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Article ; Online: Pyrogallol loaded chitosan-based polymeric hydrogel for controlling Acinetobacter baumannii wound infections: Synthesis, characterization, and topical application.

Abirami, Gurusamy / Alexpandi, Rajaiah / Jayaprakash, Erusappan / Roshni, Prithiviraj Swasthikka / Ravi, Arumugam Veera

International journal of biological macromolecules

2024 Volume 259, Issue Pt 1, Page(s) 129161

Abstract: Antibacterial hydrogels have emerged as a promising approach for wound healing, owing to their ability to integrate antibacterial agents into the hydrogel matrix. Benefiting from its remarkable antibacterial and wound-healing attributes, pyrogallol has ... ...

Abstract	Antibacterial hydrogels have emerged as a promising approach for wound healing, owing to their ability to integrate antibacterial agents into the hydrogel matrix. Benefiting from its remarkable antibacterial and wound-healing attributes, pyrogallol has been introduced into chitosan-gelatin for the inaugural development of an innovative antibacterial polymeric hydrogel tailored for applications in wound healing. Hence, we observed the effectiveness of pyrogallol in inhibiting the growth of A. baumannii, disrupting mature biofilms, and showcasing robust antioxidant activity both in vitro and in vivo. In addition, pyrogallol promoted the migration of human epidermal keratinocytes and exhibited wound healing activity in zebrafish. These findings suggest that pyrogallol holds promise as a therapeutic agent for wound healing. Interestingly, the pyrogallol-loaded chitosan-gelatin (Pyro-CG) hydrogel exhibited enhanced mechanical strength, stability, controlled drug release, biodegradability, antibacterial activity, and biocompatibility. In vivo results established that Pyro-CG hydrogel promotes wound closure and re-epithelialization in A. baumannii-induced wounds in molly fish. Therefore, the prepared Pyro-CG polymeric hydrogel stands poised as a potent and promising agent for wound healing with antibacterial properties. This holds considerable promise for the development of effective therapeutic interventions to address the increasing menace of A. baumannii-induced wound infections.
MeSH term(s)	Animals ; Humans ; Hydrogels/pharmacology ; Chitosan ; Pyrogallol ; Acinetobacter baumannii ; Gelatin ; Zebrafish ; Anti-Bacterial Agents/pharmacology ; Wound Infection
Chemical Substances	Hydrogels ; Chitosan (9012-76-4) ; Pyrogallol (01Y4A2QXY0) ; Gelatin (9000-70-8) ; Anti-Bacterial Agents
Language	English
Publishing date	2024-01-04
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2023.129161
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Article ; Online: Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model.

Karthika, Chandrasekar / Malligarjunan, Nambiraman / Jothi, Ravi / Kasthuri, Thirupathi / Alexpandi, Rajaiah / Ravi, Arumugam Veera / Pandian, Shunmugiah Karutha / Gowrishankar, Shanmugaraj

Scientific reports

2023 Volume 13, Issue 1, Page(s) 19033

Abstract: The present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, specific to ...

Abstract	The present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, specific to P. aeruginosa, in which in vitro evaluations were carried out to assess the therapeutic potential of phages. Both the identified phages exhibited host specificity by showing antagonistic activity of about 96.43% (27/28) and 92.85% (26/28) towards the 28 MDR clinical isolates of P. aeruginosa. The PSPa phage was found to have linear dsDNA with a sequence length of 66,368 bp and 92 ORFs, of which 32 were encoded for known functions of the phage life cycle and the remaining 60 were hypothetical functions. The APPa phage was found to have linear dsDNA with 59,591 bp of genome length and 79 ORFs, of which 15 were found to have known phage functions and the remaining 64 were found to be hypothetical proteins. Notably, the genome of both the phages lacks genes coding for tRNA, rRNA, and tmRNA. The phylogenetic analysis revealed that PSPa and APPa share > 95% sequence similarity with previously sequenced Pseudomonas viruses of their respective families. Further, the in vivo efficacy evaluation using the zebrafish model revealed that the treatment with PSPa and APPa has remarkably improved the survival rate of bacterial-infected zebrafish, reinforcing the anti-infective potential of the isolated phages PSPa and APPa against P. aeruginosa infection.
MeSH term(s)	Humans ; Animals ; Bacteriophages ; Pseudomonas aeruginosa/genetics ; Zebrafish ; Virulence ; Phylogeny ; Plankton ; Pseudomonas Phages
Chemical Substances	diadenosine pyrophosphate (14938-28-4)
Language	English
Publishing date	2023-11-03
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-023-45313-x
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Article ; Online: Hesperidin methyl chalcone, a citrus flavonoid, inhibits Aeromonas hydrophila infection mediated by quorum sensing.

Roshni, Prithiviraj Swasthikka / Alexpandi, Rajaiah / Abirami, Gurusamy / Durgadevi, Ravindran / Cai, Yurong / Kumar, Ponnuchamy / Ravi, Arumugam Veera

Microbial pathogenesis

2023 Volume 177, Page(s) 106029

Abstract: Plant-derived phytocompounds are effective in treating a variety of ailments and disorders, the most common of which are bacterial infections in humans, which are a major public health concern. Flavonoids, one of the groups of phytocompounds, are known ... ...

Abstract	Plant-derived phytocompounds are effective in treating a variety of ailments and disorders, the most common of which are bacterial infections in humans, which are a major public health concern. Flavonoids, one of the groups of phytocompounds, are known to have significant antimicrobial and anti-infective properties. Hence, the current study investigates the efficacy of the citrus flavonoid hesperidin methylchalcone (HMC) in addressing this major issue. The results of this study indicate that the anti-quorum sensing (anti-QS) action against Aeromonas hydrophila infections is exhibited with a decrease in biofilm development and virulence factors production through in vitro and in silico analyses. In addition, the qPCR findings indicate that HMC has antivirulence action on A. hydrophila by reducing the expression of QS-related virulence genes, including ahyR, ahyB, ahh1, aerA, and lip. Interestingly, HMC significantly rescued the A. hydrophila-infected zebrafish by reducing the internal colonization, demonstrating the in vivo anti-infective potential of HMC against A. hydrophila infection. Based on these results, this study recommends that HMC could be employed as a possible therapeutic agent to treat A. hydrophila-related infections in humans.
MeSH term(s)	Animals ; Humans ; Chalcones/pharmacology ; Hesperidin/pharmacology ; Hesperidin/metabolism ; Aeromonas hydrophila ; Zebrafish ; Flavonoids/pharmacology ; Flavonoids/metabolism ; Biofilms ; Virulence Factors/genetics ; Bacterial Proteins/genetics ; Bacterial Proteins/metabolism
Chemical Substances	hesperidin methylchalcone (4T2GVA922X) ; Chalcones ; Hesperidin (E750O06Y6O) ; Flavonoids ; Virulence Factors ; Bacterial Proteins
Language	English
Publishing date	2023-02-10
Publishing country	England
Document type	Journal Article
ZDB-ID	632772-2
ISSN	1096-1208 ; 0882-4010
ISSN (online)	1096-1208
ISSN	0882-4010
DOI	10.1016/j.micpath.2023.106029
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Article: Inhibitory Effect of Morin Against

Abirami, Gurusamy / Alexpandi, Rajaiah / Durgadevi, Ravindran / Kannappan, Arunachalam / Veera Ravi, Arumugam

Frontiers in microbiology

2020 Volume 11, Page(s) 561298

Abstract: ... Candida ... ...

Abstract	Candida albicans
Keywords	covid19
Language	English
Publishing date	2020-10-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.561298
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Article ; Online: Tocopherol-assisted magnetic Ag-Fe

Alexpandi, Rajaiah / Abirami, Gurusamy / Murugesan, Balaji / Durgadevi, Ravindran / Swasthikka, Roshni Prithiviraj / Cai, Yurong / Ragupathi, Thennarasu / Ravi, Arumugam Veera

Journal of hazardous materials

2022 Volume 442, Page(s) 130044

Abstract: In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag- ... ...

Abstract	In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag-Fe
MeSH term(s)	Animals ; Zebrafish ; Catalysis ; Tocopherols ; Reactive Oxygen Species ; Tandem Mass Spectrometry ; Nanocomposites/toxicity ; Titanium/toxicity ; Sunlight ; Bacteria ; Nucleic Acids
Chemical Substances	titanium dioxide (15FIX9V2JP) ; Tocopherols (R0ZB2556P8) ; Reactive Oxygen Species ; Titanium (D1JT611TNE) ; Nucleic Acids
Language	English
Publishing date	2022-09-23
Publishing country	Netherlands
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130044
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Article ; Online: Two novel phages PSPa and APPa inhibit planktonic, sessile and persister populations of Pseudomonas aeruginosa, and mitigate its virulence in Zebrafish model

Chandrasekar Karthika / Nambiraman Malligarjunan / Ravi Jothi / Thirupathi Kasthuri / Rajaiah Alexpandi / Arumugam Veera Ravi / Shunmugiah Karutha Pandian / Shanmugaraj Gowrishankar

Scientific Reports, Vol 13, Iss 1, Pp 1-

2023 Volume 20

Abstract: Abstract The present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, ... ...

Abstract	Abstract The present study explores the avenue of phage therapy as an alternative antimicrobial therapeutic approach to counter multidrug-resistant (MDR) Pseudomonas aeruginosa infection. Our study investigated two novel virulent phages PSPa and APPa, specific to P. aeruginosa, in which in vitro evaluations were carried out to assess the therapeutic potential of phages. Both the identified phages exhibited host specificity by showing antagonistic activity of about 96.43% (27/28) and 92.85% (26/28) towards the 28 MDR clinical isolates of P. aeruginosa. The PSPa phage was found to have linear dsDNA with a sequence length of 66,368 bp and 92 ORFs, of which 32 were encoded for known functions of the phage life cycle and the remaining 60 were hypothetical functions. The APPa phage was found to have linear dsDNA with 59,591 bp of genome length and 79 ORFs, of which 15 were found to have known phage functions and the remaining 64 were found to be hypothetical proteins. Notably, the genome of both the phages lacks genes coding for tRNA, rRNA, and tmRNA. The phylogenetic analysis revealed that PSPa and APPa share > 95% sequence similarity with previously sequenced Pseudomonas viruses of their respective families. Further, the in vivo efficacy evaluation using the zebrafish model revealed that the treatment with PSPa and APPa has remarkably improved the survival rate of bacterial-infected zebrafish, reinforcing the anti-infective potential of the isolated phages PSPa and APPa against P. aeruginosa infection.
Keywords	Medicine ; R ; Science ; Q
Subject code	572
Language	English
Publishing date	2023-11-01T00:00:00Z
Publisher	Nature Portfolio
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sunlight-active phytol-ZnO@TiO

Alexpandi, Rajaiah / Abirami, Gurusamy / Balaji, Murugesan / Jayakumar, Rengarajan / Ponraj, Jeyaraj Godfred / Cai, Yurong / Pandian, Shunmugiah Karutha / Ravi, Arumugam Veera

Water research

2022 Volume 212, Page(s) 118081

Abstract: With a growing consciousness of the importance of nature stewardship, researchers are focusing their efforts on utilizing renewable energy, particularly solar energy, to address environmental concerns. In this context, photocatalysis has long been viewed ...

Abstract	With a growing consciousness of the importance of nature stewardship, researchers are focusing their efforts on utilizing renewable energy, particularly solar energy, to address environmental concerns. In this context, photocatalysis has long been viewed as one of the most promising cleaning methods. Hence, we have prepared a sunlight-active phytol-assisted ZnO-TiO
MeSH term(s)	Aquaculture ; Bacteria ; Catalysis ; Humans ; Nanocomposites ; Phytol ; Sunlight ; Titanium ; Zinc Oxide
Chemical Substances	Phytol (150-86-7) ; titanium dioxide (15FIX9V2JP) ; Titanium (D1JT611TNE) ; Zinc Oxide (SOI2LOH54Z)
Language	English
Publishing date	2022-01-15
Publishing country	England
Document type	Journal Article
ZDB-ID	202613-2
ISSN	1879-2448 ; 0043-1354
ISSN (online)	1879-2448
ISSN	0043-1354
DOI	10.1016/j.watres.2022.118081
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Article: Tocopherol-assisted Magnetic Ag-Fe3O4-TiO2 Nanocomposite for Photocatalytic Bacterial-inactivation With Elucidation of Mechanism and its Hazardous Level Assessment With Zebrafish Model

Alexpandi, Rajaiah / Abirami, Gurusamy / Murugesan, Balaji / Durgadevi, Ravindran / Swasthikka, Roshni Prithiviraj / Cai, Yurong / Ragupathi, Thennarasu / Ravi, Arumugam Veera

Journal of hazardous materials. 2022 Sept. 19,

2022

Abstract	In recent years, many endeavours have been prompted with photocatalytic nanomaterials by the need to eradicate pathogenic microorganisms from water bodies. Herein, a tocopherol-assisted Ag-Fe₃O₄-TiO₂ nanocomposite (TAFTN) was synthesized for photocatalytic bacterial inactivation. The prepared TAFTN became active under sunlight due to its narrowed bandgap, inactivating the bacterial contaminants via photo-induced ROS stress. The ROS radicals destroy bacteria by creating oxidative stress, which damages the cell membrane and cellular components such as nucleic acids and proteins. For the first time, the nano-LC-MS/MS-based quantitative proteomics reveals that the disrupted proteins are involved in a variety of cellular functions; the most of these are involved in the metabolic pathway, eventually leading to bacterial death during TAFTN-photocatalysis under sunlight. Furthermore, the toxicity analysis confirmed that the inactivated bacteria seemed to have no detrimental impact on zebrafish model, showing that the disinfected water via TAFTN-photocatalysis is enormously safe. Furthermore, the TAFTN-photocatalysis successfully killed the bacterial cells in natural seawater, indicating the consistent photocatalytic efficacy when recycled repeatedly. The results of this work demonstrate that the produced nanocomposite might be a powerful recyclable and sunlight-active photocatalyst for environmental water treatment.
Keywords	Danio rerio ; bacterial contamination ; biochemical pathways ; cell membranes ; death ; magnetism ; models ; nanocomposites ; nanomaterials ; oxidative stress ; photocatalysis ; photocatalysts ; proteomics ; seawater ; solar radiation ; toxicity ; water treatment
Language	English
Dates of publication	2022-0919
Publishing place	Elsevier B.V.
Document type	Article
Note	Pre-press version
ZDB-ID	1491302-1
ISSN	1873-3336 ; 0304-3894
ISSN (online)	1873-3336
ISSN	0304-3894
DOI	10.1016/j.jhazmat.2022.130044
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Article ; Online: Pyrogallol downregulates the expression of virulence-associated proteins in Acinetobacter baumannii and showing anti-infection activity by improving non-specific immune response in zebrafish model.

Abirami, Gurusamy / Alexpandi, Rajaiah / Sudhin, Sadasivan / Durgadevi, Ravindran / Swasthikka, Roshni Prithiviraj / Kumar, Ponnuchamy / Ravi, Arumugam Veera

International journal of biological macromolecules

2022

Abstract: Acinetobacter baumannii, a virulent uropathogen with widespread antibiotic resistance, has arisen as a critical scientific challenge, necessitating the development of innovative therapeutic agents. This is the first study reveal the proteomic changes in ... ...

Abstract	Acinetobacter baumannii, a virulent uropathogen with widespread antibiotic resistance, has arisen as a critical scientific challenge, necessitating the development of innovative therapeutic agents. This is the first study reveal the proteomic changes in A. baumannii upon pyrogallol treatment for understanding the mechanisms using nano-LC-MS/MS-based quantitative proteomics and qPCR analysis. The obtained results found that pyrogallol treatment dramatically downregulated the expression level of several key proteins such as GroEL, DnaK, ClpB, SodB, KatE, Bap, CsuA/B, PgaA, PgaC, BfmR, OmpA, and SecA in A. baumannii, which are involved in chaperone-mediated oxidative stress responses, antioxidant defence system, biofilm formation, virulence enzyme production, bacterial adhesion, capsule formation, and antibiotic resistance. Accordingly, the pyrogallol dramatically enhanced the lifespan of A. baumannii-infected zebrafish by inhibiting bacterial colonization, demonstrating the anti-infective potential of pyrogallol against A. baumannii. Further, the histopathological results also demonstrated the disease protection efficacy of pyrogallol against the pathognomonic sign of A. baumannii infection. In addition, the pyrogallol treatment effectively improved the immune parameters such as serum myeloperoxidase activity, leukocyte respiratory burst activity, and serum lysozyme activity in zebrafish against A. baumannii infection. Based on the results, the present study strongly proposes pyrogallol as a promising therapeutic agent for treating A. baumannii infection.
Language	English
Publishing date	2022-12-13
Publishing country	Netherlands
Document type	Journal Article
ZDB-ID	282732-3
ISSN	1879-0003 ; 0141-8130
ISSN (online)	1879-0003
ISSN	0141-8130
DOI	10.1016/j.ijbiomac.2022.12.045
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Article: Quinolines-Based SARS-CoV-2 3CLpro and RdRp Inhibitors and Spike-RBD-ACE2 Inhibitor for Drug-Repurposing Against COVID-19: An

Alexpandi, Rajaiah / De Mesquita, Joelma Freire / Pandian, Shunmugiah Karutha / Ravi, Arumugam Veera

Frontiers in microbiology

2020 Volume 11, Page(s) 1796

Abstract: The novel coronavirus SARS-CoV-2 disease "COVID-19" emerged in China and rapidly spread to other countries; due to its rapid worldwide spread, the WHO has declared this as a global emergency. As there is no specific treatment prescribed to treat COVID-19, ...

Abstract	The novel coronavirus SARS-CoV-2 disease "COVID-19" emerged in China and rapidly spread to other countries; due to its rapid worldwide spread, the WHO has declared this as a global emergency. As there is no specific treatment prescribed to treat COVID-19, the seeking of suitable therapeutics among existing drugs seems valuable. The structure availability of coronavirus macromolecules has encouraged the finding of conceivable anti-SARS-CoV-2 therapeutics through
Keywords	covid19
Language	English
Publishing date	2020-07-23
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2587354-4
ISSN	1664-302X
ISSN	1664-302X
DOI	10.3389/fmicb.2020.01796
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