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  1. Article ; Online: H

    Kigundu, Gabriel / Cooper, Jennifer L / Smith, Susan M E

    The Journal of eukaryotic microbiology

    2018  Volume 65, Issue 6, Page(s) 928–933

    Abstract: Bioluminescence in dinoflagellates is controlled by H ...

    Abstract Bioluminescence in dinoflagellates is controlled by H
    MeSH term(s) Cluster Analysis ; Dinoflagellida/genetics ; Dinoflagellida/metabolism ; Genes, Protozoan/genetics ; Genome ; Ion Channels/classification ; Ion Channels/genetics ; Ion Channels/metabolism ; Luminescent Proteins/metabolism ; Phylogeny ; Protons ; Sequence Alignment ; Transcriptome
    Chemical Substances HVCN1 protein, human ; Ion Channels ; Luminescent Proteins ; Protons
    Keywords covid19
    Language English
    Publishing date 2018-05-17
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
    ZDB-ID 1147218-2
    ISSN 1550-7408 ; 1066-5234
    ISSN (online) 1550-7408
    ISSN 1066-5234
    DOI 10.1111/jeu.12627
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    Zs.B 2292: Show issues Location:
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  2. Article ; Online: H

    Smith, Roxanne P / Mohanty, Biswaranjan / Williams, Martin L / Scanlon, Martin J / Heras, Begoña

    Biomolecular NMR assignments

    2017  Volume 11, Issue 2, Page(s) 181–186

    Abstract: ... for the development of antibiotics. Here we report the chemical shift assignments (H ...

    Abstract DsbD is a disulfide bond reductase present in the inner membrane of many Gamma-Proteobacteria. In the human pathogen Neisseria meningitidis, DsbD is required for viability and represents a potential target for the development of antibiotics. Here we report the chemical shift assignments (H
    MeSH term(s) Amino Acid Sequence ; Bacterial Proteins/chemistry ; Neisseria meningitidis ; Nuclear Magnetic Resonance, Biomolecular ; Periplasm/metabolism ; Protein Domains
    Chemical Substances Bacterial Proteins
    Language English
    Publishing date 2017-10
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2388861-1
    ISSN 1874-270X ; 1874-2718
    ISSN (online) 1874-270X
    ISSN 1874-2718
    DOI 10.1007/s12104-017-9743-x
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  3. Article ; Online: Advances and Opportunities in H

    Smith, Haley M / Pluth, Michael D

    JACS Au

    2023  Volume 3, Issue 10, Page(s) 2677–2691

    Abstract: Hydrogen sulfide (H ...

    Abstract Hydrogen sulfide (H
    Language English
    Publishing date 2023-09-21
    Publishing country United States
    Document type Journal Article ; Review
    ISSN 2691-3704
    ISSN (online) 2691-3704
    DOI 10.1021/jacsau.3c00427
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  4. Article ; Online: Different reactivities of H

    Španěl, Patrik / Dryahina, Kseniya / Omezzine Gnioua, Maroua / Smith, David

    Rapid communications in mass spectrometry : RCM

    2023  Volume 37, Issue 9, Page(s) e9496

    Abstract: Rationale: The detection sensitivity of secondary electrospray ionisation mass spectrometry (SESI-MS) is much lower for saturated aldehydes than for unsaturated aldehydes. This needs to be understood in terms of gas phase ion-molecule reaction kinetics ... ...

    Abstract Rationale: The detection sensitivity of secondary electrospray ionisation mass spectrometry (SESI-MS) is much lower for saturated aldehydes than for unsaturated aldehydes. This needs to be understood in terms of gas phase ion-molecule reaction kinetics and energetics to make SESI-MS analytically more quantitative.
    Methods: Parallel SESI-MS and selected ion flow tube mass spectrometry (SIFT-MS) analyses were carried out of air containing variable accurately determined concentrations of saturated (C5, pentanal; C7, heptanal; C8 octanal) and unsaturated (C5, 2-pentenal; C7, 2-heptenal; C8, 2-octenal) aldehyde vapours. The influence of the source gas humidity and the ion transfer capillary temperature, 250 and 300°C, in a commercial SESI-MS instrument was explored. Separate experiments were carried out using SIFT to determine the rate coefficients, k
    Results: The relative slopes of the plots of SESI-MS ion signal against SIFT-MS concentration were interpreted as the relative SESI-MS sensitivities for these six compounds. The sensitivities for the unsaturated aldehydes were 20 to 60 times greater than for the corresponding C5, C7 and C8 saturated aldehydes. Additionally, the SIFT experiments revealed that the measured k
    Conclusions: The trends in SESI-MS sensitivities are rationally explained by differences in the rates of the ligand-switching reactions, which are justified by theoretically calculated equilibrium rate constants derived from thermochemical density functional theory (DFT) calculations of Gibb's free energy changes. The humidity of SESI gas thus favours the reverse reactions of the saturated aldehyde analyte ions, effectively suppressing their signals in contrast to their unsaturated counterparts.
    Language English
    Publishing date 2023-02-18
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9496
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 3461: Show issues Location:
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    Jg. 1995 - 2021: Lesesall (2.OG)
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  5. Article ; Online: Homodimeric Minimal Factor H:

    Kamala, Ola / Malik, Talat H / Hallam, Thomas M / Cox, Thomas E / Yang, Yi / Vyas, Falguni / Luli, Saimir / Connelly, Chloe / Gibson, Beth / Smith-Jackson, Kate / Denton, Harriet / Pappworth, Isabel Y / Huang, Lei / Kavanagh, David / Pickering, Matthew C / Marchbank, Kevin J

    Frontiers in immunology

    2021  Volume 12, Page(s) 752916

    Abstract: ... of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP ...

    Abstract C3 glomerulopathy (C3G) is associated with dysregulation of the alternative pathway (AP) of complement and treatment options remain inadequate. Factor H (FH) is a potent regulator of the AP. An in-depth analysis of FH-related protein dimerised minimal (mini)-FH constructs has recently been published. This analysis showed that addition of a dimerisation module to mini-FH not only increased serum half-life but also improved complement regulatory function, thus providing a potential treatment option for C3G. Herein, we describe the production of a murine version of homodimeric mini-FH [mHDM-FH (mFH
    MeSH term(s) Animals ; Complement C3/immunology ; Complement Factor H/deficiency ; Complement Factor H/immunology ; Kidney/immunology ; Mice ; Mice, Inbred C57BL ; Mice, Knockout
    Chemical Substances Complement C3 ; Complement Factor H (80295-65-4)
    Language English
    Publishing date 2021-12-09
    Publishing country Switzerland
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2606827-8
    ISSN 1664-3224 ; 1664-3224
    ISSN (online) 1664-3224
    ISSN 1664-3224
    DOI 10.3389/fimmu.2021.752916
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  6. Article ; Online: Spectroscopic detection of the stannylidene (H

    Smith, Tony C / Gharaibeh, Mohammed / Clouthier, Dennis J

    The Journal of chemical physics

    2022  Volume 157, Issue 20, Page(s) 204306

    Abstract: The H ...

    Abstract The H
    Language English
    Publishing date 2022-11-14
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3113-6
    ISSN 1089-7690 ; 0021-9606
    ISSN (online) 1089-7690
    ISSN 0021-9606
    DOI 10.1063/5.0127449
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    Z 4' 49/16: Show issues

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  7. Article ; Online: Role of compliance in Helicobacter pylori eradication treatment: Results of the European Registry on H. pylori management.

    Huguet, Jose M / Ferrer-Barceló, Luis / Suárez, Patrícia / Barcelo-Cerda, Susana / Sempere, Javier / Saracino, Ilaria Maria / Fiorini, Giulia / Vaira, Dino / Pérez-Aísa, Ángeles / Jonaitis, Laimas / Tepes, Bojan / Castro-Fernandez, M / Pabón-Carrasco, Manuel / Keco-Huerga, Alma / Voynovan, Irina / Lucendo, Alfredo J / Lanas, Ángel / Martínez-Domínguez, Samuel J / Alfaro Almajano, Enrique /
    Rodrigo, Luis / Vologzanina, Ludmila / Bordin, Dmitry S / Gasbarrini, Antonio / Babayeva, Gülüstan / Lerang, Frode / Leja, Mārcis / Kupčinskas, Juozas / Rokkas, Theodore / Marcos-Pinto, Ricardo / Meštrović, Antonio / Gridnyev, Oleksiy / Phull, Perminder S / Smith, Sinead M / Boltin, Doron / Buzás, György Miklós / Kral, Jan / Şimşek, Halis / Matysiak-Budnik, Tamara / Milivojevic, Vladimir / Marlicz, Wojciech / Venerito, Marino / Boyanova, Lyudmila / Doulberis, Michael / Capelle, Lisette G / Cano-Català, Anna / Moreira, Leticia / Nyssen, Olga P / Mégraud, Francis / O'Morain, Colm / Gisbert, Javier P

    United European gastroenterology journal

    2024  

    Abstract: Background: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone ...

    Abstract Background: Adherence to Helicobacter pylori (H. pylori) eradication treatment is a cornerstone for achieving adequate treatment efficacy.
    Objective: To determine which factors influence compliance with treatment.
    Methods: A systematic prospective non-interventional registry (Hp-EuReg) of the clinical practice of European gastroenterologists. Compliance was considered adequate if ≥90% drug intake. Data were collected until September 2021 using the AEG-REDCap e-CRF and were subjected to quality control. Modified intention-to-treat analyses were performed. Multivariate analysis carried out the factors associated with the effectiveness of treatment and compliance.
    Results: Compliance was inadequate in 646 (1.7%) of 38,698 patients. The non-compliance rate was higher in patients prescribed longer regimens (10-, 14-days) and rescue treatments, patients with uninvestigated dyspepsia/functional dyspepsia, and patients reporting adverse effects. Prevalence of non-adherence was lower for first-line treatment than for rescue treatment (1.5% vs. 2.2%; p < 0.001). Differences in non-adherence in the three most frequent first-line treatments were shown: 1.1% with proton pump inhibitor + clarithromycin + amoxicillin; 2.3% with proton pump inhibitor clarithromycin amoxicillin metronidazole; and 1.8% with bismuth quadruple therapy. These treatments were significantly more effective in compliant than in non-compliant patients: 86% versus 44%, 90% versus 71%, and 93% versus 64%, respectively (p < 0.001). In the multivariate analysis, the variable most significantly associated with higher effectiveness was adequate compliance (odds ratio, 6.3 [95%CI, 5.2-7.7]; p < 0.001).
    Conclusions: Compliance with Helicobacter pylori eradication treatment is very good. Factors associated with poor compliance include uninvestigated/functional dyspepsia, rescue-treatment, prolonged treatment regimens, the presence of adverse events, and the use of non-bismuth sequential and concomitant treatment. Adequate treatment compliance was the variable most closely associated with successful eradication.
    Language English
    Publishing date 2024-04-29
    Publishing country England
    Document type Journal Article
    ZDB-ID 2728585-6
    ISSN 2050-6414 ; 2050-6406
    ISSN (online) 2050-6414
    ISSN 2050-6406
    DOI 10.1002/ueg2.12569
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  8. Book ; Online: CSM-H-R

    Yue, Songhui / Hong, Xiaoyan / Smith, Randy K.

    A Context Modeling Framework in Supporting Reasoning Automation for Interoperable Intelligent Systems and Privacy Protection

    2023  

    Abstract: ... this issue, we propose an automatic context reasoning framework CSM-H-R, which programmatically combines ... songhui01/CSM-H-R. ... Comment: 11 pages, 8 figures, Keywords: Context Reasoning, Automation, Intelligent ...

    Abstract Automation of High-Level Context (HLC) reasoning for intelligent systems at scale is imperative due to the unceasing accumulation of contextual data in the IoT era, the trend of the fusion of data from multi-sources, and the intrinsic complexity and dynamism of the context-based decision-making process. To mitigate this issue, we propose an automatic context reasoning framework CSM-H-R, which programmatically combines ontologies and states at runtime and the model-storage phase for attaining the ability to recognize meaningful HLC, and the resulting data representation can be applied to different reasoning techniques. Case studies are developed based on an intelligent elevator system in a smart campus setting. An implementation of the framework - a CSM Engine, and the experiments of translating the HLC reasoning into vector and matrix computing especially take care of the dynamic aspects of context and present the potentiality of using advanced mathematical and probabilistic models to achieve the next level of automation in integrating intelligent systems; meanwhile, privacy protection support is achieved by anonymization through label embedding and reducing information correlation. The code of this study is available at: https://github.com/songhui01/CSM-H-R.

    Comment: 11 pages, 8 figures, Keywords: Context Reasoning, Automation, Intelligent Systems, Context Modeling, Context Dynamism, Privacy Protection, Context Sharing, Interoperability, System Integration
    Keywords Computer Science - Artificial Intelligence ; Electrical Engineering and Systems Science - Systems and Control
    Subject code 004
    Publishing date 2023-08-21
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: On the Structure and Lithium Adsorption Mechanism of Layered H

    Marthi, Rajashekhar / Asgar, Hassnain / Gadikota, Greeshma / Smith, York R

    ACS applied materials & interfaces

    2021  Volume 13, Issue 7, Page(s) 8361–8369

    Abstract: Layered H ...

    Abstract Layered H
    Language English
    Publishing date 2021-02-11
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.0c20691
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  10. Article ; Online: Ternary association reactions of H

    Smith, David / Španěl, Patrik

    Rapid communications in mass spectrometry : RCM

    2021  Volume 36, Issue 6, Page(s) e9241

    Abstract: Rationale: The reactions of the reagent ions used for trace gas analysis in selected ion flow tube mass spectrometry (SIFT-MS), R: Methods: The ternary association rate coefficients mediated by helium (He) carrier gas atoms, k: Results: Values of ... ...

    Abstract Rationale: The reactions of the reagent ions used for trace gas analysis in selected ion flow tube mass spectrometry (SIFT-MS), R
    Methods: The ternary association rate coefficients mediated by helium (He) carrier gas atoms, k
    Results: Values of k
    Conclusions: The significance of these adduct ions for trace gas analysis by SIFT-MS in the low m/z region is alluded to, and some examples are given of m/z spectral overlaps of the R
    MeSH term(s) Air/analysis ; Breath Tests ; Carbon Dioxide/chemistry ; Humans ; Ions/chemistry ; Mass Spectrometry ; Nitric Oxide/chemistry ; Oxygen/chemistry ; Reactive Oxygen Species/chemistry ; Volatile Organic Compounds/chemistry ; Water/chemistry
    Chemical Substances Ions ; Reactive Oxygen Species ; Volatile Organic Compounds ; Water (059QF0KO0R) ; Carbon Dioxide (142M471B3J) ; Nitric Oxide (31C4KY9ESH) ; Oxygen (S88TT14065)
    Language English
    Publishing date 2021-12-21
    Publishing country England
    Document type Journal Article
    ZDB-ID 58731-x
    ISSN 1097-0231 ; 0951-4198
    ISSN (online) 1097-0231
    ISSN 0951-4198
    DOI 10.1002/rcm.9241
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