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  1. Article ; Online: A fluorescent electrophile for CLIPS: self indicating TrkB binders.

    Thompson, Tye / Pewklang, Thitima / Piyanuch, Pornthip / Wanichacheva, Nantanit / Kamkaew, Anyanee / Burgess, Kevin

    Organic & biomolecular chemistry

    2024  Volume 22, Issue 3, Page(s) 506–512

    Abstract: Combination of cysteine-containing peptides with electrophiles provides efficient access ... ...

    Abstract Combination of cysteine-containing peptides with electrophiles provides efficient access to
    MeSH term(s) Humans ; Cysteine ; HEK293 Cells ; Cell Membrane
    Chemical Substances Cysteine (K848JZ4886)
    Language English
    Publishing date 2024-01-17
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 2097583-1
    ISSN 1477-0539 ; 1477-0520
    ISSN (online) 1477-0539
    ISSN 1477-0520
    DOI 10.1039/d3ob01654d
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Unraveling the photophysical characteristics and biological applications of vinyl sulfones as viscosity sensors.

    Khaikate, Onnicha / Pewklang, Thitima / Khrootkaew, Tunyawat / Chansaenpak, Kantapat / Muangsopa, Prapassara / Kuhakarn, Chutima / Kamkaew, Anyanee

    RSC advances

    2023  Volume 13, Issue 24, Page(s) 16671–16677

    Abstract: For the first time, a series of vinyl sulfone- ... ...

    Abstract For the first time, a series of vinyl sulfone-NH
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d3ra02354k
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Cationic styryl dyes for DNA labelling and selectivity toward cancer cells and Gram-negative bacteria.

    Wangngae, Sirilak / Ngivprom, Utumporn / Khrootkaew, Tunyawat / Worakaensai, Suphanida / Lai, Rung-Yi / Kamkaew, Anyanee

    RSC advances

    2023  Volume 13, Issue 3, Page(s) 2115–2122

    Abstract: Fluorescence-based methods are important tools for the analysis of nucleic ... ...

    Abstract Fluorescence-based methods are important tools for the analysis of nucleic acids
    Language English
    Publishing date 2023-01-11
    Publishing country England
    Document type Journal Article
    ISSN 2046-2069
    ISSN (online) 2046-2069
    DOI 10.1039/d2ra07601b
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Hybrid Cyanine/Methotrexate Nanoparticles for Synergistic PDT/Chemotherapy of Breast Cancer.

    Muangsopa, Prapassara / Chansaenpak, Kantapat / Kampaengsri, Sastiya / Saetiew, Jadsada / Noisa, Parinya / Meemon, Panomsak / Kamkaew, Anyanee

    ACS applied bio materials

    2023  Volume 6, Issue 2, Page(s) 603–614

    Abstract: Typically, nanomedicine was prepared using a nanocarrier to load cargo for specific purposes. In this work, a carrier-free nanosystem for imaging and photodynamic (PDT)/chemo combination therapy was developed using simple self-assembly of a dye and a ... ...

    Abstract Typically, nanomedicine was prepared using a nanocarrier to load cargo for specific purposes. In this work, a carrier-free nanosystem for imaging and photodynamic (PDT)/chemo combination therapy was developed using simple self-assembly of a dye and a chemotherapeutic agent. The resulting nanoparticles (
    MeSH term(s) Humans ; Animals ; Mice ; Female ; Breast Neoplasms/diagnostic imaging ; Breast Neoplasms/drug therapy ; Methotrexate ; Photochemotherapy/methods ; Combined Modality Therapy ; Nanoparticles/therapeutic use
    Chemical Substances Methotrexate (YL5FZ2Y5U1)
    Language English
    Publishing date 2023-01-09
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2576-6422
    ISSN (online) 2576-6422
    DOI 10.1021/acsabm.2c00893
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Revolutionary Pyrazole-based Aza-BODIPY: Harnessing Photothermal Power Against Cancer Cells and Bacteria.

    Pewklang, Thitima / Saiyasombat, Worakrit / Chueakwon, Piyasiri / Ouengwanarat, Bongkot / Chansaenpak, Kantapat / Kampaengsri, Sastiya / Lai, Rung-Yi / Kamkaew, Anyanee

    Chembiochem : a European journal of chemical biology

    2024  Volume 25, Issue 3, Page(s) e202300653

    Abstract: In the realm of cancer therapy and treatment of bacterial infection, photothermal therapy (PTT) stands out as a potential strategy. The challenge, however, is to create photothermal agents that can perform both imaging and PTT, a so-called theranostic ... ...

    Abstract In the realm of cancer therapy and treatment of bacterial infection, photothermal therapy (PTT) stands out as a potential strategy. The challenge, however, is to create photothermal agents that can perform both imaging and PTT, a so-called theranostic agent. Photothermal agents that absorb and emit in the near-infrared region (750-900 nm) have recently received a lot of attention due to the extensive penetration of NIR light in biological tissues. In this study, we combined pyrazole with aza-BODIPY (PY-AZB) to develop a novel photothermal agent. PY-AZB demonstrated great photostability with a photothermal conversion efficiency (PCE) of up to 33 %. Additionally, PY-AZB can permeate cancer cells at a fast accumulation rate in less than 6 hours, according to the confocal images. Furthermore, in vitro photothermal therapy results showed that PY-AZB effectively eliminated cancer cells by up to 70 %. Interestingly, PY-AZB exhibited antibacterial activities against both gram-negative bacteria, Escherichia coli 780, and gram-positive bacteria, Staphylococcus aureus 1466. The results exhibit a satisfactory bactericidal effect against bacteria, with a killing efficiency of up to 100 % upon laser irradiation. As a result, PY-AZB may provide a viable option for photothermal treatment.
    MeSH term(s) Phototherapy ; Photochemotherapy ; Boron Compounds/pharmacology ; Boron Compounds/therapeutic use ; Escherichia coli ; Bacteria ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Neoplasms/drug therapy
    Chemical Substances azaBDPBA compound ; Boron Compounds ; Anti-Bacterial Agents
    Language English
    Publishing date 2024-01-09
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2020469-3
    ISSN 1439-7633 ; 1439-4227
    ISSN (online) 1439-7633
    ISSN 1439-4227
    DOI 10.1002/cbic.202300653
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Enhancing Glucose Biosensing with Graphene Oxide and Ferrocene-Modified Linear Poly(ethylenimine).

    Monkrathok, Jirawan / Janphuang, Pattanaphong / Suphachiaraphan, Somphong / Kampaengsri, Sastiya / Kamkaew, Anyanee / Chansaenpak, Kantapat / Lisnund, Sireerat / Blay, Vincent / Pinyou, Piyanut

    Biosensors

    2024  Volume 14, Issue 4

    Abstract: We designed and optimized a glucose biosensor system based on a screen-printed electrode modified with the NAD-GDH enzyme. To enhance the electroactive surface area and improve the electron transfer efficiency, we introduced graphene oxide (GO) and ... ...

    Abstract We designed and optimized a glucose biosensor system based on a screen-printed electrode modified with the NAD-GDH enzyme. To enhance the electroactive surface area and improve the electron transfer efficiency, we introduced graphene oxide (GO) and ferrocene-modified linear poly(ethylenimine) (LPEI-Fc) onto the biosensor surface. This strategic modification exploits the electrostatic interaction between graphene oxide, which possesses a negative charge, and LPEI-Fc, which is positively charged. This interaction results in increased catalytic current during glucose oxidation and helps improve the overall glucose detection sensitivity by amperometry. We integrated the developed glucose sensor into a flow injection (FI) system. This integration facilitates a swift and reproducible detection of glucose, and it also mitigates the risk of contamination during the analyses. The incorporation of an FI system improves the efficiency of the biosensor, ensuring precise and reliable results in a short time. The proposed sensor was operated at a constant applied potential of 0.35 V. After optimizing the system, a linear calibration curve was obtained for the concentration range of 1.0-40 mM (R
    MeSH term(s) Graphite/chemistry ; Biosensing Techniques ; Metallocenes/chemistry ; Ferrous Compounds/chemistry ; Polyethyleneimine/chemistry ; Glucose/analysis ; Electrodes ; Oxidation-Reduction
    Chemical Substances Graphite (7782-42-5) ; Metallocenes ; Ferrous Compounds ; ferrocene (U96PKG90JQ) ; Polyethyleneimine (9002-98-6) ; Glucose (IY9XDZ35W2) ; graphene oxide
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios14040161
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Aza-BODIPY based carbonic anhydrase IX: Strategy to overcome hypoxia limitation in photodynamic therapy.

    Pewklang, Thitima / Chansaenpak, Kantapat / Bakar, Siti Nursyahirah / Lai, Rung-Yi / Kue, Chin Siang / Kamkaew, Anyanee

    Frontiers in chemistry

    2022  Volume 10, Page(s) 1015883

    Abstract: Hypoxia caused by photodynamic therapy (PDT) is a major hurdle to cancer treatment since it can promote recurrence and progression by activating angiogenic factors, lowering therapeutic efficacy dramatically. In this work, AZB-I- ... ...

    Abstract Hypoxia caused by photodynamic therapy (PDT) is a major hurdle to cancer treatment since it can promote recurrence and progression by activating angiogenic factors, lowering therapeutic efficacy dramatically. In this work, AZB-I-CAIX
    Language English
    Publishing date 2022-11-02
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2022.1015883
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Controlling the Photocatalytic Activity and Benzylamine Photooxidation Selectivity of Bi

    Waehayee, Anurak / Duangkamol, Chuthamat / Chotsawat, Maneerat / Lerdwiriyanupap, Tharit / Pewklang, Thitima / Nakajima, Hideki / Butburee, Teera / Kamkaew, Anyanee / Suthirakun, Suwit / Siritanon, Theeranun

    Inorganic chemistry

    2023  Volume 62, Issue 8, Page(s) 3506–3517

    Abstract: Doping or ion substitution is often used as an effective strategy to improve photocatalytic activities of several semiconductors. Most frequently, the dopants provide extra states to increase light absorption, alter the electronic structure, or lower the ...

    Abstract Doping or ion substitution is often used as an effective strategy to improve photocatalytic activities of several semiconductors. Most frequently, the dopants provide extra states to increase light absorption, alter the electronic structure, or lower the carrier recombination. This work focuses on ion substitution in Bi
    Language English
    Publishing date 2023-02-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1484438-2
    ISSN 1520-510X ; 0020-1669
    ISSN (online) 1520-510X
    ISSN 0020-1669
    DOI 10.1021/acs.inorgchem.2c03860
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Quinoline-Malononitrile-Based Aggregation-Induced Emission Probe for Monoamine Oxidase Detection in Living Cells.

    Duangkamol, Chuthamat / Wangngae, Sirilak / Wet-Osot, Sirawit / Khaikate, Onnicha / Chansaenpak, Kantapat / Lai, Rung-Yi / Kamkaew, Anyanee

    Molecules (Basel, Switzerland)

    2023  Volume 28, Issue 6

    Abstract: A quinoline-malononitrile (QM)-based aggregation-induced emission probe was developed to detect MAOs in cells through an enzymatic reaction followed by β-elimination. After being incubated at 37 °C, ...

    Abstract A quinoline-malononitrile (QM)-based aggregation-induced emission probe was developed to detect MAOs in cells through an enzymatic reaction followed by β-elimination. After being incubated at 37 °C,
    MeSH term(s) Humans ; Neuroblastoma ; Monoamine Oxidase/metabolism ; Monoamine Oxidase Inhibitors/pharmacology ; Quinolines
    Chemical Substances dicyanmethane (EBL1KKS93J) ; Monoamine Oxidase (EC 1.4.3.4) ; Monoamine Oxidase Inhibitors ; Quinolines
    Language English
    Publishing date 2023-03-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules28062655
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: BODIPY-Based Fluorescent Probes for Selective Visualization of Endogenous Hypochlorous Acid in Living Cells via Triazolopyridine Formation.

    Hiranmartsuwan, Peraya / Wangngae, Sirilak / Nootem, Jukkrit / Kamkaew, Anyanee / Daengngern, Rathawat / Wattanathana, Worawat / Chansaenpak, Kantapat

    Biosensors

    2022  Volume 12, Issue 11

    Abstract: In this work, the two pyridylhydrazone-tethered BODIPY compounds ( ...

    Abstract In this work, the two pyridylhydrazone-tethered BODIPY compounds (
    MeSH term(s) Mice ; Animals ; Hypochlorous Acid/analysis ; Hypochlorous Acid/chemistry ; Fluorescent Dyes/chemistry ; Boron Compounds/chemistry ; Fluorescence
    Chemical Substances Hypochlorous Acid (712K4CDC10) ; 4,4-difluoro-4-bora-3a,4a-diaza-s-indacene ; Fluorescent Dyes ; Boron Compounds
    Language English
    Publishing date 2022-10-25
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662125-3
    ISSN 2079-6374 ; 2079-6374
    ISSN (online) 2079-6374
    ISSN 2079-6374
    DOI 10.3390/bios12110923
    Database MEDical Literature Analysis and Retrieval System OnLINE

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