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  1. Article ; Online: Who Is at Risk? The Role of Airway Imaging in Chronic Lung Disease Risk Assessment.

    Kirby, Miranda / Coxson, Harvey O

    Annals of the American Thoracic Society

    2018  Volume 15, Issue 6, Page(s) 669–670

    MeSH term(s) Atherosclerosis ; Humans ; Lung ; Lung Diseases ; Prognosis ; Risk Assessment
    Language English
    Publishing date 2018-05-09
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.201804-244ED
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    Zs.A 5828: Show issues Location:
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  2. Article ; Online: Sources of variation in quantitative computed tomography of the lung.

    Coxson, Harvey O

    Journal of thoracic imaging

    2013  Volume 28, Issue 5, Page(s) 272–279

    Abstract: The goal of quantitative analysis of computed tomography (CT) scans is to understand the anatomic structure that is responsible for the physiological function of the lung. The gold standard for structural analysis requires the examination of tissue, ... ...

    Abstract The goal of quantitative analysis of computed tomography (CT) scans is to understand the anatomic structure that is responsible for the physiological function of the lung. The gold standard for structural analysis requires the examination of tissue, which is not practical in most studies. Quantitative CT allows valuable information on lung structure to be obtained without removal of tissue from the body, thereby aiding longitudinal studies on chronic lung diseases. This review briefly discusses CT analysis of the lung and some of the sources of variation that can cause differences in the CT metrics used for analysis of lung disease. Although there are many sources of variation, this review will show that, if the study is properly designed to take into account these variations and if the CT scanner is properly calibrated, valuable information can be obtained from CT scans that should allow us to study the pathogenesis of lung disease and the effect of treatment.
    MeSH term(s) Calibration ; Humans ; Lung Diseases/diagnostic imaging ; Lung Diseases/pathology ; Lung Volume Measurements ; Radiation Dosage ; Radiographic Image Interpretation, Computer-Assisted/methods ; Tomography, X-Ray Computed/methods
    Language English
    Publishing date 2013-08-10
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 632900-7
    ISSN 1536-0237 ; 0883-5993
    ISSN (online) 1536-0237
    ISSN 0883-5993
    DOI 10.1097/RTI.0b013e31829efbe9
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    Zs.A 2187: Show issues Location:
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  3. Article ; Online: Safety and pharmacokinetics of BI 685509, a soluble guanylyl cyclase activator, in patients with cirrhosis: A randomized Phase Ib study.

    Lawitz, Eric J / Reiberger, Thomas / Schattenberg, Jörn M / Schoelch, Corinna / Coxson, Harvey O / Wong, Diane / Ertle, Judith

    Hepatology communications

    2023  Volume 7, Issue 11

    Abstract: Background: Portal hypertension is a severe complication of cirrhosis. This Phase Ib study (NCT03842761) assessed the safety, tolerability, and pharmacokinetics of soluble guanylyl cyclase activator BI 685509 in patients with mild or moderate hepatic ... ...

    Abstract Background: Portal hypertension is a severe complication of cirrhosis. This Phase Ib study (NCT03842761) assessed the safety, tolerability, and pharmacokinetics of soluble guanylyl cyclase activator BI 685509 in patients with mild or moderate hepatic impairment (Child-Pugh [CP] A or B cirrhosis) and healthy volunteers (HVs).
    Methods: In this single-center, randomized, placebo-controlled study, patients received BI 685509 (maximum doses: 1, 2, or 3 mg, twice daily [BID]) or placebo for 28 days. HVs received one 0.5 mg dose of BI 685509 or placebo.
    Results: In total, 64 participants (CP-A, n=24; CP-B, n=25; HVs, n=15) were included; most commonly with NAFLD (36.7%), alcohol-associated (30.6%), or chronic viral hepatitis-related cirrhosis (28.6%). In patients with CP-A cirrhosis, drug-related adverse events (AEs) occurred in 5.6% of BI 685509-treated patients and 16.7% of placebo recipients. In patients with CP-B cirrhosis, drug-related AEs occurred in 26.3% of BI 685509-treated patients only. No serious AEs occurred in patients with CP-A cirrhosis; in patients with CP-B cirrhosis, serious AEs (not drug-related) occurred in 10.5% of BI 685509-treated patients and 16.7% of patients receiving placebo. BI 685509 was rapidly absorbed; exposure increased with dosage and was similar between etiologies and between patients with CP-A cirrhosis and patients with CP-A cirrhosis but lower in HVs. The mean percentage portal-systemic shunt fraction was measured in patients with CP-A cirrhosis and decreased at the end of treatment in the 2 mg BID (-11.2 ± 11.9%) and 3 mg BID (-14.0 ± 8.4%) BI 685509 dose groups, but not in the placebo group (+1.0 ± 27.3%).
    Conclusion: BI 685509 was generally well tolerated, with 3 serious, not drug-related AEs reported in patients with CP-B cirrhosis. In patients with CP-A cirrhosis, portal-systemic shunt fraction in the exploratory efficacy analysis was reduced by 2 mg BID and 3 mg BID BI 685509.
    MeSH term(s) Humans ; Soluble Guanylyl Cyclase ; Liver Cirrhosis/complications ; Liver Cirrhosis/drug therapy
    Chemical Substances Soluble Guanylyl Cyclase (EC 4.6.1.2)
    Language English
    Publishing date 2023-10-27
    Publishing country United States
    Document type Randomized Controlled Trial ; Clinical Trial, Phase I ; Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2471-254X
    ISSN (online) 2471-254X
    DOI 10.1097/HC9.0000000000000276
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  4. Article ; Online: Reply: Quantitative Computed Tomography in Systemic Sclerosis-Interstitial Lung Disease: Are We Ready to Go beyond Standard Assessment?

    Castillo Saldana, Daniela / Coxson, Harvey O / Ryerson, Christopher J

    Annals of the American Thoracic Society

    2019  Volume 18, Issue 1, Page(s) 184

    MeSH term(s) Densitometry ; Humans ; Lung Diseases, Interstitial/diagnostic imaging ; Reference Standards ; Scleroderma, Systemic/complications ; Scleroderma, Systemic/diagnostic imaging ; Severity of Illness Index
    Language English
    Publishing date 2019-12-11
    Publishing country United States
    Document type Letter ; Comment
    ZDB-ID 2717461-X
    ISSN 2325-6621 ; 1943-5665 ; 2325-6621
    ISSN (online) 2325-6621 ; 1943-5665
    ISSN 2325-6621
    DOI 10.1513/AnnalsATS.202009-1184LE
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Using computed tomography to measure the site of airflow obstruction.

    Coxson, Harvey O

    Respirology (Carlton, Vic.)

    2012  Volume 17, Issue 1, Page(s) 5–6

    MeSH term(s) Airway Remodeling ; Asthma/physiopathology ; Bronchi/pathology ; Female ; Humans ; Lung/pathology ; Male ; Pulmonary Disease, Chronic Obstructive/physiopathology ; Pulmonary Emphysema/physiopathology
    Language English
    Publishing date 2012-01
    Publishing country Australia
    Document type Comment ; Editorial ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 1435849-9
    ISSN 1440-1843 ; 1323-7799
    ISSN (online) 1440-1843
    ISSN 1323-7799
    DOI 10.1111/j.1440-1843.2011.02084.x
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    Zs.A 4957: Show issues Location:
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  6. Article ; Online: Lung resistance and elastance are different in ex vivo sheep lungs ventilated by positive and negative pressures.

    Dong, Shou-Jin / Wang, Lu / Chitano, Pasquale / Coxson, Harvey O / Vasilescu, Dragoş M / Paré, Peter D / Seow, Chun Y

    American journal of physiology. Lung cellular and molecular physiology

    2022  Volume 322, Issue 5, Page(s) L673–L682

    Abstract: Lung resistance ( ...

    Abstract Lung resistance (
    MeSH term(s) Airway Resistance/physiology ; Animals ; Lung/physiology ; Positive-Pressure Respiration ; Respiratory Function Tests ; Respiratory Mechanics/physiology ; Respiratory Physiological Phenomena ; Sheep
    Language English
    Publishing date 2022-03-10
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00464.2021
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    Zs.A 2749: Show issues Location:
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  7. Article ; Online: Airway diameter at different transpulmonary pressures in ex vivo sheep lungs: implications for deep inspiration-induced bronchodilation and bronchoprotection.

    Dong, Shou-Jin / Wang, Lu / Chitano, Pasquale / Coxson, Harvey O / Paré, Peter D / Seow, Chun Y

    American journal of physiology. Lung cellular and molecular physiology

    2021  Volume 321, Issue 4, Page(s) L663–L674

    Abstract: Deep inspiration (DI)-induced bronchodilation is the first line of defense against bronchoconstriction in healthy subjects. A hallmark of asthma is the lack of this beneficial effect of DI. The mechanism underlying the bronchodilatory effect of DI is not ...

    Abstract Deep inspiration (DI)-induced bronchodilation is the first line of defense against bronchoconstriction in healthy subjects. A hallmark of asthma is the lack of this beneficial effect of DI. The mechanism underlying the bronchodilatory effect of DI is not clear. Understanding the mechanism will help us unravel the mystery of asthma pathophysiology. It has been postulated that straining airway smooth muscle (ASM) during a DI could lead to bronchodilation and bronchoprotection. The hypothesis is currently under debate, and a central question is whether ASM is sufficiently stretched during a DI for its contractility to be compromised. Besides bronchoconstriction, another contributor to lung resistance is airway heterogeneity. The present study examines changes in airway diameter and heterogeneity at different lung volumes. Freshly explanted sheep lungs were used in plethysmographic measurements of lung resistance and elastance at different lung volumes, whereas the airway dimensions were measured by computed tomography (CT). The change in airway diameter informed by CT measurements was applied to isolated airway ring preparations to determine the strain-induced loss of ASM contractility. We found that changing the transpulmonary pressure from 5 to 30 cmH
    MeSH term(s) Airway Resistance/physiology ; Animals ; Asthma/physiopathology ; Bronchi/physiopathology ; Bronchoconstriction/physiology ; Inhalation/physiology ; Lung ; Lung Volume Measurements ; Muscle, Smooth/metabolism ; Respiratory Function Tests ; Sheep ; Tomography, X-Ray Computed
    Language English
    Publishing date 2021-07-21
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1013184-x
    ISSN 1522-1504 ; 1040-0605
    ISSN (online) 1522-1504
    ISSN 1040-0605
    DOI 10.1152/ajplung.00208.2021
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  8. Article ; Online: Uncovering the bronchovascular links in patients with chronic obstructive pulmonary disease with pulmonary hypertension.

    Kirby, Miranda / Coxson, Harvey O

    American journal of respiratory and critical care medicine

    2015  Volume 191, Issue 1, Page(s) 8–10

    MeSH term(s) Airway Remodeling/physiology ; Female ; Humans ; Hypertension, Pulmonary/etiology ; Male ; Pulmonary Disease, Chronic Obstructive/complications ; Pulmonary Emphysema/etiology
    Language English
    Publishing date 2015-01-01
    Publishing country United States
    Document type Comment ; Editorial
    ZDB-ID 1180953-x
    ISSN 1535-4970 ; 0003-0805 ; 1073-449X
    ISSN (online) 1535-4970
    ISSN 0003-0805 ; 1073-449X
    DOI 10.1164/rccm.201411-2101ED
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  9. Article ; Online: Quantitative CT Lung Imaging and Machine Learning Improves Prediction of Emergency Room Visits and Hospitalizations in COPD.

    Moslemi, Amir / Makimoto, Kalysta / Tan, Wan C / Bourbeau, Jean / Hogg, James C / Coxson, Harvey O / Kirby, Miranda

    Academic radiology

    2022  Volume 30, Issue 4, Page(s) 707–716

    Abstract: Rationale: Predicting increased risk of future healthcare utilization in chronic obstructive pulmonary disease (COPD) patients is an important goal for improving patient management.: Objective: Our objective was to determine the importance of ... ...

    Abstract Rationale: Predicting increased risk of future healthcare utilization in chronic obstructive pulmonary disease (COPD) patients is an important goal for improving patient management.
    Objective: Our objective was to determine the importance of computed tomography (CT) lung imaging measurements relative to other demographic and clinical measurements for predicting future health services use with machine learning in COPD.
    Materials and methods: In this retrospective study, lung function measurements and chest CT images were acquired from Canadian Cohort of Obstructive Lung Disease study participants from 2010 to 2017 (https://clinicaltrials.gov, NCT00920348). Up to two follow-up visits (1.5- and 3-year follow-up) were performed and participants were asked for details related to healthcare utilization. Healthcare utilization was defined as any COPD hospitalization or emergency room visit due to respiratory problems in the 12 months prior to the follow-up visits. CT analysis was performed (VIDA Diagnostics Inc.); a total of 108 CT quantitative emphysema, airway and vascular measurements were investigated. A hybrid feature selection method with support vector machine classifier was used to predict healthcare utilization. Performance was determined using accuracy, F1-measure and area under the receiver operating characteristic curve (AUC) and Matthews's correlation coefficient (MC).
    Results: Of the 527 COPD participants evaluated, 179 (35%) used healthcare services at follow-up. There were no significant differences between the participants with or without healthcare utilization at follow-up for age (p = 0.50), sex (p = 0.44), BMI (p = 0.05) or pack-years (p = 0.76). The accuracy for predicting subsequent healthcare utilization was 80% ± 3% (F1-measure = 74%, AUC = 0.80, MC = 0.6) when all measurements were considered, 76% ± 6% (F1-measure = 72%, AUC = 0.77, MC = 0.55) for CT measurements alone and 65% ± 5% (F1-measure = 60%, AUC = 0.67, MC = 0.34) for demographic and lung function measurements alone.
    Conclusion: The combination of CT lung imaging and conventional measurements leads to greater prediction accuracy of subsequent health services use than conventional measurements alone, and may provide needed prognostic information for patients suffering from COPD.
    MeSH term(s) Humans ; Retrospective Studies ; Canada ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive/therapy ; Lung/diagnostic imaging ; Tomography, X-Ray Computed/methods ; Machine Learning ; Hospitalization ; Emergency Service, Hospital
    Language English
    Publishing date 2022-06-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1355509-1
    ISSN 1878-4046 ; 1076-6332
    ISSN (online) 1878-4046
    ISSN 1076-6332
    DOI 10.1016/j.acra.2022.05.009
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    Zs.A 4594: Show issues Location:
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  10. Article: Quantitative chest tomography in COPD research: chairman's summary.

    Coxson, Harvey O

    Proceedings of the American Thoracic Society

    2009  Volume 5, Issue 9, Page(s) 874–877

    MeSH term(s) Humans ; Lung/diagnostic imaging ; Pulmonary Disease, Chronic Obstructive/diagnostic imaging ; Radiation Dosage ; Research Design ; Tomography, X-Ray Computed
    Language English
    Publishing date 2009-01-11
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
    ZDB-ID 2132421-9
    ISSN 1943-5665 ; 1546-3222
    ISSN (online) 1943-5665
    ISSN 1546-3222
    DOI 10.1513/pats.200810-118QC
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