Article: The neuroprotective effect of picroside II from hu-huang-lian against oxidative stress.
The American journal of Chinese medicine
2007 Volume 35, Issue 4, Page(s) 681–691
Abstract: ... huang-lian. To evaluate the neuroprotective effect of picroside II, PC12 cells were treated ... Picroside II is an active constituent extracted from the traditional Chinese medicine (TCM) hu ...
| Abstract | Picroside II is an active constituent extracted from the traditional Chinese medicine (TCM) hu-huang-lian. To evaluate the neuroprotective effect of picroside II, PC12 cells were treated with glutamate in vitro and male ICR mice were treated with AlCl(3) in vivo. Pre-treatment of PC12 cells with picroside II could enhance the cell viability and decrease the level of intracellular reactive oxygen species (ROS) induced by glutamate. By DNA fragmentation and flow cytometry assay, picroside II (1.2 mg/ml) significantly prevented glutamate-induced cell apoptosis. In the animal study, amnesia was induced in mice by AlCl(3) (100 mg/kg/d, i.v.). Pricroside II, at the dose of 20 and 40 mg/kg/d (i.g.), markedly ameliorated AlCl(3)-induced learning and memory dysfunctions and attenuated AlCl(3)-induced histological changes. This was associated with the significant increased superoxide dismutase (SOD) activity in the brain of experimental mice. All these results indicated that picroside II possessed the therapeutic potential in protecting against neurological injuries damaged by oxidative stress. |
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| MeSH term(s) | Adrenal Gland Neoplasms/pathology ; Aluminum Compounds ; Animals ; Apoptosis/drug effects ; Cell Survival/drug effects ; Chlorides ; Cinnamates/pharmacology ; Cinnamates/therapeutic use ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Glucosides/pharmacology ; Glucosides/therapeutic use ; Glutamates ; Iridoid Glucosides ; Learning/drug effects ; Male ; Medicine, Chinese Traditional ; Memory Disorders/chemically induced ; Memory Disorders/prevention & control ; Mice ; Mice, Inbred ICR ; Oxidative Stress/drug effects ; PC12 Cells ; Pheochromocytoma/pathology ; Phytotherapy/methods ; Random Allocation ; Rats |
| Chemical Substances | Aluminum Compounds ; Chlorides ; Cinnamates ; Drugs, Chinese Herbal ; Glucosides ; Glutamates ; Iridoid Glucosides ; picroside II (39012-20-9) ; aluminum chloride (3CYT62D3GA) |
| Language | English |
| Publishing date | 2007 |
| Publishing country | Singapore |
| Document type | Journal Article ; Research Support, Non-U.S. Gov't |
| ZDB-ID | 193085-0 |
| ISSN | 0192-415X ; 0090-2942 |
| ISSN | 0192-415X ; 0090-2942 |
| DOI | 10.1142/S0192415X0700517X |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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