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Article ; Online: Adverse events after left ventricular assist device implantation linked to psychosocial risk in women and men.

Maukel, Lisa-Marie / Weidner, Gerdi / Beyersmann, Jan / Spaderna, Heike

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

2023 Volume 42, Issue 11, Page(s) 1557–1568

Abstract: Background: Reasons for women's increased probability to experience adverse events (AEs) after left ventricular assist device (LVAD) implantation compared with men's remain uncertain. We explored the role of psychosocial risk in the experience of AEs in ...

Abstract	Background: Reasons for women's increased probability to experience adverse events (AEs) after left ventricular assist device (LVAD) implantation compared with men's remain uncertain. We explored the role of psychosocial risk in the experience of AEs in women and men. Methods: INTERMACS patients receiving a primary continuous-flow LVAD between July 2006 and December 2017, median follow-up 13.6 months, were included (n = 20,123, 21.3% women). Time-to-event was calculated with cumulative incidence functions for 10 types of AEs separately (e.g., infection, device malfunction), each time accounting for the competing outcomes death, heart transplant, and device explant due to recovery. Event-specific Cox proportional hazard models were run with a binary psychosocial risk variable (including substance abuse, psychiatric diagnosis, limited social support, limited cognition, repeated noncompliance), controlled for covariates. Results: Psychosocial risk was more prevalent in men than in women (21.4% vs 17.5%, p < 0.001). Seven out of 10 AEs were more likely in women than in men (e.g., infection 44.5% vs 39.2%, p < 0.001). The association of psychosocial risk with each AE was either stronger in women than in men (e.g., device malfunction HR Conclusions: Independent of clinical parameters, the presence of psychosocial risk is associated with increases in AEs. This suggests that early modification of psychosocial risk factors may have the potential to lower the risk for AEs in this patient population.
MeSH term(s)	Male ; Humans ; Female ; Heart Failure ; Heart-Assist Devices/adverse effects ; Heart Transplantation ; Risk Factors ; Proportional Hazards Models ; Treatment Outcome ; Retrospective Studies
Language	English
Publishing date	2023-06-26
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1062522-7
ISSN	1557-3117 ; 1053-2498
ISSN (online)	1557-3117
ISSN	1053-2498
DOI	10.1016/j.healun.2023.06.013
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Zs.A 2056: Show issues

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Article: Heart Failure Relapses in Response to Acute Stresses - Role of Immunological and Inflammatory Pathways.

Hasselbach, Lisa / Weidner, Johannes / Elsässer, Albrecht / Theilmeier, Gregor

Frontiers in cardiovascular medicine

2022 Volume 9, Page(s) 809935

Abstract: Cardiovascular diseases continue to be the most imminent health care problems in the western world, accounting for numerous deaths per year. Heart failure (HF), namely the reduction of left ventricular function, is one of the major cardiovascular disease ...

Abstract	Cardiovascular diseases continue to be the most imminent health care problems in the western world, accounting for numerous deaths per year. Heart failure (HF), namely the reduction of left ventricular function, is one of the major cardiovascular disease entities. It is chronically progressing with relapsing acute decompensations and an overall grave prognosis that is little different if not worse than most malignant diseases. Interestingly acute metabolically and/or immunologically challenging events like infections or major surgical procedures will cause relapses in the course of preexisting chronic heart failure, decrease the patients wellbeing and worsen myocardial function. HF itself and or its progression has been demonstrated to be driven at least in part by inflammatory pathways that are similarly turned on by infectious or non-infectious stress responses. These thus add to HF progression or relapse. TNF-α plasma levels are associated with disease severity and progression in HF. In addition, several cytokines (e.g., IL-1β, IL-6) are involved in deteriorating left ventricular function. Those observations are based on clinical studies using inhibitors of cytokines or their receptors or they stem from animal studies examining the effect of cytokine mediated inflammation on myocardial remodeling in models of heart failure. This short review summarizes the known underlying immunological processes that are shared by and drive all: chronic heart failure, select infectious diseases, and inflammatory stress responses. In conclusion the text provides a brief summary of the current development in immunomodulatory therapies for HF and their overlap with treatments of other disease entities.
Language	English
Publishing date	2022-04-25
Publishing country	Switzerland
Document type	Journal Article ; Review
ZDB-ID	2781496-8
ISSN	2297-055X
ISSN	2297-055X
DOI	10.3389/fcvm.2022.809935
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Article ; Online: Sonographically Detected Hepatic Portal Venous Gas - Prevalence, Causes, and Clinical Implications.

Mehl, Lisa / Schmidt, Christa / Weidner, Ulrike / Lock, Guntram

Ultraschall in der Medizin (Stuttgart, Germany : 1980)

2022 Volume 44, Issue 4, Page(s) 408–413

Abstract: Purpose: Hepatic portal venous gas (HPVG) is a rare clinical finding, often caused by a severe underlying disease. In the literature as well as in clinical practice, HPVG is considered "signum malum" with a poor prognosis and bowel ischemia as the most ...

Title translation	Portalvenöses Gas im Ultraschall – Prävalenz, Ursachen und klinische Implikationen.
Abstract	Purpose: Hepatic portal venous gas (HPVG) is a rare clinical finding, often caused by a severe underlying disease. In the literature as well as in clinical practice, HPVG is considered "signum malum" with a poor prognosis and bowel ischemia as the most common cause. Most studies are based on the results of computed tomography (CT) examinations. The aim of this retrospective study is to report on the prevalence, causes, and clinical course of HPVG in a monocentric cohort of abdominal ultrasound (US) investigations. Materials and methods: The US database of an academic teaching hospital was searched with specific keywords (timespan 01/2000 to 12/2020). Reports, pictures, and clinical data of all cases with HPVG were re-evaluated. Results: Out of 134 804 US examinations, 8 HPVG cases were identified. There was a wide variety of underlying diseases, with mesenteric ischemia being seen in only 2 cases. 5 patients were discharged in stable condition, with 4 of them having undergone surgical treatment. 2 patients who had rejected further measures died, and one was lost to follow-up. Discussion: HPVG is a rare phenomenon in clinical US. However, ultrasonographic prevalence is comparable to the prevalence in CT studies. Underlying diseases are mostly severe, and in nearly all cases an underlying cause can be found by thorough investigation. In some cases, US may even be superior to CT scans for the detection of HPVG. Despite its rarity, every sonographer should know the typical sonographic presentation of HPVG, and appropriate images should be included in US teaching modules.
MeSH term(s)	Humans ; Portal Vein/diagnostic imaging ; Retrospective Studies ; Prevalence ; Tomography, X-Ray Computed
Language	English
Publishing date	2022-04-28
Publishing country	Germany
Document type	Journal Article
ZDB-ID	801064-x
ISSN	1438-8782 ; 1439-0914 ; 1431-4894 ; 0172-4614
ISSN (online)	1438-8782
ISSN	1439-0914 ; 1431-4894 ; 0172-4614
DOI	10.1055/a-1797-9986
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Zs.A 1572: Show issues

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ab Jg. 2022: Lesesaal (EG)

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Article ; Online: Sex Differences in Recovery and Device Replacement After Left Ventricular Assist Device Implantation as Destination Therapy.

Maukel, Lisa-Marie / Weidner, Gerdi / Beyersmann, Jan / Spaderna, Heike

Journal of the American Heart Association

2022 Volume 11, Issue 5, Page(s) e023294

Abstract: Background The relevance of sex and preimplant factors for clinical outcomes among patients with left ventricular assist devices intended for destination therapy is unclear. Methods and Results INTERMACS (Interagency Registry for Mechanically Assisted ... ...

Abstract	Background The relevance of sex and preimplant factors for clinical outcomes among patients with left ventricular assist devices intended for destination therapy is unclear. Methods and Results INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) data (2006-2017) from 6771 men and 1690 women with left ventricular assist devices as destination therapy were analyzed to evaluate the contribution of preimplant clinical, demographic, and clinically judged psychosocial characteristics to time until death, heart transplant, device explant due to recovery, or complication-related device replacement. Associations of sex with time until each competing outcome were evaluated using cumulative incidence functions and event-specific Cox proportional hazards models. Women were younger, more likely to have nonischemic diagnoses, and reported less substance abuse but were more likely to be unmarried, not working for an income, overweight, and depressed than men. After 2 years, women had higher probabilities for recovery (3.7% versus 1.6%,
MeSH term(s)	Female ; Heart Failure/diagnosis ; Heart Failure/surgery ; Heart Transplantation/adverse effects ; Heart-Assist Devices/adverse effects ; Humans ; Male ; Registries ; Sex Characteristics ; Treatment Outcome
Language	English
Publishing date	2022-02-22
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2653953-6
ISSN	2047-9980 ; 2047-9980
ISSN (online)	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.023294
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: DIAGNOSIS AND TREATMENT OF A NATURAL INFECTION WITH

McCain, Stephanie / Sim, Richard R / Weidner, Bridget / Rivas, Anne E / White, Brooke / Auckland, Lisa D / Tarleton, Rick L / Hamer, Sarah

Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians

2023 Volume 54, Issue 2, Page(s) 412–416

Abstract: Trypanosoma ... ...

Abstract	Trypanosoma cruzi
MeSH term(s)	Animals ; Male ; Humans ; Trypanosoma cruzi ; Alabama ; Chagas Disease/diagnosis ; Chagas Disease/drug therapy ; Chagas Disease/veterinary ; Cercopithecus
Chemical Substances	benzonidazole (YC42NRJ1ZD)
Language	English
Publishing date	2023-07-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	2174930-9
ISSN	1937-2825 ; 1042-7260
ISSN (online)	1937-2825
ISSN	1042-7260
DOI	10.1638/2022-0095
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Neutralizing Antibodies against SARS-CoV-2 and HLA Class I and II Polymorphism.

Weidner, Lisa / Kalser, Julia / Kreil, Thomas R / Jungbauer, Christof / Mayr, Wolfgang R

Transfusion medicine and hemotherapy : offizielles Organ der Deutschen Gesellschaft fur Transfusionsmedizin und Immunhamatologie

2021 Volume 48, Issue 3, Page(s) 173–174

Language	English
Publishing date	2021-03-11
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2100848-6
ISSN	1660-3818 ; 1660-3796
ISSN (online)	1660-3818
ISSN	1660-3796
DOI	10.1159/000515149
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Zs.A 959: Show issues

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Article ; Online: When the available blood supply mismatches the needs of the patient.

Weidner, Lisa / Allhoff, Wolfgang / Pistorius, Charlotte / Witt, Volker / Rohde, Eva / Schistal, Elisabeth / Jungbauer, Christof

Blood transfusion = Trasfusione del sangue

2022 Volume 21, Issue 5, Page(s) 378–384

Abstract: Background: Substantial regional differences in the genetic patterns related to blood group have been observed across different continents. This diversity means that the blood supply, as an essential part of patient care, is increasingly impacted by ... ...

Abstract	Background: Substantial regional differences in the genetic patterns related to blood group have been observed across different continents. This diversity means that the blood supply, as an essential part of patient care, is increasingly impacted by global migration. Consequently, the Austrian blood donor population does not match the immigrant patient population. This mismatch is likely to result in the formation of alloantibodies to red cell antigens in the chronically transfused. Subsequently, major difficulties in providing compatible blood emerge. Material and methods: The study included patients of African origin (n=290) and Caucasians who represent the Austrian donor population (n=1,017). Genetic typing was performed for up to 69 blood group polymorphisms with a multiplex sequence specific primer-PCR including high frequency antigens and antigens for which antisera are not commercially available. By assessing differences in antigen frequencies between the two populations, and using these data for prophylactic matching, we aim to develop tools to increase the quality of patient care. Results: Results indicate various and significant differences (p<0.0001) in antigen frequencies between African patients and the European donor population, especially in the MNS, Duffy, Knops and Rhesus systems. Discussion: Our data highlight the importance of matching the donor population to the demographics of the patient population. In addition, it underlines the need to recruit donors of African origin and to focus on the upcoming challenges, such as malaria semi-immunity and a significantly higher rate of infectious disease in this population. It is also recommended to apply extended genetic typing to detect rare blood types, and (cryo)storage of rare blood in national and international rare blood banks. Co-operation with regional blood banks should also be encouraged.
MeSH term(s)	Humans ; Blood Group Antigens/genetics ; Polymorphism, Genetic ; Isoantibodies/genetics ; Blood Banks ; Blood Donors
Chemical Substances	Blood Group Antigens ; Isoantibodies
Language	English
Publishing date	2022-11-04
Publishing country	Italy
Document type	Journal Article
ZDB-ID	2135732-8
ISSN	2385-2070 ; 0041-1787 ; 1723-2007
ISSN (online)	2385-2070
ISSN	0041-1787 ; 1723-2007
DOI	10.2450/2022.0166-22
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Zs.A 798: Show issues

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Jg. 1995 - 2021: Lesesall (1.OG)
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Article: Sonographically Detected Hepatic Portal Venous Gas – Prevalence, Causes, and Clinical Implications

Mehl, Lisa / Schmidt, Christa / Weidner, Ulrike / Lock, Guntram

Ultraschall in der Medizin - European Journal of Ultrasound

2022 Volume 44, Issue 04, Page(s) 408–413

Abstract: Purpose: Hepatic portal venous gas (HPVG) is a rare clinical finding, often caused by a severe underlying disease. In the literature as well as in clinical practice, HPVG is considered “signum malum” with a poor prognosis and bowel ischemia as the most ... ...

Abstract	Purpose: Hepatic portal venous gas (HPVG) is a rare clinical finding, often caused by a severe underlying disease. In the literature as well as in clinical practice, HPVG is considered “signum malum” with a poor prognosis and bowel ischemia as the most common cause. Most studies are based on the results of computed tomography (CT) examinations. The aim of this retrospective study is to report on the prevalence, causes, and clinical course of HPVG in a monocentric cohort of abdominal ultrasound (US) investigations. Materials and Methods: The US database of an academic teaching hospital was searched with specific keywords (timespan 01/2000 to 12/2020). Reports, pictures, and clinical data of all cases with HPVG were re-evaluated. Results: Out of 134 804 US examinations, 8 HPVG cases were identified. There was a wide variety of underlying diseases, with mesenteric ischemia being seen in only 2 cases. 5 patients were discharged in stable condition, with 4 of them having undergone surgical treatment. 2 patients who had rejected further measures died, and one was lost to follow-up. Discussion: HPVG is a rare phenomenon in clinical US. However, ultrasonographic prevalence is comparable to the prevalence in CT studies. Underlying diseases are mostly severe, and in nearly all cases an underlying cause can be found by thorough investigation. In some cases, US may even be superior to CT scans for the detection of HPVG. Despite its rarity, every sonographer should know the typical sonographic presentation of HPVG, and appropriate images should be included in US teaching modules.
Keywords	ultrasound ; retrospective study ; hepatic portal venous gas
Language	English
Publishing date	2022-04-28
Publisher	Georg Thieme Verlag KG
Publishing place	Stuttgart ; New York
Document type	Article
ZDB-ID	801064-x
ISSN	1438-8782 ; 0172-4614 ; 1439-0914 ; 1431-4894
ISSN (online)	1438-8782
ISSN	0172-4614 ; 1439-0914 ; 1431-4894
DOI	10.1055/a-1797-9986
Database	Thieme publisher's database

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Article ; Online: Comment on "Does vaping cause seizures? The need for comprehensive drug testing".

Weidner, Anna-Sophie / Rudy, Susan F / Faulcon, Lisa M

Clinical toxicology (Philadelphia, Pa.)

2019 Volume 58, Issue 5, Page(s) 435–436

MeSH term(s)	Electronic Nicotine Delivery Systems ; Humans ; Seizures ; Substance Abuse Detection ; Vaping
Language	English
Publishing date	2019-09-09
Publishing country	England
Document type	Letter ; Comment
ZDB-ID	204476-6
ISSN	1556-9519 ; 0009-9309 ; 0731-3810 ; 1556-3650
ISSN (online)	1556-9519
ISSN	0009-9309 ; 0731-3810 ; 1556-3650
DOI	10.1080/15563650.2019.1650940
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Zs.B 419: Show issues

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Article: Sex differences in recovery and device replacement after left ventricular assist device implantation as destination therapy

Maukel, Lisa-Marie / Weidner, Gerdi / Beyersmann, Jan / Spaderna, Heike

Journal of the American Heart Association

2022 Volume 11, Issue 5, Page(s) No

Abstract: Background: The relevance of sex and preimplant factors for clinical outcomes among patients with left ventricular assist devices intended for destination therapy is unclear. Methods and Results: INTERMACS (Interagency Registry for Mechanically Assisted ... ...

Title translation	Geschlechtsunterschiede bei der Genesung und dem Austausch von Geräten nach der Implantation eines linksventrikulären Unterstützungsgeräts als Zieltherapie. (DeepL)
Abstract	Background: The relevance of sex and preimplant factors for clinical outcomes among patients with left ventricular assist devices intended for destination therapy is unclear. Methods and Results: INTERMACS (Interagency Registry for Mechanically Assisted Circulatory Support) data (2006-2017) from 6771 men and 1690 women with left ventricular assist devices as destination therapy were analyzed to evaluate the contribution of preimplant clinical, demographic, and clinically judged psychosocial characteristics to time until death, heart transplant, device explant due to recovery, or complication-related device replacement. Associations of sex with time until each competing outcome were evaluated using cumulative incidence functions and event-specific Cox proportional hazards models. Women were younger, more likely to have nonischemic diagnoses, and reported less substance abuse but were more likely to be unmarried, not working for an income, overweight, and depressed than men. After 2 years, women had higher probabilities for recovery (3.7% versus 1.6%, P<0.001) and device replacement (12.1% versus 10%, P=0.019) than men but not for death and transplant (P>0.12). The sex differences remained after controlling for covariates (adjusted hazard ratio [HRadj] recovery, 1.85; 95% CI, 1.30-2.70; P<0.001; HRadj device replacement, 1.22; 95% CI, 1.04-1.33; P=0.015). Female-specific diagnoses (eg, postpartum heart failure) contributed to women's enhanced rate of recovery. Demographic and psychosocial factors were unrelated to women's increased event rates. Conclusions: In destination therapy, women have higher rates of device replacement and recovery than men. The latter was partly explained by female-specific diagnoses. Standardized assessments of psychosocial characteristics are needed to elucidate their association with sex differences in outcomes.
Keywords	Genesung ; Geschlechtsunterschiede beim Menschen ; Heart Disorders ; Herzkrankheiten ; Human Sex Differences ; Medical Therapeutic Devices ; Medizinisch-therapeutische Hilfsmittel ; Psychosocial Factors ; Psychosoziale Faktoren ; Recovery (Disorders)
Language	English
Document type	Article
ZDB-ID	2653953-6
ISSN	2047-9980
ISSN	2047-9980
DOI	10.1161/JAHA.121.023294
Database	PSYNDEX

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