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  1. Article ; Online: December 2019.

    Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2019  Volume 35, Issue 52, Page(s) 16969

    Language English
    Publishing date 2019-12-27
    Publishing country United States
    Document type Editorial
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.9b03841
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Editorial.

    Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2018  Volume 34, Issue 1, Page(s) 1–2

    Language English
    Publishing date 2018--09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.7b04375
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Analysis of Silicon Quantum Dots and Serum Proteins Interactions Using Asymmetrical Flow Field-Flow Fractionation.

    Nagarajan, Usharani / Chandra, Sourov / Yamazaki, Tomohiko / Shirahata, Naoto / Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2023  Volume 39, Issue 22, Page(s) 7557–7565

    Abstract: Semiconductor nanocrystals or quantum dots (QDs) have gained significant attention in biomedical research as versatile probes for imaging, sensing, and therapies. However, the interactions between proteins and QDs, which are crucial for their use in ... ...

    Abstract Semiconductor nanocrystals or quantum dots (QDs) have gained significant attention in biomedical research as versatile probes for imaging, sensing, and therapies. However, the interactions between proteins and QDs, which are crucial for their use in biological applications, are not yet fully understood. Asymmetric flow field-flow fractionation (AF4) is a promising method for analyzing the interactions of proteins with QDs. This technique uses a combination of hydrodynamic and centrifugal forces to separate and fractionate particles based on their size and shape. By coupling AF4 with other techniques, such as fluorescence spectroscopy and multi-angle light scattering, it is possible to determine the binding affinity and stoichiometry of protein-QD interactions. Herein, this approach has been utilized to determine the interaction between fetal bovine serum (FBS) and silicon quantum dots (SiQDs). Unlike metal-containing conventional QDs, SiQDs are highly biocompatible and photostable in nature, making them attractive for a wide range of biomedical applications. In this study, AF4 has provided crucial information on the size and shape of the FBS/SiQD complexes, their elution profile, and their interaction with serum components in real time. The differential scanning microcalorimetric technique has also been employed to monitor the thermodynamic behavior of proteins in the presence of SiQDs. We have investigated their binding mechanisms by incubating them at temperatures below and above the protein denaturation. This study yields various significant characteristics such as their hydrodynamic radius, size distribution, and conformational behavior. The compositions of SiQD and FBS influence the size distribution of their bioconjugates; the size increases by intensifying the concentration of FBS, with their hydrodynamic radii ranging between 150 and 300 nm. The results signify that in the alliance of SiQDs to the system, there is an augmentation of the denaturation point of the proteins and hence their thermal stability, providing a more comprehensive understanding of the interactions between FBS and QDs.
    MeSH term(s) Quantum Dots/chemistry ; Silicon ; Serum Albumin, Bovine/chemistry ; Fractionation, Field Flow/methods ; Temperature
    Chemical Substances Silicon (Z4152N8IUI) ; Serum Albumin, Bovine (27432CM55Q)
    Language English
    Publishing date 2023-05-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.3c00109
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Comparative Thermodynamic Studies of the Micellization of Amphiphilic Block Copolymers before and after Cyclization.

    Yamamoto, Takuya / Masuda, Yuki / Tezuka, Yasuyuki / Korchagina, Evgeniya / Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2022  Volume 38, Issue 17, Page(s) 5033–5039

    Abstract: The enthalpy and entropy of micellization in water, ... ...

    Abstract The enthalpy and entropy of micellization in water, Δ
    Language English
    Publishing date 2022-01-04
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c03358
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Editorial.

    Winnik, Françoise M / Crooks, Richard M

    Langmuir : the ACS journal of surfaces and colloids

    2017  Volume 33, Issue 1, Page(s) 1

    Language English
    Publishing date 2017--10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.6b04616
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Phototropic Multiresponsive Active Nanogels.

    Otsuka, Issei / Zhang, Xuewei / Winnik, Françoise M

    Macromolecular rapid communications

    2019  Volume 40, Issue 24, Page(s) e1900479

    Abstract: Aqueous dispersions of nanogels that respond to switches in environmental pH and/or temperature by changes in their hydrodynamic radius ( ... ...

    Abstract Aqueous dispersions of nanogels that respond to switches in environmental pH and/or temperature by changes in their hydrodynamic radius (R
    MeSH term(s) Acrylamides/chemical synthesis ; Acrylamides/chemistry ; Hydrodynamics ; Hydrogen-Ion Concentration ; Molecular Structure ; Nanogels/chemistry ; Particle Size ; Photochemical Processes ; Polymerization ; Surface Properties ; Temperature ; Ultraviolet Rays
    Chemical Substances Acrylamides ; Nanogels ; N-isopropylacrylamide (B7GFF17L9U)
    Language English
    Publishing date 2019-11-10
    Publishing country Germany
    Document type Journal Article
    ZDB-ID 1475027-2
    ISSN 1521-3927 ; 1022-1336
    ISSN (online) 1521-3927
    ISSN 1022-1336
    DOI 10.1002/marc.201900479
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Our Vision for a Bright Future.

    Winnik, Françoise M / Crooks, Richard M

    Langmuir : the ACS journal of surfaces and colloids

    2016  Volume 32, Issue 1, Page(s) 1

    Language English
    Publishing date 2016-01-12
    Publishing country United States
    Document type Editorial
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.5b04453
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article ; Online: Preface to the Nanobubbles Special Issue.

    Zhang, Xi / Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2016  Volume 32, Issue 43, Page(s) 11071

    Language English
    Publishing date 2016--01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.6b03429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article: Comparative Thermodynamic Studies of the Micellization of Amphiphilic Block Copolymers before and after Cyclization

    Yamamoto, Takuya / Masuda, Yuki / Tezuka, Yasuyuki / Korchagina, Evgeniya / Winnik, Françoise M.

    Langmuir. 2022 Jan. 04, v. 38, no. 17

    2022  

    Abstract: The enthalpy and entropy of micellization in water, ΔHₘᵢc and ΔSₘᵢc, respectively, of three linear amphiphilic BAB block copolymers consisting of either poly(methyl acrylate) (Mₙ ∼ 1200 and 700 Da) or poly(ethyl acrylate) (Mₙ ∼ 800 Da) as hydrophobic (B) ...

    Abstract The enthalpy and entropy of micellization in water, ΔHₘᵢc and ΔSₘᵢc, respectively, of three linear amphiphilic BAB block copolymers consisting of either poly(methyl acrylate) (Mₙ ∼ 1200 and 700 Da) or poly(ethyl acrylate) (Mₙ ∼ 800 Da) as hydrophobic (B) segments and poly(ethylene oxide) (PEO) as the hydrophilic (A, Mₙ ∼ 3000 Da) segment were determined by isothermal titration calorimetry (ITC). The ΔHₘᵢc and ΔSₘᵢc of the cyclic AB block copolymers obtained by cyclization of the linear triblock copolymers were determined under the same conditions. The ΔHₘᵢc value of the cyclic copolymers was smaller than that of their linear precursors. The ΔSₘᵢc value showed the same trend, but the relative difference between the cyclized and linear copolymers was less pronounced. The hydrodynamic diameter (Dₕ), critical micelle concentration (CMC), molecular weight (Mw₋ₘᵢc), and second virial coefficient (A₂) of the micelles were determined. The Dₕ value of the cyclic copolymer micelles was smaller than the linear counterpart. On the other hand, the CMC value became larger, whereas the A₂ value was comparable or increased by cyclization. Overall, the results suggest that, in the unimer state, the hydrophobic segments of the cyclized copolymers form a tightly coiled structure to minimize contact with water, resulting in the smaller ΔHₘᵢc value. Contrary to the linear copolymer micelles, the cyclic copolymer micelles have no “dangling chains”, which may explain the topology-driven slight difference in the ΔSₘᵢc value.
    Keywords calorimetry ; composite polymers ; enthalpy ; entropy ; hydrodynamics ; hydrophilicity ; hydrophobicity ; micelles ; molecular weight ; titration
    Language English
    Dates of publication 2022-0104
    Size p. 5033-5039.
    Publishing place American Chemical Society
    Document type Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.0c03358
    Database NAL-Catalogue (AGRICOLA)

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  10. Article ; Online: Heat-Induced Flower Nanogels of Both Cholesterol End-Capped Poly(

    Morimoto, Nobuyuki / Segui, Florence / Qiu, Xing-Ping / Akiyoshi, Kazunari / Winnik, Françoise M

    Langmuir : the ACS journal of surfaces and colloids

    2021  Volume 38, Issue 17, Page(s) 5218–5225

    Abstract: Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly( ...

    Abstract Thermoresponsive self-assembled nanogels were conveniently prepared by cholesterol end-capped poly(
    MeSH term(s) Acrylic Resins ; Cholesterol/chemistry ; Hot Temperature ; Nanogels ; Polymers/chemistry ; Temperature ; Water
    Chemical Substances Acrylic Resins ; Nanogels ; Polymers ; Water (059QF0KO0R) ; poly-N-isopropylacrylamide (25189-55-3) ; Cholesterol (97C5T2UQ7J)
    Language English
    Publishing date 2021-11-03
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2005937-1
    ISSN 1520-5827 ; 0743-7463
    ISSN (online) 1520-5827
    ISSN 0743-7463
    DOI 10.1021/acs.langmuir.1c02394
    Database MEDical Literature Analysis and Retrieval System OnLINE

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