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  1. Article ; Online: Quantification of Live Bacterial Sensing for Chemotaxis and Phagocytosis and of Macropinocytosis.

    Meena, Netra P / Kimmel, Alan R

    Frontiers in cellular and infection microbiology

    2018  Volume 8, Page(s) 62

    Abstract: Initial immunological defense mechanisms to pathogen invasion rely on innate pathways of chemotaxis and phagocytosis, original to ancient phagocytes. Although chemotaxis has been well-studied in mammalian and model systems using purified chemoattractants ...

    Abstract Initial immunological defense mechanisms to pathogen invasion rely on innate pathways of chemotaxis and phagocytosis, original to ancient phagocytes. Although chemotaxis has been well-studied in mammalian and model systems using purified chemoattractants in defined conditions, directed movement toward live bacteria has been more difficult to assess.
    MeSH term(s) Bacteria/metabolism ; Cell Movement/drug effects ; Cell Movement/physiology ; Chemotactic Factors ; Chemotaxis ; Cyclic AMP/pharmacology ; Dictyostelium/drug effects ; Dictyostelium/growth & development ; Dictyostelium/metabolism ; Dose-Response Relationship, Drug ; Folic Acid/pharmacology ; Immunity, Innate ; Phagocytes ; Phagocytosis ; Pinocytosis ; Pterins/pharmacology ; Signal Transduction/drug effects ; Signal Transduction/physiology
    Chemical Substances Chemotactic Factors ; Pterins ; Folic Acid (935E97BOY8) ; Cyclic AMP (E0399OZS9N)
    Language English
    Publishing date 2018-03-02
    Publishing country Switzerland
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2018.00062
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article: An integrated, cross-regulation pathway model involving activating/adaptive and feed-forward/feed-back loops for directed oscillatory cAMP signal-relay/response during the development of

    Jaiswal, Pundrik / Meena, Netra Pal / Chang, Fu-Sheng / Liao, Xin-Hua / Kim, Lou / Kimmel, Alan R

    Frontiers in cell and developmental biology

    2024  Volume 11, Page(s) 1263316

    Abstract: Self-organized and excitable signaling activities play important roles in a wide range of cellular functions in eukaryotic and prokaryotic cells. Cells require signaling networks to communicate amongst themselves, but also for response to environmental ... ...

    Abstract Self-organized and excitable signaling activities play important roles in a wide range of cellular functions in eukaryotic and prokaryotic cells. Cells require signaling networks to communicate amongst themselves, but also for response to environmental cues. Such signals involve complex spatial and temporal loops that may propagate as oscillations or waves. When
    Language English
    Publishing date 2024-01-31
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2737824-X
    ISSN 2296-634X
    ISSN 2296-634X
    DOI 10.3389/fcell.2023.1263316
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Impact of energy devices on the post-operative systemic immune response in women undergoing total laparoscopic hysterectomy for benign disease of the uterus.

    Roy, Kallol Kumar / Gc, Netra / Singhal, Seema / Bharti, Juhi / Kumar, Sunesh / Mitra, Dipendra K / Ray, Ruma / Meena, Jyoti / Vanamail, Perumal

    Journal of the Turkish German Gynecological Association

    2018  Volume 19, Issue 1, Page(s) 1–6

    Abstract: ... at 24 hours (p=0.010). No significant difference was found in the post-operative course between ...

    Abstract Objective: Laparoscopic surgery is associated with reduced surgical stress response, lesser post- operative immune function, and consequent early recovery compared with conventional open surgery. There is a lack of evidence regarding the inflammatory stress response with the use of different energy devices. The present study was conducted to evaluate and compare the inflammatory response in total laparoscopic hysterectomy (TLH) using three different energy devices.
    Material and methods: A prospective randomized controlled study was conducted in 60 women with abnormal uterine bleeding undergoing TLH. They were divided into three groups based on the energy devices used, namely integrated bipolar and ultrasonic energy (Thunderbeat), ultrasonic (Harmonic) and electrothermal bipolar vessel sealing system (Ligasure). Cytokines and chemokines were measured in all three groups at different time points.
    Results: Serum levels of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) increased postsurgery in all three groups and gradually declined by 72 hours. The geometric mean serum (IL)-6 levels was highest with Ligasure at 24 hours as compared with the other groups. Levels of TNF-α, macrophage inflammatory protein (MIP-1) α, MIP-1 β were also higher at 3 hours in the Ligasure group. When the differences between the groups were measured at different time points, there was a significantly greater increase in serum IL-6 levels in the Ligasure group at 24 hours (p=0.010). No significant difference was found in the post-operative course between the groups.
    Conclusion: A greater inflammatory response was seen after the use of Ligasure indicating greater tissue damage. However, this response was not correlated with any difference in postoperative recovery.
    Keywords covid19
    Language English
    Publishing date 2018-03-02
    Publishing country Turkey
    Document type Journal Article
    ZDB-ID 2425806-4
    ISSN 1309-0380 ; 1303-9695 ; 1309-0399
    ISSN (online) 1309-0380 ; 1303-9695
    ISSN 1309-0399
    DOI 10.4274/jtgga.2017.0076
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: DPF is a cell-density sensing factor, with cell-autonomous and non-autonomous functions during Dictyostelium growth and development.

    Meena, Netra Pal / Jaiswal, Pundrik / Chang, Fu-Sheng / Brzostowski, Joseph / Kimmel, Alan R

    BMC biology

    2019  Volume 17, Issue 1, Page(s) 97

    Abstract: Background: Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, ... ...

    Abstract Background: Cellular functions can be regulated by cell-cell interactions that are influenced by extra-cellular, density-dependent signaling factors. Dictyostelium grow as individual cells in nutrient-rich sources, but, as nutrients become depleted, they initiate a multi-cell developmental program that is dependent upon a cell-density threshold. We hypothesized that novel secreted proteins may serve as density-sensing factors to promote multi-cell developmental fate decisions at a specific cell-density threshold, and use Dictyostelium in the identification of such a factor.
    Results: We show that multi-cell developmental aggregation in Dictyostelium is lost upon minimal (2-fold) reduction in local cell density. Remarkably, developmental aggregation response at non-permissive cell densities is rescued by addition of conditioned media from high-density, developmentally competent cells. Using rescued aggregation of low-density cells as an assay, we purified a single, 150-kDa extra-cellular protein with density aggregation activity. MS/MS peptide sequence analysis identified the gene sequence, and cells that overexpress the full-length protein accumulate higher levels of a development promoting factor (DPF) activity than parental cells, allowing cells to aggregate at lower cell densities; cells deficient for this DPF gene lack density-dependent developmental aggregation activity and require higher cell density for cell aggregation compared to WT. Density aggregation activity co-purifies with tagged versions of DPF and tag-affinity-purified DPF possesses density aggregation activity. In mixed development with WT, cells that overexpress DPF preferentially localize at centers for multi-cell aggregation and define cell-fate choice during cytodifferentiation. Finally, we show that DPF is synthesized as a larger precursor, single-pass transmembrane protein, with the p150 fragment released by proteolytic cleavage and ectodomain shedding. The TM/cytoplasmic domain of DPF possesses cell-autonomous activity for cell-substratum adhesion and for cellular growth.
    Conclusions: We have purified a novel secreted protein, DPF, that acts as a density-sensing factor for development and functions to define local collective thresholds for Dictyostelium development and to facilitate cell-cell communication and multi-cell formation. Regions of high DPF expression are enriched at centers for cell-cell signal-response, multi-cell formation, and cell-fate determination. Additionally, DPF has separate cell-autonomous functions for regulation of cellular adhesion and growth.
    MeSH term(s) Cell Communication ; Dictyostelium/genetics ; Dictyostelium/growth & development ; Protozoan Proteins/genetics ; Protozoan Proteins/metabolism
    Chemical Substances Protozoan Proteins
    Language English
    Publishing date 2019-12-02
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Intramural
    ISSN 1741-7007
    ISSN (online) 1741-7007
    DOI 10.1186/s12915-019-0714-9
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Impact of energy devices on the post-operative systemic immune response in women undergoing total laparoscopic hysterectomy for benign disease of the uterus

    Kallol Kumar Roy / Netra GC / Seema Singhal / Juhi Bharti / Sunesh Kumar / Dipendra K. Mitra / Ruma Ray / Jyoti Meena / Perumal Vanamail

    Journal of the Turkish-German Gynecological Association, Vol 19, Iss 1, Pp 1-

    2018  Volume 6

    Abstract: ... at 24 hours (p=0.010). No significant difference was found in the post-operative course between ...

    Abstract Objective:Laparoscopic surgery is associated with reduced surgical stress response, lesser post- operative immune function, and consequent early recovery compared with conventional open surgery. There is a lack of evidence regarding the inflammatory stress response with the use of different energy devices. The present study was conducted to evaluate and compare the inflammatory response in total laparoscopic hysterectomy (TLH) using three different energy devices.Material and Methods:A prospective randomized controlled study was conducted in 60 women with abnormal uterine bleeding undergoing TLH. They were divided into three groups based on the energy devices used, namely integrated bipolar and ultrasonic energy (Thunderbeat), ultrasonic (Harmonic) and electrothermal bipolar vessel sealing system (Ligasure). Cytokines and chemokines were measured in all three groups at different time points.Results:Serum levels of interleukin (IL)-6 and tumor necrosis factor-alpha (TNF-α) increased postsurgery in all three groups and gradually declined by 72 hours. The geometric mean serum (IL)-6 levels was highest with Ligasure at 24 hours as compared with the other groups. Levels of TNF-α, macrophage inflammatory protein (MIP-1) α, MIP-1 β were also higher at 3 hours in the Ligasure group. When the differences between the groups were measured at different time points, there was a significantly greater increase in serum IL-6 levels in the Ligasure group at 24 hours (p=0.010). No significant difference was found in the post-operative course between the groups.Conclusion:A greater inflammatory response was seen after the use of Ligasure indicating greater tissue damage. However, this response was not correlated with any difference in postoperative recovery.
    Keywords total laparoscopic hysterectomy ; immune response ; cytokines ; chemokines ; Medicine ; R ; Gynecology and obstetrics ; RG1-991
    Subject code 610
    Language English
    Publishing date 2018-03-01T00:00:00Z
    Publisher Galenos Yayinevi
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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