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  1. Article: LRRK2 kinase activity is necessary for development and regeneration in Nematostella vectensis.

    Holmes, Grace / Ferguson, Sophie R / Lewis, Patrick Alfryn / Echeverri, Karen

    Research square

    2023  

    Abstract: Background: The starlet sea anemone, : Methods: We used bioinformatics to determine the cross-species conservation of LRRK2, then applied drugs targeting the kinase activity of LRRK2 to examine its function in development, homeostasis and ... ...

    Abstract Background: The starlet sea anemone,
    Methods: We used bioinformatics to determine the cross-species conservation of LRRK2, then applied drugs targeting the kinase activity of LRRK2 to examine its function in development, homeostasis and regeneration in
    Results: An
    Conclusions: Our work introduces a new model organism with which to study LRRK biology. We show a necessity for LRRK2 in development and regeneration. Given the short generation time, genetic trackability and in vivo imaging capabilities, this work introduces
    Language English
    Publishing date 2023-11-07
    Publishing country United States
    Document type Preprint
    DOI 10.21203/rs.3.rs-3525606/v1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Why did Rubens add a parrot to Titian's The Fall of Man? A pictorial manipulation of joint attention.

    Alexander, Robert G / Venkatakrishnan, Ashwin / Chanovas, Jordi / Ferguson, Sophie / Macknik, Stephen L / Martinez-Conde, Susana

    Journal of vision

    2024  Volume 24, Issue 4, Page(s) 1

    Abstract: Almost 400 years ago, Rubens copied Titian's The Fall of Man, albeit with important changes. Rubens altered Titian's original composition in numerous ways, including by changing the gaze directions of the depicted characters and adding a striking red ... ...

    Abstract Almost 400 years ago, Rubens copied Titian's The Fall of Man, albeit with important changes. Rubens altered Titian's original composition in numerous ways, including by changing the gaze directions of the depicted characters and adding a striking red parrot to the painting. Here, we quantify the impact of Rubens's choices on the viewer's gaze behavior. We displayed digital copies of Rubens's and Titian's artworks-as well as a version of Rubens's painting with the parrot digitally removed-on a computer screen while recording the eye movements produced by observers during free visual exploration of each image. To assess the effects of Rubens's changes to Titian's composition, we directly compared multiple gaze parameters across the different images. We found that participants gazed at Eve's face more frequently in Rubens's painting than in Titian's. In addition, gaze positions were more tightly focused for the former than for the latter, consistent with different allocations of viewer interest. We also investigated how gaze fixation on Eve's face affected the perceptual visibility of the parrot in Rubens's composition and how the parrot's presence versus its absence impacted gaze dynamics. Taken together, our results demonstrate that Rubens's critical deviations from Titian's painting have powerful effects on viewers' oculomotor behavior.
    MeSH term(s) Male ; Animals ; Humans ; Parrots ; Eye Movements ; Attention ; Fixation, Ocular ; Paintings
    Language English
    Publishing date 2024-04-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2106064-2
    ISSN 1534-7362 ; 1534-7362
    ISSN (online) 1534-7362
    ISSN 1534-7362
    DOI 10.1167/jov.24.4.1
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  3. Article: Transporting babies in an emergency.

    Ferguson, Sophie

    Nursing New Zealand (Wellington, N.Z. : 1995)

    2016  Volume 22, Issue 4, Page(s) 16–17

    MeSH term(s) Administration, Inhalation ; Air Ambulances ; Bronchodilator Agents/therapeutic use ; Humans ; Incubators, Infant ; Infant, Newborn ; Intensive Care, Neonatal ; Neonatal Nursing ; New Zealand ; Nitric Oxide/therapeutic use ; Patient Transfer ; Respiratory Distress Syndrome, Newborn/therapy ; Transportation of Patients
    Chemical Substances Bronchodilator Agents ; Nitric Oxide (31C4KY9ESH)
    Language English
    Publishing date 2016-05
    Publishing country New Zealand
    Document type Journal Article
    ZDB-ID 1155405-8
    ISSN 1173-2032 ; 1172-1979
    ISSN 1173-2032 ; 1172-1979
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3724: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  4. Article ; Online: Revisiting the ownership effect in adults with and without autism.

    Smith, Marchella / Williams, David / Lind, Sophie / Ferguson, Heather J

    PloS one

    2023  Volume 18, Issue 12, Page(s) e0293898

    Abstract: Self-owned items are better remembered than other-owned items; this ownership effect reflects privileged processing of self-related information. The size of this ownership effect has been shown to decrease in neurotypical adults as the number of autistic ...

    Abstract Self-owned items are better remembered than other-owned items; this ownership effect reflects privileged processing of self-related information. The size of this ownership effect has been shown to decrease in neurotypical adults as the number of autistic traits increases, and is reduced in autistic adults. However, emerging evidence has questioned the reliability of these findings. This paper aimed to replicate previous work using well-powered, pre-registered designs, and Bayesian analyses. Experiment 1 (N = 100) found a significant ownership effect in neurotypical adults; however, the size of this was unrelated to individual differences in autistic traits. Experiment 2 (N = 56) found an ownership effect in neurotypical but not autistic adults. The findings suggest that individual differences in autistic traits in the neurotypical population do not impact the ownership effect, but a clinical diagnosis of autism might. We discuss how these findings can be explained by differences in psychological self-awareness in autism.
    MeSH term(s) Adult ; Child ; Humans ; Autistic Disorder/psychology ; Ownership ; Bayes Theorem ; Reproducibility of Results ; Child Development Disorders, Pervasive ; Autism Spectrum Disorder
    Language English
    Publishing date 2023-12-22
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2267670-3
    ISSN 1932-6203 ; 1932-6203
    ISSN (online) 1932-6203
    ISSN 1932-6203
    DOI 10.1371/journal.pone.0293898
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  5. Article ; Online: Thyroid neoplasia associated with nutritional deficiency in cultured jade perch in Hong Kong.

    Chan, Stephen C H / Lim, Zwok Zu / Leung, Aaron C F / Cheng, Tzu Hsuan / Cheng, Ka Po F / St-Hilaire, Sophie / Ferguson, Andrew M D

    Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc

    2024  , Page(s) 10406387231218733

    Abstract: Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We ...

    Abstract Non-neoplastic thyroid hyperplasia is common in terrestrial animals, secondary to nutritional imbalances or other goitrogenic compounds. Thyroid hyperplasia is relatively common in teleost fish; however, malignant thyroid neoplasia is rarely reported. We diagnosed cases of thyroid neoplasia in a population of jade perch (
    Language English
    Publishing date 2024-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 287603-6
    ISSN 1943-4936 ; 1040-6387
    ISSN (online) 1943-4936
    ISSN 1040-6387
    DOI 10.1177/10406387231218733
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    Zs.A 3645: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  6. Article ; Online: Comparison of Blastema Formation after Injury in Two Cephalopod Species.

    Chavez Ramirez, Carlos / Khoo, Miya / Lopez G, Marco / Ferguson, Sophie / Walker, Sarah / Echeverri, Karen

    microPublication biology

    2023  Volume 2023

    Abstract: Regeneration is the ability to functionally replace significant amounts of lost tissue or whole appendages like arms, limbs or tentacles. The amount of tissue that can be regenerated varies among species, but regeneration is found in both invertebrate ... ...

    Abstract Regeneration is the ability to functionally replace significant amounts of lost tissue or whole appendages like arms, limbs or tentacles. The amount of tissue that can be regenerated varies among species, but regeneration is found in both invertebrate and vertebrate animals. Cephalopods have been broadly reported in the literature to regenerate their arms. There are over 800 species of Cephalopod; however, regeneration has only been documented in the literature in a few species (1). Here we compare arm regeneration in two species of cephalopod, the
    Language English
    Publishing date 2023-09-19
    Publishing country United States
    Document type Journal Article
    ISSN 2578-9430
    ISSN (online) 2578-9430
    DOI 10.17912/micropub.biology.000946
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  7. Article ; Online: Ramicrusta invasive alga causes mortality in Caribbean coral larvae

    Kayla Cayemitte / Nadège Aoki / Sophie R. Ferguson / T. Aran Mooney / Amy Apprill

    Frontiers in Marine Science, Vol

    2023  Volume 10

    Abstract: The settlement of coral larvae is an important process which contributes to the success and longevity of coral reefs. Coral larvae often recruit to benthic structures covered with crustose coralline algae (CCA) which produce cues that promote settlement ... ...

    Abstract The settlement of coral larvae is an important process which contributes to the success and longevity of coral reefs. Coral larvae often recruit to benthic structures covered with crustose coralline algae (CCA) which produce cues that promote settlement and metamorphosis. The Peysonneliaceae Ramicrusta spp. are red-brown encrusting alga that have recently become abundant on shallow Caribbean reefs, replacing CCA habitat, overgrowing corals and potentially threatening coral recruitment. In order to assess the threat of Ramicrusta to coral recruitment, we compared the survival and settlement of Porites astreoides and Favia fragum larvae to 0.5 – 2 mg ml-1 solutions of Ramicrusta sp. or CCA as well as sterile seawater (control). In all cases larval mortality was extremely high in the Ramicrusta treatments compared to the CCA and control treatments. We found 96% (± 8.9% standard deviation, SD) mortality of P. astreoides larvae when exposed to solutions of Ramicrusta and 0 - 4% (± 0 - 8.9% SD) mortality in the CCA treatments. We observed 100% F. fragum larval mortality when exposed to Ramicrusta and 5 – 10% (± 10 – 20% SD) mortality in the CCA treatments. Settlement or surface interaction of larvae in the CCA treatments was 40 - 68% (± 22 - 37% SD) for P. astreoides and 65 - 75% (± 10 - 19% SD) for F. fragum. Two P. astreoides larva that survived Ramicrusta exposure did settle/surface interact, suggesting that some larvae may be tolerant to Ramicrusta. These results suggest that Ramicrusta is a lethal threat to Caribbean coral recruitment.
    Keywords coral reef ; ecology ; USVI ; coral larvae ; settlement ; recruitment ; Science ; Q ; General. Including nature conservation ; geographical distribution ; QH1-199.5
    Subject code 590
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Frontiers Media S.A.
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Catalyzing Singlet Fission by Transition Metals: Second versus Third Row Effects.

    Hou, Yuxuan / Papadopoulos, Ilias / Bo, Yifan / Wollny, Anna-Sophie / Ferguson, Michael J / Mai, Lukas A / Tykwinski, Rik R / Guldi, Dirk M

    Precision chemistry

    2023  Volume 1, Issue 9, Page(s) 555–564

    Abstract: The synthesis and characterization of platinum(II) and palladium(II) complexes bearing two (dimers Pt( ... ...

    Abstract The synthesis and characterization of platinum(II) and palladium(II) complexes bearing two (dimers Pt(L
    Language English
    Publishing date 2023-10-25
    Publishing country United States
    Document type Journal Article
    ISSN 2771-9316
    ISSN (online) 2771-9316
    DOI 10.1021/prechem.3c00082
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  9. Article ; Online: The invasive cell coat at the microsporidian Trachipleistophora hominis-host cell interface contains secreted hexokinases.

    Ferguson, Sophie / Lucocq, John

    MicrobiologyOpen

    2018  Volume 8, Issue 4, Page(s) e00696

    Abstract: Microsporidia are obligate intracellular parasites causing significant disease in humans and economically important animals. In parallel to their extreme genetic reduction, Microsporidia have evolved novel mechanisms for exploiting host metabolism. A ... ...

    Abstract Microsporidia are obligate intracellular parasites causing significant disease in humans and economically important animals. In parallel to their extreme genetic reduction, Microsporidia have evolved novel mechanisms for exploiting host metabolism. A number of microsporidians confer secretion of otherwise cytosolic proteins by coding for signal peptides that direct entry into the endoplasmic reticulum. The human pathogen Trachipleistophora hominis encodes for four hexokinases, three of which have signal peptides at the N-terminus. Here, we localized hexokinase 2 and hexokinase 3 through developmental stages of T. hominis using light and electron microscopy. Both proteins were concentrated in an extracellular coat previously termed the plaque matrix (PQM). The PQM (containing hexokinases) was morphologically dynamic, infiltrating the host cytoplasm predominantly during replicative stages. Throughout development the PQM interacted closely with endoplasmic reticulum that was demonstrated to be active in membrane protein biosynthesis and export. The impact of hexokinase on the host metabolism was probed using the fluorescent analog of glucose, 2-NBDG, which displayed spatially restricted increases in signal intensity at the parasite/vacuole surface, coincident with hexokinase/PQM distribution. Gross metabolic aberrations, measured using metabolic profiling with the Seahorse XF Analyzer, were not detectable in mixed stage cocultures. Overall, these results highlight a role for the extended cell coat of T. hominis in host-parasite interactions, within which secreted hexokinases may work as part of a metabolic machine to increase glycolytic capacity or ATP generation close to the parasite surface.
    MeSH term(s) Animals ; Cell Line ; Fungal Proteins/genetics ; Fungal Proteins/metabolism ; Glycocalyx/metabolism ; Glycocalyx/microbiology ; Hexokinase/genetics ; Hexokinase/metabolism ; Host-Pathogen Interactions ; Humans ; Microsporidia/enzymology ; Microsporidia/genetics ; Microsporidia/physiology ; Microsporidiosis/metabolism ; Microsporidiosis/microbiology ; Protein Transport ; Rabbits
    Chemical Substances Fungal Proteins ; Hexokinase (EC 2.7.1.1)
    Language English
    Publishing date 2018-07-27
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2661368-2
    ISSN 2045-8827 ; 2045-8827
    ISSN (online) 2045-8827
    ISSN 2045-8827
    DOI 10.1002/mbo3.696
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  10. Article ; Online: Indigenous food sources as vectors of Escherichia coli and antibiotic resistance.

    van Hamelsveld, Sophie / Kurenbach, Brigitta / Paull, Deborah J / Godsoe, William A / Ferguson, Gayle C / Heinemann, Jack A

    Environmental pollution (Barking, Essex : 1987)

    2023  Volume 334, Page(s) 122155

    Abstract: The contamination of surface waters by fecal bacteria, measured by the number of Escherichia coli, is a significant public health issue. When these bacteria are also resistant to antimicrobials, infections are more complicated to treat. While water is ... ...

    Abstract The contamination of surface waters by fecal bacteria, measured by the number of Escherichia coli, is a significant public health issue. When these bacteria are also resistant to antimicrobials, infections are more complicated to treat. While water is regularly tested at recreational sites, wild-harvested foods, known as mahinga kai by the indigenous Māori people of Aotearoa New Zealand, are commonly overlooked as a source of exposure to potential pathogens and antimicrobial resistance (AMR). We investigate two likely sources of risk from harvesting aquatic wild foods. The first is water contact, and the second is contact with/ingestion of the harvest. We used E. coli as a proxy for microbial water quality at harvesting sites. Two popular mahinga kai species were also harvested and assessed. We found antibiotic-resistant bacteria on watercress (Nasturtium officinale) and cockles (Austrovenus stutchburyi). One-third of E. coli isolates were conjugative donors of at least one resistance phenotype. Tank experiments were used to track the internalization of E. coli by Greenshell/lip mussels (Perna canaliculus). Greenshell mussels kept at environmentally relevant concentrations of E. coli were colonized to levels considered unsafe for human consumption in 24 h. Finally, we measured horizontal gene transfer between bacteria within the shellfish, what we termed 'intra-shellular' conjugation. The transmission frequency of plasmid RP4 was significantly higher in mussels than in water alone. Our results indicate that shellfish could promote the dissemination of antibiotic resistance. They highlight the need to limit or reduce human pathogenic bacteria where food is gathered.
    MeSH term(s) Animals ; Humans ; Anti-Bacterial Agents/pharmacology ; Bivalvia ; Drug Resistance, Microbial ; Escherichia coli ; Maori People ; Plasmids ; Water Microbiology ; Food Contamination
    Chemical Substances Anti-Bacterial Agents
    Language English
    Publishing date 2023-07-12
    Publishing country England
    Document type Journal Article
    ZDB-ID 280652-6
    ISSN 1873-6424 ; 0013-9327 ; 0269-7491
    ISSN (online) 1873-6424
    ISSN 0013-9327 ; 0269-7491
    DOI 10.1016/j.envpol.2023.122155
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2599: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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