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  1. Article ; Online: Preparation and antitumor study of intelligent injectable hydrogel: Carboxymethyl chitosan-aldehyde gum Arabic composite graphene oxide hydrogel.

    Li, Li / Xiang, Fengting / Wang, Fan / Liu, Yu

    International journal of biological macromolecules

    2024  Volume 259, Issue Pt 2, Page(s) 129429

    Abstract: In this study, we used polyaldehyde gum Arabic (OGA) and carboxymethyl chitosan (CMCS) as a gel matrix to form an injectable self-healing hydrogel by Schiff-base bonding. Further, graphene oxide (GO) was loaded with doxorubicin (DOX) to the hydrogel, ... ...

    Abstract In this study, we used polyaldehyde gum Arabic (OGA) and carboxymethyl chitosan (CMCS) as a gel matrix to form an injectable self-healing hydrogel by Schiff-base bonding. Further, graphene oxide (GO) was loaded with doxorubicin (DOX) to the hydrogel, which resulted in a CMCS-OGA/GO@DOX hydrogel. We achieved a DOX drug loading capacity of 43.80 ± 1.13 %. Rheological studies showed that GO hydrogels have improved mechanical properties. The in vitro release profile showed pH responsiveness with 88.21 % DOX release at pH 5.5. Biocompatibility studies showed that the hydrogel composition had good cytocompatibility with L929 cells. The 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay showed a cell survival rate of 93.88 % within 48 h. The DOX-loaded hydrogel exhibited higher cell mortality in breast cancer cells (4 T1), with an inhibition rate of 79.4 % at 48 h. Acridine orange/ethidium bromide staining experiments on 4 T1 cells showed that when loaded with the same DOX concentration, the hydrogel significantly reduced the toxic effects on normal cells, whereas it had significant cytotoxic effects on cancer cells. This result indicates that the prepared GO hydrogel drug delivery system can serve as a novel approach for localized breast cancer treatment.
    MeSH term(s) Humans ; Female ; Hydrogels/chemistry ; Gum Arabic ; Chitosan/chemistry ; Doxorubicin/pharmacology ; Doxorubicin/chemistry ; Breast Neoplasms ; Graphite
    Chemical Substances Hydrogels ; graphene oxide ; Gum Arabic (9000-01-5) ; Chitosan (9012-76-4) ; Doxorubicin (80168379AG) ; Graphite (7782-42-5)
    Language English
    Publishing date 2024-01-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 282732-3
    ISSN 1879-0003 ; 0141-8130
    ISSN (online) 1879-0003
    ISSN 0141-8130
    DOI 10.1016/j.ijbiomac.2024.129429
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 2374: Show issues Location:
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    ab Jg. 2022: Lesesaal (EG)

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  2. Article ; Online: Preparation and sustained-release mechanism of hydroxybutyl chitosan/graphene oxide temperature-sensitive hypoglycaemic subcutaneous implants.

    Li, Li / Xiang, Fengting / Wang, Fan / Chen, Anqi / Liu, Yu

    Colloids and surfaces. B, Biointerfaces

    2024  Volume 236, Page(s) 113801

    Abstract: The current situation of diabetes prevention and control is extremely severe. For instance, glimepiride (GLM), a third-generation sulfonylurea, demonstrates suboptimal clinical efficacy in oral dosage forms, which underscores the pressing need for the ... ...

    Abstract The current situation of diabetes prevention and control is extremely severe. For instance, glimepiride (GLM), a third-generation sulfonylurea, demonstrates suboptimal clinical efficacy in oral dosage forms, which underscores the pressing need for the development of a new dosage form. Recently, in situ gel subcutaneous implants have garnered considerable attention. Hydroxybutyl chitosan (HBC) can spontaneously crosslink to form a thermosensitive hydrogel and has good biocompatibility. However, its application is hindered by its limited mechanical properties. Graphene oxide (GO), known for its stable dispersion in water, can load GLM through π-π stacking interactions. When combined with HBC, GO enhances the mechanical properties and stability of the hydrogel. Therefore, an HBC-GO@GLM hydrogel was prepared. Rheological analysis revealed that the incorporation of GO increased the critical gelation temperature of the 5 wt% HBC hydrogel from 19.1°C to 27.2°C, considerably enhancing the mechanical properties of the hydrogel. Using encapsulation efficiency as an evaluation index, the optimal encapsulation efficiency of GO@GLM was determined to be 73.53% ± 0.45% with a drug loading capacity of 27.39 ± 0.17% using the Box-Behnken design model. Computer simulation technology validated the interaction between the materials and the drug release mechanism. Pharmacokinetic results showed that compared to the HBC@GLM group, the half-life (t1/2), mean residence time and the area under the curve for the HBC-GO@GLM group were approximately 3 times those of the HBC@GLM group. Subcutaneous implantation of the HBC-GO@GLM hydrogel for drug delivery considerably extended the drug's action time in the body, thereby maintaining blood sugar levels within a normal and stable range for an extended period.
    MeSH term(s) Temperature ; Hypoglycemic Agents ; Computer Simulation ; Delayed-Action Preparations ; Chitosan/analogs & derivatives ; Hydrogels ; Graphite
    Chemical Substances hydroxybutyl chitosan ; graphene oxide ; Hypoglycemic Agents ; Delayed-Action Preparations ; Chitosan (9012-76-4) ; Hydrogels ; Graphite (7782-42-5)
    Language English
    Publishing date 2024-02-14
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1500523-9
    ISSN 1873-4367 ; 0927-7765
    ISSN (online) 1873-4367
    ISSN 0927-7765
    DOI 10.1016/j.colsurfb.2024.113801
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  3. Article ; Online: In situ

    Jiang, Xi / Luo, Fengting / Liu, Ya / Yu, Pei / Chen, Shijian

    Nanotechnology

    2023  Volume 34, Issue 32

    Abstract: Transition metal sulfides (TMSs) for electrochemical water splitting undergo significant self-reconstruction to form actual active species favorable for high oxygen evolution reaction (OER) performance. However, the complete self-reconstruction of most ... ...

    Abstract Transition metal sulfides (TMSs) for electrochemical water splitting undergo significant self-reconstruction to form actual active species favorable for high oxygen evolution reaction (OER) performance. However, the complete self-reconstruction of most reported TMSs in alkaline media is unfrequent and the active species cannot be efficiently used. Herein, self-supported FeS
    Language English
    Publishing date 2023-05-26
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/acd3f6
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  4. Article: Application of thermosensitive-hydrogel combined with dental pulp stem cells on the injured fallopian tube mucosa in an animal model.

    Luo, Lihua / Zhu, Qunyan / Li, Yejian / Hu, Fengting / Yu, Jiangtao / Liao, Xiangyan / Xing, Zhenjie / He, Yan / Ye, Qingsong

    Frontiers in bioengineering and biotechnology

    2023  Volume 10, Page(s) 1062646

    Abstract: Objectives: ...

    Abstract Objectives:
    Language English
    Publishing date 2023-01-06
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2719493-0
    ISSN 2296-4185
    ISSN 2296-4185
    DOI 10.3389/fbioe.2022.1062646
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article: The origin of two divergent ovine β-globin haplotypes and their potential association with environmental adaptation.

    Kang, Yuxin / Liang, Yilin / Fan, Fengting / Asadollahpour Nanaei, Hojjat / Cao, Chunna / Jiang, Yu / Lan, Xianyong / Pan, Chuanying / Li, Ran

    Journal of genetics and genomics = Yi chuan xue bao

    2024  

    Language English
    Publishing date 2024-04-06
    Publishing country China
    Document type Letter
    ZDB-ID 2374568-X
    ISSN 1873-5533 ; 1673-8527
    ISSN (online) 1873-5533
    ISSN 1673-8527
    DOI 10.1016/j.jgg.2024.03.014
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  6. Article ; Online: Spatiotemporal impacts of climate change and human activities on water resources and ecological sensitivity in the Mekong subregion in Cambodia

    Lin, Yi / Rong, Yu / Li, Lang / Li, Fengting / Zhang, Hanchao / Yu, Jie

    Environ Sci Pollut Res. 2023 Jan., v. 30, no. 2 p.4023-4043

    2023  

    Abstract: Water resources in the Mekong subregion in Cambodia (MSC) have experienced dramatic changes in past decades, threatening regional ecosystem quality and sustainable development. Thus, it is important to explore the spatiotemporal impacts of climate change ...

    Abstract Water resources in the Mekong subregion in Cambodia (MSC) have experienced dramatic changes in past decades, threatening regional ecosystem quality and sustainable development. Thus, it is important to explore the spatiotemporal impacts of climate change and human activities on water resources and ecological sensitivity. This study proposed an effective framework including spatiotemporal analysis of land use/cover change (LUCC) and ecological sensitivity assessment by combining remote sensing (RS) and geographic information system/science (GIS). An optimized feature space and a machine learning classification algorithm were constructed to extract four typical land cover types in the MSC from 1990 to 2020. An ecological sensitivity evaluation system, including four sub-sensitivities calculated by twelve indicators, was then constructed. The results suggest that severe shrinkage of water resources occurred before 2006, decreasing by 21.68%. The correlation between water resources and climate conditions displays a high to low level as human activity becomes involved. A significant spatiotemporal evolutionary pattern of ecological sensitivity was observed under the impact of external interference. Generally, the largest proportion of MSC belongs to the lightly sensitive level, which is mainly concentrated in the lower reaches, with an average of 33.93%. The highly sensitive area with a significant value in ecological protection has a slightly downward trend from 23.72 in 1990 to 22.55% in 2020.
    Keywords algorithms ; climate ; climate change ; ecosystems ; geographic information systems ; humans ; land cover ; land use ; shrinkage ; sustainable development ; Cambodia
    Language English
    Dates of publication 2023-01
    Size p. 4023-4043.
    Publishing place Springer Berlin Heidelberg
    Document type Article ; Online
    ZDB-ID 1178791-0
    ISSN 1614-7499 ; 0944-1344
    ISSN (online) 1614-7499
    ISSN 0944-1344
    DOI 10.1007/s11356-022-22469-z
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    In stock of ZB MED Bonn / Germany

    Z 5915: Show issues

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  7. Article ; Online: Utilizing microbial metabolite in catalytic cascade synthesis of conjugated oligomers for In-Situ regulation of biological activity.

    Li, Yuke / Huang, Yiming / Shen, Qi / Yu, Wen / Yang, Zhiwen / Gao, Zhiqiang / Lv, Fengting / Bai, Haotian / Wang, Shu

    Bioorganic chemistry

    2024  Volume 145, Page(s) 107188

    Abstract: Despite the advances of multistep enzymatic cascade reactions, their incorporation with abiotic reactions in living organisms remains challenging in synthetic biology. Herein, we combined microbial metabolic pathways and Pd-catalyzed processes for in- ... ...

    Abstract Despite the advances of multistep enzymatic cascade reactions, their incorporation with abiotic reactions in living organisms remains challenging in synthetic biology. Herein, we combined microbial metabolic pathways and Pd-catalyzed processes for in-situ generation of bioactive conjugated oligomers. Our biocompatible one-pot coupling reaction utilized the fermentation process of engineered E. coli that converted glucose to styrene, which participated in the Pd-catalyzed Heck reaction for in-situ synthesis of conjugated oligomers. This process serves a great interest in understanding resistance evolution by utilizing the inhibitory activity of the synthesized conjugated oligomers. The approach allows for the in-situ combination of biological metabolism and CC coupling reactions, opening up new possibilities for the biosynthesis of unnatural molecules and enabling the in-situ regulation of the bioactivity of the obtained products.
    MeSH term(s) Escherichia coli/metabolism ; Palladium ; Catalysis ; Fermentation
    Chemical Substances Palladium (5TWQ1V240M)
    Language English
    Publishing date 2024-02-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 120080-x
    ISSN 1090-2120 ; 0045-2068
    ISSN (online) 1090-2120
    ISSN 0045-2068
    DOI 10.1016/j.bioorg.2024.107188
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 4207: Show issues Location:
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  8. Article ; Online: Alterations in circulating markers in HIV/AIDS patients with poor immune reconstitution: Novel insights from microbial translocation and innate immunity.

    Xiao, Qing / Yu, Fengting / Yan, Liting / Zhao, Hongxin / Zhang, Fujie

    Frontiers in immunology

    2022  Volume 13, Page(s) 1026070

    Abstract: After long-term anti-retroviral therapy (ART) treatment, most human immunodeficiency virus (HIV)/Acquired Immure Deficiency Syndrome (AIDS) patients can achieve virological suppression and gradual recovery of ... ...

    Abstract After long-term anti-retroviral therapy (ART) treatment, most human immunodeficiency virus (HIV)/Acquired Immure Deficiency Syndrome (AIDS) patients can achieve virological suppression and gradual recovery of CD4
    MeSH term(s) Humans ; Immune Reconstitution ; CD4 Lymphocyte Count ; Antiretroviral Therapy, Highly Active ; Acquired Immunodeficiency Syndrome ; HIV Infections ; Biomarkers ; Immunity, Innate ; Malnutrition
    Chemical Substances Biomarkers
    Language English
    Publishing date 2022-10-17
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2022.1026070
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  9. Article ; Online: Post treatment and properties of PVA/SS composite nanofibers

    Zhang, Xianhua / Yao, Fengting / Jin, Xuling / Yu, Bing / Zhou, Jinlong

    The Journal of The Textile Institute. 2023 Oct. 3, v. 114, no. 10 p.1566-1572

    2023  

    Abstract: Using deionized water as a solvent, the polyvinyl alcohol/silk sericin (PVA/SS) mixed solution was prepared, and the PVA/SS composite nanofiber membrane was spun by the electrostatic spinning method. The characteristics and properties of the PVA/SS ... ...

    Abstract Using deionized water as a solvent, the polyvinyl alcohol/silk sericin (PVA/SS) mixed solution was prepared, and the PVA/SS composite nanofiber membrane was spun by the electrostatic spinning method. The characteristics and properties of the PVA/SS composite nanofiber membrane untreated and treated with methanol and ethanol steam were analyzed by scanning electron microscope, infrared spectrum and X-ray diffraction. The results showed that the morphology of the PVA/SS composite nanofibers was fine in this experiment. The average diameter and standard deviation of diameter first increased, then decreased and at last increased with the increase of the SS content. The average diameter of nanofibers treated with methanol and ethanol steam was smaller than that without treatment. The infrared spectrum showed that the peak value of SS in the PVA/SS composite nanofibers treated with methanol steam and ethanol steam for 3 d changed. X-ray diffraction showed that the crystallization of the PVA/SS composite nanofiber membrane after being treated with methanol and ethanol vapor was changed. The results provide theoretical support for biomedical materials and tissue engineering scaffolds.
    Keywords X-ray diffraction ; crystallization ; ethanol ; fabrics ; methanol ; nanofibers ; polyvinyl alcohol ; sericin ; silk ; solvents ; standard deviation ; steam ; Electrospinning ; PVA/SS ; composite nanofibers ; post-treatment ; properties
    Language English
    Dates of publication 2023-1003
    Size p. 1566-1572.
    Publishing place Taylor & Francis
    Document type Article ; Online
    ISSN 1754-2340
    DOI 10.1080/00405000.2022.2145421
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  10. Article ; Online: Organic Semiconducting Polymers for Augmenting Biosynthesis and Bioconversion.

    Chen, Weijian / Lin, Hongrui / Yu, Wen / Huang, Yiming / Lv, Fengting / Bai, Haotian / Wang, Shu

    JACS Au

    2023  Volume 4, Issue 1, Page(s) 3–19

    Abstract: Solar-driven biosynthesis and bioconversion are essential for achieving sustainable resources and renewable energy. These processes harness solar energy to produce biomass, chemicals, and fuels. While they offer promising avenues, some challenges and ... ...

    Abstract Solar-driven biosynthesis and bioconversion are essential for achieving sustainable resources and renewable energy. These processes harness solar energy to produce biomass, chemicals, and fuels. While they offer promising avenues, some challenges and limitations should be investigated and addressed for their improvement and widespread adoption. These include the low utilization of light energy, the inadequate selectivity of products, and the limited utilization of inorganic carbon/nitrogen sources. Organic semiconducting polymers offer a promising solution to these challenges by collaborating with natural microorganisms and developing artificial photosynthetic biohybrid systems. In this Perspective, we highlight the latest advancements in the use of appropriate organic semiconducting polymers to construct artificial photosynthetic biohybrid systems. We focus on how these systems can enhance the natural photosynthetic efficiency of photosynthetic organisms, create artificial photosynthesis capability of nonphotosynthetic organisms, and customize the value-added chemicals of photosynthetic synthesis. By examining the structure-activity relationships and emphasizing the mechanism of electron transfer based on organic semiconducting polymers in artificial photosynthetic biohybrid systems, we aim to shed light on the potential of this novel strategy for artificial photosynthetic biohybrid systems. Notably, these coupling strategies between organic semiconducting polymers and organisms during artificial photosynthetic biohybrid systems will pave the way for a more sustainable future with solar fuels and chemicals.
    Language English
    Publishing date 2023-12-15
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00576
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