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  1. Article: Quantifying the association between Campylobacter infection and Guillain-Barré syndrome: a systematic review.

    Poropatich, Kate O / Walker, Christa L Fischer / Black, Robert E

    Journal of health, population, and nutrition

    2010  Volume 28, Issue 6, Page(s) 545–552

    Abstract: Guillain-Barré Syndrome (GBS) is a neurologic disease that causes ascending paralysis and is triggered by a preceding bacterial or viral infection. Several studies have shown that patients with GBS have a recent history of infection due to Campylobacter ... ...

    Abstract Guillain-Barré Syndrome (GBS) is a neurologic disease that causes ascending paralysis and is triggered by a preceding bacterial or viral infection. Several studies have shown that patients with GBS have a recent history of infection due to Campylobacter jejuni. A literature review of published studies that reported rates of Campylobacter infection before or in conjunction with GBS was done. These reported data were used for calculating the proportion of GBS cases who tested positive for Campylobacter compared to the control population and the incidence of GBS among patients infected with Campylobacter. Results of the analysis suggest that 31% of 2,502 GBS cases included in these papers are attributable to Campylobacter infection.
    MeSH term(s) Campylobacter Infections/complications ; Campylobacter jejuni ; Case-Control Studies ; Guillain-Barre Syndrome/epidemiology ; Guillain-Barre Syndrome/etiology ; Humans ; Incidence
    Language English
    Publishing date 2010-11-17
    Publishing country Bangladesh
    Document type Journal Article ; Review ; Systematic Review
    ZDB-ID 2025045-9
    ISSN 2072-1315 ; 1606-0997
    ISSN (online) 2072-1315
    ISSN 1606-0997
    DOI 10.3329/jhpn.v28i6.6602
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Elemental Zn and its Binding Protein Zinc-α2-Glycoprotein are Elevated in HPV-Positive Oropharyngeal Squamous Cell Carcinoma.

    Poropatich, Kate / Paunesku, Tatjana / Zander, Alia / Wray, Brian / Schipma, Matthew / Dalal, Prarthana / Agulnik, Mark / Chen, Si / Lai, Barry / Antipova, Olga / Maxey, Evan / Brown, Koshonna / Wanzer, Michael Beau / Gursel, Demirkan / Fan, Hanli / Rademaker, Alfred / Woloschak, Gayle E / Mittal, Bharat B

    Scientific reports

    2019  Volume 9, Issue 1, Page(s) 16965

    Abstract: Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is biologically distinct from HPV-negative HNSCC. Outside of HPV-status, few tumor-intrinsic variables have been identified that correlate to improved survival. As part of ... ...

    Abstract Human papillomavirus (HPV)-positive head and neck squamous cell carcinoma (HNSCC) is biologically distinct from HPV-negative HNSCC. Outside of HPV-status, few tumor-intrinsic variables have been identified that correlate to improved survival. As part of exploratory analysis into the trace elemental composition of oropharyngeal squamous cell carcinoma (OPSCC), we performed elemental quanitification by X-ray fluorescence microscopy (XFM) on a small cohort (n = 32) of patients with HPV-positive and -negative OPSCC and identified in HPV-positive cases increased zinc (Zn) concentrations in tumor tissue relative to normal tissue. Subsequent immunohistochemistry of six Zn-binding proteins-zinc-α2-glycoprotein (AZGP1), Lipocalin-1, Albumin, S100A7, S100A8 and S100A9-revealed that only AZGP1 expression significantly correlated to HPV-status (p < 0.001) and was also increased in tumor relative to normal tissue from HPV-positive OPSCC tumor samples. AZGP1 protein expression in our cohort significantly correlated to a prolonged recurrence-free survival (p = 0.029), similar to HNSCC cases from the TCGA (n = 499), where highest AZGP1 mRNA levels correlated to improved overall survival (p = 0.023). By showing for the first time that HPV-positive OPSCC patients have increased intratumoral Zn levels and AZGP1 expression, we identify possible positive prognostic biomarkers in HNSCC as well as possible mechanisms of increased sensitivity to chemoradiation in HPV-positive OPSCC.
    MeSH term(s) Calgranulin A/metabolism ; Calgranulin B/metabolism ; Female ; Humans ; Lipocalin 1/metabolism ; Male ; Middle Aged ; Oropharyngeal Neoplasms/metabolism ; Oropharyngeal Neoplasms/mortality ; Oropharyngeal Neoplasms/virology ; Papillomavirus Infections/metabolism ; S100 Calcium Binding Protein A7/metabolism ; Seminal Plasma Proteins/genetics ; Seminal Plasma Proteins/metabolism ; Spectrometry, X-Ray Emission ; Squamous Cell Carcinoma of Head and Neck/metabolism ; Squamous Cell Carcinoma of Head and Neck/mortality ; Squamous Cell Carcinoma of Head and Neck/virology ; Zinc/metabolism
    Chemical Substances Calgranulin A ; Calgranulin B ; Lipocalin 1 ; S100 Calcium Binding Protein A7 ; S100A7 protein, human ; S100A8 protein, human ; S100A9 protein, human ; Seminal Plasma Proteins ; Zn-alpha-2-glycoprotein ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2019-11-18
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-019-53268-1
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: CD8(+) T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types.

    Migueles, Stephen A / Mendoza, Daniel / Zimmerman, Matthew G / Martins, Kelly M / Toulmin, Sushila A / Kelly, Elizabeth P / Peterson, Bennett A / Johnson, Sarah A / Galson, Eric / Poropatich, Kate O / Patamawenu, Andy / Imamichi, Hiromi / Ober, Alexander / Rehm, Catherine A / Jones, Sara / Hallahan, Claire W / Follmann, Dean A / Connors, Mark

    EBioMedicine

    2015  Volume 2, Issue 1, Page(s) 46–58

    Abstract: Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies. Durable ... ...

    Abstract Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies. Durable control in LTNP/EC is likely mediated by highly functional virus-specific CD8(+) T-cells. Protective Human Leukocyte Antigen (HLA) class I alleles, like B*27 and B*57, are present in most, but not all LTNP/EC, providing an opportunity to investigate features shared by their HIV-specific immune responses. To better understand the contribution of epitope targeting and conservation to immune control, we compared the CD8(+) T-cell specificity and function of B*27/57(neg) LTNP/EC (n = 23), B*27/57(pos) LTNP/EC (n = 23) and B*27/57(neg) progressors (n = 13). Fine mapping revealed 11 previously unreported immunodominant responses. Although B*27/57(neg) LTNP/EC did not target more highly conserved epitopes, their CD8(+) T-cell cytotoxic capacity was significantly higher than progressors. Similar to B*27/57(pos) LTNP/EC, this superior cytotoxicity was mediated by preferential expansion of immunodominant responses and lysis through the predicted HLA. These findings suggest that increased CD8(+) T-cell cytotoxic capacity is a common mechanism of control in most LTNP/EC regardless of HLA type. They also suggest that potent cytotoxicity can be mediated through various epitopes and HLA molecules and could, in theory, be induced in most people.
    MeSH term(s) Amino Acid Sequence ; CD8-Positive T-Lymphocytes/immunology ; Cytotoxicity, Immunologic ; Entropy ; HIV Infections/immunology ; HIV Infections/virology ; HIV-1/immunology ; HLA Antigens/immunology ; Humans ; Immunodominant Epitopes/chemistry ; Immunodominant Epitopes/immunology ; Molecular Sequence Data ; gag Gene Products, Human Immunodeficiency Virus/immunology
    Chemical Substances HLA Antigens ; Immunodominant Epitopes ; gag Gene Products, Human Immunodeficiency Virus
    Language English
    Publishing date 2015-01
    Publishing country Netherlands
    Document type Journal Article ; Research Support, N.I.H., Extramural
    ZDB-ID 2851331-9
    ISSN 2352-3964 ; 2352-3964
    ISSN (online) 2352-3964
    ISSN 2352-3964
    DOI 10.1016/j.ebiom.2014.12.009
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 7090: Show issues Location:
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  4. Article ; Online: CD8+ T-cell Cytotoxic Capacity Associated with Human Immunodeficiency Virus-1 Control Can Be Mediated through Various Epitopes and Human Leukocyte Antigen Types

    Stephen A. Migueles / Daniel Mendoza / Matthew G. Zimmerman / Kelly M. Martins / Sushila A. Toulmin / Elizabeth P. Kelly / Bennett A. Peterson / Sarah A. Johnson / Eric Galson / Kate O. Poropatich / Andy Patamawenu / Hiromi Imamichi / Alexander Ober / Catherine A. Rehm / Sara Jones / Claire W. Hallahan / Dean A. Follmann / Mark Connors

    EBioMedicine, Vol 2, Iss 1, Pp 46-

    2015  Volume 58

    Abstract: Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies. Durable ... ...

    Abstract Understanding natural immunologic control over Human Immunodeficiency Virus (HIV)-1 replication, as occurs in rare long-term nonprogressors/elite controllers (LTNP/EC), should inform the design of efficacious HIV vaccines and immunotherapies. Durable control in LTNP/EC is likely mediated by highly functional virus-specific CD8+ T-cells. Protective Human Leukocyte Antigen (HLA) class I alleles, like B*27 and B*57, are present in most, but not all LTNP/EC, providing an opportunity to investigate features shared by their HIV-specific immune responses. To better understand the contribution of epitope targeting and conservation to immune control, we compared the CD8+ T-cell specificity and function of B*27/57neg LTNP/EC (n = 23), B*27/57pos LTNP/EC (n = 23) and B*27/57neg progressors (n = 13). Fine mapping revealed 11 previously unreported immunodominant responses. Although B*27/57neg LTNP/EC did not target more highly conserved epitopes, their CD8+ T-cell cytotoxic capacity was significantly higher than progressors. Similar to B*27/57pos LTNP/EC, this superior cytotoxicity was mediated by preferential expansion of immunodominant responses and lysis through the predicted HLA. These findings suggest that increased CD8+ T-cell cytotoxic capacity is a common mechanism of control in most LTNP/EC regardless of HLA type. They also suggest that potent cytotoxicity can be mediated through various epitopes and HLA molecules and could, in theory, be induced in most people.
    Keywords Long-term nonprogressors/elite controllers ; Immune control ; CD8+ T cells ; Cytotoxic capacity ; Epitope specificity ; Medicine ; R ; Medicine (General) ; R5-920
    Subject code 570
    Language English
    Publishing date 2015-01-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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