dentistry, and orthodontics and dentofacial orthopaedics were the dental specialties with the greatest number/proportion of included studies with 45 (29%) and 28 (18%) studies, respectively. These findings may help to prioritize future meta-research in dentistry, consequently avoiding unnessecary investigations, and increasing the value of oral and dental research.
    MeSH term(s) Dentistry ; Research Design
    Language English
    Publishing date 2021-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 1224820-4
    ISSN 1600-0722 ; 0909-8836
    ISSN (online) 1600-0722
    ISSN 0909-8836
    DOI 10.1111/eos.12748
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Animal research as a basis for clinical trials.

    Faggion, Clovis M

    European journal of oral sciences

    2015  Volume 123, Issue 2, Page(s) 61–64

    Abstract: Animal experiments are critical for the development of new human therapeutics because they provide mechanistic information, as well as important information on efficacy and safety. Some evidence suggests that authors of animal research in dentistry do ... ...

    Abstract Animal experiments are critical for the development of new human therapeutics because they provide mechanistic information, as well as important information on efficacy and safety. Some evidence suggests that authors of animal research in dentistry do not observe important methodological issues when planning animal experiments, for example sample-size calculation. Low-quality animal research directly interferes with development of the research process in which multiple levels of research are interconnected. For example, high-quality animal experiments generate sound information for the further planning and development of randomized controlled trials in humans. These randomized controlled trials are the main source for the development of systematic reviews and meta-analyses, which will generate the best evidence for the development of clinical guidelines. Therefore, adequate planning of animal research is a sine qua non condition for increasing efficacy and efficiency in research. Ethical concerns arise when animal research is not performed with high standards. This Focus article presents the latest information on the standards of animal research in dentistry, more precisely in the field of implant dentistry. Issues on precision and risk of bias are discussed, and strategies to reduce risk of bias in animal research are reported.
    MeSH term(s) Animal Experimentation/ethics ; Animal Experimentation/standards ; Animals ; Bias ; Checklist ; Clinical Trials as Topic ; Dental Implantation/ethics ; Dental Implantation/standards ; Dental Research/ethics ; Dental Research/standards ; Ethics, Research ; Humans ; Meta-Analysis as Topic ; Models, Animal ; Practice Guidelines as Topic ; Randomized Controlled Trials as Topic ; Research Design/standards ; Review Literature as Topic ; Sample Size
    Language English
    Publishing date 2015-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 1224820-4
    ISSN 1600-0722 ; 0909-8836
    ISSN (online) 1600-0722
    ISSN 0909-8836
    DOI 10.1111/eos.12175
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Promoting integrity in scholarly research and its publication: International Endodontic Journal policy on reporting conflicts of interest, funding and acknowledgments within manuscripts submitted for publication.

    Nagendrababu, Venkateshbabu / Murray, Peter E / Faggion, Clovis M / Dummer, Paul M H

    International endodontic journal

    2021  Volume 54, Issue 11, Page(s) 1969–1973

    MeSH term(s) Conflict of Interest ; Peer Review, Research ; Policy ; Publishing
    Language English
    Publishing date 2021-10-30
    Publishing country England
    Document type Editorial
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13599
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: Methodological assessment and overall confidence in the results of systematic reviews with network meta-analyses in Endodontics.

    Nagendrababu, Venkateshbabu / Faggion, Clovis M / Pulikkotil, Shaju Jacob / Alatta, Alaa / Dummer, Paul M H

    International endodontic journal

    2022  Volume 55, Issue 5, Page(s) 393–404

    Abstract: Aim: The aims of the study were to assess the methodological quality of systematic reviews with network meta-analyses (NMAs) in Endodontics using the 'A MeaSurement Tool to Assess systematic Reviews' (AMSTAR 2) tool, and to evaluate the overall ... ...

    Abstract Aim: The aims of the study were to assess the methodological quality of systematic reviews with network meta-analyses (NMAs) in Endodontics using the 'A MeaSurement Tool to Assess systematic Reviews' (AMSTAR 2) tool, and to evaluate the overall confidence in the results of the individual reviews included in the analysis.
    Methodology: Systematic reviews with NMAs within the specialty of Endodontics published in English were identified from the PubMed, EbBSCOhost and SCOPUS databases from inception to July 2021. Two reviewers were involved independently in the selection of the reviews, data extraction, methodological quality assessment and overall confidence rating. Disagreements were resolved by discussion between the reviewers to achieve consensus; if disagreements persisted, a third reviewer made the final decision. The methodological quality of the included NMAs was appraised using the AMSTAR 2 checklist, which contains 16 items. The reviewers scored each item-'Yes'-when the item was fully addressed, 'Partial Yes'-when the item was not fully addressed, or 'No'-when the item was not addressed. The overall confidence in the results of each review was classified as 'High', 'Moderate', 'Low' or 'Critically low' based on the criteria reported by the AMSTAR 2 developers.
    Results: Twelve systematic reviews with NMAs were included. All the NMAs adequately reported Item 1 ('Did the research questions and inclusion criteria for the review include the components of PICO?'), Item 8 ('Did the review authors describe the included studies in adequate detail?'), Item 9 ('Did the review authors use a satisfactory technique for assessing the risk of bias (RoB) in individual studies that were included in the review?') and Item 16 ('Did the review authors report any potential sources of conflict of interest, including any funding they received for conducting the review?'), whereas only one NMA reported Item 10 adequately ('Did the review authors report on the sources of funding for the studies included in the review?'). The overall confidence in the results of eight reviews was categorized as 'Critically low', one review was 'Low', two reviews were 'Moderate' and one review was 'High'.
    Conclusion: The overall confidence in the results for the majority of systematic reviews with NMAs in Endodontics was judged to be 'Critically low' as their methodological quality was below the necessary standard. AMSTAR 2 and PRISMA for NMA guidelines are available to guide authors to produce high-quality systematic reviews with NMAs and for editors and peer-reviewers when assessing submissions to journals.
    MeSH term(s) Databases, Factual ; Endodontics ; Network Meta-Analysis ; Research Report
    Language English
    Publishing date 2022-02-16
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 603734-3
    ISSN 1365-2591 ; 0143-2885
    ISSN (online) 1365-2591
    ISSN 0143-2885
    DOI 10.1111/iej.13693
    Database MEDical Literature Analysis and Retrieval System OnLINE

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