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  1. Article ; Online: Sung Shu Chien: the founder of modern Chinese botany.

    Liu, Huan / Huang, Kaijing / Yuan, Xuefan / Cheng, Hao

    Protein & cell

    2022  Volume 14, Issue 2, Page(s) 79–83

    MeSH term(s) Humans ; Botany/history ; History, 20th Century ; China
    Language English
    Publishing date 2022-10-27
    Publishing country Germany
    Document type Biography ; Journal Article
    ZDB-ID 2543451-2
    ISSN 1674-8018 ; 1674-8018
    ISSN (online) 1674-8018
    ISSN 1674-8018
    DOI 10.1093/procel/pwac047
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Yang-Xin-Shu-Mai granule alleviates atherosclerosis by regulating macrophage polarization via the TLR9/MyD88/NF-κB signaling pathway.

    Huang, Hong / Sun, Zeqi / Xu, Junyao / Wang, Linjie / Zhao, Jing / Li, Jie / Zhang, Siqi / Yuan, Fang / Liu, Ming / Fang, Zhuyuan

    Journal of ethnopharmacology

    2023  Volume 318, Issue Pt A, Page(s) 116868

    Abstract: Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG ...

    Abstract Ethnopharmacological relevance: Previous studies have found that Yang-Xin-Shu-Mai granule (YXSMG) has certain advantages in the treatment of stable coronary heart disease. However, YXSMG can inhibit the progression of atherosclerotic plaque and stabilize vulnerable plaque needs to be further explored and studied. This research, mass spectrometry analysis, network pharmacology, in vivo and in vitro experimental studies were conducted to explore the mechanism of YXSMG on atherosclerosis.
    Aim of the study: To decipher the mechanism of atherosclerotic plaque, stabilization for YXSMG by analysis of its active ingredients and biological network and activity in whole animal and at cellular and molecular levels.
    Methods: The active components of YXSMG were determined using high performance liquid chromatography-mass spectrometry/mass spectrometry (HPLC-MS/MS) analysis. The 'Disease-Compound-Target-Pathway' network diagram was constructed using network pharmacology, and the stability of binding between core targets and core compounds was analyzed with molecular docking. After intervention with YXSMG, the pathology of aortic plaque, inflammation in the surrounding tissue, expression of TLR9/MyD88/NF-κB pathway protein in plaque and M1/M2 polarization of plaque macrophages were evaluated in vivo in apolipoprotein E-deficient (ApoE
    Results: Five active compounds were identified in YXSMG: catechin, formononetin, tanshinone IIA, cryptotanshinone and glycitein. Network pharmacology studies revealed TLR9 as one of the core targets of YXSMG intervention in atherosclerosis. Computer simulation of molecular docking showed that TLR9 could interact with the core compound to form a stable complex. In vivo experiments confirmed that YXSMG could significantly inhibit atherosclerotic plaque, reduce levels of blood lipids and inflammatory factors, downregulate TLR9/MyD88/NF-κB pathway protein and inhibit aortic sinus macrophages polarization to M1, but promote their polarization to M2 to inhibit inflammation. In vitro experiments revealed that YXSMG could downregulate expression of TLR9 gene and protein in ODN1826-activated RAW264.7 macrophages. ODN2088 had a synergistic effect with YXSMG on the TLR9/MyD88/NF-κB signaling pathway, and reprogrammed macrophages polarization from M1 to M2 by inhibiting TLR9, thus reducing immuno-inflammatory response.
    Conclusion: YXSMG can reduce the level of blood lipid and improve the size of atherosclerotic plaque and inflammatory infiltration in ApoE
    MeSH term(s) Mice ; Animals ; Plaque, Atherosclerotic/pathology ; NF-kappa B/metabolism ; Myeloid Differentiation Factor 88/metabolism ; Toll-Like Receptor 9/metabolism ; Computer Simulation ; Molecular Docking Simulation ; Tandem Mass Spectrometry ; Atherosclerosis/genetics ; Signal Transduction ; Macrophages ; Adaptor Proteins, Signal Transducing/metabolism ; Inflammation/pathology ; Lipids/pharmacology ; Apolipoproteins E/genetics ; Mice, Inbred C57BL
    Chemical Substances NF-kappa B ; Myeloid Differentiation Factor 88 ; Toll-Like Receptor 9 ; Adaptor Proteins, Signal Transducing ; Lipids ; Apolipoproteins E
    Language English
    Publishing date 2023-07-16
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.116868
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 1494: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  3. Article ; Online: The types of skippers described by Shu-Iti Murayama (Lepidoptera: Hesperiidae).

    Chiba, Hideyuki / Tsukiyama, Hiroshi / Liang, Jia-Yuan / Wang, Shou-Ming / Shen, Zong-Yu / Hsu, Yu-Feng

    Zootaxa

    2020  Volume 4801, Issue 2, Page(s) zootaxa.4801.2.4

    Abstract: Fifteen holotypes of Asian Hesperiidae taxa described by Shu-iti Murayama were examined, and ...

    Abstract Fifteen holotypes of Asian Hesperiidae taxa described by Shu-iti Murayama were examined, and their taxonomic status is discussed. We confirm that five are valid names while the rest are synonyms as indicated partially by previous authors. Valid species-level names are Aeromachus matudai (Murayama), Aeromachus bandaishanus Murayama Shimonoya, Coladenia pinsbukana (Shimonoya Murayama), and Sebastonyma suthepiana Murayama Kimura. Valid subspecies-level name is Ochlodes yuchingkina Murayama Shimonoya. In order to settle the taxonomic status of Pedesta masuriensis cuneomaculata Murayama, masuriensis and tali were studied morphologically and molecularly. As a result, we consider that masuriensis and tali are two different species and treat cuneomaculata as a junior subjective synonym of tali.
    MeSH term(s) Animals ; Butterflies
    Language English
    Publishing date 2020-06-18
    Publishing country New Zealand
    Document type Journal Article
    ISSN 1175-5334
    ISSN (online) 1175-5334
    DOI 10.11646/zootaxa.4801.2.4
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A tribute to Professor Shu Dong Xiao (1931-2016).

    Fang, Jing Yuan

    Gut

    2017  Volume 66, Issue 4, Page(s) 737

    Language English
    Publishing date 2017-04
    Publishing country England
    Document type Journal Article
    ZDB-ID 80128-8
    ISSN 1468-3288 ; 0017-5749
    ISSN (online) 1468-3288
    ISSN 0017-5749
    DOI 10.1136/gutjnl-2017-313951
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 160: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)

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  5. Article: The Influence of Stomach Back-Shu and Front-Mu Points on Insular Functional Connectivity in Functional Dyspepsia Rat Models.

    Chen, Yuan / Zhao, Ying / Tan, Robert Yu-Sheng / Zhang, Pu-Yue / Long, Tao / Shi, Yu / Zheng, Hua-Bin

    Evidence-based complementary and alternative medicine : eCAM

    2021  Volume 2021, Page(s) 2771094

    Abstract: Functional Dyspepsia (FD) is a common functional gastrointestinal disease, which can reduce the quality of life in patients. Prior research has indicated that insula is closely related to FD and that acupuncture can regulate the functional connectivity ( ... ...

    Abstract Functional Dyspepsia (FD) is a common functional gastrointestinal disease, which can reduce the quality of life in patients. Prior research has indicated that insula is closely related to FD and that acupuncture can regulate the functional connectivity (FC) of FD. Therefore, we hypothesized that acupuncture on FD was effected through the insular pathway. To test our hypothesis, we performed electroacupuncture (EA) on FD rat models and then examined the FC between insula and other brain regions through resting-state functional magnetic resonance imaging (rs-fMRI). Seven-day-old male infant Sprague-Dawley (SD) rats were randomly divided into control group, FD model group, and FD acupuncture group, with twelve rats per group (
    Language English
    Publishing date 2021-09-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2021/2771094
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5995: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  6. Article ; Online: Textual Research on the Eye Diseases Names in Mai Shu (《脉书》 The Book of Pulse) Excavated from Zhangjiashan, China

    Kai- Hui Yuan

    Chinese Medicine and Culture, Vol 4, Iss 2, Pp 107-

    2021  Volume 113

    Keywords Other systems of medicine ; RZ201-999
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Wolters Kluwer Health/LWW
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  7. Article ; Online: The Influence of Stomach Back-Shu and Front-Mu Points on Insular Functional Connectivity in Functional Dyspepsia Rat Models

    Yuan Chen / Ying Zhao / Robert Yu-Sheng Tan / Pu-yue Zhang / Tao Long / Yu Shi / Hua-bin Zheng

    Evidence-Based Complementary and Alternative Medicine, Vol

    2021  Volume 2021

    Abstract: ... to EA intervention using Stomach back-shu (BL-21) and front-mu (RN-12) points for ten consecutive days ...

    Abstract Functional Dyspepsia (FD) is a common functional gastrointestinal disease, which can reduce the quality of life in patients. Prior research has indicated that insula is closely related to FD and that acupuncture can regulate the functional connectivity (FC) of FD. Therefore, we hypothesized that acupuncture on FD was effected through the insular pathway. To test our hypothesis, we performed electroacupuncture (EA) on FD rat models and then examined the FC between insula and other brain regions through resting-state functional magnetic resonance imaging (rs-fMRI). Seven-day-old male infant Sprague-Dawley (SD) rats were randomly divided into control group, FD model group, and FD acupuncture group, with twelve rats per group (n = 36). Upon establishing successful models, the FD acupuncture group was subjected to EA intervention using Stomach back-shu (BL-21) and front-mu (RN-12) points for ten consecutive days for durations of 20 minutes each day. After intervention, each group was subject to rs-fMRI. The digital image data obtained were analyzed using FC analysis methods. Subsequently, gastric ligation was performed to measure gastric emptying rates. Before EA intervention, the FD model group exhibited decreased functional connections between the insula and a number of brain regions. After EA intervention, FD acupuncture group exhibited increasing FC between insula and regions when compared to the FD model group, such as the primary somatosensory cortex (S1), hippocampal CA3 (CA3), polymorphic layer of dentate gyrus (PoDG), caudate putamen (CPu), and oral pontine reticular nuclei (PnO) P<0.05; decreasing FC was also exhibited between insula and regions such as the bilateral primary and secondary motor cortexes (M1/2), paraventricular hypothalamic nucleus (PVA), and limbic cortex (LC). These findings indicate that the effective treatment of FD using EA may be through regulating the abnormal FC between insula and several brain regions, in particular CA3, PoDG, and PVA.
    Keywords Other systems of medicine ; RZ201-999
    Subject code 796
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Comparative pharmacokinetics of naringin in rat after oral administration of chaihu-shu-gan-san aqueous extract and naringin alone.

    Li, Shu-Qi / Dong, Shu / Su, Zhi-Heng / Zhang, Hong-Wu / Peng, Jing-Bo / Yu, Chang-Yuan / Zou, Zhong-Mei

    Metabolites

    2013  Volume 3, Issue 4, Page(s) 867–880

    Abstract: Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven ...

    Abstract Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression in China. In order to explore the interaction between naringin and other constituents in CSGS, the pharmacokinetic difference of naringin in rats after oral administration of CSGS aqueous extract and naringin alone was investigated. The pharmacokinetic parameters of naringin in rats were achieved by quantification of its aglycone, naringenin by LC-MS/MS method. The double peaks phenomenon was observed in both serum profiles of rats after orally administered CSGS aqueous extract and naringin alone. However, the T1/2b was significantly decreased in rats given CSGS aqueous extract compared with naringin alone, and the mean residence time (MRT) and the area under the serum concentration-time curve (AUC0-τ) were higher than those of naringin, which indicated that naringin in CSGS had higher bioavailability, longer term efficacy and somewhat faster metabolism and excretion than those of naringin. The results suggested that certain ingredients co-exist in CSGS could influence pharmacokinetic behavior of naringin. This also provides a reference for human studies.
    Language English
    Publishing date 2013-09-30
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662251-8
    ISSN 2218-1989
    ISSN 2218-1989
    DOI 10.3390/metabo3040867
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Comparative Pharmacokinetics of Naringin in Rat after Oral Administration of Chaihu-Shu-Gan-San Aqueous Extract and Naringin Alone

    Hong-Wu Zhang / Jing-Bo Peng / Chang-Yuan Yu / Zhong-Mei Zou / Shu-Qi Li / Zhi-Heng Su / Shu Dong

    Metabolites, Vol 3, Iss 4, Pp 867-

    2013  Volume 880

    Abstract: Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven ...

    Abstract Chaihu-Shu-Gan-San (CSGS), a traditional Chinese medicine (TCM) formula containing seven herbal medicines, has been used in the clinical treatment of gastritis, peptic ulcer, irritable bowel syndrome and depression in China. In order to explore the interaction between naringin and other constituents in CSGS, the pharmacokinetic difference of naringin in rats after oral administration of CSGS aqueous extract and naringin alone was investigated. The pharmacokinetic parameters of naringin in rats were achieved by quantification of its aglycone, naringenin by LC-MS/MS method. The double peaks phenomenon was observed in both serum profiles of rats after orally administered CSGS aqueous extract and naringin alone. However, the T1/2b was significantly decreased in rats given CSGS aqueous extract compared with naringin alone, and the mean residence time (MRT) and the area under the serum concentration–time curve (AUC0-τ) were higher than those of naringin, which indicated that naringin in CSGS had higher bioavailability, longer term efficacy and somewhat faster metabolism and excretion than those of naringin. The results suggested that certain ingredients co-exist in CSGS could influence pharmacokinetic behavior of naringin. This also provides a reference for human studies.
    Keywords pharmacokinetics ; naringin ; Chaihu-Shu-Gan-San ; LC-MS/MS ; Biochemistry ; QD415-436 ; Organic chemistry ; QD241-441 ; Chemistry ; QD1-999 ; Science ; Q ; DOAJ:Biochemistry ; DOAJ:Life Sciences ; DOAJ:Biology and Life Sciences
    Language English
    Publishing date 2013-09-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: 專論／專利指標發展研究／阮明淑、梁峻齊(Ming-Shu Yuan, Chun-Chi Liang)

    阮明淑、梁峻齊 Ming-Shu Yuan, Chun-Chi Liang

    Tushuguanxue yu Zixun Kexue, Vol 35, Iss

    2009  Volume 2

    Abstract: 有鑑於專利資訊在現今產業發展中扮演重要的角色，專利指標成為度量專利資訊的重要參考。本文整理專利指標的發展演進及其在臺灣地區的相關研究，歸納出專利指標的應用分類與意涵。目前在臺灣地區的專利指標相關應用研究中，可以將專利指標區分為專利一般特性指標、專利引用指標與專利技術指標等，分別描述專利的一般特徵、引用與被引用的情況，以及技術的表現。如此正好呈現專利資訊的本質，若再配合時間與專業領域的因素，並以數量、頻率或複合指標的形式呈現，即可對公司、產業與國家等不同的對象���供適切之參考依據。 ... ...

    Abstract 有鑑於專利資訊在現今產業發展中扮演重要的角色，專利指標成為度量專利資訊的重要參考。本文整理專利指標的發展演進及其在臺灣地區的相關研究，歸納出專利指標的應用分類與意涵。目前在臺灣地區的專利指標相關應用研究中，可以將專利指標區分為專利一般特性指標、專利引用指標與專利技術指標等，分別描述專利的一般特徵、引用與被引用的情況，以及技術的表現。如此正好呈現專利資訊的本質，若再配合時間與專業領域的因素，並以數量、頻率或複合指標的形式呈現，即可對公司、產業與國家等不同的對象���供適切之參考依據。本研究說明目前專利指標研究的概況，可以作為未來相關專利指標研究發展的基礎，更希望可以提供相關政策制定和產業佈局上專利指標選用之參考。 Because nowadays the patent information plays the important role of the industrial development, the patent indexes become the important reference to evaluate the patent information. This article provides the development of the patent indexes and related researches in Taiwan, and generalizes the application of classification and implication of the patent indexes. Presently the related patent index researches in Taiwan could be distinguished the patent indexes into general characteristic, the quotation and the technology and so on. Such discrimination shows the essence of the patent information and if it can compare with the factors of time and professional fields and presents in the forms of the quantity, frequency or composite indexes, it can provide the appropriate information to the company, the industry or the country. This article not only offers the understanding of the present researches of the patent indexes, but also provides the reference of the policy formulation and the industrial layout. 頁次：88-106
    Keywords Bibliography. Library science. Information resources ; Z
    Subject code 330
    Language English
    Publishing date 2009-10-01T00:00:00Z
    Publisher National Taiwan Normal University
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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