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Article ; Online: Macroanévrisme artériel rétinien en OCT-angiographie.

Tibi, K / Riou, B / Barreau, E / Labétoulle, M / Rousseau, A

2022 Volume 45, Issue 2, Page(s) 251–252

Title translation	Retinal arterial macroaneurysm on OCT angiography.
MeSH term(s)	Fluorescein Angiography ; Humans ; Retinal Arterial Macroaneurysm ; Retinal Artery/diagnostic imaging ; Retinal Diseases ; Retinal Hemorrhage ; Tomography, Optical Coherence
Language	French
Publishing date	2022-01-06
Publishing country	France
Document type	Journal Article
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2021.08.028
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Article ; Online: Performance and Safety of a Sodium Hyaluronate Tear Substitute with Polyethylene Glycol in Dry Eye Disease: A Multicenter, Investigator-Masked, Randomized, Noninferiority Trial.

Labetoulle, Marc / Mortemousque, Bruno

Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics

2022 Volume 38, Issue 9, Page(s) 607–616

Abstract: ... ...

Abstract	Purpose
MeSH term(s)	Humans ; Hyaluronic Acid/adverse effects ; Dry Eye Syndromes/drug therapy ; Tears ; Polyethylene Glycols/adverse effects ; Ophthalmic Solutions/adverse effects
Chemical Substances	Hyaluronic Acid (9004-61-9) ; polyethylene glycol 8000 (Q662QK8M3B) ; Polyethylene Glycols (3WJQ0SDW1A) ; Ophthalmic Solutions
Language	English
Publishing date	2022-10-21
Publishing country	United States
Document type	Randomized Controlled Trial ; Multicenter Study ; Journal Article
ZDB-ID	1237021-6
ISSN	1557-7732 ; 1080-7683
ISSN (online)	1557-7732
ISSN	1080-7683
DOI	10.1089/jop.2022.0048
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Article ; Online: Le JFO tourne la page : le passage au tout numérique.

Desjardins, L / Labetoulle, M / Weise, F / Baudouin, C

Journal francais d'ophtalmologie

2023 Volume 46, Issue 10, Page(s) 1140–1141

Title translation	JFO turns the page: The switch to all-digital technology.
Language	French
Publishing date	2023-12-01
Publishing country	France
Document type	Editorial
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2023.11.003
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Article ; Online: COVID-19 pandemic and impact of universal face mask wear on ocular surface health and risk of infection.

Navel, V / Labetoulle, M / Lazreg, S / Brémond-Gignac, D / Chiambaretta, F

Journal francais d'ophtalmologie

2024 Volume 47, Issue 6, Page(s) 104170

Abstract: Universal mask wear is an effective public health intervention to reduce SARS-Cov-2 transmission, especially in enclosed public spaces and healthcare environments. Concerns have been raised about possible transmission of the SARS-Cov-2 through ocular ... ...

Abstract	Universal mask wear is an effective public health intervention to reduce SARS-Cov-2 transmission, especially in enclosed public spaces and healthcare environments. Concerns have been raised about possible transmission of the SARS-Cov-2 through ocular secretions, leading to enhanced protective measures during ophthalmic procedures. However, there is some evidence for air jets from the upper edge of the surgical mask to the ocular surface, especially when the mask is not well fit. Prolonged airflow towards the ocular surface during expiration may alter tear-film stability, leading to hyperosmolarity and ocular surface inflammation. This also raises the question of whether the ocular surface is contaminated with oral flora from airflow directed toward the eyes, thus increasing the risk of ocular infection. Herein we review the impact of patient face mask wear on the ocular surface, eyelids and risk of ocular infection, particularly during ocular surgery. There is some evidence for increased incidence of dry eye or eyelid disease during periods of mandatory face mask wear. While high daily exposure is consistent with a direct association, this should be mitigated by various cofounding factors which could also affect the ocular health during the COVID-19 pandemic. An increased risk of post-intravitreal injection endophthalmitis, possibly due to face mask wear by the patient, including culture-positive endophthalmitis, has been reported in one retrospective study. Several measures have been shown to prevent or limit the risk of developing dry eye disease or exacerbation, eyelid cyst, and ocular infection during intravitreal injections.
Language	English
Publishing date	2024-04-02
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2024.104170
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Article ; Online: IS CATARACT SURGERY SAFE IN PATIENTS WITH STELLATE NONHEREDITARY IDIOPATHIC FOVEOMACULAR RETINOSCHISIS?

Aziria, Ahmed / Rousseau, Antoine / Barreau, Emmanuel / Labetoulle, Marc

Retinal cases & brief reports

2022 Volume 17, Issue 6, Page(s) 719–722

Abstract: Purpose: To assess the retinal modifications after cataract surgery in a patient presenting with stellate nonhereditary idiopathic foveomacular retinoschisis.: Methods: Retrospective analysis of the evolution of retinal status in a 64-year-old ... ...

Abstract	Purpose: To assess the retinal modifications after cataract surgery in a patient presenting with stellate nonhereditary idiopathic foveomacular retinoschisis. Methods: Retrospective analysis of the evolution of retinal status in a 64-year-old patient with unilateral stellate nonhereditary idiopathic foveomacular retinoschisis who underwent cataract surgery in the affected eye. Results: Visual acuity improved after surgery, reaching back the level described by the patient before the cataract onset, whereas fundus retinographies and optical coherence tomographies were stable at one month after surgery, compared with the preoperative images. Discussion: This first case-report of the evolution of stellate nonhereditary idiopathic foveomacular retinoschisis after cataract surgery suggests that this retinal condition is not modified by the surgical procedure, which however needs to confirmed by larger cohorts.
MeSH term(s)	Humans ; Middle Aged ; Retinoschisis/diagnosis ; Retinoschisis/surgery ; Retrospective Studies ; Fluorescein Angiography/methods ; Retina ; Tomography, Optical Coherence/methods ; Cataract
Language	English
Publishing date	2022-07-18
Publishing country	United States
Document type	Case Reports ; Journal Article
ISSN	1937-1578
ISSN (online)	1937-1578
DOI	10.1097/ICB.0000000000001270
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Article: Atteintes oculaires liées aux virus herpes simplex.

Rousseau, Antoine / Labetoulle, Marc

Virologie (Montrouge, France)

2020 Volume 24, Issue 5, Page(s) 295–306

Abstract: Ocular manifestations of herpes simplex virus are mostly caused by herpes simplex (HSV-1), and are the second most frequent clinical manifestation of HSV-1 after cold sore. Corneal involvement, known as herpetic keratitis is by far the most frequent: in ... ...

Title translation	Ocular manifestations of herpes simplex viruses.
Abstract	Ocular manifestations of herpes simplex virus are mostly caused by herpes simplex (HSV-1), and are the second most frequent clinical manifestation of HSV-1 after cold sore. Corneal involvement, known as herpetic keratitis is by far the most frequent: in France, it affects 90,000 people with nearly 20,000 attacks each year. Herpes keratitis is considered to be the leading cause of infectious blindness in industrialized countries. In addition to its visual consequences, this recurrent disease may severely impact the quality of life. This review will first focus on current pathophysiological concepts and epidemiological data, then detail clinical forms and their treatment and finish with new therapeutic challenges and developing therapeutic strategies.
MeSH term(s)	France ; Herpes Simplex/diagnosis ; Herpesvirus 1, Human ; Humans ; Keratitis, Herpetic/diagnosis ; Quality of Life
Language	French
Publishing date	2020-11-12
Publishing country	France
Document type	Journal Article ; Review
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2020.0863
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Article ; Online: How gut microbiota may impact ocular surface homeostasis and related disorders.

Labetoulle, Marc / Baudouin, Christophe / Benitez Del Castillo, Jose M / Rolando, Maurizio / Rescigno, Maria / Messmer, Elisabeth M / Aragona, Pasquale

Progress in retinal and eye research

2024 Volume 100, Page(s) 101250

Abstract: Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the ... ...

Abstract	Changes in the bacterial flora in the gut, also described as gut microbiota, are readily acknowledged to be associated with several systemic diseases, especially those with an inflammatory, neuronal, psychological or hormonal factor involved in the pathogenesis and/or the perception of the disease. Maintaining ocular surface homeostasis is also based on all these four factors, and there is accumulating evidence in the literature on the relationship between gut microbiota and ocular surface diseases. The mechanisms involved are mostly interconnected due to the interaction of central and peripheral neuronal networks, inflammatory effectors and the hormonal system. A better understanding of the influence of the gut microbiota on the maintenance of ocular surface homeostasis, and on the onset or persistence of ocular surface disorders could bring new insights and help elucidate the epidemiology and pathology of ocular surface dynamics in health and disease. Revealing the exact nature of these associations could be of paramount importance for developing a holistic approach using highly promising new therapeutic strategies targeting ocular surface diseases.
Language	English
Publishing date	2024-03-08
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	1182683-6
ISSN	1873-1635 ; 1350-9462
ISSN (online)	1873-1635
ISSN	1350-9462
DOI	10.1016/j.preteyeres.2024.101250
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Article ; Online: Variole du singe : les points importants pour l’ophtalmologiste.

Hoarau, G / Vauloup Fellous, C / Haigh, O / Labetoulle, M / Rousseau, A

Journal francais d'ophtalmologie

2023 Volume 46, Issue 2, Page(s) 185–193

Abstract: The current monkeypox virus (MPXV) outbreak, raging since May 2022, is the largest ever observed on a world-wide scale. Despite previously being endemic in west and central Africa with a mortality rate of up to 10%, it remained a neglected tropical ... ...

Title translation	Monkeypox: Important facts for the ophthalmologist.
Abstract	The current monkeypox virus (MPXV) outbreak, raging since May 2022, is the largest ever observed on a world-wide scale. Despite previously being endemic in west and central Africa with a mortality rate of up to 10%, it remained a neglected tropical disease. Along with other recent pandemics gaining much attention, this MPXV outbreak has provided an opportunity to improve our understanding of its physiopathology and better define management strategies, particularly in patients with more serious disease. From the ophthalmologist's perspective, eyelid involvement and conjunctivitis or keratoconjunctivitis are frequently observed and may precede systemic signs or even remain the major site of involvement. While the course of MPXV keratoconjunctivitis is most often favorable, severe cases pose a functional threat, in particular for immunocompromised patients. This review provides an overview of MPXV pathophysiology, diagnosis and treatment, as well as considerations for prevention of transmission. During such an epidemic, the ophthalmologist can be the first to diagnose MPXV, treat the ocular involvement, and set up adequate preventative measures in collaboration with infectious disease specialists.
MeSH term(s)	Humans ; Mpox (monkeypox)/diagnosis ; Ophthalmologists ; Monkeypox virus/physiology
Language	French
Publishing date	2023-01-11
Publishing country	France
Document type	English Abstract ; Journal Article ; Review
ZDB-ID	426662-6
ISSN	1773-0597 ; 0181-5512
ISSN (online)	1773-0597
ISSN	0181-5512
DOI	10.1016/j.jfo.2022.11.002
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Article: Latence et réactivation de HSV1, LAT et ICP0 : les deux faces d’une seule médaille.

Crépin, S / Picard, C / Labetoulle, M

Virologie (Montrouge, France)

2021 Volume 10, Issue 6, Page(s) 415–422

Abstract: The virus herpes simplex type 1 (HSV1) is characterized by its ability to become latent within the nervous system after a primary infection that is almost always located into the oral mucosa. Several factors may trigger HSV1 reactivation, thus inducing ... ...

Title translation	Latency and reactivation of HSV: role of LAT and ICP0.
Abstract	The virus herpes simplex type 1 (HSV1) is characterized by its ability to become latent within the nervous system after a primary infection that is almost always located into the oral mucosa. Several factors may trigger HSV1 reactivation, thus inducing recurrences, which are mostly located on the lips (cold sore), sometimes in the eye (most frequently into the cornea) and, exceptionally, in the central nervous system (meningitis and encephalitis). Considering the frequency of the HSV1 infection in the general population and the associated morbidity (approximately 15 % of people have relapsing cold sores, and 90,000 French people have an history of ocular herpes disease), many research projects are focused on the biologic patterns regulating the switch between viral latency and reactivation. In spite of the multitude of scientific publications, numerous points are still poorly understood. However, molecular biology allowed consequent progress. The putative roles of Latency Associated Transcripts (LAT), until recently considered as the only viral transcripts during viral latency, are now better identified. It is now obvious that LAT interact with other viral partners. The transcripts encoding ICP0, a viral protein which is known to have a key role in the reactivation process, could be involved in this phenomenon, since their properties are opposite to those of LAT. The couple LAT-ICP0 transcripts could thus represent the molecular aspect of the classic opposition between latency and reactivation of HSV1.
Language	French
Publishing date	2021-11-09
Publishing country	France
Document type	English Abstract ; Journal Article
ZDB-ID	2118387-9
ISSN	1950-6961 ; 1267-8694
ISSN (online)	1950-6961
ISSN	1267-8694
DOI	10.1684/vir.2011.8641
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Article ; Online: Review of clinical outcomes of a cationic emulsion tear substitute in patients with dry eye disease.

Labetoulle, Marc / Garhöfer, Gerhard / Ismail, Dahlia / Garrigue, Jean-Sébastien / Amrane, Mourad / Guillon, Michel / Aragona, Pasquale / Baudouin, Christophe

Acta ophthalmologica

2024 Volume 102, Issue 4, Page(s) 382–390

Abstract: First-line options for the treatment of dry eye disease (DED) rely on artificial tears (ATs), among which cationic emulsion (CE)-based ATs have been developed in order to mimic the healthy tear film for an improved restoration of the ocular surface ... ...

Abstract	First-line options for the treatment of dry eye disease (DED) rely on artificial tears (ATs), among which cationic emulsion (CE)-based ATs have been developed in order to mimic the healthy tear film for an improved restoration of the ocular surface homeostasis. In this review, we describe the outcomes reported in several studies, assessing the mode of action, ocular tolerance and clinical performance of a CE-based AT. Pilot studies have revealed that CE-based ATs can increase the volume and stability of the tear film while limiting its evaporation rate. Larger studies have demonstrated that CE-based ATs play a significant role in the improvement of both objective and subjective DED parameters, including superior efficacy on DED symptoms compared to several other available AT formulation types. Concomitantly, CE-based ATs have been shown to help patients to prevent or recover from corneal defects associated with refractive surgery. These positive outcomes on ocular surface epithelia are likely due to the combination of unique rheological behaviour and intrinsic anti-inflammatory properties. Based on all clinical findings, CE-based ATs represent a valuable treatment option for patients with various etiologies of DED including evaporative forms and would deserve evaluation of benefits in other surgical intervention types triggering DED.
MeSH term(s)	Humans ; Dry Eye Syndromes/drug therapy ; Dry Eye Syndromes/physiopathology ; Emulsions ; Lubricant Eye Drops/administration & dosage ; Tears/metabolism ; Tears/physiology ; Cations ; Treatment Outcome
Chemical Substances	Emulsions ; Lubricant Eye Drops ; Cations
Language	English
Publishing date	2024-01-31
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2408333-1
ISSN	1755-3768 ; 1755-375X
ISSN (online)	1755-3768
ISSN	1755-375X
DOI	10.1111/aos.16629
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