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  1. Article ; Online: High Salt Remodels Kidney Metabolism: Metabolite Fuel, Fate, and Signals.

    Lassé, Moritz / Rinschen, Markus M

    Function (Oxford, England)

    2024  Volume 5, Issue 2, Page(s) zqae006

    MeSH term(s) Rats ; Animals ; Sodium Chloride, Dietary/adverse effects ; Sodium Chloride/metabolism ; Kidney/metabolism
    Chemical Substances Sodium Chloride, Dietary ; Sodium Chloride (451W47IQ8X)
    Language English
    Publishing date 2024-01-29
    Publishing country England
    Document type Journal Article ; Comment
    ISSN 2633-8823
    ISSN (online) 2633-8823
    DOI 10.1093/function/zqae006
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  2. Article ; Online: Navigating the Omics Frontier: Challenges, Opportunities, and the Future of Precision Nephrology.

    Rinschen, Markus M / Knepper, Mark A

    Journal of the American Society of Nephrology : JASN

    2023  Volume 34, Issue 12, Page(s) 1943–1944

    MeSH term(s) Nephrology ; Genomics ; Proteomics ; Forecasting
    Language English
    Publishing date 2023-10-30
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1085942-1
    ISSN 1533-3450 ; 1046-6673
    ISSN (online) 1533-3450
    ISSN 1046-6673
    DOI 10.1681/ASN.0000000000000255
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  3. Article ; Online: Metabolic Rewiring and Communication: An Integrative View of Kidney Proximal Tubule Function.

    Chrysopoulou, Maria / Rinschen, Markus M

    Annual review of physiology

    2023  Volume 86, Page(s) 405–427

    Abstract: The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic ... ...

    Abstract The kidney proximal tubule is a key organ for human metabolism. The kidney responds to stress with altered metabolite transformation and perturbed metabolic pathways, an ultimate cause for kidney disease. Here, we review the proximal tubule's metabolic function through an integrative view of transport, metabolism, and function, and embed it in the context of metabolome-wide data-driven research. Function (filtration, transport, secretion, and reabsorption), metabolite transformation, and metabolite signaling determine kidney metabolic rewiring in disease. Energy metabolism and substrates for key metabolic pathways are orchestrated by metabolite sensors. Given the importance of renal function for the inner milieu, we also review metabolic communication routes with other organs. Exciting research opportunities exist to understand metabolic perturbation of kidney and proximal tubule function, for example, in hypertension-associated kidney disease. We argue that, based on the integrative view outlined here, kidney diseases without genetic cause should be approached scientifically as metabolic diseases.
    MeSH term(s) Humans ; Kidney Tubules, Proximal/metabolism ; Kidney/metabolism ; Energy Metabolism ; Kidney Diseases
    Language English
    Publishing date 2023-11-27
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 207933-1
    ISSN 1545-1585 ; 0066-4278
    ISSN (online) 1545-1585
    ISSN 0066-4278
    DOI 10.1146/annurev-physiol-042222-024724
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  4. Article: Single glomerular proteomics: A novel tool for translational glomerular cell biology.

    Rinschen, Markus M

    Methods in cell biology

    2019  Volume 154, Page(s) 1–14

    Abstract: The glomerulus harbors the renal filtration barrier and needs to be precisely maintained. In this chapter, the concept of single glomerular proteomics is described. Single glomerular proteomics has recently been enabled by advances in glomerular ... ...

    Abstract The glomerulus harbors the renal filtration barrier and needs to be precisely maintained. In this chapter, the concept of single glomerular proteomics is described. Single glomerular proteomics has recently been enabled by advances in glomerular isolation, ultrasensitive peptide sample preparation and mass spectrometry based technology and acquisition strategies. It generates protein content information on a single glomerulus that can be overlaid with morphological and other multi-layered omics analyses. The novel method consists of four essential steps: preparation of single glomeruli-by microdissection, glomerular preparation, or laser microdissection-followed by proteomic sample preparation, mass spectrometry analysis and bioinformatics analysis. It enables for the first time the generation of sub-biopsy level proteomics data. In perspective, comprehensive data from individual glomeruli could be used in order to pinpoint novel druggable targets in animal models of kidney disease or in patients with proteinuria and glomerular disease.
    MeSH term(s) Alkylation ; Animals ; Computational Biology/methods ; Humans ; Kidney Diseases/diagnosis ; Kidney Diseases/metabolism ; Kidney Diseases/pathology ; Kidney Glomerulus/chemistry ; Laser Capture Microdissection/methods ; Mice ; Peptides/isolation & purification ; Proteinuria/diagnosis ; Proteinuria/metabolism ; Proteinuria/pathology ; Proteome/isolation & purification ; Proteomics/methods ; Rats ; Solid Phase Extraction/methods ; Translational Medical Research/methods
    Chemical Substances Peptides ; Proteome
    Language English
    Publishing date 2019-04-24
    Publishing country United States
    Document type Journal Article
    ISSN 0091-679X
    ISSN 0091-679X
    DOI 10.1016/bs.mcb.2019.03.010
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  5. Article ; Online: Integrative physiology of lysine metabolites.

    Tan, Yifan / Chrysopoulou, Maria / Rinschen, Markus M

    Physiological genomics

    2023  Volume 55, Issue 12, Page(s) 579–586

    Abstract: Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular, ... ...

    Abstract Lysine is an essential amino acid that serves as a building block in protein synthesis. Beside this, the metabolic activity of lysine has only recently been unraveled. Lysine metabolism is tissue specific and is linked to several renal, cardiovascular, and endocrinological diseases through human metabolomics datasets. As a free molecule, lysine takes part in the antioxidant response and engages in protein modifications, and its chemistry shapes both proteome and metabolome. In the proteome, it is an acceptor for a plethora of posttranslational modifications. In the metabolome, it can be modified, conjugated, and degraded. Here, we provide an update on integrative physiology of mammalian lysine metabolites such as α-aminoadipic acid, saccharopine, pipecolic acid, and lysine conjugates such as acetyl-lysine, and sugar-lysine conjugates such as advanced glycation end products. We also comment on their emerging associative and mechanistic links to renal disease, hypertension, diabetes, and cancer.
    MeSH term(s) Animals ; Humans ; Lysine/metabolism ; Proteome ; Mammals/metabolism
    Chemical Substances Lysine (K3Z4F929H6) ; Proteome
    Language English
    Publishing date 2023-10-02
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2038823-8
    ISSN 1531-2267 ; 1094-8341
    ISSN (online) 1531-2267
    ISSN 1094-8341
    DOI 10.1152/physiolgenomics.00061.2023
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  6. Article ; Online: A stressed barrier left behind: stochastic podocyte ablation triggers secondary injury.

    Koehler, Sybille / Rinschen, Markus M

    American journal of physiology. Renal physiology

    2021  Volume 320, Issue 5, Page(s) F866–F869

    MeSH term(s) Podocytes
    Language English
    Publishing date 2021-03-29
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 603837-2
    ISSN 1522-1466 ; 0363-6127
    ISSN (online) 1522-1466
    ISSN 0363-6127
    DOI 10.1152/ajprenal.00109.2021
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    Uc I Zs.89: Show issues Location:
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  7. Article ; Online: (Sugar-) Sweet Biomarkers? Clinical Proteomics Enters Sepsis Research.

    Rinschen, Markus M

    Critical care medicine

    2015  Volume 43, Issue 10, Page(s) 2245–2246

    MeSH term(s) Female ; Glycoproteins/blood ; Humans ; Male ; Proteomics ; Sepsis/blood ; Sepsis/mortality
    Chemical Substances Glycoproteins
    Language English
    Publishing date 2015-10
    Publishing country United States
    Document type Comment ; Editorial ; Research Support, Non-U.S. Gov't
    ZDB-ID 197890-1
    ISSN 1530-0293 ; 0090-3493
    ISSN (online) 1530-0293
    ISSN 0090-3493
    DOI 10.1097/CCM.0000000000001220
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    Zs.A 1261: Show issues Location:
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  8. Article ; Online: A knowledge-guided kidney cell census-reconciling bulk omics with cellular heterogeneity?

    Rinschen, Markus M / Müller, Roman-Ulrich

    Kidney international

    2019  Volume 95, Issue 4, Page(s) 733–735

    Abstract: Clark et al. present a curated knowledge-based census of 43 known canonical kidney cell types, based on calculated contribution to total kidney mass and expression of molecular markers. Their study illustrates limitations of bulk transcriptomics but also ...

    Abstract Clark et al. present a curated knowledge-based census of 43 known canonical kidney cell types, based on calculated contribution to total kidney mass and expression of molecular markers. Their study illustrates limitations of bulk transcriptomics but also provides guidance to their fruitful interpretation. In the light of their findings, the use of bulk sequencing datasets in conjunction with single-cell transcriptomics could contribute to the exploitation of integrative omics analyses in kidney research.
    MeSH term(s) Biomarkers ; Censuses ; Kidney ; RNA
    Chemical Substances Biomarkers ; RNA (63231-63-0)
    Language English
    Publishing date 2019-03-20
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 120573-0
    ISSN 1523-1755 ; 0085-2538
    ISSN (online) 1523-1755
    ISSN 0085-2538
    DOI 10.1016/j.kint.2018.12.016
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  9. Article ; Online: Water transport running deep. Focus on "Deep proteomic profiling of vasopressin-sensitive collecting duct cells".

    Rinschen, Markus M

    American journal of physiology. Cell physiology

    2015  Volume 309, Issue 12, Page(s) C783–4

    MeSH term(s) Animals ; Aquaporin 2/metabolism ; Blotting, Western/methods ; Cell Line/metabolism ; Computational Biology/methods ; Kidney Tubules, Collecting/metabolism ; Proteomics/methods
    Chemical Substances Aquaporin 2
    Language English
    Publishing date 2015-09-30
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 392098-7
    ISSN 1522-1563 ; 0363-6143
    ISSN (online) 1522-1563
    ISSN 0363-6143
    DOI 10.1152/ajpcell.00280.2015
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  10. Article ; Online: The tissue proteome in the multi-omic landscape of kidney disease.

    Rinschen, Markus M / Saez-Rodriguez, Julio

    Nature reviews. Nephrology

    2020  Volume 17, Issue 3, Page(s) 205–219

    Abstract: Kidney research is entering an era of 'big data' and molecular omics data can provide comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics, proteomics and metabolomics generate data that relate more directly to ... ...

    Abstract Kidney research is entering an era of 'big data' and molecular omics data can provide comprehensive insights into the molecular footprints of cells. In contrast to transcriptomics, proteomics and metabolomics generate data that relate more directly to the pathological symptoms and clinical parameters observed in patients. Owing to its complexity, the proteome still holds many secrets, but has great potential for the identification of drug targets. Proteomics can provide information about protein synthesis, modification and degradation, as well as insight into the physical interactions between proteins, and between proteins and other biomolecules. Thus far, proteomics in nephrology has largely focused on the discovery and validation of biomarkers, but the systematic analysis of the nephroproteome can offer substantial additional insights, including the discovery of mechanisms that trigger and propagate kidney disease. Moreover, proteome acquisition might provide a diagnostic tool that complements the assessment of a kidney biopsy sample by a pathologist. Such applications are becoming increasingly feasible with the development of high-throughput and high-coverage technologies, such as versatile mass spectrometry-based techniques and protein arrays, and encourage further proteomics research in nephrology.
    MeSH term(s) Biomarkers/metabolism ; Computational Biology/methods ; Humans ; Kidney Diseases/metabolism ; Proteome/metabolism ; Proteomics/methods
    Chemical Substances Biomarkers ; Proteome
    Language English
    Publishing date 2020-10-07
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2490366-8
    ISSN 1759-507X ; 1759-5061
    ISSN (online) 1759-507X
    ISSN 1759-5061
    DOI 10.1038/s41581-020-00348-5
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