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  1. Article ; Online: Designing proteins with language models.

    Ruffolo, Jeffrey A / Madani, Ali

    Nature biotechnology

    2024  Volume 42, Issue 2, Page(s) 200–202

    MeSH term(s) Protein Engineering
    Language English
    Publishing date 2024-02-15
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 1311932-1
    ISSN 1546-1696 ; 1087-0156
    ISSN (online) 1546-1696
    ISSN 1087-0156
    DOI 10.1038/s41587-024-02123-4
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2167: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (1.OG)
    ab Jg. 2022: Lesesaal (EG)
    Zs.MO 137: Show issues
    Zs.MG 43: Show issues

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  2. Article: Melorheostosis: A Pediatric Case of a Rare Association With Carpal Tunnel Syndrome.

    Aboufirass, Yasmina / Madani, Afarine

    Cureus

    2023  Volume 15, Issue 9, Page(s) e45773

    Abstract: Melorheostosis is a rare chronic disease commonly affecting long bones of the lower extremity with the typical imaging feature of hyperostosis "candle wax pattern." Typically associated with pain, deformities, stiffness, and joint movement restriction ( ... ...

    Abstract Melorheostosis is a rare chronic disease commonly affecting long bones of the lower extremity with the typical imaging feature of hyperostosis "candle wax pattern." Typically associated with pain, deformities, stiffness, and joint movement restriction (due to contracture and fibrosis), it may also be asymptomatic. Melorheostosis is considered a benign disease but can be extremely debilitating, especially in a pediatric context where progression can be faster than in adults. An even rarer occurrence seems to be its association with nerve impingement. In this paper, we present the case of an 8-year-old girl with a known condition of melorheostosis of the upper limbs who developed bilateral carpal syndrome. To our knowledge, very few cases of the sort have been described, and even less in a pediatric context.
    Language English
    Publishing date 2023-09-22
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.45773
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  3. Article ; Online: Gaza's broken health-care system is compounding the risk of disease.

    Rimawi, Ru'a / Madani, Navid

    Nature

    2023  Volume 623, Issue 7985, Page(s) 32

    MeSH term(s) Humans ; Armed Conflicts ; Delivery of Health Care/organization & administration ; Delivery of Health Care/trends ; Middle East ; Disease Outbreaks ; Risk
    Language English
    Publishing date 2023-11-01
    Publishing country England
    Document type Letter
    ZDB-ID 120714-3
    ISSN 1476-4687 ; 0028-0836
    ISSN (online) 1476-4687
    ISSN 0028-0836
    DOI 10.1038/d41586-023-03349-z
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    Zs.A 26: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
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    Zs.MG 9: Show issues
    Zs.MO 244: Show issues

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  4. Article: Acquired perforating dermatosis associated with risankizumab.

    Alhadlg, Munira / Alhammad, Ghadah / Madani, Abdulaziz

    JAAD case reports

    2024  Volume 45, Page(s) 88–90

    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2834220-3
    ISSN 2352-5126
    ISSN 2352-5126
    DOI 10.1016/j.jdcr.2024.01.023
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  5. Article ; Online: Mixed-Grade Urothelial Carcinoma: Insights Into Clinical Behavior and Prognostic Implications Compared to Pure Low-Grade and High-Grade Urothelial Carcinomas.

    Khalatbari, Fateme / Moafi-Madani, Miremad / Amin, Ali

    Archives of pathology & laboratory medicine

    2024  

    Abstract: Context.—: Low-grade urothelial carcinoma (LGUC) and high-grade urothelial carcinoma (HGUC) are distinguished based on architectural and cytological features, with the anticipation that HGUC exhibits more aggressive behavior and a worse prognosis ... ...

    Abstract Context.—: Low-grade urothelial carcinoma (LGUC) and high-grade urothelial carcinoma (HGUC) are distinguished based on architectural and cytological features, with the anticipation that HGUC exhibits more aggressive behavior and a worse prognosis compared to LGUC. The current World Health Organization classification recognizes mixed-grade urothelial carcinoma (MGUC, for the purposes of this study) as a separate category that behaves like LGUC if the high-grade component is <5% and states that any tumor with ≥5% high-grade component should be graded as HGUC.
    Objective.—: To evaluate the risk of tumor recurrence, grade, and stage progression of MGUC compared to LGUC and HGUC.
    Design.—: A total of 150 de novo noninvasive polypoid urothelial carcinomas (41 cases of MGUC, 59 of LGUC, and 50 of HGUC) were included. Tumor recurrence, grade, and stage progression were compared among the MGUC, LGUC, and HGUC cases.
    Results.—: Tumor recurrence was observed in 14 of 41 (34.2%) of MGUC, 33 of 59 (55.9%) of LGUC, and 28 of 50 (56%) of HGUC. Grade progression occurred in 5 of 41 (12.2%) of MGUC cases and 5 of 59 (8.5%) of LGUC cases. No stage progression was observed in LGUC or MGUC cases, while 7 of 50 (14%) of HGUC cases showed stage progression. MGUC was associated with lower odds and hazard of recurrence compared to LGUC. The rate of grade progression was higher in MGUC and occurred after a shorter interval compared to LGUC.
    Conclusions.—: MGUC showed a prognosis closer to LGUC. Our study supports the current recommendation to classify tumors with <5% high-grade component as MGUC, as these tumors display clinical characteristics and outcomes close to that of pure LGUC.
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 194119-7
    ISSN 1543-2165 ; 0363-0153 ; 0096-8528 ; 0003-9985
    ISSN (online) 1543-2165
    ISSN 0363-0153 ; 0096-8528 ; 0003-9985
    DOI 10.5858/arpa.2023-0367-OA
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    In stock of ZB MED Cologne/Königswinter

    Ud II Zs.36: Show issues Location:
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  6. Article: Isolated tuberculous orchitis presented as epididymo-orchitis: An unusual presentation of tuberculosis.

    Mehboob, Khurram / Madani, Tariq A

    Urology annals

    2022  Volume 14, Issue 2, Page(s) 189–195

    Abstract: Urogenital tuberculosis (UGTB) is almost 8%-15% of the extrapulmonary site of TB of all kinds, and epididymal involvement is rarer, counted only 28% of UGTB. Isolated tuberculous epididymitis (ITE), without the inclusion of prostate or clinical evidence ... ...

    Abstract Urogenital tuberculosis (UGTB) is almost 8%-15% of the extrapulmonary site of TB of all kinds, and epididymal involvement is rarer, counted only 28% of UGTB. Isolated tuberculous epididymitis (ITE), without the inclusion of prostate or clinical evidence of renal involvement, is an even more rare entity and is challenging to diagnose. However, isolated epididymis TB presented as a huge scrotal abscess with scrotal sack involvement is exceptionally uncommon. The symptoms of such ITE resemble the epididymo-orchitis or malignant tumor, which results in misdiagnosis or delay in diagnosis. A 32-year-young man, sexually inactive, was presented with a rapid, painless scrotal growing. There was no clinical evidence for TB. Clinical examination of the genitalia revealed an enlarged right tactical with intratesticular masses (abuses) and swollen spermatic cord along with inflamed epididymitis. The radiological and laboratory shows no evidence of TB with clear chest X-rays, normal blood, and urine analysis. There were no symptoms of Mycobacterium tuberculosis during the microdot enzyme immunoassay analysis. A repeated magnetic resonance imaging and ultrasonic investigations were performed that revealed findings suggesting a chronic inflammatory process with severe abscess involving the spasmatic cord and scrotal sack, which mislead the diagnosis of epididymo-orchitis. Later, the extensive formation of superficial abscess breaches the scrotal sack. A pathological investigation of excretion and intrascrotal tissues established the diagnosis of ITE. The patient was kept on anti TB treatment medications for 12 months due to delay in diagnosis (12 weeks), continuous discharge, and severe involvement of epididymitis along with a scrotal sack and spermatic cord and had a remarkable recovery. The delayed diagnosis of ITE could lead the severe complication, which could result in surgical intervention or an orchiectomy. The first line of treatment should be the pharmacological approach for cases of epididymis TB, and surgery should be the 2
    Language English
    Publishing date 2022-02-15
    Publishing country India
    Document type Case Reports
    ISSN 0974-7796
    ISSN 0974-7796
    DOI 10.4103/ua.ua_12_21
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  7. Book ; Online: Distance-Preserving Graph Compression Techniques

    Madani, Amirali / Maheshwari, Anil

    2023  

    Abstract: We study the problem of distance-preserving graph compression for weighted paths and trees. The problem entails a weighted graph $G = (V, E)$ with non-negative weights, and a subset of edges $E^{\prime} \subset E$ which needs to be removed from G (with ... ...

    Abstract We study the problem of distance-preserving graph compression for weighted paths and trees. The problem entails a weighted graph $G = (V, E)$ with non-negative weights, and a subset of edges $E^{\prime} \subset E$ which needs to be removed from G (with their endpoints merged as a supernode). The goal is to redistribute the weights of the deleted edges in a way that minimizes the error. The error is defined as the sum of the absolute differences of the shortest path lengths between different pairs of nodes before and after contracting $E^{\prime}$. Based on this error function, we propose optimal approaches for merging any subset of edges in a path and a single edge in a tree. Previous works on graph compression techniques aimed at preserving different graph properties (such as the chromatic number) or solely focused on identifying the optimal set of edges to contract. However, our focus in this paper is on achieving optimal edge contraction (when the contracted edges are provided as input) specifically for weighted trees and paths.
    Keywords Computer Science - Data Structures and Algorithms ; Computer Science - Discrete Mathematics
    Subject code 511
    Publishing date 2023-07-11
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article: Fertility Rate and Sperm DNA Fragmentation Index following Varicocelectomy in Primary Infertile Men with Clinical Varicocele: A Prospective Longitudinal Study.

    Hamidi Madani, Ali / Pakdaman, Mohammad / Mokhtari, Gholamreza / Kazemnezhad, Ehsan / Hamidi Madani, Mohammad / Fathollahi, Ali / Rastjou Herfeh, Nadia / Roohinezhad, Roozbeh

    International journal of fertility & sterility

    2024  Volume 18, Issue 2, Page(s) 167–172

    Abstract: Background: Varicocele is one of the most common treatable causes of male infertility, and its treatment may be beneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomy in primary ... ...

    Abstract Background: Varicocele is one of the most common treatable causes of male infertility, and its treatment may be beneficial for fertility. This study aimed to evaluate fertility rate and DNA fragmentation index (DFI) following varicocelectomy in primary infertile men with clinical varicocele.
    Materials and methods: This prospective longitudinal study was conducted on primary infertility men, in a tertiary center from December 2018 to December 2019 with one-year follow-up. Data of the semen parameters, DFI (%), and fertility rate were gathered before, as well as 4 and 12 months after undergoing varicocelectomy. For data analysis, SPSS software and analytical test were used.
    Results: Out of 76 patients who were analyzed, 22 (29%) became fertile and 54 (71%) remained infertile. Semen parameters and DFI (%) were improved significantly following varicocelectomy (P<0.001). Smoking history, occupational heated exposure, body mass index (BMI), and infertility duration were determined as predictors associated with fertility status (P<0.05).
    Conclusion: Although varicocele repair improved the DFI, the fertility rate was achieved in less than one-third of patients; it seems that the other parameters, such as the history of smoking, occupational heated exposure, overweight, and duration of infertility should be considered as predictors of fertility status, in primary infertile men who are a candidate for varicocelectomy.
    Language English
    Publishing date 2024-02-02
    Publishing country Iran
    Document type Journal Article
    ZDB-ID 2570865-X
    ISSN 2008-0778 ; 2008-076X
    ISSN (online) 2008-0778
    ISSN 2008-076X
    DOI 10.22074/ijfs.2023.1990486.1441
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  9. Article: Delayed Irreversible Fanconi Syndrome Associated With Vertebral Fracture After Tenofovir Discontinuation.

    Qorban, Ghofran N / Alyami, Jameelah / Samargandy, Shaza / Madani, Tariq A

    Cureus

    2024  Volume 16, Issue 1, Page(s) e53280

    Abstract: The use of tenofovir disoproxil fumarate (TDF) as an antiretroviral agent has been reported to adversely affect both renal tubules and bone health, leading to pathological fractures. While such an effect is largely reversible, substituting TDF with ... ...

    Abstract The use of tenofovir disoproxil fumarate (TDF) as an antiretroviral agent has been reported to adversely affect both renal tubules and bone health, leading to pathological fractures. While such an effect is largely reversible, substituting TDF with tenofovir alafenamide (TAF) might result in lower rates of adverse events with the preservation of tenofovir effectiveness. We report a case of a 40-year-old lady with HIV infection who had a vertebral fragility fracture secondary to TDF-associated Fanconi syndrome. The syndrome developed four years after TDF cessation and switching to TAF. Other etiologies for decreased bone mass were excluded, and the diagnosis of Fanconi syndrome was established based on her bone mineral density (BMD) and urine parameters. She was treated conservatively with active vitamin D, calcium, and progesterone/estrogen combination, but her phosphate wasting persisted despite switching to TAF; this likely represents a delayed irreversible effect of TDF on the patient's bone remodeling. This case report highlights the chronic sequelae of TDF therapy and the importance of monitoring for and early detection of renal tubulopathy and osteoporotic fractures in this patient population.
    Language English
    Publishing date 2024-01-31
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.53280
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  10. Article ; Online: Mallampati score in patients with temporomandibular joint disorders: A pilot case-control study.

    Mirmortazavi, Amirtaher / Madani, Azam Sadat / Hassanzadeh, Saeed / Shakiba, Reza

    Clinical and experimental dental research

    2024  Volume 10, Issue 2, Page(s) e866

    Abstract: Objectives: Temporomandibular joint disorder (TMD) is defined as any functional abnormalities in different parts of the face and neck. The Mallampati index is an indicator for determining the extent of airway blockage. No study has examined the ... ...

    Abstract Objectives: Temporomandibular joint disorder (TMD) is defined as any functional abnormalities in different parts of the face and neck. The Mallampati index is an indicator for determining the extent of airway blockage. No study has examined the relationship between TMD and Mallampati score. Most studies have investigated the relationship between temporomandibular joint problems and sleep problems. This pilot study aimed to assess the Mallampati index scores among TMD patients.
    Material and methods: Eighty-four people were divided into the case (based on RDC/TMD) and control groups. Demographic information, neck circumference, tongue size, Mallampati score, and other variables were asked of people. STOP-BANG and Pittsburgh Sleep Quality Index (PSQI) were also completed for each patient. Data were analyzed with Chi-square, Fisher's exact, and Mann-Whitney tests.
    Results: The Mallampati and PSQI questionnaire scores in the case group were significantly higher than those in the control group (p < 0.001). The results showed that larger tongue and neck circumference patients had a higher Mallampati score. Pearson correlation coefficient showed that the Mallampati score had a direct and significant relationship with body mass index and PSQI (p < 0.001).
    Conclusions: The results of this study show that Mallampati scores were significantly higher among patients with TMD than among healthy individuals.
    MeSH term(s) Humans ; Case-Control Studies ; Pilot Projects ; Temporomandibular Joint Disorders/diagnosis ; Temporomandibular Joint ; Health Status
    Language English
    Publishing date 2024-03-04
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2829558-4
    ISSN 2057-4347 ; 2057-4347
    ISSN (online) 2057-4347
    ISSN 2057-4347
    DOI 10.1002/cre2.866
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