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Article ; Online: Are N-heterocyclic carbenes "better" ligands than phosphines in main group chemistry? A theoretical case study of ligand-stabilized E2 molecules, L-E-E-L (L = NHC, phosphine; E = C, Si, Ge, Sn, Pb, N, P, As, Sb, Bi).

Wilson, David J D / Couchman, Shannon A / Dutton, Jason L

2012 Volume 51, Issue 14, Page(s) 7657–7668

Abstract: ... group 15 element; L = N-heterocyclic carbene, phosphine), for which Si, Ge, P, and As-NHC complexes have ... A theoretical examination of the L-E-E-L class of molecules has been carried out (E = group 14 ... the elusive E(2) molecule via formation of L-E-E-L beyond the few known examples, and if the ligand set ...

Abstract	A theoretical examination of the L-E-E-L class of molecules has been carried out (E = group 14, group 15 element; L = N-heterocyclic carbene, phosphine), for which Si, Ge, P, and As-NHC complexes have recently been synthesized. The focus of this study is to predict whether it is possible to stabilize the elusive E(2) molecule via formation of L-E-E-L beyond the few known examples, and if the ligand set for this class of compounds can be extended from the NHC to the phosphine class of ligands. It is predicted that thermodynamically stable L-E-E-L complexes are possible for all group 14 and 15 elements, with the exception of nitrogen. The unknown ligand-stabilized Sn(2) and Pb(2) complexes may be considered attractive synthetic targets. In all cases the NHC complexes are more stable than the phosphines, however several of the phosphine derivatives may be isolable. The root of the extra stability conferred by the NHC ligands over the phosphines is determined to be a combination of the NHCs greater donating ability, and for the group 15 complexes, superior π acceptor capability from the E-E core. This later factor is the opposite as to what is normally observed in transition metal chemistry when comparing NHC and phosphine ligands, and may be an important consideration in the ongoing "renaissance" of low-valent main group compounds supported by ligands.
Language	English
Publishing date	2012-07-16
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/ic300686n
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Article: A focus on coordination chemistry at chlorine.

Dutton, Jason L

Chemical science

2023 Volume 14, Issue 15, Page(s) 3961–3962

Abstract: The first crystallographic characterization of chloronium cations stabilized by pyridine ligands (P ...

Abstract	The first crystallographic characterization of chloronium cations stabilized by pyridine ligands (P. Pröhm, W. Berg, S. M. Rupf, C. Müller and S. Riedel,
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	2559110-1
ISSN	2041-6539 ; 2041-6520
ISSN (online)	2041-6539
ISSN	2041-6520
DOI	10.1039/d3sc90047a
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Article ; Online: Formation of Strong Boron Lewis Acid Sites on Silica.

Samudrala, Kavyasripriya K / Akram, Manjur O / Dutton, Jason L / Martin, Caleb D / Conley, Matthew P

Inorganic chemistry

2024 Volume 63, Issue 11, Page(s) 4939–4946

Abstract: Bis(1-methyl- ...

Abstract	Bis(1-methyl-
Language	English
Publishing date	2024-03-07
Publishing country	United States
Document type	Journal Article
ZDB-ID	1484438-2
ISSN	1520-510X ; 0020-1669
ISSN (online)	1520-510X
ISSN	0020-1669
DOI	10.1021/acs.inorgchem.3c04121
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Article: The l(3)S12 locus of Drosophila melanogaster: heterochromatic position effects and stage-specific misexpression of the gene in P element transposons.

Dutton, F L / Chovnick, A

Genetics

1991 Volume 128, Issue 1, Page(s) 103–118

Abstract: ... not only of the l(3)S12 message, but also of a P element-l(3)S12 fusion transcript. Certain ... l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and ... oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional ...

Abstract	l(3)S12 is a vital locus whose function is required in embryos, early larvae, late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional misexpression of the gene associated with this mutation as well as with several euchromatic insertions of l(3)S12+ transposons. Surviving cold-sensitive mutants as well as underexpression variants generated by P element transformation display a phenotypic syndrome that can include delayed development, abnormal bristle morphology, and female sterility. Using these phenotypes, defects in putative "early" and "late" l(3)S12 expression can be identified. The sensitivity of certain l(3)S12+ insertions to site-specific euchromatic position effect appears to be due to separation of the gene from an endogenous enhancer element during cloning. This enhancerless construct can be used to identify and perhaps to select "permissive" euchromatic sites, presumably adjacent to enhancer elements, which in some cases permit elevated production not only of the l(3)S12 message, but also of a P element-l(3)S12 fusion transcript. Certain of these permissive sites appear to control stage-specific expression, and we propose that this system may be used to identify, clone, and characterize such loci. Heterochromatic position effect on this locus has been demonstrated. Available evidence suggests that the l(3)S12 gene may be involved in protein synthesis, perhaps encoding a ribosomal protein.
MeSH term(s)	Alleles ; Amino Acid Sequence ; Animals ; Animals, Genetically Modified ; Base Sequence ; Blotting, Northern ; Crosses, Genetic ; DNA ; DNA Transposable Elements/genetics ; Drosophila melanogaster/genetics ; Drosophila melanogaster/growth & development ; Female ; Gene Expression Regulation ; Genes, Lethal ; Genetic Complementation Test ; Male ; Molecular Sequence Data ; Mutation ; Phenotype ; Reproduction/genetics ; Restriction Mapping ; Temperature ; Transcription, Genetic ; Transformation, Genetic
Chemical Substances	DNA Transposable Elements ; DNA (9007-49-2)
Language	English
Publishing date	1991-05
Publishing country	United States
Document type	Journal Article ; Research Support, U.S. Gov't, P.H.S.
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
DOI	10.1093/genetics/128.1.103
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Article ; Online: Contemporary anesthesia practice for cataract surgery: analysis of the National Anesthesia Clinical Outcomes Registry.

Phero, Anthony / Dutton, Richard P / Chen, Catherine L / Whitlock, Elizabeth L

Journal of cataract and refractive surgery

2022 Volume 48, Issue 12, Page(s) 1472–1474

MeSH term(s)	Humans ; Cataract Extraction ; Anesthesia ; Lens, Crystalline ; Cataract ; Registries
Language	English
Publishing date	2022-11-28
Publishing country	United States
Document type	Letter ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural
ZDB-ID	632744-8
ISSN	1873-4502 ; 0886-3350
ISSN (online)	1873-4502
ISSN	0886-3350
DOI	10.1097/j.jcrs.0000000000001065
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Article: The l(3) S12 locus of Drosophila melanogaster, Heterochromatic position effects and stage-specific misexpression of the gene in P element transposons

Dutton, F.L. Jr / Chovnick, A

Genetics. May 1991. v. 128 (1)

1991

Abstract: ... not only of the l(3)S12 message, but also of a P element-l(3)S12 fusion transcript. Certain ... l(3)S12 is a vital locus whose function is required in embryos, early larvae late pupae and ... oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional ...

Abstract	l(3)S12 is a vital locus whose function is required in embryos, early larvae late pupae and oogenesis. We have identified a cold-sensitive allele, l(3)S12(3), and characterized conditional misexpression of the gene associated with this mutation as well as with several euchromatic insertions of l(3)S12+ transposons. Surviving cold-sensitive mutants as well as underexpression variants generated by P element transformation display a phenotypic syndrome that can include delayed development, abnormal bristle morphology, and female sterility. Using these phenotypes, defects in putative "early" and "late" l(3)S12 expression can be identified. The sensitivity of certain l(3)S12+ insertions to site-specific euchromatic position effect appears to be due to separation of the gene from an endogenous element during cloning. This enhancerless construct can be used to identify and perhaps to select "permissive" euchromatic sites, presumably adjacent to enhancer elements, which in some cases permit elevated production not only of the l(3)S12 message, but also of a P element-l(3)S12 fusion transcript. Certain of these permissive sites appear to control stage-specific expression, and we propose that this system may be used to identify, clone, and characterize such loci. Heterochromatic position effect on this locus has been demonstrated. Available evidence suggests that the l(3)S12 gene may be involved in protein synthesis, perhaps encoding a ribosomal protein.
Keywords	Drosophila melanogaster ; loci ; alleles ; gene expression ; transposons ; messenger RNA ; restriction mapping ; chromosome mapping ; nucleotide sequences ; genetic transformation ; mutants ; developmental stages ; embryogenesis ; cytogenetics ; viability ; heterochromatin ; female fertility ; cold ; mutation ; transcription (genetics) ; genetic complementation
Language	English
Dates of publication	1991-05
Size	p. 103-118.
Document type	Article
ZDB-ID	2167-2
ISSN	1943-2631 ; 0016-6731
ISSN (online)	1943-2631
ISSN	0016-6731
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The effect of particle size on oral bioavailability and bioaccessibility of soil Ni from different sources.

Vasiluk, Luba / Sowa, Jessica / Sanborn, Paul / Dutton, Michael D / Hale, Beverley

Environmental pollution (Barking, Essex : 1987)

2023 Volume 339, Page(s) 122761

Abstract: The goal of the work was to contribute to a unified approach to assessing the risk to human health of soil ingestion, for contaminated sites with elevated [Ni]. Robust relationships between in vitro bioaccessibility and in vivo bioavailability of Ni in ... ...

Abstract	The goal of the work was to contribute to a unified approach to assessing the risk to human health of soil ingestion, for contaminated sites with elevated [Ni]. Robust relationships between in vitro bioaccessibility and in vivo bioavailability of Ni in various soils, with mechanistic understanding, would enable site-specific assessments of human exposure through soil ingestion. Four soils (three ultramafic Brunisols with geogenic Ni and one Organic soil with anthropogenic Ni) were sieved into PS < 10 μm, 10-41 μm, 41-70 μm, 70-105 μm, 105-150 μm, and 150-250 μm, the [Ni]
MeSH term(s)	Rats ; Animals ; Humans ; Rats, Sprague-Dawley ; Biological Availability ; Soil/chemistry ; Particle Size ; Soil Pollutants/analysis
Chemical Substances	Soil ; Soil Pollutants
Language	English
Publishing date	2023-10-14
Publishing country	England
Document type	Journal Article
ZDB-ID	280652-6
ISSN	1873-6424 ; 0013-9327 ; 0269-7491
ISSN (online)	1873-6424
ISSN	0013-9327 ; 0269-7491
DOI	10.1016/j.envpol.2023.122761
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Zs.A 2599: Show issues

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Article: Incidence of intraoperative hypotension during non-cardiac surgery in community anesthesia practice: a retrospective observational analysis.

Saasouh, Wael / Christensen, Anna L / Xing, Fei / Chappell, Desirée / Lumbley, Josh / Woods, Brian / Mythen, Monty / Dutton, Richard P

Perioperative medicine (London, England)

2023 Volume 12, Issue 1, Page(s) 29

Abstract: Background: Intraoperative hypotension (IOH) is well-described in the academic setting but not in community practice. IOH is associated with risk of postoperative morbidity and mortality. This is the first report of IOH in the community setting using ... ...

Abstract	Background: Intraoperative hypotension (IOH) is well-described in the academic setting but not in community practice. IOH is associated with risk of postoperative morbidity and mortality. This is the first report of IOH in the community setting using the IOH measure definition from the Centers for Medicare and Medicaid Services Merit-based Incentive Payment System program. Objectives: To describe the incidence of IOH in the community setting; assess variation in IOH by patient-, procedure-, and facility-level characteristics; and describe variation in risk-adjusted IOH across clinicians. Methods: Design Cross-sectional descriptive analysis of retrospective data from anesthesia records in 2020 and 2021. Setting Forty-five facilities affiliated with two large anesthesia providers in the USA. Participants Patients aged 18 years or older having non-emergent, non-cardiac surgery under general, neuraxial, or regional anesthesia. Cases were excluded based on criteria for the IOH measure: baseline mean arterial pressure (MAP) below 65 mmHg prior to anesthesia induction; American Society of Anesthesiologists (ASA) physical status classification of I, V, or VI; monitored anesthesia care only; deliberate induced hypotension; obstetric non-operative procedures; liver or lung transplant; cataract surgery; non-invasive gastrointestinal cases. Main outcomes IOH, using four definitions. Primary definition: binary assessment of whether the case had MAP < 65 mmHg for 15 min or more. Secondary definitions: total number of minutes of MAP < 65 mmHg, total area under MAP of 65 mmHg, time-weighted average MAP < 65 mmHg. Results: Among 127,095 non-emergent, non-cardiac cases in community anesthesia settings, 29% had MAP < 65 mmHg for at least 15 min cumulatively, with an overall mean of 12.4 min < 65 mmHg. IOH was slightly more common in patients who were younger, female, and ASA II (versus III or IV); in procedures that were longer and had higher anesthesia base units; and in ambulatory surgery centers. Incidence of IOH varied widely across individual clinicians in both unadjusted and risk-adjusted analyses. Conclusion: Intraoperative hypotension is common in community anesthesia practice, including among patients and settings typically considered "low risk." Variation in incidence across clinicians remains after risk-adjustment, suggesting that IOH is a modifiable risk worth pursuing in quality improvement initiatives.
Language	English
Publishing date	2023-06-24
Publishing country	England
Document type	Journal Article
ZDB-ID	2683800-X
ISSN	2047-0525
ISSN	2047-0525
DOI	10.1186/s13741-023-00318-y
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Article ; Online: Intraoperative hypotension in ambulatory surgery centers.

Saasouh, Wael / Christensen, Anna L / Chappell, Desirée / Lumbley, Josh / Woods, Brian / Xing, Fei / Mythen, Monty / Dutton, Richard P

Journal of clinical anesthesia

2023 Volume 90, Page(s) 111181

Abstract: Study objectives: To measure the incidence of intraoperative hypotension (IOH) during surgery in ambulatory surgery centers (ASCs) and describe associated characteristics of patients and procedures.: Design: Retrospective analysis.: Setting: 20 ... ...

Abstract	Study objectives: To measure the incidence of intraoperative hypotension (IOH) during surgery in ambulatory surgery centers (ASCs) and describe associated characteristics of patients and procedures. Design: Retrospective analysis. Setting: 20 ASCs. Patients: 16,750 patients having non-emergent, non-cardiac surgery; ASA physical status 2 through 4. Interventions: None. Measurements: We assessed incidence of IOH using the definition from the Centers for Medicare & Medicaid Services (CMS) Merit-based Incentive Payment System (MIPS)-mean arterial pressure (MAP) < 65 mmHg for at least 15 cumulative minutes-and three secondary definitions: minutes of MAP <65 mmHg, area under MAP of 65 mmHg, and time-weighted average MAP <65 mmHg. Main results: 30.9% of ASC cases had a MAP <65 mmHg for at least 15 min. The incidence of IOH varied significantly, and was higher among younger adults (age 18-39; 36.2%), females (35.2%), and patients with ASA physical status 2 (32.8%). IOH increased with increasing surgery length, even when time-weighted, and was higher among low complexity (30.6%) than moderate complexity (28.8%) procedures, and highest among high complexity procedures (44.1%). Conclusions: There was substantial occurrence of IOH in ASCs, similar to that described in academic hospital settings in previous literature. We hypothesize that this may reflect clinician preference not to intervene in perceived healthy patients or assumptions about ability to tolerate lower blood pressures on behalf of these patients. Future research will determine whether IOH in ACSs is associated with adverse outcomes to the same extent as described in more complex hospital-based surgeries.
MeSH term(s)	Adult ; Female ; Humans ; Aged ; United States ; Adolescent ; Young Adult ; Retrospective Studies ; Cohort Studies ; Ambulatory Surgical Procedures/adverse effects ; Intraoperative Complications/epidemiology ; Intraoperative Complications/etiology ; Medicare ; Hypotension/etiology ; Hypotension/complications
Language	English
Publishing date	2023-07-14
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1011618-7
ISSN	1873-4529 ; 0952-8180
ISSN (online)	1873-4529
ISSN	0952-8180
DOI	10.1016/j.jclinane.2023.111181
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Article: Origins of juvenile green sea turtles (

Kynoch, Camille / Fuentes, Mariana M P B / Dutton, Peter H / LaCasella, Erin L / Silver-Gorges, Ian

Ecology and evolution

2022 Volume 12, Issue 11, Page(s) e9548

Abstract: Conservation of green sea turtles ( ...

Abstract	Conservation of green sea turtles (
Language	English
Publishing date	2022-11-27
Publishing country	England
Document type	Journal Article
ZDB-ID	2635675-2
ISSN	2045-7758
ISSN	2045-7758
DOI	10.1002/ece3.9548
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