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Article ; Online: RAGE receptor: May be a potential inflammatory mediator for SARS-COV-2 infection?

Kerkeni, Mohsen / Gharbi, Jawhar

2020 Volume 144, Page(s) 109950

MeSH term(s)	Angiotensin-Converting Enzyme 2/metabolism ; Antigens, Neoplasm/physiology ; COVID-19/immunology ; COVID-19/metabolism ; Cytokines/metabolism ; Disease Progression ; HMGB1 Protein/genetics ; HMGB1 Protein/metabolism ; Humans ; Inflammation ; Inflammation Mediators ; Ligands ; Lung/physiology ; Mitogen-Activated Protein Kinases/physiology ; Models, Theoretical ; Protein Binding ; Protein Domains ; S100 Proteins/metabolism ; Signal Transduction
Chemical Substances	Antigens, Neoplasm ; Cytokines ; HMGB1 Protein ; HMGB1 protein, human ; Inflammation Mediators ; Ligands ; S100 Proteins ; MOK protein, human (EC 2.7.11.22) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; ACE2 protein, human (EC 3.4.17.23) ; Angiotensin-Converting Enzyme 2 (EC 3.4.17.23)
Keywords	covid19
Language	English
Publishing date	2020-06-05
Publishing country	United States
Document type	Editorial
ZDB-ID	193145-3
ISSN	1532-2777 ; 0306-9877
ISSN (online)	1532-2777
ISSN	0306-9877
DOI	10.1016/j.mehy.2020.109950
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Article: RAGE receptor: May be a potential inflammatory mediator for SARS-COV-2 infection?

Kerkeni, Mohsen / Gharbi, Jawhar

Med Hypotheses

Keywords	covid19
Publisher	WHO
Document type	Article
Note	WHO #Covidence: #548594
Database	COVID19

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Article: Lipid and oxidative profile in hemodialysis patients: Clinical follow-up for three years.

Ben Omrane Sioud, Olfa / El Ati, Zohra / Bouzidi, Hassan / Kerkeni, Mohsen / Hammami, Mohamed

La Tunisie medicale

2019 Volume 97, Issue 4, Page(s) 551–555

Abstract: Background: The major cause of death for hemodialysis (HD) patients was cardiovascular morbidity; it was closely related to oxidative stress (OS).: Aim: Firstly, to evaluate lipid peroxidation biomarkers on HD patients through measuring ... ...

Abstract	Background: The major cause of death for hemodialysis (HD) patients was cardiovascular morbidity; it was closely related to oxidative stress (OS). Aim: Firstly, to evaluate lipid peroxidation biomarkers on HD patients through measuring malondialdehyde (MDA) and conjugated dienes (CD), and secondly, to follow these parameters after three years undergoing HD. Methods: One hundred patients with end stage renal diseases receiving regular hemodialysis and 100 healthy volunteers were included in this study. Routine chemical data, lipid profile and levels of MDA and CD were measured. Results: The plasmatic and erythrocyte MDA levels were significantly increased in the HD patients compared to healthy subjects (p <0.001). However, an increased level on erythrocyte CD was only observed between the two study groups (p<0.001). After 3 years, a significant increased level of lipid peroxidation biomarkers was observed. Conclusion: The disturbance in lipid peroxidation state in HD patients was observed. At three years follow-up, oxidative stress is more pronounced with a significant increase in MDA and CD.
MeSH term(s)	Biomarkers/metabolism ; Case-Control Studies ; Erythrocytes/metabolism ; Female ; Follow-Up Studies ; Humans ; Kidney Failure, Chronic/therapy ; Lipid Peroxidation ; Lipids/blood ; Male ; Malondialdehyde/blood ; Middle Aged ; Oxidative Stress ; Renal Dialysis
Chemical Substances	Biomarkers ; Lipids ; Malondialdehyde (4Y8F71G49Q)
Language	English
Publishing date	2019-11-15
Publishing country	Tunisia
Document type	Journal Article
ZDB-ID	128627-4
ISSN	0041-4131
ISSN	0041-4131
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Article ; Online: Methylglyoxal: A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis.

Knani, Ines / Bouzidi, Hassan / Zrour, Saoussen / Bergaoui, Naceur / Hammami, Mohamed / Kerkeni, Mohsen

Disease markers

2018 Volume 2018, Page(s) 8735926

Abstract: Background: The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence ... ...

Abstract	Background: The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA. Methods: 80 patients with RA and 30 control subjects were included in a cross-sectional study. The severity of RA was assessed using the disease activity score for 28 joints (DAS28). Serum MGO and sRAGE were measured by ELISA. Results: Serum MGO levels were significantly higher in patients with RA versus control subjects ( Conclusion: Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.
MeSH term(s)	Adult ; Arthritis, Rheumatoid/blood ; Biomarkers/blood ; Cross-Sectional Studies ; Female ; Glycation End Products, Advanced/blood ; Humans ; Logistic Models ; Male ; Middle Aged ; Pyruvaldehyde/blood ; Severity of Illness Index
Chemical Substances	Biomarkers ; Glycation End Products, Advanced ; Pyruvaldehyde (722KLD7415)
Language	English
Publishing date	2018-02-11
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2018/8735926
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study.

Sánchez, Enric / Kerkeni, Mohsen / Hernández, Marta / Gavaldà, Ricard / Rius, Ferran / Sauret, Ariadna / Torres, Gerard / Bermúdez-López, Marcelino / Fernández, Elvira / Castro-Boqué, Eva / Purroy, Francisco / Mauricio, Dídac / Farràs-Sallés, Cristina / Buti, Miquel / Godoy, Pere / Pamplona, Reinald / Lecube, Albert

Nutrients

2022 Volume 14, Issue 5

Abstract: A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and ... ...

Abstract	A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m2, and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population.
MeSH term(s)	Cross-Sectional Studies ; Female ; Fluorescence ; Glycated Hemoglobin/analysis ; Humans ; Male ; Middle Aged ; Optical Imaging/methods ; Prediabetic State/blood ; Prediabetic State/diagnosis ; Prediabetic State/diagnostic imaging ; Skin/chemistry ; Skin/diagnostic imaging
Chemical Substances	Glycated Hemoglobin A
Language	English
Publishing date	2022-03-05
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2518386-2
ISSN	2072-6643 ; 2072-6643
ISSN (online)	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051102
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Article ; Online: Increased serum concentrations of N

Knani, Ines / Bouzidi, Hassan / Zrour, Saoussen / Bergaoui, Naceur / Hammami, Mohamed / Kerkeni, Mohsen

Annals of clinical biochemistry

2017 Volume 55, Issue 4, Page(s) 430–436

Abstract: Background There are limited data regarding the contribution of advanced glycation end products in the presence of rheumatoid arthritis. We investigated whether serum ... ...

Abstract	Background There are limited data regarding the contribution of advanced glycation end products in the presence of rheumatoid arthritis. We investigated whether serum N
MeSH term(s)	Adult ; Arginine/analogs & derivatives ; Arginine/blood ; Arthritis, Rheumatoid/blood ; Arthritis, Rheumatoid/pathology ; Biomarkers/blood ; Case-Control Studies ; Cross-Sectional Studies ; Enzyme-Linked Immunosorbent Assay/methods ; Female ; Humans ; Lysine/analogs & derivatives ; Lysine/blood ; Male ; Middle Aged ; Severity of Illness Index
Chemical Substances	Biomarkers ; N(6)-carboxymethyllysine (70YDX3Z2O7) ; Arginine (94ZLA3W45F) ; pentosidine (BJ4I2X2CQJ) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2017-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	390309-6
ISSN	1758-1001 ; 0004-5632
ISSN (online)	1758-1001
ISSN	0004-5632
DOI	10.1177/0004563217733500
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Article ; Online: Methylglyoxal

Ines Knani / Hassan Bouzidi / Saoussen Zrour / Naceur Bergaoui / Mohamed Hammami / Mohsen Kerkeni

Disease Markers, Vol

A Relevant Marker of Disease Activity in Patients with Rheumatoid Arthritis

2018 Volume 2018

Abstract: Background. The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence ... ...

Abstract	Background. The contribution of methylglyoxal (MGO) and soluble receptor for advanced glycation end products (sRAGE) in the presence of rheumatoid arthritis (RA) is still unknown. We investigated whether serum MGO and sRAGE were related to the presence of disease activity in RA. Methods. 80 patients with RA and 30 control subjects were included in a cross-sectional study. The severity of RA was assessed using the disease activity score for 28 joints (DAS28). Serum MGO and sRAGE were measured by ELISA. Results. Serum MGO levels were significantly higher in patients with RA versus control subjects (P<0.001) and were increased in RA patients with higher disease activity versus RA patients with moderate disease activity (P=0.019). Serum sRAGE concentrations were significantly decreased in RA patients with higher disease activity versus RA patients with moderate disease activity and versus control subjects (P=0.004; P=0.002, resp.). A multiple logistic regression analysis demonstrated that MGO was independently associated with the presence of activity disease in RA (OR = 1.17, 95% CI: 1.02–1.31, P=0.01). Conclusion. Serum MGO and sRAGE levels are inversely related to the activity of RA, and MGO is independently associated with a higher disease activity of RA.
Keywords	Medicine (General) ; R5-920
Subject code	610
Language	English
Publishing date	2018-01-01T00:00:00Z
Publisher	Hindawi Limited
Document type	Article ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article: Weak Association between Skin Autofluorescence Levels and Prediabetes with an ILERVAS Cross-Sectional Study

Nutrients. 2022 Mar. 05, v. 14, no. 5

2022

Abstract	A large body of evidence demonstrates a relationship between hyperglycemia and increased concentrations of advanced glycation end-products (AGEs). However, there is little information about subcutaneous AGE accumulation in subjects with prediabetes, and whether or not this measurement could assist in the diagnosis of prediabetes is unclear. A cross-sectional study was conducted in 4181 middle-aged subjects without diabetes. Prediabetes (n = 1444) was defined as a glycosylated hemoglobin (HbA1c) level between 39 and 47 mmol/mol (5.7 to 6.4%), and skin autofluorescence (SAF) measurement was performed to assess AGEs. A multivariable logistic regression model and receiver operating characteristic curve were used. The cohort consisted of 50.1% women with an age of 57 [52;62] years, a BMI of 28.3 [25.4;31.6] kg/m², and a prevalence of prediabetes of 34.5%. Participants with prediabetes showed higher SAF than control participants (2.0 [1.7;2.2] vs. 1.9 [1.7;2.2], p < 0.001). However, HbA1c was not significantly correlated with SAF levels (r = 0.026, p = 0.090). In addition, the SAF level was not independently associated with prediabetes (OR = 1.12 (0.96 to 1.30)). Finally, there was no good cutoff point for SAF to identify patients with prediabetes (AUC = 0.52 (0.50 to 0.54), sensitivity = 0.61, and 1-specificity = 0.56). Given all of this evidence, we can conclude that although there is an increase in SAF levels in participants with prediabetes, the applicability and clinical relevance of the results is low in this population.
Keywords	advanced glycation end products ; cross-sectional studies ; diabetes ; glycosylation ; hemoglobin ; hyperglycemia ; regression analysis
Language	English
Dates of publication	2022-0305
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2518386-2
ISSN	2072-6643
ISSN	2072-6643
DOI	10.3390/nu14051102
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: Plasma Levels of Pentosidine, Carboxymethyl-Lysine, Soluble Receptor for Advanced Glycation End Products, and Metabolic Syndrome: The Metformin Effect.

Haddad, Mohamed / Knani, Ines / Bouzidi, Hsan / Berriche, Olfa / Hammami, Mohamed / Kerkeni, Mohsen

Disease markers

2016 Volume 2016, Page(s) 6248264

Abstract: Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and ... ...

Abstract	Metabolic syndrome (MetS) is considered one of the most important public health problems. Several and controversial studies showed that the role of advanced glycation end products (AGEs) and their receptor in the development of metabolic syndrome and therapeutic pathways is still unsolved. We have investigated whether plasma pentosidine, carboxymethyl-lysine (CML), and soluble receptor for advanced glycation end products (sRAGE) levels were increased in patients with MetS and the effect of metformin in plasma levels of pentosidine, CML, and sRAGE. 80 control subjects and 86 patients were included in this study. Pentosidine, CML, and sRAGE were measured in plasma by enzyme-linked immunosorbent assay (ELISA). Plasma pentosidine, CML, and sRAGE levels were significantly increased in patients compared to control subjects (
MeSH term(s)	Adult ; Arginine/analogs & derivatives ; Arginine/blood ; Biomarkers ; Case-Control Studies ; Diabetes Mellitus, Type 2/drug therapy ; Diabetes Mellitus, Type 2/pathology ; Enzyme-Linked Immunosorbent Assay ; Female ; Follow-Up Studies ; Humans ; Hypoglycemic Agents/therapeutic use ; Lysine/analogs & derivatives ; Lysine/blood ; Male ; Metabolic Syndrome/diagnosis ; Metabolic Syndrome/drug therapy ; Metabolic Syndrome/metabolism ; Metformin/therapeutic use ; Middle Aged ; Prognosis ; Receptor for Advanced Glycation End Products/blood
Chemical Substances	Biomarkers ; Hypoglycemic Agents ; Receptor for Advanced Glycation End Products ; sRAGE protein, human ; N(6)-carboxymethyllysine (70YDX3Z2O7) ; Metformin (9100L32L2N) ; Arginine (94ZLA3W45F) ; pentosidine (BJ4I2X2CQJ) ; Lysine (K3Z4F929H6)
Language	English
Publishing date	2016
Publishing country	United States
Document type	Journal Article
ZDB-ID	604951-5
ISSN	1875-8630 ; 0278-0240
ISSN (online)	1875-8630
ISSN	0278-0240
DOI	10.1155/2016/6248264
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Zs.A 1856: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (1.OG) ab Jg. 2022: Lesesaal (EG)
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Article ; Online: Increased serum homocitrulline concentrations are associated with the severity of coronary artery disease.

Jaisson, Stéphane / Kerkeni, Mohsen / Santos-Weiss, Izabella C R / Addad, Faouzi / Hammami, Mohammed / Gillery, Philippe

Clinical chemistry and laboratory medicine

2015 Volume 53, Issue 1, Page(s) 103–110

Abstract: Background: Carbamylation is a non-enzymatic post-translational modification of proteins that has been recently identified as a non-traditional risk factor for atherosclerosis. The aim of this study was to determine whether serum homocitrulline (HCit), ... ...

Abstract	Background: Carbamylation is a non-enzymatic post-translational modification of proteins that has been recently identified as a non-traditional risk factor for atherosclerosis. The aim of this study was to determine whether serum homocitrulline (HCit), a characteristic carbamylation-derived product, was related to the presence and the severity of coronary artery disease (CAD). Methods: Forty-five control subjects and 109 patients were included in this cross-sectional study. After coronary angiography, the patients were classified as non-CAD patients (patients with normal arteries, n=33) and CAD patients (n=76). The severity of CAD was then evaluated using the Gensini scoring system. Serum total HCit concentrations were determined by LC-MS/MS. Results: Serum HCit concentrations were significantly (p<0.001) higher in CAD patients than in control or non-CAD subjects. The receiver operating characteristic curve analysis showed an area under the curve equal to 0.908 (95% confidence interval, 0.853-0.964, p<0.001) and a threshold HCit concentration of 0.16 mmol/mol Lys for predicting the presence of CAD (78.9% sensitivity and 78.8% specificity). HCit concentrations significantly (p<0.001) increased concomitantly with the severity of CAD and were positively correlated with Gensini scores (r=0.725, p<0.001) as well as with the number of stenotic coronary arteries (p<0.001). Furthermore, in a multiple stepwise regression analysis, HCit was significantly (p<0.001) and independently associated with the presence of CAD, the Gensini score, and the number of stenotic arteries (standardized β values of 0.525, 0.722, and 0.642, respectively). Conclusions: Our results demonstrate that serum HCit concentrations are increased during CAD and are positively associated with the severity of the disease.
MeSH term(s)	Case-Control Studies ; Citrulline/analogs & derivatives ; Citrulline/blood ; Coronary Artery Disease/blood ; Coronary Artery Disease/diagnostic imaging ; Cross-Sectional Studies ; Female ; Humans ; Male ; Middle Aged ; Radiography
Chemical Substances	homocitrulline (1190-49-4) ; Citrulline (29VT07BGDA)
Language	English
Publishing date	2015-01
Publishing country	Germany
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1418007-8
ISSN	1437-4331 ; 1434-6621 ; 1437-8523
ISSN (online)	1437-4331
ISSN	1434-6621 ; 1437-8523
DOI	10.1515/cclm-2014-0642
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