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  1. Book ; Online ; E-Book: Emerging trends in environmental biotechnology

    Mondal, Sukanta / Pratap Singh, Shivesh / Kumar Lahir, Yogendra

    2023  

    Author's details edited by Sukanta Mondal, Shivesh Pratap Singh and Yogendra Kumar Lahir
    Keywords Electronic books
    Language English
    Size 1 Online-Ressource (xvi, 298 Seiten), Illustrationen
    Publisher CRC Press
    Publishing place Boca Raton, Fla
    Publishing country Great Britain
    Document type Book ; Online ; E-Book
    Note Description based on publisher supplied metadata and other sources
    Remark Zugriff für angemeldete ZB MED-Nutzerinnen und -Nutzer
    HBZ-ID HT021431922
    ISBN 978-1-00-055730-5 ; 9781032030258 ; 1-00-055730-8 ; 1032030259
    Database ZB MED Catalogue: Medicine, Health, Nutrition, Environment, Agriculture

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  2. Article ; Online: Multitasking functions of bacterial extracellular DNA in biofilms.

    Sharma, Dhirendra Kumar / Rajpurohit, Yogendra Singh

    Journal of bacteriology

    2024  Volume 206, Issue 4, Page(s) e0000624

    Abstract: Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) ... ...

    Abstract Bacterial biofilms are intricate ecosystems of microbial communities that adhere to various surfaces and are enveloped by an extracellular matrix composed of polymeric substances. Within the context of bacterial biofilms, extracellular DNA (eDNA) originates from cell lysis or is actively secreted, where it exerts a significant influence on the formation, stability, and resistance of biofilms to environmental stressors. The exploration of eDNA within bacterial biofilms holds paramount importance in research, with far-reaching implications for both human health and the environment. An enhanced understanding of the functions of eDNA in biofilm formation and antibiotic resistance could inspire the development of strategies to combat biofilm-related infections and improve the management of antibiotic resistance. This comprehensive review encapsulates the latest discoveries concerning eDNA, encompassing its origins, functions within bacterial biofilms, and significance in bacterial pathogenesis.
    MeSH term(s) Humans ; DNA, Bacterial/genetics ; Ecosystem ; Biofilms ; Bacteria/genetics ; Extracellular Matrix
    Chemical Substances DNA, Bacterial
    Language English
    Publishing date 2024-03-06
    Publishing country United States
    Document type Journal Article ; Review
    ZDB-ID 2968-3
    ISSN 1098-5530 ; 0021-9193
    ISSN (online) 1098-5530
    ISSN 0021-9193
    DOI 10.1128/jb.00006-24
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: DNA damage response and cell cycle regulation in bacteria: a twist around the paradigm.

    Misra, Hari Sharan / Rajpurohit, Yogendra Singh

    Frontiers in microbiology

    2024  Volume 15, Page(s) 1389074

    Abstract: The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control. This process is called the SOS response, and genes that are expressed in response to DNA ... ...

    Abstract The co-protease activity in the RecA-ssDNA complex cleaves the autorepressor LexA, resulting in the derepression of a large number of genes under LexA control. This process is called the SOS response, and genes that are expressed in response to DNA damage are called SOS genes. The proteins encoded by the SOS genes are involved in both DNA repair and maintaining the functions of crucial cell division proteins (e.g., FtsZ) under check until the damaged DNA is presumably repaired. This mechanism of SOS response is the only known mechanism of DNA damage response and cell cycle regulation in bacteria. However, there are bacteria that do not obey this rule of DNA damage response and cell cycle regulation, yet they respond to DNA damage, repair it, and survive. That means such bacteria would have some alternate mechanism(s) of DNA damage response and cell cycle regulation beyond the canonical pathway of the SOS response. In this study, we present the perspectives that bacteria may have other mechanisms of DNA damage response and cell cycle regulation mediated by bacterial eukaryotic type Ser/Thr protein kinases as an alternate to the canonical SOS response and herewith elaborate on them with a well-studied example in the radioresistant bacterium
    Language English
    Publishing date 2024-03-28
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2587354-4
    ISSN 1664-302X
    ISSN 1664-302X
    DOI 10.3389/fmicb.2024.1389074
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Novel Bottom-Side Polished PCF-Based Plasmonic Biosensor for Early Detection of Hazardous Cancerous Cells.

    Singh, Shivam / Prajapati, Yogendra Kumar

    IEEE transactions on nanobioscience

    2023  Volume 22, Issue 3, Page(s) 647–654

    Abstract: This work presents a single-core bowl-shaped bottom-side polished (BSP) photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) concept for the early detection of hazardous cancer cells in human blood, skin, cervical, breast, and ... ...

    Abstract This work presents a single-core bowl-shaped bottom-side polished (BSP) photonic crystal fiber (PCF) sensor based on surface plasmon resonance (SPR) concept for the early detection of hazardous cancer cells in human blood, skin, cervical, breast, and adrenal glands. We have studied liquid samples of cancer-affected and healthy samples with their concentrations/refractive indices in the sensing medium. To induce a plasmonic effect in the PCF sensor, the bottom flat section of a silica PCF fiber is coated with a 40nm plasmonic material, such as gold. To strengthen this effect, a thin TiO
    MeSH term(s) Humans ; Female ; Gold ; Metal Nanoparticles ; Early Detection of Cancer ; Uterine Cervical Neoplasms/diagnosis ; Surface Plasmon Resonance
    Chemical Substances Gold (7440-57-5)
    Language English
    Publishing date 2023-06-29
    Publishing country United States
    Document type Journal Article
    ISSN 1558-2639
    ISSN (online) 1558-2639
    DOI 10.1109/TNB.2023.3233990
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Natural transformation-specific DprA coordinate DNA double-strand break repair pathways in heavily irradiated

    Sharma, Dhirendra Kumar / Soni, Ishu / Misra, Hari S / Rajpurohit, Yogendra Singh

    Applied and environmental microbiology

    2024  Volume 90, Issue 2, Page(s) e0194823

    Abstract: Deinococcus ... ...

    Abstract Deinococcus radiodurans
    MeSH term(s) Bacterial Proteins/genetics ; Bacterial Proteins/metabolism ; DNA Repair ; DNA Breaks, Double-Stranded ; DNA/metabolism ; DNA Damage ; Deinococcus/genetics ; Deinococcus/metabolism ; DNA, Bacterial/genetics ; DNA, Bacterial/metabolism
    Chemical Substances Bacterial Proteins ; DNA (9007-49-2) ; DNA, Bacterial
    Language English
    Publishing date 2024-01-09
    Publishing country United States
    Document type Journal Article
    ZDB-ID 223011-2
    ISSN 1098-5336 ; 0099-2240
    ISSN (online) 1098-5336
    ISSN 0099-2240
    DOI 10.1128/aem.01948-23
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: A Giant Scrotal Neurofibroma in a Child Masquerading as Filariasis: Uncommon Presentation of a Common Disease.

    Singh, Anurag / Singh, Gyanendra / Verma, Anuragani / Verma, Yogendra Narayan

    Prague medical report

    2024  Volume 125, Issue 1, Page(s) 56–61

    Abstract: Neurofibroma of the scrotum is a very uncommon benign neoplasm, specifically when it affects teenagers and is not associated with neurofibromatosis type I. To the best of our knowledge, only a couple of cases of neurofibroma in children have been ... ...

    Abstract Neurofibroma of the scrotum is a very uncommon benign neoplasm, specifically when it affects teenagers and is not associated with neurofibromatosis type I. To the best of our knowledge, only a couple of cases of neurofibroma in children have been documented. Here, we report a case study of a 17-year-old boy who had a giant scrotal lump for ten years masquerading clinically as filariasis. A provisional diagnosis of benign nerve sheath neoplasm was made based on cytology findings. The lump was surgically removed from the patient, and a histopathological and immunohistochemistry examination established the diagnosis of neurofibroma. The combined clinical, preoperative cytological, histological, and immunohistochemistry findings were not presented in the literature in any of the formerly documented cases of scrotal neurofibroma. The current case expands the spectrum of differential diagnoses for scrotal tumours that clinicians have previously observed.
    MeSH term(s) Male ; Adolescent ; Child ; Humans ; Scrotum/pathology ; Neurofibroma/diagnosis ; Neurofibroma/pathology ; Neurofibroma/surgery ; Neurofibromatosis 1/complications ; Neurofibromatosis 1/pathology ; Genital Neoplasms, Male/diagnosis ; Genital Neoplasms, Male/surgery ; Genital Neoplasms, Male/complications ; Filariasis/diagnosis ; Filariasis/complications ; Filariasis/pathology ; Nematode Infections/complications ; Nematode Infections/pathology
    Language English
    Publishing date 2024-02-21
    Publishing country Czech Republic
    Document type Case Reports ; Journal Article
    ZDB-ID 2148569-0
    ISSN 1214-6994
    ISSN 1214-6994
    DOI 10.14712/23362936.2024.5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article: Low abundance of healthy bacteria in the gastric microbiota can be a potential biomarker for gastrointestinal diseases: A pilot study.

    Arfi, Safiya / Sharma, Prateek / Das, Kunal / Bhaskar, Yogendra / Goel, Isha / Singh, Harpreet / Das, Rajashree

    The Indian journal of medical research

    2024  Volume 159, Issue 2, Page(s) 254–258

    MeSH term(s) Humans ; Pilot Projects ; Microbiota ; Bacteria/genetics ; Gastrointestinal Diseases/diagnosis ; Biomarkers ; RNA, Ribosomal, 16S
    Chemical Substances Biomarkers ; RNA, Ribosomal, 16S
    Language English
    Publishing date 2024-04-04
    Publishing country India
    Document type Journal Article
    ZDB-ID 390883-5
    ISSN 0971-5916 ; 0019-5340
    ISSN 0971-5916 ; 0019-5340
    DOI 10.4103/ijmr.ijmr_864_23
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  8. Article ; Online: Neuroleptic Malignant Syndrome in a 15-Month-Old Child: A Case Report.

    Penugonda, Asha Jyothi / Singh, Yogendra / Kattula, Dheeraj / Bhaskar, Mona

    Journal of clinical psychopharmacology

    2023  Volume 43, Issue 5, Page(s) 455–456

    MeSH term(s) Humans ; Infant ; Neuroleptic Malignant Syndrome/diagnosis
    Language English
    Publishing date 2023-08-07
    Publishing country United States
    Document type Case Reports ; Letter
    ZDB-ID 604631-9
    ISSN 1533-712X ; 0271-0749
    ISSN (online) 1533-712X
    ISSN 0271-0749
    DOI 10.1097/JCP.0000000000001749
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  9. Article ; Online: A perspective on tumor radiation resistance following high-LET radiation treatment.

    Rajpurohit, Yogendra Singh / Sharma, Dhirendra Kumar / Lal, Mitu / Soni, Ishu

    Journal of cancer research and clinical oncology

    2024  Volume 150, Issue 5, Page(s) 226

    Abstract: High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation ... ...

    Abstract High-linear energy transfer (LET) radiation is a promising alternative to conventional low-LET radiation for therapeutic gain against cancer owing to its ability to induce complex and clustered DNA lesions. However, the development of radiation resistance poses a significant barrier. The potential molecular mechanisms that could confer resistance development are translesion synthesis (TLS), replication gap suppression (RGS) mechanisms, autophagy, epithelial-mesenchymal transition (EMT) activation, release of exosomes, and epigenetic changes. This article will discuss various types of complex clustered DNA damage, their repair mechanisms, mutagenic potential, and the development of radiation resistance strategies. Furthermore, it highlights the importance of careful consideration and patient selection when employing high-LET radiotherapy in clinical settings.
    MeSH term(s) Humans ; Neoplasms/radiotherapy ; Neoplasms/pathology ; Radiation Tolerance ; Linear Energy Transfer ; DNA Damage/radiation effects ; DNA Repair/radiation effects ; Animals
    Language English
    Publishing date 2024-05-02
    Publishing country Germany
    Document type Journal Article ; Review ; Letter
    ZDB-ID 134792-5
    ISSN 1432-1335 ; 0171-5216 ; 0084-5353 ; 0943-9382
    ISSN (online) 1432-1335
    ISSN 0171-5216 ; 0084-5353 ; 0943-9382
    DOI 10.1007/s00432-024-05757-8
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  10. Article ; Online: Gelatin-based electrospun and lyophilized scaffolds with nano scale feature for bone tissue engineering application: review.

    Singh, Yogendra Pratap / Dasgupta, Sudip

    Journal of biomaterials science. Polymer edition

    2022  Volume 33, Issue 13, Page(s) 1704–1758

    Abstract: The rebuilding of the normal functioning of the damaged human body bone tissue is one of the main objectives of bone tissue engineering (BTE). Fabricated scaffolds are mostly treated as artificial supports and as materials for regeneration of neo bone ... ...

    Abstract The rebuilding of the normal functioning of the damaged human body bone tissue is one of the main objectives of bone tissue engineering (BTE). Fabricated scaffolds are mostly treated as artificial supports and as materials for regeneration of neo bone tissues and must closely biomimetic the native extracellular matrix of bone. The materials used for developing scaffolds should be biodegradable, nontoxic, and biocompatible. For the resurrection of bone disorder, specifically natural and synthetic polymers such as chitosan, PCL, gelatin, PGA, PLA, PLGA, etc. meet the requirements for serving their functions as artificial bone substitute materials. Gelatin is one of the potential candidates which could be blended with other polymers or composites to improve its physicochemical, mechanical, and biological performances as a bone graft. Scaffolds are produced by several methods including electrospinning, self-assembly, freeze-drying, phase separation, fiber drawing, template synthesis, etc. Among them, freeze-drying and electrospinning are among the popular, simplest, versatile, and cost-effective techniques. The design and preparation of freeze-dried and electrospun scaffolds are of intense research over the last two decades. Freeze-dried and electrospun scaffolds offer a distinctive architecture at the micro to nano range with desired porosity and pore interconnectivity for selective movement of small biomolecules and play its role as an appropriate matrix very similar to the natural bone extracellular matrix. This review focuses on the properties and functionalization of gelatin-based polymer and its composite in the form of bone scaffolds fabricated primarily using lyophilization and electrospinning technique and their applications in BTE.
    MeSH term(s) Biocompatible Materials ; Bone and Bones ; Gelatin/chemistry ; Humans ; Polyesters/chemistry ; Polymers ; Porosity ; Tissue Engineering/methods ; Tissue Scaffolds/chemistry
    Chemical Substances Biocompatible Materials ; Polyesters ; Polymers ; Gelatin (9000-70-8)
    Language English
    Publishing date 2022-05-28
    Publishing country England
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 1014190-x
    ISSN 1568-5624 ; 1568-5616 ; 0920-5063
    ISSN (online) 1568-5624 ; 1568-5616
    ISSN 0920-5063
    DOI 10.1080/09205063.2022.2068943
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