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Article ; Online: MIG in autoimmune thyroiditis: review of the literature.

Pezzano, M

2019 Volume 170, Issue 4, Page(s) e295–e300

Abstract: The monokine induced by interferon (IFN)-γ (MIG) and its receptor, the chemokine (C-X-C motif) receptor (CXCR)3, appear to contribute to the pathogenesis of autoimmune thyroiditis (AT). MIG is secreted by thyrocytes under the influence of IFN-γ. In ... ...

Abstract	The monokine induced by interferon (IFN)-γ (MIG) and its receptor, the chemokine (C-X-C motif) receptor (CXCR)3, appear to contribute to the pathogenesis of autoimmune thyroiditis (AT). MIG is secreted by thyrocytes under the influence of IFN-γ. In tissue, recruited Th1 lymphocytes may be responsible for enhanced IFN-γ, which in turn stimulates MIG secretion from thyrocytes creating an amplification feedback loop, and perpetuating the autoimmune process. Circulating MIG and IFN-inducible T-cell α chemoattractant (I-TAC) levels are increased in patients with thyroiditis and hypothyroidism and are related to each other. The importance of a Th1 immune attack in the initiation of AT has been demonstrated. MIG levels were significantly higher in elder patients, or in those with a hypoechoic ultrasonographic pattern, or with hypothyroidism. In peripheral fluids, high MIG levels are considered a marker of host immune response, in particular Th1 orientated T-cells. Other studies are needed to continue to investigate the role of MIG as a novel therapeutic target in AT.
MeSH term(s)	Aged ; Animals ; Chemokine CXCL9/immunology ; Hashimoto Disease/immunology ; Humans ; Interferon-gamma ; Receptors, CXCR3/immunology ; Th1 Cells/immunology
Chemical Substances	CXCR3 protein, human ; Chemokine CXCL9 ; Receptors, CXCR3 ; Interferon-gamma (82115-62-6)
Language	English
Publishing date	2019-07-15
Publishing country	Italy
Document type	Journal Article ; Review
ZDB-ID	123320-8
ISSN	1972-6007 ; 0009-9074
ISSN (online)	1972-6007
ISSN	0009-9074
DOI	10.7417/CT.2019.2151
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Article ; Online: Randomized Trial of Surfactant Therapy via Laryngeal Mask Airway Versus Brief Tracheal Intubation in Neonates Born Preterm.

Gallup, Jacqueline A / Ndakor, Sussan Mbi / Pezzano, Chad / Pinheiro, Joaquim M B

The Journal of pediatrics

2022 Volume 254, Page(s) 17–24.e2

Abstract: Objective: To evaluate the possible noninferiority of surfactant administration via laryngeal mask airway (LMA) vs endotracheal tube (ETT) in avoiding the requirement for mechanical ventilation in preterm neonates with respiratory distress syndrome (RDS) ...

Abstract	Objective: To evaluate the possible noninferiority of surfactant administration via laryngeal mask airway (LMA) vs endotracheal tube (ETT) in avoiding the requirement for mechanical ventilation in preterm neonates with respiratory distress syndrome (RDS). Study design: This was a randomized controlled trial including infants born at 27 to 36 weeks of gestation, >800 g, diagnosed with RDS and receiving fraction of inspired oxygen 0.30-0.60 via noninvasive respiratory support. Infants were randomized to surfactant via LMA (with atropine premedication) or ETT (InSuRE approach with atropine and remifentanil premedication). Primary outcome was failure of surfactant treatment to prevent the need for mechanical ventilation. Results: Patients were randomized, 51 to LMA and 42 to the ETT group. Both groups had similar baseline characteristics, with birth weights ranging from 810 to 3560 g. Failure rate was 29% in the ETT group and 20% in the LMA group (P = .311). This difference was due to early failures (within 1 hour), with 12.5% in the ETT group and 2% in the LMA group (P = .044). Surfactant therapy via LMA was non-inferior to administration via ETT; failure risk difference -9.0% (CI -∞ to 5.7%). Efficacy in decreasing fraction of inspired oxygen, number of surfactant doses administered, time to wean off all respiratory support, rates of adverse events, and outcomes including pneumothorax and BPD diagnosis did not differ between groups. Conclusions: Surfactant therapy via LMA was noninferior to administration via ETT and it decreased early failures, possibly by avoiding adverse effects of premedication, laryngoscopy, and intubation. These characteristics make LMA a desirable conduit for surfactant administration. Trial registration: ClinicalTrials.gov, NCT02164734.
MeSH term(s)	Infant, Newborn ; Humans ; Laryngeal Masks ; Surface-Active Agents/therapeutic use ; Infant, Premature ; Intubation, Intratracheal ; Pulmonary Surfactants/therapeutic use ; Lipoproteins ; Respiratory Distress Syndrome, Newborn/drug therapy ; Oxygen/therapeutic use ; Atropine Derivatives/therapeutic use
Chemical Substances	Surface-Active Agents ; Pulmonary Surfactants ; Lipoproteins ; Oxygen (S88TT14065) ; Atropine Derivatives
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Randomized Controlled Trial ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	3102-1
ISSN	1097-6833 ; 0022-3476
ISSN (online)	1097-6833
ISSN	0022-3476
DOI	10.1016/j.jpeds.2022.10.009
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Article: Can Seismocardiogram Fiducial Points Be Used for the Routine Estimation of Cardiac Time Intervals in Cardiac Patients?

Işilay Zeybek, Zeynep Melike / Racca, Vittorio / Pezzano, Antonio / Tavanelli, Monica / Di Rienzo, Marco

Frontiers in physiology

2022 Volume 13, Page(s) 825918

Abstract: The indexes of cardiac mechanics can be derived from the cardiac time intervals, CTIs, i.e., the timings among the opening and closure of the aortic and mitral valves and the Q wave in the ECG. Traditionally, CTIs are estimated by ultrasound (US) ... ...

Abstract	The indexes of cardiac mechanics can be derived from the cardiac time intervals, CTIs, i.e., the timings among the opening and closure of the aortic and mitral valves and the Q wave in the ECG. Traditionally, CTIs are estimated by ultrasound (US) techniques, but they may also be more easily assessed by the identification of specific fiducial points (FPs) inside the waveform of the seismocardiogram (SCG), i.e., the measure of the thorax micro-accelerations produced by the heart motion. While the correspondence of the FPs with the valve movements has been verified in healthy subjects, less information is available on whether this methodology may be routinely employed in the clinical practice for the monitoring of cardiac patients, in which an SCG waveform distortion is expected because of the heart dysfunction. In this study we checked the SCG shape in 90 patients with myocardial infarction (MI), heart failure (HF), or transplanted heart (TX), referred to our hospital for rehabilitation after an acute event or after surgery. The SCG shapes were classified as traditional (T) or non-traditional (NT) on whether the FPs were visible or not on the basis of nomenclature previously proposed in literature. The T shape was present in 62% of the patients, with a higher ∓ prevalence in MI (79%). No relationship was found between T prevalence and ejection fraction (EF). In 20 patients with T shape, we checked the FPs correspondence with the real valve movements by concomitant SCG and US measures. When compared with reference values in healthy subjects available in the literature, we observed that the Echo vs. FP differences are significantly more dispersed in the patients than in the healthy population with higher differences for the estimation of the mitral valve closure (-17 vs. 4 ms on average). Our results indicate that not every cardiac patient has an SCG waveform suitable for the CTI estimation, thus before starting an SCG-based CTI monitoring a preliminary check by a simultaneous SCG-US measure is advisable to verify the applicability of the methodology.
Language	English
Publishing date	2022-03-18
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.825918
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Article: Impact of COVID-19 on Respiratory Admissions in a Tertiary Pediatric Intensive Care Unit.

Ambati, Shashikanth / Mihic, Maya / Wilkinson, Kristy / Sanchez, Javier L / Pezzano, Chad

Cureus

2022 Volume 14, Issue 5, Page(s) e25369

Abstract: Background Pediatric inpatient admissions for viral respiratory infections decreased worldwide during the early part of the coronavirus disease 2019 (COVID-19) pandemic. This was likely due to social distancing measures and mask mandates leading to a ... ...

Abstract	Background Pediatric inpatient admissions for viral respiratory infections decreased worldwide during the early part of the coronavirus disease 2019 (COVID-19) pandemic. This was likely due to social distancing measures and mask mandates leading to a decreased spread of viruses. We question if there was an increase in respiratory admissions during the winter of 2020-2021 due to the overlap of seasonal respiratory viruses and COVID-19 and the severity of those admissions. Methods We performed a single-center retrospective chart review of all respiratory admissions to our pediatric intensive care unit (PICU) from October to April during the years 2018-2019, 2019-2020, and 2020-2021. We compared the total number of respiratory admissions from different viruses and respiratory admissions by diagnoses among those time periods. Second, we compared the PICU length of stay and duration of mechanical ventilation (both invasive and non-invasive) for these respiratory admissions during those years. Results We saw a drastic decrease in the total respiratory admissions to the PICU in 2020-2021 compared to the same period of time in the last two years. The greatest contributor to this decrease was admissions secondary to bronchiolitis. We noticed a statistically significant decrease in both asthma (p<0.001) and chronic respiratory failure admissions (p=0.0029) during the pandemic winter compared to previous winters. Although, the total number of all respiratory viral admissions is not significant, admissions specific to the respiratory syncytial virus (RSV) (p<0.0001), rhino-enterovirus (p<0.0001), and multi-virus (p=0.0016), achieved statistical significance. There was no statistical difference between the PICU length of stay and duration of mechanical ventilation during the three years. Conclusion Despite a decrease in pediatric respiratory admissions during the COVID-19 pandemic, the severity of illness based on length of stay in the PICU and length of time on respiratory support remains unchanged compared to the previous two years.
Language	English
Publishing date	2022-05-26
Publishing country	United States
Document type	Journal Article
ZDB-ID	2747273-5
ISSN	2168-8184
ISSN	2168-8184
DOI	10.7759/cureus.25369
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Article ; Online: Evolutionary bioenergetics of ciliates.

Lynch, Michael / Schavemaker, Paul E / Licknack, Timothy J / Hao, Yue / Pezzano, Arianna

The Journal of eukaryotic microbiology

2022 Volume 69, Issue 5, Page(s) e12934

Abstract: Understanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject ... ...

Abstract	Understanding why various organisms evolve alternative ways of living requires information on both the fitness advantages of phenotypic modifications and the costs of constructing and operating cellular features. Although the former has been the subject of a myriad of ecological studies, almost no attention has been given to how organisms allocate resources to alternative structures and functions. We address these matters by capitalizing on an array of observations on diverse ciliate species and from the emerging field of evolutionary bioenergetics. A relatively robust and general estimator for the total cost of a cell per cell cycle (in units of ATP equivalents) is provided, and this is then used to understand how the magnitudes of various investments scale with cell size. Among other things, we examine the costs associated with the large macronuclear genomes of ciliates, as well as ribosomes, various internal membranes, osmoregulation, cilia, and swimming activities. Although a number of uncertainties remain, the general approach taken may serve as blueprint for expanding this line of work to additional traits and phylogenetic lineages.
MeSH term(s)	Cell Cycle ; Cilia ; Ciliophora/genetics ; Energy Metabolism ; Phylogeny
Language	English
Publishing date	2022-07-28
Publishing country	United States
Document type	Journal Article ; Review ; Research Support, Non-U.S. Gov't ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	1147218-2
ISSN	1550-7408 ; 1066-5234
ISSN (online)	1550-7408
ISSN	1066-5234
DOI	10.1111/jeu.12934
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Article ; Online: Lo que necesita este país es más internacionalistas

Leopoldo M. A. Godio / Luciano Pezzano

Relaciones Internacionales (2021)

el recurso a la serie animada “Los Simpsons” para la enseñanza del derecho internacional

2021

Abstract: El artículo propone analizar la utilización de la conocida serie animada de televisión Los Simpson como instrumento multifuncional para el diseño de nuevas estrategias metodológicas dedicadas a la enseñanza del derecho internacional. Sobre la base de que ...

Abstract	El artículo propone analizar la utilización de la conocida serie animada de televisión Los Simpson como instrumento multifuncional para el diseño de nuevas estrategias metodológicas dedicadas a la enseñanza del derecho internacional. Sobre la base de que su empleo con fines pedagógicos en otras disciplinas ha sido bien documentada –y dado el impacto en la cultura popular de nuestro país que ha marcado a varias generaciones de estudiantes–, la propuesta plantea que la riqueza de la trama de Los Simpson abunda en ejemplos que permiten acercar a los estudiantes a las más diversas cuestiones abordadas en el derecho internacional público, así como desarrollar actividades íntegramente centradas en torno a episodios de la serie, de las que se aporta un caso concreto.
Keywords	Metodología de la enseñanza ; derecho internacional público ; cultura popular ; Los Simpson ; Political science ; J ; International relations ; JZ2-6530
Language	Spanish
Publishing date	2021-09-01T00:00:00Z
Publisher	Universidad Nacional de La Plata
Document type	Article ; Online
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Article: L'ecocardiogramma del ventricolo sinistro prima e dopo by pass aorto-coronarico. Studio M-mode in 30 pazienti.

Castagnone, M / Corallo, S / Faletra, F / Mantero, A / Pezzano, A

Giornale italiano di cardiologia

1980 Volume 10, Issue 4, Page(s) 405–413

Abstract: 30 coronary artery disease (CAD) patients (pts) were studied by echocardiography before and after left anterior descending (LAD) coronary bypass graft in order to evaluate left ventricular (LV) behaviour. Echocardiograms were recorded early pre- (48 ... ...

Title translation	Left ventricular behaviour before and after left anterior descending coronary artery bypass graft. M-mode echocardiographic study in 30 patients (author's transl).
Abstract	30 coronary artery disease (CAD) patients (pts) were studied by echocardiography before and after left anterior descending (LAD) coronary bypass graft in order to evaluate left ventricular (LV) behaviour. Echocardiograms were recorded early pre- (48 hours) and post-operatively (mean 12 days) and at a mean distance of 12 months (6 to 15) after operation. The following parameters were considered: left ventricular end diastolic dimension (LVDD), right ventricular diastolic dimension (LVDD), right ventricular diastolic dimension (RVDD), diastolic thickness, systolic thickening and motion of the interventricular septum (IVS) and of the LV posterior wall (LVPW). 21 pts (70%) showed reduced systolic thickening (RST less than or equal to 30%) and 17 (57%) reduced systolic motion (RSM less than or equal to 3 mm) of the septum. Before surgery no patient showed IVS paradoxical movement, left bundle branch block, valvular regurgitation, shunt, LV aneurysm. A previous myocardial infarction was present in the story of 7 pts: anterior location in 4 pts, inferior in 3 pts. Soon after operation (mean 12 days) 4 pts showed normal IVS motion; in 7 pts it was reduced (less than or equal to 3 mm) and in 19 IVS was paradoxical. In 15 pts of this last group LVPW motion resulted remarkably increased after the bypass graft. The other echo parameters didn't show significant variation. Averaging 12 months after operation, IVS systolic thickening resulted normal in 21 of the 30 pts. (70%); in 14 of the last group of 21 there was a RST preoperatively. IVS motion resulted normal in 21 of the 30 pts (70%), reduced in 5 (17%), paradoxical in 4 (13%). LVPW motion returned to the preoperative value in all but 3 pts, in whom it remained elevated. The other echo parameters didn't show any significant variation. We conclude that: 1) IVS paradoxical motion is frequently recorded by echo shortly after coronary bypass graft surgery. 2) In most pts it is accompanied by an increased excursion of LVPW, probably compensatory in origin. Both tend to normalize within few months in most of the subjects.
MeSH term(s)	Angina Pectoris/diagnosis ; Angina Pectoris/surgery ; Coronary Artery Bypass ; Coronary Disease/diagnosis ; Coronary Disease/surgery ; Echocardiography ; Follow-Up Studies ; Heart/physiopathology ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Myocardial Infarction/diagnosis ; Myocardial Infarction/surgery ; Postoperative Period
Language	Italian
Publishing date	1980
Publishing country	Italy
Document type	Comparative Study ; English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Article ; Online: Bone Marrow-Derived Cells Contribute to the Maintenance of Thymic Stroma including TECs.

Chakrabarti, Shami / Hoque, Mohammed / Jamil, Nawshin Zara / Singh, Varan J / Pollacksmith, Daniel / Meer, Neelab / Pezzano, Mark T

Journal of immunology research

2022 Volume 2022, Page(s) 6061746

Abstract: In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable ...

Abstract	In paradox to critical functions for T-cell selection and self-tolerance, the thymus undergoes profound age-associated atrophy and loss of T-cell function, further enhanced by cancer therapies. Identifying thymic epithelial progenitor populations capable of forming functional thymic tissue will be critical in understanding thymic epithelial cell (TEC) ontogeny and designing strategies to reverse involution. We identified a new population of progenitor cells, present in both the thymus and bone marrow (BM) of mice, that coexpress the hematopoietic marker CD45 and the definitive thymic epithelial marker EpCAM and maintain the capacity to form functional thymic tissue. Confocal analysis and qRT-PCR of sorted cells from both BM and thymus confirmed coexpression of CD45 and EpCAM. Grafting of C57BL/6 fetal thymi under the kidney capsule of H2BGFP transgenic mice revealed that peripheral CD45+ EpCAM+ GFP-expressing cells migrate into the developing thymus and contribute to both TECs and FSP1-expressing thymic stroma. Sorted BM-derived CD45+ EpCAM+ cells contribute to reaggregate thymic organ cultures (RTOCs) and differentiate into keratin and FoxN1-expressing TECs, demonstrating that BM cells can contribute to the maintenance of TEC microenvironments previously thought to be derived solely from endoderm. BM-derived CD45+ EpCAM+ cells represent a new source of progenitor cells that contribute to thymic homeostasis. Future studies will characterize the contribution of BM-derived CD45+ EpCAM+ TEC progenitors to distinct functional TEC microenvironments in both the steady-state thymus and under conditions of demand. Cell therapies utilizing this population may help counteract thymic involution in cancer patients.
MeSH term(s)	Animals ; Bone Marrow ; Epithelial Cell Adhesion Molecule/genetics ; Epithelial Cells ; Humans ; Mice ; Mice, Inbred C57BL ; Stem Cells ; Thymus Gland
Chemical Substances	Epithelial Cell Adhesion Molecule
Language	English
Publishing date	2022-04-29
Publishing country	Egypt
Document type	Journal Article
ZDB-ID	2817541-4
ISSN	2314-7156 ; 2314-7156
ISSN (online)	2314-7156
ISSN	2314-7156
DOI	10.1155/2022/6061746
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Article: Valore e limiti dell'ecocardiografia M-mode nella malattia coronarica. Studio in 100 pazienti anginosi.

Corallo, S / Pezzano, A / Castagnone, M / Brusoni, B / Augello, M / Morandi, G / Rovelli, F

Giornale italiano di cardiologia

1979 Volume 9, Issue 8, Page(s) 806–816

Title translation	Value and limitations of M-mode echocardiography in coronary disease. Study in 100 patients with angina pectoris.
MeSH term(s)	Adult ; Aged ; Angina Pectoris/diagnosis ; Angina Pectoris/etiology ; Coronary Disease/complications ; Coronary Disease/diagnosis ; Echocardiography ; Electrocardiography ; Female ; Humans ; Male ; Middle Aged ; Myocardial Contraction
Language	Italian
Publishing date	1979
Publishing country	Italy
Document type	English Abstract ; Journal Article
ZDB-ID	184670-x
ISSN	0046-5968
ISSN	0046-5968
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Article ; Online: RDS-NExT workshop: consensus statements for the use of surfactant in preterm neonates with RDS.

Bhandari, Vineet / Black, Rachel / Gandhi, Bheru / Hogue, Susan / Kakkilaya, Venkatakrishna / Mikhael, Michel / Moya, Fernando / Pezzano, Chad / Read, Pam / Roberts, Kari D / Ryan, Rita M / Stanford, Richard H / Wright, Clyde J

Journal of perinatology : official journal of the California Perinatal Association

2023 Volume 43, Issue 8, Page(s) 982–990

Abstract: Objective: To provide the best clinical practice guidance for surfactant use in preterm neonates with respiratory distress syndrome (RDS). The RDS-Neonatal Expert Taskforce (RDS-NExT) initiative was intended to add to existing evidence and clinical ... ...

Abstract	Objective: To provide the best clinical practice guidance for surfactant use in preterm neonates with respiratory distress syndrome (RDS). The RDS-Neonatal Expert Taskforce (RDS-NExT) initiative was intended to add to existing evidence and clinical guidelines, where evidence is lacking, with input from an expert panel. Study design: An expert panel of healthcare providers specializing in neonatal intensive care was convened and administered a survey questionnaire, followed by 3 virtual workshops. A modified Delphi method was used to obtain consensus around topics in surfactant use in neonatal RDS. Result: Statements focused on establishing RDS diagnosis and indicators for surfactant administration, surfactant administration methods and techniques, and other considerations. After discussion and voting, consensus was achieved on 20 statements. Conclusion: These consensus statements provide practical guidance for surfactant administration in preterm neonates with RDS, with a goal to contribute to improving the care of neonates and providing a stimulus for further investigation to bridge existing knowledge gaps.
MeSH term(s)	Infant, Newborn ; Humans ; Infant, Premature ; Surface-Active Agents/therapeutic use ; Respiratory Distress Syndrome, Newborn/drug therapy ; Pulmonary Surfactants/therapeutic use ; Intensive Care, Neonatal
Chemical Substances	Surface-Active Agents ; Pulmonary Surfactants
Language	English
Publishing date	2023-05-15
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	645021-0
ISSN	1476-5543 ; 0743-8346
ISSN (online)	1476-5543
ISSN	0743-8346
DOI	10.1038/s41372-023-01690-9
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