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  1. Article ; Online: Amputations of Lower Limb in Subjects with Diabetes Mellitus: Reasons and 30-Day Mortality.

    Walicka, Magdalena / Raczyńska, Marta / Marcinkowska, Karolina / Lisicka, Iga / Czaicki, Arthur / Wierzba, Waldemar / Franek, Edward

    Journal of diabetes research

    2021  Volume 2021, Page(s) 8866126

    Abstract: Background: Diabetic foot is one of the leading causes of patient disability worldwide. Lower-extremity amputations (LEAs) resulting from this disease massively decrease quality of life, the function of the patient, and incur significant healthcare ... ...

    Abstract Background: Diabetic foot is one of the leading causes of patient disability worldwide. Lower-extremity amputations (LEAs) resulting from this disease massively decrease quality of life, the function of the patient, and incur significant healthcare costs. The aim of this study was to assess trends in the number of amputations, the diagnosis at discharge, and diagnosis-related mortality after LEA procedures in a nationwide population.
    Methods: Datasets of the National Heath Fund containing information about all services within the public healthcare system in Poland, spanning the years 2010-2019, were analyzed. The source of data regarding mortality was the database of the Polish Ministry of Digital Affairs.
    Results: Between 2010 and 2019, the annual number of amputations in patients with diabetes increased significantly from 5,049 to 7,759 (
    Conclusions: The number of LEA in patients with diabetes in Poland increased substantially between 2010 and 2019 along with an increasing number of diabetics. Vascular pathologies, infections, and ulcerations were the most common causes of LEA. The 30-day mortality rate after amputation was rather high and varied depending on the diagnoses at discharge.
    MeSH term(s) Amputation/statistics & numerical data ; Diabetic Foot/mortality ; Diabetic Foot/surgery ; Humans ; Lower Extremity/surgery
    Language English
    Publishing date 2021-07-24
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2021/8866126
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  2. Article ; Online: A diagnostic mishap: solitary splenic carcinomatous metastases from the breast.

    Iga, Arthur M / Robertson, John H P / Al-Hejazi, Mohammed

    The breast journal

    2009  Volume 15, Issue 6, Page(s) 660–661

    MeSH term(s) Breast Neoplasms/pathology ; Female ; Humans ; Middle Aged ; Positron-Emission Tomography ; Splenic Neoplasms/diagnostic imaging ; Splenic Neoplasms/secondary
    Language English
    Publishing date 2009-11
    Publishing country United States
    Document type Case Reports ; Journal Article
    ZDB-ID 1289960-4
    ISSN 1524-4741 ; 1075-122X
    ISSN (online) 1524-4741
    ISSN 1075-122X
    DOI 10.1111/j.1524-4741.2009.00808.x
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4483: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  3. Article ; Online: Yeast carboxymethyl-glucan improves endothelial function and inhibits platelet aggregation in spontaneously hypertensive rats.

    Bezerra, Lorena Soares / Magnani, Marciane / Pimentel, Tatiana Colombo / de Oliveira, Júlio César Pinheiro Lúcio / Freire, Francisca Manuela de Souza / de Almeida, Arthur José Pontes Oliveira / Rezende, Mathania Silva de Almeida / Gonçalves, Islânia Giselia Albuquerque / de Medeiros, Isac Almeida / Veras, Robson Cavalcante

    Food & function

    2022  Volume 13, Issue 9, Page(s) 5406–5415

    Abstract: Carboxymethyl-glucan is a semi-synthetic derivative of β-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. ...

    Abstract Carboxymethyl-glucan is a semi-synthetic derivative of β-D-glucan, a polysaccharide widely found in several natural sources, such as yeast, fungi, and cereals. This compound has beneficial effects on health and is considered an important immunomodulator. However, studies exploring carboxymethyl-glucan bioactivity in cardiovascular health remain lacking, mainly in hypertension. Thus, this study sought to expand understanding of the effects of carboxymethyl-glucan on vascular and platelet functions in a hypertensive animal model. Spontaneously hypertensive rats and their normotensive Wistar-Kyoto controls were assigned to five groups: control, carboxymethyl-glucan (60 mg kg
    MeSH term(s) Animals ; Glucans ; Hypertension/drug therapy ; Platelet Aggregation ; Rats ; Rats, Inbred SHR ; Rats, Inbred WKY ; Reactive Oxygen Species ; Saccharomyces cerevisiae
    Chemical Substances Glucans ; Reactive Oxygen Species
    Language English
    Publishing date 2022-05-10
    Publishing country England
    Document type Journal Article
    ZDB-ID 2612033-1
    ISSN 2042-650X ; 2042-6496
    ISSN (online) 2042-650X
    ISSN 2042-6496
    DOI 10.1039/d1fo03492h
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    In stock of ZB MED Bonn / Germany

    Z 7872: Show issues

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  4. Article: Clinical potential of quantum dots.

    Iga, Arthur M / Robertson, John H P / Winslet, Marc C / Seifalian, Alexander M

    Journal of biomedicine & biotechnology

    2008  Volume 2007, Issue 10, Page(s) 76087

    Abstract: Advances in nanotechnology have led to the development of novel fluorescent probes called quantum dots. Quantum dots have revolutionalized the processes of tagging molecules within research settings and are improving sentinel lymph node mapping and ... ...

    Abstract Advances in nanotechnology have led to the development of novel fluorescent probes called quantum dots. Quantum dots have revolutionalized the processes of tagging molecules within research settings and are improving sentinel lymph node mapping and identification in vivo studies. As the unique physical and chemical properties of these fluorescent probes are being unraveled, new potential methods of early cancer detection, rapid spread and therapeutic management, that is, photodynamic therapy are being explored. Encouraging results of optical and real time identification of sentinel lymph nodes and lymph flow using quantum dots in vivo models are emerging. Quantum dots have also superseded many of the limitations of organic fluorophores and are a promising alternative as a research tool. In this review, we examine the promising clinical potential of quantum dots, their hindrances for clinical use and the current progress in abrogating their inherent toxicity.
    Language English
    Publishing date 2008-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2052552-7
    ISSN 1110-7251 ; 1110-7243
    ISSN (online) 1110-7251
    ISSN 1110-7243
    DOI 10.1155/2007/76087
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 5540: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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  5. Article ; Online: An in vivo rat model for early development of colorectal cancer metastasis to liver.

    Robertson, John H P / Yang, Shi Yu / Iga, Arthur M / Seifalian, Alexander M / Winslet, Marc C

    International journal of experimental pathology

    2008  Volume 89, Issue 6, Page(s) 447–457

    Abstract: At diagnosis of colorectal cancer, approximately 25% of the patients have established colorectal liver metastasis. Optimal management of disseminated disease requires therapies targeting multiple stages in hepatic colorectal cancer metastasis development. ...

    Abstract At diagnosis of colorectal cancer, approximately 25% of the patients have established colorectal liver metastasis. Optimal management of disseminated disease requires therapies targeting multiple stages in hepatic colorectal cancer metastasis development. To facilitate this, biologically accurate in vivo models are required. Early colonic cancer liver metastases development was studied using BDIX and Sprague-Dawley rat strains with human HT29 and rat DHDK12 colonic cancer cell lines. Different cancer cell-host combinations were used. Rat DHDK12 was previously chemically induced in the BDIX rat. Real-time intra-vital microscopy was employed to analyse the early development of liver metastases in four groups (n = 6 per group) (HT29-BDIX, DHDK12-BDIX, HT29-SD and DHDK12-SD). Data were compared using one-way anova with Bonferroni's multiple comparison test. The total number of tumour cells visualized, adherent cells within the hepatic sinusoids, extravasated tumour cells and migration rates were significantly higher in the DHDK12-BDIX combination. Maximum number of visualized cells and maximum migration rate were also significantly higher in this group. No significant differences were observed in these experimental parameters among the other three groups or in the haemodynamic parameters among all groups. In conclusion, cancer cell line-host selection has a significant effect on early colonic cancer liver metastasis development.
    MeSH term(s) Animals ; Cell Line, Tumor ; Colorectal Neoplasms/pathology ; HT29 Cells ; Humans ; Liver Neoplasms/pathology ; Liver Neoplasms/secondary ; Male ; Microscopy, Fluorescence/methods ; Models, Animal ; Neoplasm Metastasis ; Neoplasm Transplantation/methods ; Neoplastic Cells, Circulating/pathology ; Rats ; Rats, Mutant Strains ; Rats, Sprague-Dawley ; Species Specificity ; Vivisection/methods
    Language English
    Publishing date 2008-12-24
    Publishing country England
    Document type Comparative Study ; Journal Article
    ZDB-ID 1016006-1
    ISSN 1365-2613 ; 0958-4625 ; 0007-1021 ; 0959-9673
    ISSN (online) 1365-2613
    ISSN 0958-4625 ; 0007-1021 ; 0959-9673
    DOI 10.1111/j.1365-2613.2008.00605.x
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.52: Show issues Location:
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  6. Article: Quantitating therapeutic disruption of tumor blood flow with intravital video microscopy.

    Iga, Arthur M / Sarkar, Sandip / Sales, Kevin M / Winslet, Marc C / Seifalian, Alexander M

    Cancer research

    2006  Volume 66, Issue 24, Page(s) 11517–11519

    Abstract: Vascular-disrupting agents (VDA) kill tumor cells by selectively disrupting blood circulation in tumors. In vivo analysis of this intensely studied class of anticancer agents is invaluable for preclinical assessment of pharmacodynamic end points and ... ...

    Abstract Vascular-disrupting agents (VDA) kill tumor cells by selectively disrupting blood circulation in tumors. In vivo analysis of this intensely studied class of anticancer agents is invaluable for preclinical assessment of pharmacodynamic end points and effective therapeutic windows. In this review, we consider the role of intravital video microscopy in measuring tumor vascular response to VDAs, the potential of which lies in the opportunity to quantitate specific variables and to obtain real-time information on how VDAs affect tumor microcirculation.
    MeSH term(s) Angiogenesis Inhibitors/therapeutic use ; Humans ; Magnetic Resonance Imaging ; Microscopy, Video/methods ; Neoplasms/blood supply ; Neoplasms/pathology ; Neovascularization, Pathologic/pathology ; Neovascularization, Pathologic/prevention & control
    Chemical Substances Angiogenesis Inhibitors
    Language English
    Publishing date 2006-12-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1432-1
    ISSN 1538-7445 ; 0008-5472
    ISSN (online) 1538-7445
    ISSN 0008-5472
    DOI 10.1158/0008-5472.CAN-06-1743
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    In stock of ZB MED Cologne/Königswinter

    Uh III Zs.135/5: Show issues Location:
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  7. Article ; Online: Integrins: a method of early intervention in the treatment of colorectal liver metastases.

    Robertson, John H / Iga, Arthur M / Sales, Kevin M / Winslet, Marc C / Seifalian, Alexander M

    Current pharmaceutical design

    2006  Volume 14, Issue 3, Page(s) 296–305

    Abstract: The integrin family of cell surface receptors were principally thought to be involved in cell adhesion. Intense study has shown that these glycoproteins also regulate a diverse range of physiological processes. Inappropriate activation of integrins has ... ...

    Abstract The integrin family of cell surface receptors were principally thought to be involved in cell adhesion. Intense study has shown that these glycoproteins also regulate a diverse range of physiological processes. Inappropriate activation of integrins has been implicated in many pathological processes. Recent studies have shown that these molecules play a key role in the early stages of liver metastasis in colorectal cancer. In vivo experiments have demonstrated that integrins are involved in tumour cell targeting, arrest, adhesion and migration within the hepatic microcirculation. Indeed functional blocking of specific integrins has been shown to significantly impair these early stages of metastasis development. This review examines the current knowledge of integrin participation in this area and highlights the future therapeutic implications. Future targeted therapy against specific integrins would allow not only functional blocking but would provide the potential to deliver specific anti-cancer therapy.
    MeSH term(s) Animals ; Antineoplastic Agents/pharmacology ; Cell Adhesion/physiology ; Colorectal Neoplasms/pathology ; Drug Delivery Systems ; Humans ; Integrins/antagonists & inhibitors ; Integrins/metabolism ; Liver Neoplasms/drug therapy ; Liver Neoplasms/physiopathology ; Liver Neoplasms/secondary ; Neoplasm Staging ; Prognosis
    Chemical Substances Antineoplastic Agents ; Integrins
    Language English
    Publishing date 2006-01-23
    Publishing country United Arab Emirates
    Document type Journal Article ; Review
    ZDB-ID 1304236-1
    ISSN 1873-4286 ; 1381-6128
    ISSN (online) 1873-4286
    ISSN 1381-6128
    DOI 10.2174/138161208783413284
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4714: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  8. Article ; Online: Antioxidant and vasorelaxant activities induced by northeastern Brazilian fermented grape skins.

    Albuquerque, José George F / Assis, Valéria L / Almeida, Arthur J P O / Basílio, Ionaldo J L D / Luciano, Melissa N / Meireles, Bruno R L A / Cordeiro, Ângela M T M / Araújo, Islânia G A / Veras, Robson C / Ribeiro, Thaís P / Medeiros, Isac A

    BMC complementary and alternative medicine

    2017  Volume 17, Issue 1, Page(s) 376

    Abstract: Background: In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from ... ...

    Abstract Background: In northeastern Brazil, grape pomace has become a potential alternative byproduct because of the recover phenolic compounds from the vinification process. Comparative analyses were performed between lyophilized extract of grape skins from pomace, described as fermented (FGS), and fresh, unfermented (UGS) grape skins to show the relevant brand's composition upon the first maceration in winemaking.
    Methods: The use of in vitro testing such as Folin-Ciocalteu's, DPPH free radical scavenger and HPLC methods were performed to evidence antioxidant effect and phenolic compounds. Additionally, vascular reactivity studies were performed in third-order branches of rat superior mesenteric arteries, which were obtained and placed in organ baths containing Krebs-Henseleit solution, maintained at 37 °C, gassed with a mixture of 95% O
    Results: We found higher phenolic content and antioxidant activity in FGS when compared to UGS. HPLC analyses identified a significant number of phenolic compounds with antioxidant potential in both samples. The vasorelaxant effect induced by FGS was more potent than that induced by UGS, and the activity was attenuated after removal of vascular endothelium or by blockade of endothelium-derived relaxing factors, such as NO and EDHF.
    Conclusions: The FGS extract may be a great source of natural polyphenol products with potent antioxidant effects and endothelium-dependent vasodilatory actions involving NO and EDHF pathways.
    MeSH term(s) Animals ; Antioxidants/analysis ; Antioxidants/pharmacology ; Arteries/drug effects ; Arteries/physiology ; Biphenyl Compounds/metabolism ; Brazil ; Chromatography, High Pressure Liquid ; Fermentation ; Fruit/chemistry ; Phenols/analysis ; Phenols/pharmacology ; Picrates/metabolism ; Plant Epidermis/chemistry ; Plant Extracts/pharmacology ; Rats ; Reactive Oxygen Species/metabolism ; Vasodilator Agents/analysis ; Vasodilator Agents/pharmacology ; Vitis/chemistry
    Chemical Substances Antioxidants ; Biphenyl Compounds ; Phenols ; Picrates ; Plant Extracts ; Reactive Oxygen Species ; Vasodilator Agents ; 1,1-diphenyl-2-picrylhydrazyl (DFD3H4VGDH)
    Language English
    Publishing date 2017-07-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2050429-9
    ISSN 1472-6882 ; 1472-6882
    ISSN (online) 1472-6882
    ISSN 1472-6882
    DOI 10.1186/s12906-017-1881-2
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  9. Article ; Online: Clinical Potential of Quantum Dots

    Arthur M. Iga / John H. P. Robertson / Marc C. Winslet / Alexander M. Seifalian

    Journal of Biomedicine and Biotechnology, Vol

    2007  Volume 2007

    Abstract: Advances in nanotechnology have led to the development of novel fluorescent probes called quantum dots. Quantum dots have revolutionalized the processes of tagging molecules within research settings and are improving sentinel lymph node mapping and ... ...

    Abstract Advances in nanotechnology have led to the development of novel fluorescent probes called quantum dots. Quantum dots have revolutionalized the processes of tagging molecules within research settings and are improving sentinel lymph node mapping and identification in vivo studies. As the unique physical and chemical properties of these fluorescent probes are being unraveled, new potential methods of early cancer detection, rapid spread and therapeutic management, that is, photodynamic therapy are being explored. Encouraging results of optical and real time identification of sentinel lymph nodes and lymph flow using quantum dots in vivo models are emerging. Quantum dots have also superseded many of the limitations of organic fluorophores and are a promising alternative as a research tool. In this review, we examine the promising clinical potential of quantum dots, their hindrances for clinical use and the current progress in abrogating their inherent toxicity.
    Keywords Biotechnology ; TP248.13-248.65 ; Medicine ; R
    Language English
    Publishing date 2007-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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