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Article: Acetate moderately attenuates the generation of neutrophil extracellular traps.

Ohbuchi, Ayako / Kono, Mari / Takenokuchi, Mariko / Imoto, Shion / Saigo, Katsuyasu

2018 Volume 53, Issue 2, Page(s) 177–180

Language	English
Publishing date	2018-06-25
Publishing country	Korea (South)
Document type	Journal Article
ZDB-ID	2711910-5
ISSN	2288-0011 ; 2287-979X
ISSN (online)	2288-0011
ISSN	2287-979X
DOI	10.5045/br.2018.53.2.177
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Labile iron, ROS, and cell death are prominently induced by haemin, but not by non-transferrin-bound iron.

Imoto, Shion / Sawamura, Tohru / Shibuya, Yukiko / Kono, Mari / Ohbuchi, Ayako / Suzuki, Takashi / Mizokoshi, Yuji / Saigo, Katsuyasu

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2021 Volume 61, Issue 2, Page(s) 103319

Abstract: Background: In transfusion-related iron overload, haem-derived iron accumulation in monocytes/macrophages is the initial event. When iron loading exceeds the ferritin storage capacity, iron is released into the plasma. When iron loading exceeds ... ...

Abstract	Background: In transfusion-related iron overload, haem-derived iron accumulation in monocytes/macrophages is the initial event. When iron loading exceeds the ferritin storage capacity, iron is released into the plasma. When iron loading exceeds transferrin binding capacity, labile, non-transferrin-bound iron (NTBI) appears and causes organ injury. Haemin-induced cell death has already been investigated; however, whether NTBI induces cell death in monocytes/macrophages remains unclear. Material and methods: Human monocytic THP-1 cells were treated with haemin or NTBI, particularly ferric ammonium citrate (FAC) or ferrous ammonium sulfate (FAS). The intracellular labile iron pool (LIP) was measured using an iron-sensitive fluorescent probe. Ferritin expression was measured by western blotting. Results: LIP was elevated after haemin treatment but not after FAC or FAS treatment. Reactive oxygen species (ROS) generation and cell death induction were remarkable after haemin treatment but not after FAC or FAS treatment. Ferritin expression was not different between the FAC and haemin treatments. The combination of an iron chelator and a ferroptosis inhibitor significantly augmented the suppression of haemin cytotoxicity (p = 0.011). Discussion: The difference in LIP suggests the different iron traffic mechanisms for haem-derived iron and NTBI. The Combination of iron chelators and antioxidants is beneficial for iron overload therapy.
MeSH term(s)	Cell Death ; Ferritins ; Hemin/pharmacology ; Humans ; Iron/metabolism ; Iron Overload ; Reactive Oxygen Species/metabolism ; Transferrin/metabolism ; Transferrin/pharmacology
Chemical Substances	Reactive Oxygen Species ; Transferrin ; Hemin (743LRP9S7N) ; Ferritins (9007-73-2) ; Iron (E1UOL152H7)
Language	English
Publishing date	2021-11-17
Publishing country	England
Document type	Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2021.103319
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Article ; Online: Publisher Correction: LimeMap: a comprehensive map of lipid mediator metabolic pathways.

Nishi, Akinori / Ohbuchi, Katsuya / Kaifuchi, Noriko / Shimobori, Chika / Kushida, Hirotaka / Yamamoto, Masahiro / Kita, Yoshihiro / Tokuoka, Suzumi M / Yachie, Ayako / Matsuoka, Yukiko / Kitano, Hiroaki

NPJ systems biology and applications

2021 Volume 7, Issue 1, Page(s) 16

Language	English
Publishing date	2021-03-08
Publishing country	England
Document type	Published Erratum
ISSN	2056-7189
ISSN (online)	2056-7189
DOI	10.1038/s41540-021-00174-w
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Article ; Online: Twelve-year single critical care center experience of nicardipine prolonged-release implants in patients with subarachnoid hemorrhage: a propensity score matching analysis.

Kuroi, Yasuhiro / Ohbuchi, Hidenori / Arai, Naoyuki / Takahashi, Yuichi / Hagiwara, Shinji / Sasahara, Atsushi / Funaki, Ayako / Itoh, Toshimasa / Sato, Yasunori / Kasuya, Hidetoshi

Journal of neurointerventional surgery

2020 Volume 12, Issue 8, Page(s) 774–776

Abstract: Objective: To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care ... ...

Abstract	Objective: To develop a nicardipine prolonged-release implant (NPRI) to prevent cerebral vasospasm in patients with subarachnoid hemorrhage in 1999, which may be used during craniotomy, and report the results of our recent 12-year single critical care center experience. Methods: Of 432 patients with aneurysmal subarachnoid hemorrhage treated between 2007 and 2019, 291 were enrolled. 97 Patients were aged >70 years (33%), 194 were female (67%), 138 were World Federation of Neurological Societies grades 1, 2, and 3 (47%), 218 were Fisher group 3 (75%), and 243 had an anterior circulation aneurysm (84%). Using a propensity score matching method for these five factors, the severity of cerebral vasospasm, occurrence of delayed cerebral infarction, and modified Rankin Scale (mRS) score at discharge were analyzed. Results: One hundred patients each with or without NPRI were selected, and the ratios of coil/clip were 0/100 and 88/12, respectively. Cerebral vasospasm and delayed cerebral infarction were both significantly less common in the NPRI group (p=0.004, OR=0.412 (95% CI 0.223 to 0.760) and p=0.005, OR=0.272 (95% CI 0.103 to 0.714, respectively); a significant difference was seen in the mRS score at discharge by Fisher's exact test (p=0.0025). A mRS score of 6 (dead) was less common in the group with NPRI, and mRS scores of 0 and 1 were also less common. No side effects were seen. Conclusions: NPRIs significantly reduced the occurrence of cerebral vasospasm and delayed cerebral infraction without any side effects. The NPRI and non-NPRI groups showed different patterns of short-term outcomes in the single critical care center, which might have been due to selection bias and patient characteristics. Differences in outcomes may become clear in comparisons with patients treated by craniotomy.
MeSH term(s)	Adult ; Aged ; Aged, 80 and over ; Cerebral Infarction ; Critical Care ; Female ; Humans ; Male ; Middle Aged ; Nicardipine/therapeutic use ; Propensity Score ; Prostheses and Implants ; Subarachnoid Hemorrhage ; Treatment Outcome ; Vasospasm, Intracranial/drug therapy ; Vasospasm, Intracranial/prevention & control
Chemical Substances	Nicardipine (CZ5312222S)
Language	English
Publishing date	2020-02-07
Publishing country	England
Document type	Journal Article
ZDB-ID	2514982-9
ISSN	1759-8486 ; 1759-8478
ISSN (online)	1759-8486
ISSN	1759-8478
DOI	10.1136/neurintsurg-2019-015664
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Article: Quantitative analysis of hemin-induced neutrophil extracellular trap formation and effects of hydrogen peroxide on this phenomenon.

Ohbuchi, Ayako / Kono, Mari / Kitagawa, Kaihei / Takenokuchi, Mariko / Imoto, Shion / Saigo, Katsuyasu

Biochemistry and biophysics reports

2017 Volume 11, Page(s) 147–153

Abstract: Formation of neutrophil extracellular traps (NETs) can perpetuate sterile inflammation; thus, it is important to clarify their pathophysiological characteristics. Free heme, derived via hemolysis, is a major contributor to organ damage, and reportedly ... ...

Abstract	Formation of neutrophil extracellular traps (NETs) can perpetuate sterile inflammation; thus, it is important to clarify their pathophysiological characteristics. Free heme, derived via hemolysis, is a major contributor to organ damage, and reportedly induces neutrophil activation as well as reactive oxygen species (ROS) production and NET formation. For this study, we examined hemin (Fe
Language	English
Publishing date	2017-07-24
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	2831046-9
ISSN	2405-5808
ISSN	2405-5808
DOI	10.1016/j.bbrep.2017.07.009
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Article ; Online: Publisher Correction

Akinori Nishi / Katsuya Ohbuchi / Noriko Kaifuchi / Chika Shimobori / Hirotaka Kushida / Masahiro Yamamoto / Yoshihiro Kita / Suzumi M. Tokuoka / Ayako Yachie / Yukiko Matsuoka / Hiroaki Kitano

npj Systems Biology and Applications, Vol 7, Iss 1, Pp 1-

LimeMap: a comprehensive map of lipid mediator metabolic pathways

2021 Volume 1

Abstract: A Correction to this paper has been published: https://doi.org/10.1038/s41540-021-00174- ... ...

Abstract	A Correction to this paper has been published: https://doi.org/10.1038/s41540-021-00174-w
Keywords	Biology (General) ; QH301-705.5
Language	English
Publishing date	2021-03-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: LimeMap: a comprehensive map of lipid mediator metabolic pathways.

NPJ systems biology and applications

2021 Volume 7, Issue 1, Page(s) 6

Abstract: Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediators. Such ... ...

Abstract	Lipid mediators are major factors in multiple biological functions and are strongly associated with disease. Recent lipidomics approaches have made it possible to analyze multiple metabolites and the associations of individual lipid mediators. Such systematic approaches have enabled us to identify key changes of biological relevance. Against this background, a knowledge-based pathway map of lipid mediators would be useful to visualize and understand the overall interactions of these factors. Here, we have built a precise map of lipid mediator metabolic pathways (LimeMap) to visualize the comprehensive profiles of lipid mediators that change dynamically in various disorders. We constructed the map by focusing on ω-3 and ω-6 fatty acid metabolites and their respective metabolic pathways, with manual curation of referenced information from public databases and relevant studies. Ultimately, LimeMap comprises 282 factors (222 mediators, and 60 enzymes, receptors, and ion channels) and 279 reactions derived from 102 related studies. Users will be able to modify the map and visualize measured data specific to their purposes using CellDesigner and VANTED software. We expect that LimeMap will contribute to elucidating the comprehensive functional relationships and pathways of lipid mediators.
MeSH term(s)	Fatty Acids, Omega-3/metabolism ; Fatty Acids, Omega-6/metabolism ; Humans ; Lipid Metabolism/physiology ; Lipidomics/methods ; Metabolic Networks and Pathways/physiology ; Software ; Systems Biology/methods
Chemical Substances	Fatty Acids, Omega-3 ; Fatty Acids, Omega-6
Language	English
Publishing date	2021-01-27
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2056-7189
ISSN (online)	2056-7189
DOI	10.1038/s41540-020-00163-5
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Article ; Online: Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection.

Nishi, Akinori / Kaifuchi, Noriko / Shimobori, Chika / Ohbuchi, Katsuya / Iizuka, Seiichi / Sugiyama, Aiko / Ogura, Keisuke / Yamamoto, Masahiro / Kuroki, Haruo / Nabeshima, Shigeki / Yachie, Ayako / Matsuoka, Yukiko / Kitano, Hiroaki

Scientific reports

2021 Volume 11, Issue 1, Page(s) 4232

Abstract: Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in ... ...

Abstract	Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host's inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.
MeSH term(s)	Animals ; Antiviral Agents ; Disease Models, Animal ; Drugs, Chinese Herbal/administration & dosage ; Ephedra sinica ; Gene Expression Profiling ; Gene Expression Regulation/drug effects ; Host-Pathogen Interactions/genetics ; Host-Pathogen Interactions/immunology ; Humans ; Inflammation Mediators/metabolism ; Influenza A virus ; Influenza, Human/drug therapy ; Influenza, Human/etiology ; Influenza, Human/metabolism ; Macrophages/immunology ; Macrophages/metabolism ; Macrophages/pathology ; Mice ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/etiology ; Plant Preparations/administration & dosage ; Symptom Assessment ; T-Lymphocytes/drug effects ; T-Lymphocytes/immunology ; T-Lymphocytes/metabolism ; Transcriptome/drug effects ; Viral Load/drug effects
Chemical Substances	Antiviral Agents ; Drugs, Chinese Herbal ; Inflammation Mediators ; Plant Preparations ; Ephedrae herba (51QBA3IQ91)
Language	English
Publishing date	2021-02-19
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-021-82707-1
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Article: After haemin treatment intracellular non-haem iron increases prior to haem oxygenase-1 induction: A study in human monocytic cell line THP-1.

Imoto, Shion / Shibuya, Yukiko / Kono, Mari / Ohbuchi, Ayako / Sawamura, Tohru / Suzuki, Takashi / Mizokoshi, Yuji / Sawada, Hirohide / Saigo, Katsuyasu

Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis

2019 Volume 58, Issue 6, Page(s) 102662

Abstract: Background: Iron overload is a major health concern for transfusion-dependent patients. Repeated transfusions result in the loading of large amounts of haem-derived iron on macrophages, in turn, inducing cell death. We previously demonstrated that ... ...

Abstract	Background: Iron overload is a major health concern for transfusion-dependent patients. Repeated transfusions result in the loading of large amounts of haem-derived iron on macrophages, in turn, inducing cell death. We previously demonstrated that haemin-induced cell death in human monocytic THP-1 cells is consistent with ferroptosis, an iron-dependent cell death regulation mechanism. However, direct measurement of iron after haemin treatment has not yet been conducted. In this study, we measured intracellular non-haem iron concentration and haem oxygenase levels after haemin treatment. Material and methods: Human monocytic THP-1 cells were treated with haemin, and the cell lysate was prepared. Non-haem iron concentration of the cell lysate was measured using the Nitroso-PSAP method. Expression of haem oxygenase-1 (HO-1) and haem oxygenase-2 (HO-2) was quantified by western blotting. Results: We measured intracellular non-haem iron and the expression of haem oxygenases post-haemin treatment. Concentration of non-haem iron post-haemin treatment increased dependently with time and dose. HO-1 expression was detected 4 h after haemin treatment, whereas HO-2 expression was constitutive. Discussion: Increase in non-haem iron prior to induction of HO-1 expression suggests the involvement of HO-2 in haem-induced cytotoxicity. (184 words).
MeSH term(s)	Cell Death/drug effects ; Enzyme Induction/drug effects ; Heme Oxygenase (Decyclizing)/metabolism ; Heme Oxygenase-1/biosynthesis ; Hemin/pharmacology ; Humans ; Intracellular Space/metabolism ; Iron/metabolism ; Monocytes/drug effects ; Monocytes/enzymology ; Reactive Oxygen Species/metabolism ; THP-1 Cells ; Time Factors
Chemical Substances	Reactive Oxygen Species ; Hemin (743LRP9S7N) ; Iron (E1UOL152H7) ; Heme Oxygenase (Decyclizing) (EC 1.14.14.18) ; Heme Oxygenase-1 (EC 1.14.14.18) ; heme oxygenase-2 (EC 1.14.14.18)
Language	English
Publishing date	2019-11-06
Publishing country	England
Document type	Journal Article
ZDB-ID	2046795-3
ISSN	1878-1683 ; 1473-0502
ISSN (online)	1878-1683
ISSN	1473-0502
DOI	10.1016/j.transci.2019.10.004
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Article ; Online: Effects of maoto (ma-huang-tang) on host lipid mediator and transcriptome signature in influenza virus infection

Akinori Nishi / Noriko Kaifuchi / Chika Shimobori / Katsuya Ohbuchi / Seiichi Iizuka / Aiko Sugiyama / Keisuke Ogura / Masahiro Yamamoto / Haruo Kuroki / Shigeki Nabeshima / Ayako Yachie / Yukiko Matsuoka / Hiroaki Kitano

Scientific Reports, Vol 11, Iss 1, Pp 1-

2021 Volume 19

Abstract: Abstract Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host ... ...

Abstract	Abstract Maoto, a traditional kampo medicine, has been clinically prescribed for influenza infection and is reported to relieve symptoms and tissue damage. In this study, we evaluated the effects of maoto as an herbal multi-compound medicine on host responses in a mouse model of influenza infection. On the fifth day of oral administration to mice intranasally infected with influenza virus [A/PR/8/34 (H1N1)], maoto significantly improved survival rate, decreased viral titer, and ameliorated the infection-induced phenotype as compared with control mice. Analysis of the lung and plasma transcriptome and lipid mediator metabolite profile showed that maoto altered the profile of lipid mediators derived from ω-6 and ω-3 fatty acids to restore a normal state, and significantly up-regulated the expression of macrophage- and T-cell-related genes. Collectively, these results suggest that maoto regulates the host’s inflammatory response by altering the lipid mediator profile and thereby ameliorating the symptoms of influenza.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2021-02-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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