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  1. Book ; Online ; E-Book: Antimicrobial resistance in the 21st Century

    Fong, Ignatius W. / Shlaes, David / Drlica, Karl

    (Emerging infectious diseases of the 21st Century)

    2018  

    Author's details I. W. Fong, David Shlaes, Karl Drlica editors
    Series title Emerging infectious diseases of the 21st Century
    Keywords Immunology ; Emerging infectious diseases ; Microbiology ; Medical virology ; Epidemiology
    Subject code 616.079
    Language English
    Size 1 Online-Ressource (XVIII, 775 Seiten), Illustrationen
    Edition Second edition
    Publisher Springer
    Publishing place Cham
    Publishing country Switzerland
    Document type Book ; Online ; E-Book
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT019936500
    ISBN 978-3-319-78538-7 ; 9783319785370 ; 3-319-78538-9 ; 3319785370
    DOI 10.1007/978-3-319-78538-7
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

    Full text online

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  2. Book: Understanding DNA and gene cloning

    Drlica, Karl

    a guide for the curious

    1997  

    Author's details Karl Drlica
    Keywords DNA, Recombinant ; Cloning, Molecular ; Genetic Engineering ; Molecular Biology ; Genklonierung
    Subject Klonierung ; Gen-Isolierung ; Molekulare Klonierung ; Kloniertes Gen
    Language English
    Size XVI, 329 S. : Ill., graph. Darst.
    Edition 3. ed.
    Publisher Wiley & Sons
    Publishing place New York u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007412314
    ISBN 0-471-13774-X ; 978-0-471-13774-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1997 A 4677 order for loan Magazin

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  3. Book: DNA und Genklonierung

    Drlica, Karl

    ein Leitfaden

    1995  

    Title translation Understanding DNA and gene cloning
    Author's details Karl Drlica
    Keywords Cloning, Molecular ; Genklonierung
    Subject Kompendium ; Klonierung ; Gen-Isolierung ; Molekulare Klonierung ; Kloniertes Gen
    Language German
    Size XV, 215 S. : Ill.
    Publisher Fischer
    Publishing place Stuttgart u.a.
    Publishing country Germany
    Document type Book
    Note Aus d. Engl. übers.
    HBZ-ID HT006670706
    ISBN 3-437-30769-X ; 978-3-437-30769-0
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 1815 order for loan Magazin

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  4. Article: Diabetes as a potential compounding factor in COVID-19-mediated male subfertility.

    Jiang, Qingkui / Linn, Thomas / Drlica, Karl / Shi, Lanbo

    Cell & bioscience

    2022  Volume 12, Issue 1, Page(s) 35

    Abstract: Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and Leydig ... ...

    Abstract Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and Leydig cells. Indirect effects on testis and concentrations of male reproductive hormones derive from (1) virus-stimulated inflammation; (2) viral-induced diabetes, and (3) an interaction between diabetes and inflammation that exacerbates the deleterious effect of each perturbation. Reproductive hormones affected include testosterone, luteinizing hormone, and follicle-stimulating hormone. Reduction of male fertility is also observed with other viral infections, but the global pandemic of COVID-19 makes demographic and public health implications of reduced male fertility of major concern, especially if it occurs in the absence of serious symptoms that would otherwise encourage vaccination. Clinical documentation of COVID-19-associated male subfertility is now warranted to obtain quantitative relationships between infection severity and subfertility; mechanistic studies using animal models may reveal ways to mitigate the problem. In the meantime, the possibility of subfertility due to COVID-19 should enter considerations of vaccine hesitancy by reproductive-age males.
    Language English
    Publishing date 2022-03-20
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 2593367-X
    ISSN 2045-3701
    ISSN 2045-3701
    DOI 10.1186/s13578-022-00766-x
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Fluoroquinolone heteroresistance, antimicrobial tolerance, and lethality enhancement.

    Singh, Amit / Zhao, Xilin / Drlica, Karl

    Frontiers in cellular and infection microbiology

    2022  Volume 12, Page(s) 938032

    Abstract: With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB. One way to reduce the emergence of resistance is to identify heteroresistant infections in which ... ...

    Abstract With tuberculosis, the emergence of fluoroquinolone resistance erodes the ability of treatment to interrupt the progression of MDR-TB to XDR-TB. One way to reduce the emergence of resistance is to identify heteroresistant infections in which subpopulations of resistant mutants are likely to expand and make the infections fully resistant: treatment modification can be instituted to suppress mutant enrichment. Rapid DNA-based detection methods exploit the finding that fluoroquinolone-resistant substitutions occur largely in a few codons of DNA gyrase. A second approach for restricting the emergence of resistance involves understanding fluoroquinolone lethality through studies of antimicrobial tolerance, a condition in which bacteria fail to be killed even though their growth is blocked by lethal agents. Studies with
    MeSH term(s) Animals ; Anti-Bacterial Agents/pharmacology ; Antitubercular Agents/pharmacology ; Antitubercular Agents/therapeutic use ; Cysteine ; DNA Gyrase/genetics ; Disinfectants ; Extensively Drug-Resistant Tuberculosis/drug therapy ; Fluoroquinolones/pharmacology ; Mice ; Microbial Sensitivity Tests ; Moxifloxacin ; Mycobacterium tuberculosis/genetics ; Mycobacterium tuberculosis/metabolism ; NAD ; Reactive Oxygen Species ; Tuberculosis, Multidrug-Resistant/drug therapy
    Chemical Substances Anti-Bacterial Agents ; Antitubercular Agents ; Disinfectants ; Fluoroquinolones ; Reactive Oxygen Species ; NAD (0U46U6E8UK) ; DNA Gyrase (EC 5.99.1.3) ; Cysteine (K848JZ4886) ; Moxifloxacin (U188XYD42P)
    Language English
    Publishing date 2022-09-29
    Publishing country Switzerland
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 2619676-1
    ISSN 2235-2988 ; 2235-2988
    ISSN (online) 2235-2988
    ISSN 2235-2988
    DOI 10.3389/fcimb.2022.938032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bacterial death from treatment with fluoroquinolones and other lethal stressors.

    Drlica, Karl / Zhao, Xilin

    Expert review of anti-infective therapy

    2020  Volume 19, Issue 5, Page(s) 601–618

    Abstract: Introduction: Lethal stressors, including antimicrobials, kill bacteria in part through a metabolic response proposed to involve reactive oxygen species (ROS). The quinolone anti-bacterials have served as key experimental tools in developing this idea.!# ...

    Abstract Introduction: Lethal stressors, including antimicrobials, kill bacteria in part through a metabolic response proposed to involve reactive oxygen species (ROS). The quinolone anti-bacterials have served as key experimental tools in developing this idea.
    Areas covered: Bacteriostatic and bactericidal action of quinolones are distinguished, with emphasis on the contribution of chromosome fragmentation and ROS accumulation to bacterial death. Action of non-quinolone antibacterials and non-antimicrobial stressors is described to provide a general framework for understanding stress-mediated, bacterial death.
    Expert opinion: Quinolones trap topoisomerases on DNA in reversible complexes that block DNA replication and bacterial growth. At elevated drug concentrations, DNA ends are released from topoisomerase-mediated constraint, leading to the idea that death arises from chromosome fragmentation. However, DNA ends also stimulate repair, which is energetically expensive. An incompletely understood metabolic shift occurs, and ROS accumulate. Even after quinolone removal, ROS continue to amplify, generating secondary and tertiary damage that overwhelms repair and causes death. Repair may also contribute to death directly via DNA breaks arising from incomplete base-excision repair of ROS-oxidized nucleotides. Remarkably, perturbations that interfere with ROS accumulation confer tolerance to many diverse lethal agents.
    MeSH term(s) Anti-Bacterial Agents/pharmacology ; Bacteria/drug effects ; Bacteria/genetics ; Bacteria/metabolism ; Cell Death/drug effects ; DNA, Bacterial/drug effects ; Fluoroquinolones/pharmacology ; Humans ; Reactive Oxygen Species/metabolism ; Stress, Physiological/drug effects
    Chemical Substances Anti-Bacterial Agents ; DNA, Bacterial ; Fluoroquinolones ; Reactive Oxygen Species
    Language English
    Publishing date 2020-11-16
    Publishing country England
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 2181279-2
    ISSN 1744-8336 ; 1478-7210
    ISSN (online) 1744-8336
    ISSN 1478-7210
    DOI 10.1080/14787210.2021.1840353
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 6106: Show issues Location:
    Je nach Verfügbarkeit (siehe Angabe bei Bestand)
    bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
    ab Jg. 2022: Lesesaal (EG)

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  7. Book: Double-edged sword

    Drlica, Karl

    the promises and risk of the genetic revolution

    (Helix books)

    1994  

    Author's details Karl A. Drlcia
    Series title Helix books
    Keywords Genetics, Medical ; Genetic Engineering ; Gentechnologie ; Sozialer Wandel ; Risiko ; Medizin
    Subject Humanmedizin ; Heilkunst ; Medicine ; Gentechnik ; Genchirurgie ; Genetic engineering ; Genetische Manipulation ; Genetische Technik ; Genmanipulation ; Gesellschaft ; Gesellschaftlicher Wandel ; Gesellschaftswandel ; Soziale Änderung ; Soziale Veränderung
    Language English
    Size IX, 242 S. : graph. Darst.
    Edition 1. print.
    Publisher Addison-Wesley
    Publishing place Reading, Mass. u.a.
    Publishing country United States
    Document type Book
    HBZ-ID HT007189524
    ISBN 0-201-40838-4 ; 978-0-201-40838-6
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1996 A 2839 order for loan Magazin

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  8. Book: The bacterial chromosome

    Drlica, Karl

    1990  

    Author's details ed. by Karl Drlica
    Keywords Chromosomes, Bacterial ; Bakterien ; Chromosom
    Subject Bacteriophyta ; Bazillen ; Schizomycetes ; Spaltpilze ; Bakterienflora ; Bacterium ; Bacteria ; Eubakterien ; Eubacteriales ; Eubacteria
    Language English
    Size XV, 469 S. : Ill., graph. Darst.
    Publisher American Society for Microbiology
    Publishing place Washington, D.C
    Publishing country United States
    Document type Book
    HBZ-ID HT003868890
    ISBN 1-55581-018-7 ; 978-1-55581-018-4
    Database Catalogue ZB MED Medicine, Health

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    In stock of ZB MED Cologne/Königswinter

    Shelf markLoan statusLocation
    1991 A 4241 order for loan Magazin

    Order via subito

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  9. Article ; Online: Diabetes as a potential compounding factor in COVID-19-mediated male subfertility

    Qingkui Jiang / Thomas Linn / Karl Drlica / Lanbo Shi

    Cell & Bioscience, Vol 12, Iss 1, Pp 1-

    2022  Volume 10

    Abstract: Abstract Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and ... ...

    Abstract Abstract Recent work indicates that male fertility is compromised by SARS-CoV-2 infection. Direct effects derive from the presence of viral entry receptors (ACE2 and/or CD147) on the surface of testicular cells, such as spermatocytes, Sertoli cells, and Leydig cells. Indirect effects on testis and concentrations of male reproductive hormones derive from (1) virus-stimulated inflammation; (2) viral-induced diabetes, and (3) an interaction between diabetes and inflammation that exacerbates the deleterious effect of each perturbation. Reproductive hormones affected include testosterone, luteinizing hormone, and follicle-stimulating hormone. Reduction of male fertility is also observed with other viral infections, but the global pandemic of COVID-19 makes demographic and public health implications of reduced male fertility of major concern, especially if it occurs in the absence of serious symptoms that would otherwise encourage vaccination. Clinical documentation of COVID-19-associated male subfertility is now warranted to obtain quantitative relationships between infection severity and subfertility; mechanistic studies using animal models may reveal ways to mitigate the problem. In the meantime, the possibility of subfertility due to COVID-19 should enter considerations of vaccine hesitancy by reproductive-age males.
    Keywords SARS-CoV-2 ; Inflammation ; Diabetes ; Spermatogenesis ; Male reproductive hormones ; Male subfertility ; Biotechnology ; TP248.13-248.65 ; Biology (General) ; QH301-705.5 ; Biochemistry ; QD415-436
    Subject code 590
    Language English
    Publishing date 2022-03-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  10. Article ; Online: Fluoroquinolones as imaging agents for bacterial infection.

    Naqvi, Syed Ali Raza / Drlica, Karl

    Dalton transactions (Cambridge, England : 2003)

    2017  Volume 46, Issue 42, Page(s) 14452–14460

    Abstract: Diagnosis of deep-seated bacterial infection is difficult, as neither standard anatomical imaging nor radiolabeled, autologous leukocytes distinguish sterile inflammation from infection. Two recent imaging efforts are receiving attention: (1) radioactive ...

    Abstract Diagnosis of deep-seated bacterial infection is difficult, as neither standard anatomical imaging nor radiolabeled, autologous leukocytes distinguish sterile inflammation from infection. Two recent imaging efforts are receiving attention: (1) radioactive derivatives of sorbitol show good specificity with Gram-negative bacterial infections, and (2) success in combining anatomical and functional imaging for cancer diagnosis has rekindled interest in
    MeSH term(s) Animals ; Bacterial Infections/diagnostic imaging ; Diagnostic Imaging/methods ; Fluoroquinolones/chemistry ; Humans
    Chemical Substances Fluoroquinolones
    Language English
    Publishing date 2017-09-18
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 1472887-4
    ISSN 1477-9234 ; 1364-5447 ; 0300-9246 ; 1477-9226
    ISSN (online) 1477-9234 ; 1364-5447
    ISSN 0300-9246 ; 1477-9226
    DOI 10.1039/c7dt01189j
    Database MEDical Literature Analysis and Retrieval System OnLINE

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