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  1. Article ; Online: Quinoxaline derivatives: Recent discoveries and development strategies towards anticancer agents.

    Montero, Vincent / Montana, Marc / Carré, Manon / Vanelle, Patrice

    European journal of medicinal chemistry

    2024  Volume 271, Page(s) 116360

    Abstract: Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, most drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, ... ...

    Abstract Cancer is a leading cause of death and a major health problem worldwide. While many effective anticancer agents are available, most drugs currently on the market are not specific, raising issues like the common side effects of chemotherapy. However, recent research hold promises for the development of more efficient and safer anticancer drugs. Quinoxaline and its derivatives are becoming recognized as a novel class of chemotherapeutic agents with activity against different tumors. The present review compiles and discusses studies concerning the therapeutic potential of the anticancer activity of quinoxaline derivatives, covering articles published between January 2018 and January 2023.
    Language English
    Publishing date 2024-04-07
    Publishing country France
    Document type Journal Article ; Review
    ZDB-ID 188597-2
    ISSN 1768-3254 ; 0009-4374 ; 0223-5234
    ISSN (online) 1768-3254
    ISSN 0009-4374 ; 0223-5234
    DOI 10.1016/j.ejmech.2024.116360
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    Zs.B 784: Show issues Location:
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  2. Article ; Online: Cobalt-Iron Oxyhydroxide Obtained from the Metal Phosphide: A Highly Effective Electrocatalyst for the Oxygen Evolution Reaction at High Current Densities.

    Díez-García, María Isabel / Montaña-Mora, Guillem / Botifoll, Marc / Cabot, Andreu / Arbiol, Jordi / Qamar, Mohammad / Morante, Joan Ramon

    ACS applied energy materials

    2023  Volume 6, Issue 11, Page(s) 5690–5699

    Abstract: The development of high current density anodes for the oxygen evolution reaction (OER) is fundamental to manufacturing practical and reliable electrochemical cells. In this work, we have developed a bimetallic electrocatalyst based on cobalt-iron ... ...

    Abstract The development of high current density anodes for the oxygen evolution reaction (OER) is fundamental to manufacturing practical and reliable electrochemical cells. In this work, we have developed a bimetallic electrocatalyst based on cobalt-iron oxyhydroxide that shows outstanding performance for water oxidation. Such a catalyst is obtained from cobalt-iron phosphide nanorods that serve as sacrificial structures for the formation of a bimetallic oxyhydroxide through phosphorous loss concomitantly to oxygen/hydroxide incorporation. CoFeP nanorods are synthesized using a scalable method using triphenyl phosphite as a phosphorous precursor. They are deposited without the use of binders on nickel foam to enable fast electron transport, a highly effective surface area, and a high density of active sites. The morphological and chemical transformation of the CoFeP nanoparticles is analyzed and compared with the monometallic cobalt phosphide in alkaline media and under anodic potentials. The resulting bimetallic electrode presents a Tafel slope as low as 42 mV dec
    Language English
    Publishing date 2023-05-25
    Publishing country United States
    Document type Journal Article
    ISSN 2574-0962
    ISSN (online) 2574-0962
    DOI 10.1021/acsaem.3c00032
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Enhanced Electrochemical Hydrogenation of Benzaldehyde to Benzyl Alcohol on Pd@Ni-MOF by Modifying the Adsorption Configuration.

    Gong, Li / Zhang, Chao Yue / Li, Junshan / Montaña-Mora, Guillem / Botifoll, Marc / Guo, Tiezhu / Arbiol, Jordi / Zhou, Jin Yuan / Kallio, Tanja / Martínez-Alanis, Paulina R / Cabot, Andreu

    ACS applied materials & interfaces

    2024  Volume 16, Issue 6, Page(s) 6948–6957

    Abstract: Electrocatalytic hydrogenation (ECH) approaches under ambient temperature and pressure offer significant potential advantages over thermal hydrogenation processes but require highly active and efficient hydrogenation electrocatalysts. The performance of ... ...

    Abstract Electrocatalytic hydrogenation (ECH) approaches under ambient temperature and pressure offer significant potential advantages over thermal hydrogenation processes but require highly active and efficient hydrogenation electrocatalysts. The performance of such hydrogenation electrocatalysts strongly depends not only on the active phase but also on the architecture and surface chemistry of the support material. Herein, Pd nanoparticles supported on a nickel metal-organic framework (MOF), Ni-MOF-74, are prepared, and their activity toward the ECH of benzaldehyde (BZH) in a 3 M acetate (pH 5.2) aqueous electrolyte is explored. An outstanding ECH rate up to 283 μmol cm
    Language English
    Publishing date 2024-02-02
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.3c13920
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  4. Article ; Online: Atypical cortical hierarchy in Aβ-positive older adults and its reflection in spontaneous speech.

    He, Rui / Al-Tamimi, Jalal / Sánchez-Benavides, Gonzalo / Montaña-Valverde, Guillermo / Domingo Gispert, Juan / Grau-Rivera, Oriol / Suárez-Calvet, Marc / Minguillon, Carolina / Fauria, Karine / Navarro, Arcadi / Hinzen, Wolfram

    Brain research

    2024  Volume 1830, Page(s) 148806

    Abstract: ... as indexed by Aβ accumulation is marked by neurofunctional changes in the cortical hierarchy, which are ...

    Abstract Abnormal deposition of Aβ amyloid is an early neuropathological marker of Alzheimer's disease (AD), arising long ahead of clinical symptoms. Non-invasive measures of associated early neurofunctional changes, together with easily accessible behavioral readouts of these changes, could be of great clinical benefit. We pursued this aim by investigating large-scale cortical gradients of functional connectivity with functional MRI, which capture the hierarchical integration of cortical functions, together with acoustic-prosodic features from spontaneous speech, in cognitively unimpaired older adults with and without Aβ positivity (total N = 188). We predicted distortions of the cortical hierarchy associated with prosodic changes in the Aβ + group. Results confirmed substantially altered cortical hierarchies and less variability in these in the Aβ + group, together with an increase in quantitative prosodic measures, which correlated with gradient variability as well as digit span test scores. Overall, these findings confirm that long before the clinical stage and objective cognitive impairment, increased risk of cognitive decline as indexed by Aβ accumulation is marked by neurofunctional changes in the cortical hierarchy, which are related to automatically extractable speech patterns and alterations in working memory functions.
    MeSH term(s) Humans ; Aged ; Amyloid beta-Peptides ; Speech ; Positron-Emission Tomography ; Alzheimer Disease ; Cognitive Dysfunction/psychology
    Chemical Substances Amyloid beta-Peptides
    Language English
    Publishing date 2024-02-15
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1200-2
    ISSN 1872-6240 ; 0006-8993
    ISSN (online) 1872-6240
    ISSN 0006-8993
    DOI 10.1016/j.brainres.2024.148806
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    Zs.A 161: Show issues Location:
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  5. Article ; Online: Quinoxaline Moiety: A Potential Scaffold against

    Montana, Marc / Montero, Vincent / Khoumeri, Omar / Vanelle, Patrice

    Molecules (Basel, Switzerland)

    2021  Volume 26, Issue 16

    Abstract: ... ...

    Abstract Background
    MeSH term(s) Anti-Bacterial Agents/chemistry ; Anti-Bacterial Agents/pharmacology ; Mycobacterium tuberculosis/drug effects ; Quinoxalines/chemistry ; Quinoxalines/pharmacology ; Structure-Activity Relationship
    Chemical Substances Anti-Bacterial Agents ; Quinoxalines
    Language English
    Publishing date 2021-08-05
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules26164742
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  6. Article ; Online: Ricin poisoning: A review on contamination source, diagnosis, treatment, prevention and reporting of ricin poisoning.

    Abbes, Melissa / Montana, Marc / Curti, Christophe / Vanelle, Patrice

    Toxicon : official journal of the International Society on Toxinology

    2021  Volume 195, Page(s) 86–92

    Abstract: Introduction: Ricin, a toxic glycoprotein derived from the castor bean plant, is one of the most potent poisons known in the world. Ricin intoxication is a fatal and uncommon medical condition and recently its use as a potential bioterrorism agent has ... ...

    Abstract Introduction: Ricin, a toxic glycoprotein derived from the castor bean plant, is one of the most potent poisons known in the world. Ricin intoxication is a fatal and uncommon medical condition and recently its use as a potential bioterrorism agent has also been reported. This study aims to identify the main characteristics of diagnosed ricin poisoning cases worldwide in order to raise awareness of this toxin among the population and clinicians.
    Methods: A collection of human case studies of ricin intoxication in the world was produced. The databases Pubmed, Sciencedirect and Google Scholar were used to extract articles from January 1980 to June 2020.
    Results: Fifty ricin-intoxicated patients worldwide described in the literature have been identified. Most cases were found in Asia (19 cases), Europe (12 cases) and America (15 cases). Intoxication was mostly accidental (37 cases). Intoxication by castor bean is characterized by acute gastroenteritis-like disease as primary manifestations leading to severe fluid and electrolyte imbalance. The mechanism of death was peripheral vascular collapse and progressing multiple organ failure occurring 10h-72h after intoxication. The questioning of patients and family made it possible to retrieve an history of castor seeds or castor oil ingestion Patients received symptomatic treatment consisting mostly to rehydration with intravenous fluids and digestive decontamination performed with activated charcoal and/or gastric lavage within one day after the ingestion, to reduce gastrointestinal absorption of ricin. This decontamination treatment administered early has been very effective. Only six deaths were observed.
    Discussion: Currently, no antidote, vaccine, or other specific effective treatment is available for ricin poisoning or prevention. Prompt treatment with supportive care was necessary to limit morbidity and mortality. To date, patient education is essential to prevent this accidental poisoning.
    Conclusion: Clinicians and health care professionals should have a high level of suspicion when faced with an outbreak of serious respiratory or gastrointestinal illness.
    MeSH term(s) Asia ; Ricinus communis ; Europe ; Humans ; Plant Poisoning/diagnosis ; Plant Poisoning/prevention & control ; Ricin/poisoning ; Ricin/toxicity
    Chemical Substances Ricin (9009-86-3)
    Language English
    Publishing date 2021-03-09
    Publishing country England
    Document type Journal Article ; Review
    ZDB-ID 204479-1
    ISSN 1879-3150 ; 0041-0101
    ISSN (online) 1879-3150
    ISSN 0041-0101
    DOI 10.1016/j.toxicon.2021.03.004
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    Zs.A 501: Show issues Location:
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  7. Article ; Online: Quinoxaline Derivatives as Antiviral Agents: A Systematic Review.

    Montana, Marc / Montero, Vincent / Khoumeri, Omar / Vanelle, Patrice

    Molecules (Basel, Switzerland)

    2020  Volume 25, Issue 12

    Abstract: Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably ... ...

    Abstract Background: In recent decades, several viruses have jumped from animals to humans, triggering sizable outbreaks. The current unprecedent outbreak SARS-COV-2 is prompting a search for new cost-effective therapies to combat this deadly pathogen. Suitably functionalized polysubstituted quinoxalines show very interesting biological properties (antiviral, anticancer, and antileishmanial), ensuring them a bright future in medicinal chemistry.
    Objectives: Focusing on the promising development of new quinoxaline derivatives as antiviral drugs, this review forms part of our program on the anti-infectious activity of quinoxaline derivatives.
    Methods: Study compiles and discusses recently published studies concerning the therapeutic potential of the antiviral activity of quinoxaline derivatives, covering the literature between 2010 and 2020.
    Results: A final total of 20 studies included in this review.
    Conclusions: This review points to a growing interest in the development of compounds bearing a quinoxaline moiety for antiviral treatment. This promising moiety with different molecular targets warrants further investigation, which may well yield even more encouraging results regarding this scaffold.
    MeSH term(s) Antiviral Agents/therapeutic use ; Betacoronavirus/drug effects ; COVID-19 ; Coronavirus Infections/drug therapy ; DNA Viruses/drug effects ; Humans ; Pandemics ; Pneumonia, Viral/drug therapy ; Quinoxalines/chemistry ; Quinoxalines/therapeutic use ; SARS-CoV-2 ; Structure-Activity Relationship
    Chemical Substances Antiviral Agents ; Quinoxalines
    Keywords covid19
    Language English
    Publishing date 2020-06-16
    Publishing country Switzerland
    Document type Journal Article ; Systematic Review
    ZDB-ID 1413402-0
    ISSN 1420-3049 ; 1431-5165 ; 1420-3049
    ISSN (online) 1420-3049
    ISSN 1431-5165 ; 1420-3049
    DOI 10.3390/molecules25122784
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  8. Article ; Online: Quinoxaline Moiety

    Marc Montana / Vincent Montero / Omar Khoumeri / Patrice Vanelle

    Molecules, Vol 26, Iss 4742, p

    A Potential Scaffold against Mycobacterium tuberculosis

    2021  Volume 4742

    Abstract: Background . The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to ... ...

    Abstract Background . The past decades have seen numerous efforts to develop new antitubercular agents. Currently, the available regimens are lengthy, only partially effective, and associated with high rates of adverse events. The challenge is therefore to develop new agents with faster and more efficient action. The versatile quinoxaline ring possesses a broad spectrum of pharmacological activities, ensuring considerable attention to it in the field of medicinal chemistry. Objectives . In continuation of our program on the pharmacological activity of quinoxaline derivatives, this review focuses on potential antimycobacterial activity of recent quinoxaline derivatives and discusses their structure—activity relationship for designing new analogs with improved activity. Methods . The review compiles recent studies published between January 2011 and April 2021. Results . The final total of 23 studies were examined. Conclusions. Data from studies of quinoxaline and quinoxaline 1,4-di- N -oxide derivatives highlight that specific derivatives show encouraging perspectives in the treatment of Mycobacterium tuberculosis and the recent growing interest for these scaffolds. These interesting results warrant further investigation, which may allow identification of novel antitubercular candidates based on this scaffold.
    Keywords quinoxaline ; Mycobacterium ; tuberculosis ; SAR ; biological applications ; chemistry ; Organic chemistry ; QD241-441
    Subject code 540
    Language English
    Publishing date 2021-08-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article: Synthesis, In Vitro Antiproliferative Activity, and In Silico Evaluation of Novel Oxiranyl-Quinoxaline Derivatives.

    Montero, Vincent / Montana, Marc / Khoumeri, Omar / Correard, Florian / Estève, Marie-Anne / Vanelle, Patrice

    Pharmaceuticals (Basel, Switzerland)

    2022  Volume 15, Issue 7

    Abstract: The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative ... ...

    Abstract The quinoxaline core is a promising scaffold in medicinal chemistry. Multiple quinoxaline derivatives, such as the topoisomerase IIβ inhibitor XK-469 and the tissue transglutaminase 2 inhibitor GK-13, have been evaluated for their antiproliferative activity. Previous work reported that quinoxaline derivatives bearing an oxirane ring present antiproliferative properties against neuroblastoma cell lines SK-N-SH and IMR-32. Likewise, quinoxalines with an arylethynyl group displayed promising antineoplastic properties against glioblastoma and lung cancer cell lines, U87-MG and A549 respectively. Here, 40 new quinoxaline derivatives bearing an oxirane ring were synthesized using a tetrakis(dimethylamino)ethylene (TDAE) strategy and a Sonogashira cross-coupling reaction. Each reaction with TDAE furnished a pair of diastereoisomers
    Language English
    Publishing date 2022-06-23
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph15070781
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  10. Article ; Online: Editors' awardees for 2023.

    Dewhirst, Mark W / Montana, Emeritus Gustavo S

    International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group

    2023  Volume 40, Issue 1, Page(s) 2283908

    Language English
    Publishing date 2023-12-04
    Publishing country England
    Document type Editorial
    ZDB-ID 632526-9
    ISSN 1464-5157 ; 0265-6736
    ISSN (online) 1464-5157
    ISSN 0265-6736
    DOI 10.1080/02656736.2023.2283908
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