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  1. Article: Validation of the Anticolitis Efficacy of the Jian-Wei-Yu-Yang Formula.

    Yan, Jing / Tang, Yan / Yu, Wei / Jiang, Lu / Liu, Chen / Li, Qi / Zhang, Zhiqiang / Shao, Changlei / Zheng, Yang / Liu, Xihao / Liu, Xincheng

    Evidence-based complementary and alternative medicine : eCAM

    2022  Volume 2022, Page(s) 9110704

    Abstract: ... to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application ...

    Abstract Background: Inflammatory bowel disease (IBD) is a major cause of morbidity and mortality due to its repetitive remission and relapse. The Jian-Wei-Yu-Yang (JW) formula has a historical application in the clinic to combat gastrointestinal disorders. The investigation aimed to explore the molecular and cellular mechanisms of JW.
    Methods: 2% dextran sodium sulfate (DSS) was diluted in drinking water and given to mice for 5 days to establish murine models of experimental colitis, and different doses of JW solution were administered for 14 days. Network pharmacology analysis and weighted gene co-expression network analysis (WGCNA) were utilized to predict the therapeutic role of JW against experimental colitis and colitis-associated colorectal cancer (CAC). 16S rRNA sequencing and untargeted metabolomics were conducted using murine feces. Western blotting, immunocytochemistry, and wound healing experiments were performed to confirm the molecular mechanisms.
    Results: (1) Liquid chromatography with mass spectrometry was utilized to confirm the validity of the JW formula. The high dose of JW treatment markedly attenuated DSS-induced experimental colitis progression, and the targets were enriched in inflammation, infection, and tumorigenesis. (2) The JW targets were related to the survival probability in patients with colorectal cancer, underlying a potential therapeutic value in CRC intervention. (3) Moreover, the JW therapy successfully rescued the decreased richness and diversity of microbiota, suppressed the potentially pathogenic phenotype of the gut microorganisms, and increased cytochrome P450 activity in murine colitis models. (4) Our
    Conclusion: The JW capsule attenuated the progression of murine colitis by a prompt resolution of inflammation and bloody stool and by re-establishing a microbiome profile that favors re-epithelization and prevents carcinogenesis.
    Language English
    Publishing date 2022-08-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2171158-6
    ISSN 1741-4288 ; 1741-427X
    ISSN (online) 1741-4288
    ISSN 1741-427X
    DOI 10.1155/2022/9110704
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    Zs.A 5995: Show issues Location:
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  2. Article ; Online: Integration of gut microbiome and serum metabolome revealed the effect of Qing-Wei-Zhi-Tong Micro-pills on gastric ulcer in rats.

    Wang, Chao / Jiang, Shengyu / Zheng, Haoyu / An, Yiming / Zheng, Wenxue / Zhang, Jiaqi / Liu, Jianming / Lin, Hongqiang / Wang, Guoqiang / Wang, Fang

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 3, Page(s) 117294

    Abstract: Ethnopharmacological relevance: Qing-Wei-Zhi-Tong Micro-pills (QWZT) is herbal compound used ...

    Abstract Ethnopharmacological relevance: Qing-Wei-Zhi-Tong Micro-pills (QWZT) is herbal compound used in the treatment of GU, whose functions include clearing the stomach and fire, softening the liver and relieving pain. However, its mechanistic profile on host intestinal microbiota and metabolism has not been determined.
    Aim of the study: The present study aimed to observe the healing effect of QWZT on acetic acid-induced gastric ulcer in a rat model and to preliminarily elucidate its possible therapeutic mechanism from the perspective of host intestinal microbiota and metabolism.
    Materials and methods: The Wistar male rats (7 weeks old; weight 180-200 g) were randomly divided into normal control group (NC), acetic acid-induced gastric ulcer group (GU), and QWZT treatment group (High dose: 1250 mg/kg/day, Middle dose: 625 mg/kg/day, Low dose: 312.5 mg/kg/day) of 6 rats each. An acetic acid-induced gastric ulcer rat model was constructed based on anatomical surgery. QWZT (High dose, Middle dose, and Low dose) was used to treat gastric ulcer rats for 7 days by gavage. At the end of treatment, the body weight, macroscopic condition of gastric tissue ulcers, pathological changes (HE staining), inflammatory factors, oxidative stress factors, and endocrine factors were assessed in each group of rats. Fresh feces and serum from each group of rats were collected for microbiome and metabolome analysis on the machine, respectively. Drug-disease common targets and functional pathways were captured based on network pharmacology. The complex network of Herbs-Targets-Pathways-Metabolites-Microbiota interactions was constructed. Ultimately, Fecal Microbiota Transplantation (FMT) evaluated the contribution of gut microbiota in disease.
    Results: QWZT increased the abundance of beneficial bacteria (Bacteroides, Alloprevotella, Rikenellaceae_RC9_gut_group, Lactobacillus, Lachnospiraceae_NK4A136_group, Parabacteroides, etc.), reduced the abundance of harmful bacteria (Micromonospora, Geobacter, Nocardioides, and Arenimonas, etc.), reduced the levels of inflammatory mediators (12,13-EpOME, 9,10-Epoxyoctadecenoic acid, SM(d18:1/16:0) and Leukotriene A4, etc.), restored host metabolic disorders (Linoleic acid metabolism, Glycerophospholipid metabolism, and Arachidonic acid metabolism), and regulated the level of cytokines (IL-6, TNF-a, SOD, MDA, PEG-2 and NO), ultimately exerting an anti-ulcer effect. Apart from that, FMT improved acetic acid-induced gastric ulcers in rats.
    Conclusion: QWZT improved acetic acid-induced gastric ulcers in rats by remodeling intestinal microbiota and regulating host metabolism. This work may promote the process of developing and utilizing clinical applications of QWZT.
    MeSH term(s) Male ; Rats ; Animals ; Stomach Ulcer/chemically induced ; Stomach Ulcer/drug therapy ; Gastrointestinal Microbiome ; Rats, Wistar ; Metabolome ; Acetic Acid
    Chemical Substances Acetic Acid (Q40Q9N063P)
    Language English
    Publishing date 2023-10-14
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117294
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    Zs.A 1494: Show issues Location:
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  3. Article ; Online: Jia-Wei-Kai-Xin-San Treatment Alleviated Mild Cognitive Impairment through Anti-Inflammatory and Antiapoptotic Mechanisms in SAMP8 Mice.

    Zhang, Xiaolu / Sun, Yingxin / Yu, Qun / Zeng, Wenyun / Zhang, Yue / Zeng, Miao / Pang, Kexin / Yu, Yifei / Gan, Jiali / Li, Huhu / Yang, Lin / Jiang, Xijuan

    Mediators of inflammation

    2023  Volume 2023, Page(s) 7807302

    Abstract: ... of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism ...

    Abstract Background: Alleviating mild cognitive impairment (MCI) is crucial to delay the progression of Alzheimer's disease (AD). Jia-Wei-Kai-Xin-San (JWKXS) is applied for treating AD with MCI. However, the mechanism of JWKXS in the treatment of MCI is unclear. Thus, this study aimed to investigate the effect and mechanism of JWKXS in SAMP8 mice models of MCI.
    Methods: MCI models were established to examine learning and memory ability and explore the pathomechanisms in brain of SAMP8 mice at 4, 6, and 8 months. The mice were treated for 8 weeks and the effects of JWKXS on MCI were characterized through Morris water maze and HE/Nissl's/immunohistochemical staining. Its mechanism was predicted by the combination of UPLC-Q-TOF/MS and system pharmacology analysis, further verified with SAMP8 mice, BV2 microglial cells, and PC12 cells.
    Results: It was found that 4-month-old SAMP8 mice exhibited MCI. Two months of JWKXS treatment improved the learning and memory ability, alleviated the hippocampal tissue and neuron damage. Through network pharmacology, four key signaling pathways were found to be involved in treatment of MCI by JWKXS, including TLR4/NF-
    Conclusion: JWKXS treatment improved the learning and memory ability and conferred neuroprotective effects against MCI by inducing anti-inflammation and antiapoptosis.
    MeSH term(s) Rats ; Mice ; Animals ; Inflammasomes/metabolism ; NF-kappa B/metabolism ; NLR Family, Pyrin Domain-Containing 3 Protein/metabolism ; Toll-Like Receptor 4/metabolism ; Cognitive Dysfunction/drug therapy ; Alzheimer Disease/drug therapy ; Anti-Inflammatory Agents/therapeutic use
    Chemical Substances Kai-Xin-San ; Inflammasomes ; NF-kappa B ; NLR Family, Pyrin Domain-Containing 3 Protein ; Toll-Like Receptor 4 ; Anti-Inflammatory Agents
    Language English
    Publishing date 2023-11-02
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2023/7807302
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  4. Article ; Online: A new non-stationary standardised streamflow index using the climate indices and the optimal anthropogenic indices as covariates in the Wei River Basin, China

    Mingming Ren / Shanhu Jiang / Liliang Ren / Baisha Weng / Menghao Wang / Hao Cui / Chong-Yu Xu

    Journal of Hydrology: Regional Studies, Vol 51, Iss , Pp 101649- (2024)

    2024  

    Abstract: Study region: Catchment area above the Huaxian station along the Wei River Basin, China. Study ... applicable to the variable streamflow sequence of the Wei River Basin based on the climate index and ... model is more suitable for quantifying anthropogenic factors in the Wei River Basin. The NSSI performs ...

    Abstract Study region: Catchment area above the Huaxian station along the Wei River Basin, China. Study focus: This study attempts to construct a new Non-stationary Standardized Streamflow Index (NSSI) applicable to the variable streamflow sequence of the Wei River Basin based on the climate index and the optimal anthropogenic index, and analyse the drought characteristics of the basin. The climate index is used to quantify climate change factors and three anthropogenic indices are used to quantify the factor of human activities, including the reservoir index, the human-induced index calculated based on the Variable Infiltration Capacity (VIC) hydrological model and the Long Short-Term Memory (LSTM) model machine learning approach, respectively. New hydrological insights for the region: The human-induced index based on the LSTM model is more suitable for quantifying anthropogenic factors in the Wei River Basin. The NSSI performs better than the SSI in drought identification. The NSSI based on the LSTM model can capture more frequent severe drought and extreme drought events. The frequency of severe drought and extreme drought is higher in summer and autumn than in the others. The NSSI can better characterize the hydrological drought processes under a non-stationary condition, thus it can provide a more effective reference for regional drought assessment and related policy-making from the perspective of a changing environment.
    Keywords Non-stationary standardized streamflow index ; Hydrological drought ; Climate index ; Anthropogenic index ; Physical geography ; GB3-5030 ; Geology ; QE1-996.5
    Subject code 550
    Language English
    Publishing date 2024-02-01T00:00:00Z
    Publisher Elsevier
    Document type Article ; Online
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  5. Article ; Online: Network pharmacology approach and molecular docking to explore the potential mechanism of Wu-Wei-Wen-Tong Chubi capsules in rheumatoid arthritis.

    Cui, Xiaoya / Liu, Jian / Zhang, Lili / Wang, Xiaoli / Liu, Xiaochuang / Jiang, Hui

    Naunyn-Schmiedeberg's archives of pharmacology

    2022  Volume 395, Issue 9, Page(s) 1061–1073

    Abstract: ... the targets of Wu-Wei-Wen-Tong Chubi capsule (WWWT) to explore the mechanism in the treatment of rheumatoid ...

    Abstract Network pharmacology, a holistic approach based on the theory of biological network technology, integrates information from biological systems, drugs, and diseases. Here, this theory was used to predict the targets of Wu-Wei-Wen-Tong Chubi capsule (WWWT) to explore the mechanism in the treatment of rheumatoid arthritis (RA). The ingredients of each herbal medicine in WWWT were collected from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP), and the active ingredients were screened through bioavailability (OB) ≥30% and drug-likeness (DL) ≥ 0.18. SwissTargetPrection and TCMSP were utilized to calculate and predict the targets of active ingredients. RA-related targets were obtained by searching the Genecards and OMIM databases. The common targets of RA and WWWT were used for gene ontology (GO), KEGG pathway enrichment, protein-protein interaction (PPI) analysis, and molecular docking. And then, four key genes were screened for subsequent verification experiments. In total, 90 active compounds and 330 potential targets of WWWT, 1310 targets of RA, and 135 intersection targets were found. Additionally, GO and pathway analysis identified 4610 significant GO terms and 147 significant KEGG pathways. Based on the PPI network, 11 key genes including IL-6, MMP-9, and TNF-α were screened out for molecular docking. Molecular docking showed that these key genes have good binding activities to active compounds of WWWT such as oroxylin a, kaempferol, and luteolin. Simultaneously, Western blot experimental validation demonstrated that the protein expressions of IL-6, MMP-9, TNF-α, and VEGFA significantly decreased after WWWT treatment. The mechanism of WWWT in treating RA involves multiple active compounds acting on multiple targets, and multiple pathways, which provides an important reference for further elucidation the mechanism and clinical applications of WWWT in the treatment of RA.
    MeSH term(s) Arthritis, Rheumatoid ; Capsules ; Drugs, Chinese Herbal ; Humans ; Interleukin-6 ; Matrix Metalloproteinase 9 ; Molecular Docking Simulation ; Network Pharmacology ; Tumor Necrosis Factor-alpha
    Chemical Substances Capsules ; Drugs, Chinese Herbal ; Interleukin-6 ; Tumor Necrosis Factor-alpha ; Matrix Metalloproteinase 9 (EC 3.4.24.35)
    Language English
    Publishing date 2022-06-07
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-022-02260-0
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  6. Article ; Online: Identification of the Active Compound of Liu Wei Di Huang Wan for Treatment of Gestational Diabetes Mellitus via Network Pharmacology and Molecular Docking.

    Xiong, Yunqi / Li, Qiutong / Chen, Xiuhui / Zhu, Ting / Lu, Qitian / Jiang, Guojing

    Journal of diabetes research

    2022  Volume 2022, Page(s) 4808303

    Abstract: Liu Wei Di Huang Wan (LWDHW) is a well-known Chinese herbal compound, which has been prescribed ...

    Abstract Liu Wei Di Huang Wan (LWDHW) is a well-known Chinese herbal compound, which has been prescribed for the treatment of gestational diabetes mellitus (GDM). We sought to clarify the potential therapeutic effects of LWDHW against GDM. Differentially expressed genes (DEGs) in GDM were firstly identified from the Gene Expression Omnibus (GEO) database. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to reveal the biological functions of the DEGs. Subsequently, the LWDHW-compound-target network was constructed based on public databases to identify the relationship between the active components in LWDHW and the corresponding targets. Furthermore, gene functional analysis and protein-protein interaction (PPI) network construction were applied to investigate the function of potential targets and to evaluate hub genes. Finally, molecular docking was used to verify the binding activities between active ingredients and hub targets. Thirteen active components and 39 corresponding therapeutic target genes were obtained via network pharmacology analysis. The enrichment analysis demonstrated that the anti-GDM effect of LWDHW included oxidoreductase activity, involvement in renal system process, and regulation of blood pressure, which may be achieved through regulation of serotonergic synapses, vascular smooth muscle contraction, and neuroactive ligand-receptor interaction pathways. Additionally, molecular docking revealed that the main active component, Mu Dan Pi, exhibited the best affinity for proteins encoded by hub genes. This study applied network pharmacology analysis and molecular docking to display the multicomponent and multitarget characteristics of LWDHW in the treatment of GDM. Our findings provide novel insights into the pathogenesis of GDM and the therapeutic mechanisms of LWDHW against GDM.
    MeSH term(s) Diabetes, Gestational/drug therapy ; Diabetes, Gestational/genetics ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Female ; Humans ; Medicine, Chinese Traditional ; Molecular Docking Simulation ; Network Pharmacology ; Pregnancy ; Protein Interaction Maps
    Chemical Substances Drugs, Chinese Herbal ; Liuwei Dihuang Decoction
    Language English
    Publishing date 2022-05-28
    Publishing country England
    Document type Journal Article
    ZDB-ID 2711897-6
    ISSN 2314-6753 ; 2314-6753
    ISSN (online) 2314-6753
    ISSN 2314-6753
    DOI 10.1155/2022/4808303
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  7. Article: Bias correction, historical evaluations, and future projections of climate simulations in the Wei River Basin using CORDEX-EA

    Wang, Yinping / Jiang, Rengui / Xie, Jiancang / Zhu, Jiwei / Zhao, Yong / Lu, Xixi / Li, Fawen

    Theoretical and applied climatology. 2022 Oct., v. 150, no. 1-2

    2022  

    Abstract: ... precipitation simulations for the period of 1980–2005 and 2026–2098 in the Wei River Basin (WRB), to evaluate ...

    Abstract The utilization of regional climate methods (RCMs) to predict future climate is an important study under the changing environment. The primary objective of the paper is to correct the temperature and precipitation simulations for the period of 1980–2005 and 2026–2098 in the Wei River Basin (WRB), to evaluate the performance of RCMs for the period of 1980–2005, and further, to analyze the future changes of projected temperature and precipitation during 2026–2098. In this paper, the linear scaling method was used to correct the temperature simulations. Quantile mapping, local intensity scaling method, and hybrid method were used to correct the precipitation simulations. The future changes of projected temperature and precipitation for the near term (2026–2050), mid-term (2051–2075), and far term (2076–2098), relative to the period of 1980–2005, were investigated under RCP 2.6 and RCP 8.5. Results indicate that (1) the temperature biases were either warm or cold in the spatial scale, and the precipitation wet biases were detected. After correction, HadGEM2-ES driven by RegCM4-4 had the best temperature reproducibility, and NCC-NorESM1-M driven by RegCM4-4 had the best precipitation reproducibility. (2) Under RCP 2.6, the projected annual, winter, and spring temperature showed decreasing trends. The temperature was higher than that for the period of 1980–2005 except for the spring temperature decreases in the Beiluo River Basin. Under RCP 8.5, the temperature showed significantly increasing trends. The temperature for the near term was similar to that of the period of 1980–2005, while the temperature increased significantly for the mid-term and far term. (3) Under RCP 2.6, the precipitation had decreasing trends. Under RCP 8.5, precipitation trends were also spatially distributed. The relative deviation of winter precipitation was the largest. Relative to the period of 1980–2005, the light- and moderate-rain days showed little change for the period of 2026–2098, while the extreme-rain days showed significantly increasing trends.
    Keywords climate ; climatology ; cold ; spring ; temperature ; watersheds ; winter
    Language English
    Dates of publication 2022-10
    Size p. 135-153.
    Publishing place Springer Vienna
    Document type Article
    ZDB-ID 1463177-5
    ISSN 1434-4483 ; 0177-798X
    ISSN (online) 1434-4483
    ISSN 0177-798X
    DOI 10.1007/s00704-022-04157-7
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  8. Article ; Online: Screening the Q-markers of TCMs from RA rat plasma using UHPLC-QTOF/MS technique for the comprehensive evaluation of Wu-Wei-Wen-Tong Capsule.

    Jiang, Hui / Liu, Jian / Wang, Yanling / Chen, Leijing / Liu, Hui / Wang, Zhen / Wang, Bin

    Journal of mass spectrometry : JMS

    2021  Volume 56, Issue 5, Page(s) e4711

    Abstract: ... quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu-Wei-Wen-Tong Capsule (WWWTC ...

    Abstract The appropriate selection of quality marker (Q-marker) for performing the comprehensive quality evaluation of traditional Chinese medicines (TCMs) has much more significance. Wu-Wei-Wen-Tong Capsule (WWWTC), a TCMs prescription, is mainly utilized to treat rheumatoid arthritis (RA) in China. However, the comprehensive quality control for WWWTC has not been achieved because of lacking system analysis for the Q-marker. In this study, a dual wavelength, 203 and 270 nm, was selected based on the feature of 15 Q-markers, and a reliable UHPLC-UV fingerprinting approach was established, achieving the comprehensive quality evaluation of WWWTC. First, we identified 91 prototypes in rat plasma after administering a set amount of WWWTC by using UHPLC-QTOF/MS technique and selected them as the candidate Q-markers. Next, based on the "five principles" of Q-marker selection, 15 absorbed components among them including coumarin, cinnamic acid, cinnamaldehyde, cinnamic alcohol, and 2-methoxycinnamaldehyde derived from Monarch medicine of Cmnamomi Mmulus; epimedin C, icariin, baohuoside I, and anhydroicaritin derived from Monarch medicine Epimedii Folium; germacrone, the sesquiterpene compound in Minister medicine Rhizoma Wenyujin Concisum; pachymic acid, the tetracyclic triterpenoid acids in Assistant medicine Poria; baicalin, baicalein, wogonin, and wogonoside in Guide medicine Scutellariae Radix, respectively, were seriously chosen as the Q-markers, indicating preferable pharmacological effect on RA, characterization of transitivity and traceability as well as measurable components in WWWTC. The effective and meaningful strategy displayed a unique perspective for the exploration of Q-markers in the quality evaluation and further ensured efficacy and safety of the TCMs.
    MeSH term(s) Acrolein/analogs & derivatives ; Acrolein/blood ; Acrolein/metabolism ; Animals ; Arthritis, Experimental ; Arthritis, Rheumatoid/drug therapy ; Biomarkers, Pharmacological/blood ; Chromatography, High Pressure Liquid ; Cinnamates/blood ; Cinnamates/metabolism ; Coumarins/blood ; Coumarins/metabolism ; Drug Development ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/metabolism ; Drugs, Chinese Herbal/pharmacology ; Flavanones/blood ; Flavanones/metabolism ; Humans ; Medicine, Chinese Traditional ; Propanols/blood ; Propanols/metabolism ; Quality Control ; Rats ; Tandem Mass Spectrometry/methods ; Triterpenes/blood ; Triterpenes/metabolism
    Chemical Substances Biomarkers, Pharmacological ; Cinnamates ; Coumarins ; Drugs, Chinese Herbal ; Flavanones ; Propanols ; Triterpenes ; cinnamic acid (140-10-3) ; 2-methoxycinnamaldehyde (4940G3R6HE) ; baicalein (49QAH60606) ; Acrolein (7864XYD3JJ) ; coumarin (A4VZ22K1WT) ; cinnamaldehyde (SR60A3XG0F) ; cinnamyl alcohol (SS8YOP444F) ; pachymic acid (X2FCK16QAH)
    Language English
    Publishing date 2021-03-25
    Publishing country England
    Document type Journal Article
    ZDB-ID 1221763-3
    ISSN 1096-9888 ; 1076-5174
    ISSN (online) 1096-9888
    ISSN 1076-5174
    DOI 10.1002/jms.4711
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  9. Article ; Online: Establishment of geology-engineering integration model for shale gas of Wei AH platform in Weiyuan Area

    Jiang Hai / Xiao Yang / Liu Ziping / Li Zhigang / Deng Xiang / Zou Longqing

    E3S Web of Conferences, Vol 329, p

    2021  Volume 01041

    Abstract: Wei AH platform is a platform composed of 8 horizontal wells in Weiyuan shale gas area. The number ... of geological model, combined with one-dimensional rock mechanics profile, the geomechanical model of Wei AH platform ...

    Abstract Wei AH platform is a platform composed of 8 horizontal wells in Weiyuan shale gas area. The number of faults in the area is small, and natural fractures are locally developed. Therefore, it is necessary to take volume reconstruction as the core mining technology and establish the geology-engineering integration model for the platform according to the geology-engineering integration concept. On the basis of geological model, combined with one-dimensional rock mechanics profile, the geomechanical model of Wei AH platform is established by means of deep diagenetic theory. Based on geological model and geomechanical model, the well trajectory design model, fracturing design model and reservoir numerical simulation model are modeled and optimized respectively. Finally, it can realize the comprehensive application of geophysical, geological, mechanical and seepage data, and complete the mutual call and matching of all kinds of understanding and models.
    Keywords wei ah platform ; shale gas ; geology-engineering integration ; geomechanical model ; fracturing design model ; Environmental sciences ; GE1-350
    Subject code 670
    Language English
    Publishing date 2021-01-01T00:00:00Z
    Publisher EDP Sciences
    Document type Article ; Online
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  10. Article: Comprehensive Management of Rural Water Pollution in Polder Wetland: a Case Study of the Chenhai Wei Polder Wetland in the Taihu Basin of China

    Yan, Lubing / Xie, Changkun / Liang, Anze / Jiang, Ruiyuan / Che, Shengquan

    Wetlands. 2021 Feb., v. 41, no. 2

    2021  

    Abstract: ... This study utilizes Chenhai Wei polder wetland in Taihu Basin of China as an example to construct a multi ... in the Chenhai Wei polder wetland and the integration of this effective localized technological system provides ...

    Abstract Polder area water systems are closed, and the farmland, villages, fish ponds, forests, river networks, and other features are all intertwined. This causes water pollution in polder wetland to be characterized by a poor self-purification ability due to the closed system and a short pollutant residence time. This study utilizes Chenhai Wei polder wetland in Taihu Basin of China as an example to construct a multi-level pollution comprehensive management system using ecological ponds, grass-growing ditches, aquatic plants, aquatic crops, ecological floating beds, etc. This system achieved its purpose of prolonging the pollutant residence time and enhancing self-purification ability of rivers in polder wetland. In addition, due to the importance of localized agricultural production, a three-level system that combines farmland production, ecological pond planting, and river surface planting was established that fully utilizes nutrients and purifies the water while generating economic benefits. Three years after construction, the total nitrogen (TN), total phosphorus (TP), ammonia nitrogen (NH+ 4-N), and chemical oxygen demand (CODcᵣ) of the river water were significantly reduced (P < 0.05). The total removal was much larger than the total production amount, which effectively protects the regional environment and enables the sustainable development of production and life in the polder wetland.This study of rural water pollution management in the Chenhai Wei polder wetland and the integration of this effective localized technological system provides a reference for similar regions.
    Keywords agricultural land ; ammonium nitrogen ; basins ; case studies ; chemical oxygen demand ; fish ; management systems ; polders ; pollutants ; river water ; rivers ; sustainable development ; total nitrogen ; total phosphorus ; water pollution ; wetlands ; China
    Language English
    Dates of publication 2021-02
    Size p. 32.
    Publishing place Springer Netherlands
    Document type Article
    Note NAL-AP-2-clean
    ZDB-ID 1097341-2
    ISSN 1943-6246 ; 0277-5212
    ISSN (online) 1943-6246
    ISSN 0277-5212
    DOI 10.1007/s13157-021-01428-3
    Database NAL-Catalogue (AGRICOLA)

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