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Article ; Online: SmartFSCV: An Artificial Intelligence Enabled Miniaturised FSCV Device Targeting Serotonin.

Corva, Dean M / Doeven, Egan H / Parke, Brenna / Adams, Scott D / Tye, Susannah J / Hashemi, Parastoo / Berk, Michael / Kouzani, Abbas Z

IEEE open journal of engineering in medicine and biology

2024 Volume 5, Page(s) 75–85

Abstract: Goal: ...

Abstract	Goal:
Language	English
Publishing date	2024-01-19
Publishing country	United States
Document type	Journal Article
ISSN	2644-1276
ISSN (online)	2644-1276
DOI	10.1109/OJEMB.2024.3356177
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Article ; Online: An insight into population structure and genetic progress of Argentinean Holstein cattle

Pardo, Alan M. / Casanova, Daniel / Rubio, Natalia / Andere, Cecilia / Rodríguez, Edgardo / Corva, Pablo M.

Journal of Animal Breeding and Genetics. 2023 July, v. 140, no. 4 p.376-389

2023

Abstract: The objective of the present study was to investigate the most critical issues associated with the limited genetic progress evidenced in the Argentinean Holstein (“Holando Argentino”) breed in the last 20 years (only 26% of the phenotypic trend in milk ... ...

Abstract	The objective of the present study was to investigate the most critical issues associated with the limited genetic progress evidenced in the Argentinean Holstein (“Holando Argentino”) breed in the last 20 years (only 26% of the phenotypic trend in milk yield was due to genetics). The study comprised the analysis of population structure, realized genetic selection differentials, genetic progress and partition of genetic trends by sex and country of origin from 1936 to 2019 (1,045,582 records; 24,680 sires and 619,322 dams in the pedigree). Average inbreeding steadily increased in the last 15 generations (ΔF = 0.6%, which translates to Ne = 75). Partition of genetic trends revealed that local genetics made a negligible contribution to genetic progress, which for most traits was highly dependent on imported genetics (>80%). Mean generation intervals were fairly constant until 2009 (8–9 years for males and 5–6 years for females, respectively) and then decreased, especially in the paths of sires of bulls and dams of bulls (to 5 and 4 years, respectively) mostly due to the influence of imported sires. The reduction in generation intervals was counterbalanced by a marked deterioration of realized selection differentials, particularly in the path of sires of bulls that nevertheless made the largest contribution to genetic progress. In the last 20 years, realized selection differentials in this path went from 533.6 to 170.8 kg for milk yield and from 16.7 to 13.3 kg for protein yield (1.7–0.5 and 1.6–1.3 standard deviation units, respectively). Among all considered traits (milk yield, fat yield, protein yield, stature, final score and daughter pregnancy rate) in the analysed period, annual genetic gain was negative for milk yield, fairly constant for composition and conformation traits, and positive only in the case of daughter pregnancy rate. Considered together, these results suggest that limited genetic progress is due to the absence of a sound breeding programme that includes genomic selection and a carefully defined selection objective, together with the absence of stronger regulations in germplasm importation; however, other factors such as potential genetics by environment interactions cannot be ruled out.
Keywords	Holstein ; cattle ; genetic improvement ; genetic selection ; germplasm ; marker-assisted selection ; milk yield ; pedigree ; phenotype ; population structure ; pregnancy rate ; standard deviation
Language	English
Dates of publication	2023-07
Size	p. 376-389.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	631363-2
ISSN	0931-2668
ISSN	0931-2668
DOI	10.1111/jbg.12766
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Characterization of experimental cattle populations from Argentina with a low‐density SNP genotyping panel

Michiels, Brian / Pardo, Alan Maxs / Ortega Masagué, Maria F. / Giovambattista, Guillermo / Corva, Pablo M.

Animal Genetics. 2023 Feb., v. 54, no. 1 p.68-72

2023

Abstract: The objectives of the present experiment were to evaluate a low‐density SNP array designed for the molecular characterisation of gene banks and to assess the genetic diversity and population structure of beef cattle herds from an Argentinean research ... ...

Abstract	The objectives of the present experiment were to evaluate a low‐density SNP array designed for the molecular characterisation of gene banks and to assess the genetic diversity and population structure of beef cattle herds from an Argentinean research station. Forty‐nine animals from three breeds (Angus, Hereford, and Argentinean Creole) were genotyped using the multi‐species IMAGE001 60‐K SNP array (10 K for cattle). Genotypes of other 19 cattle populations from Argentina, other American countries, and Europe were included in the study. Of special interest was the characterization of the Argentinean Creole, the only autochthonous cattle breed in the country. Due to the merging of different datasets, approximately 5 K SNPs were effectively used. Genetic differentiation (FST), principal component analysis, neighbour‐joining tree of Reynolds distances and ancestry analysis showed that autochthonous American breeds are clearly differentiated, but all have genetic influences of Iberian cattle. The analysed herds of Argentinean Creole showed no evidence of recent admixture and represent a unique genetic pool within local American breeds. An experimental herd and the local commercial Hereford population have also diverged, probably due to the influence of current selection objectives in the breed. Our results illustrate the utility of using low‐cost, low density SNP arrays in the evaluation of animal genetic resources. This type of panels could become a very useful resource in developing countries, where most endangered cattle breeds are located. The results also reinforce the importance of experimental herds as reservoir of genetic diversity, particularly in the case of local breeds under‐represented in traditional production systems.
Keywords	Angus ; Hereford ; ancestry ; animal genetics ; beef cattle ; data collection ; genes ; genetic variation ; genotyping ; herds ; population structure ; principal component analysis ; single nucleotide polymorphism arrays ; Argentina ; Europe
Language	English
Dates of publication	2023-02
Size	p. 68-72.
Publishing place	John Wiley & Sons, Ltd
Document type	Article ; Online
Note	JOURNAL ARTICLE
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/age.13278
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Article ; Online: Feed sorting behavior and performance of Argentinian Creole, Braford and crossbred steers during the growing and fattening phases

M.M. Della Rosa / P.M. Corva / V. Royo / M. Zimerman / D. Bottegal / J.A. Nasca

RIA: Revista Investigaciones Agropecuarias, Vol 48, Iss 1, Pp 118-

2022 Volume 123

Abstract: ... que los otros dos grupos (P <0.01) y su conversión (kg/kg) fue menor que BRA (P<0.01). Se observaron diferencias ... para seleccionar partículas largas (>19 mm, BRAP=0.03) y una tendencia para seleccionar partículas cortas (4 ... 8 mm, BRA>CRA y CXB, P=0.06). Experimento 2: el peso vivo inicial de CRA fue más bajo que en BRA y ...

Abstract	Las razas autóctonas latinoamericanas se consideran muy adaptadas a sistemas pastoriles en ambientes adversos. Sin embargo, su real potencial de producción en sistemas más intensificados y en particular en comparación con razas exóticas introducidas es todavía tema de debate. Se evaluó el desempeño de los novillos Criollo Argentino (CRA), Braford (BRA) y Criollo x Braford (CXB) en las etapas de crecimiento y engorde intensivo (Experimento 1 y Experimento 2, respectivamente). En el Experimento 1, 12 animales de cada grupo genético se asignaron a cuatro corrales y se alimentaron con una ración totalmente mezclada durante 57 días. En el Experimento 2, seis novillos de 17 meses de edad de cada grupo genético se alojaron en corrales individuales y se alimentaron con una dieta concentrada durante 55 días. Se evaluó el comportamiento productivo y la selección de dieta. Experimento 1: CRA tuvo una ganancia diaria de peso más baja que los otros dos grupos (P <0.01) y su conversión (kg/kg) fue menor que BRA (P<0.01). Se observaron diferencias para seleccionar partículas largas (>19 mm, BRA<CXB, <mark>P=0.03) y una tendencia para seleccionar partículas cortas (4-8 mm, BRA>CRA y CXB, P=0.06). Experimento 2: el peso vivo inicial de CRA fue más bajo que en BRA y CXB (P<0.01) y la diferencia con BRA también fue significativa al final del experimento (P<0.01). CRA tuvo menor espesor de grasa dorsal (P<0.01). El área inicial y final del ojo de bife fue similar entre grupos en ambos experimentos. La clasificación de las partículas en alimento fue similar entre grupos (P≥0.21). Todos los resultados sugieren que CRA tuvo un desempeño productivo inferior a BRA y CXB en ambos experimentos.
Keywords	bovinos para carne ; razas autóctonas ; cruzamientos ; crecimiento ; alimentación ; consumo ; Agriculture ; S ; Agriculture (General) ; S1-972
Language	English
Publishing date	2022-01-01T00:00:00Z
Publisher	Instituto Nacional de Tecnología Agropecuaria (INTA)
Document type	Article ; Online
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Article ; Online: Probing the Gold/Water Interface with Surface-Specific Spectroscopy.

Piontek, Stefan M / Naujoks, Dennis / Tabassum, Tadneem / DelloStritto, Mark J / Jaugstetter, Maximilian / Hosseini, Pouya / Corva, Manuel / Ludwig, Alfred / Tschulik, Kristina / Klein, Michael L / Petersen, Poul B

ACS physical chemistry Au

2023 Volume 3, Issue 1, Page(s) 119–129

Abstract: Water is an integral component in electrochemistry, in the generation of the electric double layer, and in the propagation of the interfacial electric fields into the solution; however, probing the molecular-level structure of interfacial water near ... ...

Abstract	Water is an integral component in electrochemistry, in the generation of the electric double layer, and in the propagation of the interfacial electric fields into the solution; however, probing the molecular-level structure of interfacial water near functioning electrode surfaces remains challenging. Due to the surface-specificity, sum-frequency-generation (SFG) spectroscopy offers an opportunity to investigate the structure of water near working electrochemical interfaces but probing the hydrogen-bonded structure of water at this buried electrode-electrolyte interface was thought to be impossible. Propagating the laser beams through the solvent leads to a large attenuation of the infrared light due to the absorption of water, and interrogating the interface by sending the laser beams through the electrode normally obscures the SFG spectra due to the large nonlinear response of conduction band electrons. Here, we show that the latter limitation is removed when the gold layer is thin. To demonstrate this, we prepared Au gradient films on CaF
Language	English
Publishing date	2023-01-04
Publishing country	United States
Document type	Journal Article
ISSN	2694-2445
ISSN (online)	2694-2445
DOI	10.1021/acsphyschemau.2c00044
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Article ; Online: Linking Composition, Structure and Thickness of CoOOH layers to Oxygen Evolution Reaction Activity by Correlative Microscopy.

Luan, Chenglong / Angona, Johanna / Bala Krishnan, Arjun / Corva, Manuel / Hosseini, Pouya / Heidelmann, Markus / Hagemann, Ulrich / Batsa Tetteh, Emmanuel / Schuhmann, Wolfgang / Tschulik, Kristina / Li, Tong

Angewandte Chemie (International ed. in English)

2023 Volume 62, Issue 28, Page(s) e202305982

Abstract: The role of β-CoOOH crystallographic orientations in catalytic activity for the oxygen evolution reaction (OER) remains elusive. We combine correlative electron backscatter diffraction/scanning electrochemical cell microscopy with X-ray photoelectron ... ...

Abstract	The role of β-CoOOH crystallographic orientations in catalytic activity for the oxygen evolution reaction (OER) remains elusive. We combine correlative electron backscatter diffraction/scanning electrochemical cell microscopy with X-ray photoelectron spectroscopy, transmission electron microscopy, and atom probe tomography to establish the structure-activity relationships of various faceted β-CoOOH formed on a Co microelectrode under OER conditions. We reveal that ≈6 nm β-CoOOH(01
Language	English
Publishing date	2023-06-06
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2011836-3
ISSN	1521-3773 ; 1433-7851
ISSN (online)	1521-3773
ISSN	1433-7851
DOI	10.1002/anie.202305982
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Article ; Online: Miniature Resistance Measurement Device for Structural Health Monitoring of Reinforced Concrete Infrastructure.

Corva, Dean M / Hosseini, Seyyed Sobhan / Collins, Frank / Adams, Scott D / Gates, Will P / Kouzani, Abbas Z

Sensors (Basel, Switzerland)

2020 Volume 20, Issue 15

Abstract: A vast amount of civil infrastructure is constructed using reinforced concrete, which can be susceptible to corrosion, posing significant risks. Corrosion of reinforced concrete has various causes, with chloride ingress known to be a major contributor. ... ...

Abstract	A vast amount of civil infrastructure is constructed using reinforced concrete, which can be susceptible to corrosion, posing significant risks. Corrosion of reinforced concrete has various causes, with chloride ingress known to be a major contributor. Monitoring this chloride ingress would allow for preventative maintenance to be less intrusive at a lower cost. Currently, chloride sensing methods are bulky and expensive, leaving the majority of concrete infrastructures unmonitored. This paper presents the design and fabrication of a miniature, low-cost device that can be embedded into concrete at various locations and depths. The device measures localized concrete resistance, correlating to the chloride ingress in the concrete using equations listed in this paper, and calculated results from two experiments are presented. The device benefits from a four-probe architecture, injecting a fixed frequency AC waveform across its outer electrodes within the cement block. Voltage across the internal electrodes is measured with a microcontroller and converted to a resistance value, communicated serially to an external computer. A final test showcases the ability of the device for three-dimensional mass deployment.
Language	English
Publishing date	2020-08-02
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2052857-7
ISSN	1424-8220 ; 1424-8220
ISSN (online)	1424-8220
ISSN	1424-8220
DOI	10.3390/s20154313
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Article ; Online: Association between molecular markers for beef tenderness and growth traits in Argentinian angus cattle.

Pintos, D / Corva, P M

Animal genetics

2011 Volume 42, Issue 3, Page(s) 329–332

Abstract: Molecular markers for beef tenderness are classic examples of the contribution of genome technology to animal breeding through marker-assisted selection (MAS). Markers on the μ-calpain (CAPN1) and calpastatin (CAST) genes have been extensively evaluated ... ...

Abstract	Molecular markers for beef tenderness are classic examples of the contribution of genome technology to animal breeding through marker-assisted selection (MAS). Markers on the μ-calpain (CAPN1) and calpastatin (CAST) genes have been extensively evaluated for their association with tenderness. However, little is known about their potential effect on other economically important traits. In this work, the association of molecular markers for beef tenderness with growth traits was evaluated in Angus cattle of Argentina. Expected progeny differences were extracted from the 2008 Angus Sire Summary of Argentina. Information corresponding to 268 influential bulls that had been genotyped for two markers in CAPN1 and two markers in CAST was provided by the Argentine Angus Association. Genotype probabilities were assigned, by segregation analysis, to those bulls in the Sire Summary that had no marker information. Expected progeny differences of 1365 sires were regressed on the number of alleles favouring tenderness at each locus. There was a significant effect of markers on expected progeny differences of birth weight, weaning weight (direct), weight at 18 months and rib eye area. In general, there was a negative effect of alleles favouring tenderness on growth traits. These correlated responses should be taken into account when molecular markers are used in selection schemes that aim to improve beef tenderness.
MeSH term(s)	Alleles ; Animals ; Biomarkers ; Body Composition/genetics ; Breeding ; Calcium-Binding Proteins/genetics ; Calpain/genetics ; Cattle/genetics ; Cattle/physiology ; Genetic Markers ; Genotype ; Meat
Chemical Substances	Biomarkers ; Calcium-Binding Proteins ; Genetic Markers ; calpastatin (79079-11-1) ; Calpain (EC 3.4.22.-) ; mu-calpain (EC 3.4.22.-)
Language	English
Publishing date	2011-06
Publishing country	England
Document type	Journal Article
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/j.1365-2052.2010.02160.x
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Article ; Online: Single Co 3 O 4 Nanocubes Electrocatalyzing the Oxygen Evolution Reaction

Zhibin Liu / Manuel Corva / Hatem M. A. Amin / Niclas Blanc / Julia Linnemann / Kristina Tschulik

International Journal of Molecular Sciences, Vol 22, Iss 13137, p

Nano-Impact Insights into Intrinsic Activity and Support Effects

2021 Volume 13137

Abstract: Single-entity electrochemistry allows for assessing electrocatalytic activities of individual material entities such as nanoparticles (NPs). Thus, it becomes possible to consider intrinsic electrochemical properties of nanocatalysts when researching how ... ...

Abstract	Single-entity electrochemistry allows for assessing electrocatalytic activities of individual material entities such as nanoparticles (NPs). Thus, it becomes possible to consider intrinsic electrochemical properties of nanocatalysts when researching how activity relates to physical and structural material properties. Conversely, conventional electrochemical techniques provide a normalized sum current referring to a huge ensemble of NPs constituting, along with additives (e.g., binders), a complete catalyst-coated electrode. Accordingly, recording electrocatalytic responses of single NPs avoids interferences of ensemble effects and reduces the complexity of electrocatalytic processes, thus enabling detailed description and modelling. Herein, we present insights into the oxygen evolution catalysis at individual cubic Co 3 O 4 NPs impacting microelectrodes of different support materials. Simulating diffusion at supported nanocubes, measured step current signals can be analyzed, providing edge lengths, corresponding size distributions, and interference-free turnover frequencies. The provided nano-impact investigation of (electro-)catalyst-support effects contradicts assumptions on a low number of highly active sites.
Keywords	single-entity electrochemistry ; Co 3 O 4 ; oxygen evolution reaction ; nanoparticle ; support effect ; Biology (General) ; QH301-705.5 ; Chemistry ; QD1-999
Language	English
Publishing date	2021-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Characterization of a deletion in the Hsp70 cluster in the bovine reference genome.

Suqueli García, M F / Castellote, M A / Feingold, S E / Corva, P M

Animal genetics

2017 Volume 48, Issue 4, Page(s) 377–385

Abstract: The 70 kilodalton heat shock proteins (Hsp70) are highly conserved molecular chaperones which have a crucial role in the stress response of the cell. In mammals, the Hsp70 proteins are encoded by a cluster of three genes: HSPA1A, HSPA1B and HSPA1L. In ... ...

Abstract	The 70 kilodalton heat shock proteins (Hsp70) are highly conserved molecular chaperones which have a crucial role in the stress response of the cell. In mammals, the Hsp70 proteins are encoded by a cluster of three genes: HSPA1A, HSPA1B and HSPA1L. In bovines, this cluster is located on chromosome 23 downstream of the major histocompatibility complex (BoLA). We detected inconsistencies in the location of markers on the Hsp70 genes reported in the literature that pointed to a potential deletion in the bovine reference genome UMD 3.1.1. An in silico analysis of the bovine genomic region of the Hsp70 cluster, using available information from public databases, confirmed the existence of a deletion of 11.1-kb spanning the HSPA1B gene and the intergenic region between HSPA1B and HSPA1A. Although we originally considered this an assembly error, it is most likely a particular condition of L1 Dominette 01449, the cow sequenced in the Bovine Genome Project. Moreover, we suggest a new classification of bovine Hsp70 sequences reported in NCBI and a reassignment of the location of SNPs from dbSNP that map to the deletion on BTA23. We also compared the location of selected transcription factor binding sites on the promoters of HSPA1A and HSPA1B. The results generated in the present work could be helpful to refine the reference genome of an important livestock species and also to understand the role and the regulation of the bovine Hsp70 genes.
MeSH term(s)	Animals ; Binding Sites ; Cattle/genetics ; DNA, Intergenic ; Genome ; HSP70 Heat-Shock Proteins/genetics ; Multigene Family ; Polymorphism, Single Nucleotide ; Promoter Regions, Genetic ; Sequence Analysis, DNA ; Sequence Deletion
Chemical Substances	DNA, Intergenic ; HSP70 Heat-Shock Proteins
Language	English
Publishing date	2017-08
Publishing country	England
Document type	Journal Article
ZDB-ID	632766-7
ISSN	1365-2052 ; 0268-9146 ; 0268-9154
ISSN (online)	1365-2052
ISSN	0268-9146 ; 0268-9154
DOI	10.1111/age.12561
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