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Article ; Online: Variation of shear creep properties of wood within a stem: effects of macro- and microstructural variability

Ando, Kosei / Nakamura, Ryota / Kushino, Takashi

Wood Sci Technol. 2023 Jan., v. 57, no. 1 p.93-110

2023

Abstract: This study determined the structural factors affecting the shear creep characteristics of wood. The radial (R) distribution of shear creep characteristics within a stem of Japanese cedar was investigated under constant temperature and humidity conditions. ...

Abstract	This study determined the structural factors affecting the shear creep characteristics of wood. The radial (R) distribution of shear creep characteristics within a stem of Japanese cedar was investigated under constant temperature and humidity conditions. The shear force was applied using an off-axis method. The investigated structural factors comprised the density of the wood and the width of the annual rings as macro-level factors and the microfibril angle (MFA) as a micro-level factor. The shear modulus [GTL(0)] was found to be widely distributed in the R direction within the stem. Furthermore, a multiple regression analysis revealed that GTL(0) was strongly influenced by a positive correlation with both the MFA and density. The wide distribution of GTL(0) within the stem was satisfactorily explained by the MFA-dependent theory of orthotropic elasticity. Furthermore, the shear creep compliance curve demonstrated a tendency to increase logarithmically, regardless of the location within the stem. The MFA also exhibited a significant effect on (positive correlation with) the rate at which the shear creep compliance increased, while the effect of density was found to be minimal, although it had a significant effect on the shear modulus GTL(0).
Keywords	Cryptomeria japonica ; humidity ; modulus of elasticity ; regression analysis ; temperature ; wood
Language	English
Dates of publication	2023-01
Size	p. 93-110.
Publishing place	Springer Berlin Heidelberg
Document type	Article ; Online
ZDB-ID	241313-9
ISSN	0043-7719
ISSN	0043-7719
DOI	10.1007/s00226-022-01439-1
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Article ; Online: White sponge nevus in a three-year-old boy: A case report.

Yamashita, Kosei / Samejima, Mai / Oikawa, Kosuke / Mizuno, Katsumi / Ando, Yuriko

Pediatrics international : official journal of the Japan Pediatric Society

2020 Volume 62, Issue 7, Page(s) 882–883

MeSH term(s)	Biopsy/methods ; Child, Preschool ; Humans ; Leukokeratosis, Hereditary Mucosal/diagnosis ; Male ; Mouth Mucosa/pathology ; Nevus/diagnosis
Language	English
Publishing date	2020-08-04
Publishing country	Australia
Document type	Case Reports ; Journal Article
ZDB-ID	1470376-2
ISSN	1442-200X ; 1328-8067
ISSN (online)	1442-200X
ISSN	1328-8067
DOI	10.1111/ped.14206
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Article ; Online: Linear flow-velocity gradient chromatography-An efficient method for increasing the process efficiency of batch and continuous capture chromatography of proteins.

Chen, Chyi-Shin / Ando, Kosei / Yoshimoto, Noriko / Yamamoto, Shuichi

Biotechnology and bioengineering

2021 Volume 118, Issue 3, Page(s) 1262–1272

Abstract: A new method was proposed for increasing the capture chromatography process efficiency, linear flow-velocity gradient (LFG). The method uses a linear decreasing flow-velocity gradient with time during the sample loading. The initial flow velocity, the ... ...

Abstract	A new method was proposed for increasing the capture chromatography process efficiency, linear flow-velocity gradient (LFG). The method uses a linear decreasing flow-velocity gradient with time during the sample loading. The initial flow velocity, the final flow velocity and the gradient time are the parameters to be tuned. We have developed a method for determining these parameters by using the total column capacity and the total loaded amount as a function of time. The capacity can be calculated by using the relationships between dynamic binding capacity (DBC) and residence time. By leveraging the capacity, loading amount, and the required conditions, the optimum LFG can be designed. The method was verified by ion-exchange and protein A chromatography of monoclonal antibodies (mAbs). A two-fold increase in the productivity during the sample loading was possible by LFG compared with the constant flow-velocity (CF) operation. LFG was also applied to a 4-column continuous process. The simulation showed that the cost of resin per unit amount of processed mAbs can be reduced by 13% while 1.4 times enhancement in productivity was preserved after optimization by LFG compared to CF. The process efficiency improvement is more pronounced when the isotherm is highly favorable and the loading volume is large.
MeSH term(s)	Animals ; Antibodies, Monoclonal/chemistry ; Antibodies, Monoclonal/isolation & purification ; Chromatography, Affinity ; Computer Simulation ; Models, Chemical ; Staphylococcal Protein A/chemistry
Chemical Substances	Antibodies, Monoclonal ; Staphylococcal Protein A
Language	English
Publishing date	2021-01-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	280318-5
ISSN	1097-0290 ; 0006-3592
ISSN (online)	1097-0290
ISSN	0006-3592
DOI	10.1002/bit.27649
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Article: Skipping Pedicle Screw Insertion Into Infected Vertebra is a Risk Factor for Revision Surgery for Pyogenic Spondylitis in the Lower Thoracic and Lumbar Spine.

Nagata, Kosei / Ando, Takeshi / Sasaki, Katsuyuki / Urayama, Daiki

International journal of spine surgery

2020 Volume 14, Issue 6, Page(s) 989–995

Abstract: Background: Surgical intervention for pyogenic spondylitis is indicated when conservative treatment fails and biomechanical instability persists. Whether to insert pedicle screws into all vertebrae, including the most erosive vertebrae, or whether to ... ...

Abstract	Background: Surgical intervention for pyogenic spondylitis is indicated when conservative treatment fails and biomechanical instability persists. Whether to insert pedicle screws into all vertebrae, including the most erosive vertebrae, or whether to skip 1 vertebra in pedicle screw insertion remains controversial. Methods: A single-institution retrospective cohort study was conducted in consecutive patients with pyogenic spondylitis in the lower thoracic and lumbar spine (T9-S1) between January 2008 and December 2016. The patients were treated with interbody fusion plus posterior stabilization using pedicle screws and were divided into 2 groups as follows: (1) patients in whom 1 vertebra, usually the most erosive, was skipped in pedicle screw insertion (Group Skipping) and (2) pedicle screw insertion into all vertebrae (Group All). Patients' operation data were evaluated, and clinical outcomes were compared between the 2 groups. There were no significant differences between the 2 groups in terms of age, sex, past histories, blood loss, operation time, the presence of abscesses, or operative approach. Results: The length of fixation was greater by 1 vertebral level in the Group Skipping than in the Group All, and the rate of revision surgery for pseudarthrosis was higher in the Group Skipping than in the Group All ( Conclusions: Skipping pedicle screw insertion for pyogenic spondylitis in posterior fixation led to an increased number of fixed vertebrae and may be a risk factor for revision surgery for pseudarthrosis. Level of evidence: 4. Clinical relevance: The insertion of short pedicle screws at the infected vertebra can prevent early treatment failure and increase the biomechanical stability of construct.
Language	English
Publishing date	2020-12-29
Publishing country	Netherlands
Document type	Journal Article
ISSN	2211-4599
ISSN	2211-4599
DOI	10.14444/7148
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Article ; Online: Treatment of spontaneous anterior interosseous nerve palsy.

Kodama, Narihito / Ando, Kosei / Takemura, Yoshinori / Imai, Shinji

Journal of neurosurgery

2020 Volume 132, Issue 4, Page(s) 1243–1248

Abstract: Objective: The purpose of this study was to clarify the clinical outcomes of spontaneous anterior interosseous nerve palsy (AINP) treated nonsurgically or surgically.: Methods: The authors retrospectively evaluated the clinical course of 27 patients ... ...

Abstract	Objective: The purpose of this study was to clarify the clinical outcomes of spontaneous anterior interosseous nerve palsy (AINP) treated nonsurgically or surgically. Methods: The authors retrospectively evaluated the clinical course of 27 patients affected with AINP, treated nonsurgically or surgically. Thirteen patients underwent surgical treatment (interfascicular neurolysis), and 14 patients underwent conservative nonsurgical treatment. The mean patient age at the onset of symptoms was 49 years (range 17-77 years). The mean follow-up duration from onset to the latest follow-up examination was 23 months (range 12-38 months). Rresults: In 12 of 14 patients receiving conservative treatment, signs of recovery from the palsy were obtained within 6 months. These patients showed a recovery of manual muscle test (MMT) grade ≥ 3. In contrast, 2 patients who took more than 12 months from symptom onset to initial recovery showed poor recovery (MMT grade ≤ 2). Surgical treatment was performed in 13 patients because of no sign of recovery from palsy. The mean period from symptom onset to the operation was 8.4 months (range 6-14 months). Ten of 13 patients who underwent surgical treatment within 8 months after symptom onset showed good recovery, with MMT grade ≥ 4. However, 3 patients who underwent surgical treatment more than 12 months after onset showed recovery with MMT grade ≤ 3. Conclusions: Conservative treatment for AINP may be continued when patients show signs of recovery within 6 months after symptom onset. In contrast, surgical treatment may be performed within 8 months from the onset of symptoms when the patients show no recovery signs for 6 months. Abbreviations: AIN = anterior interosseous nerve; AINP = anterior interosseous nerve palsy; FDP1 = flexor digitorum profundus of the index finger; FPL = flexor pollicis longus; MMT = manual muscle test; NSG = nonsurgical treatment group; SG = surgical treatment group.
MeSH term(s)	Adolescent ; Adult ; Aged ; Conservative Treatment ; Female ; Forearm/innervation ; Humans ; Male ; Middle Aged ; Mononeuropathies/surgery ; Mononeuropathies/therapy ; Neurosurgical Procedures ; Retrospective Studies ; Treatment Outcome ; Young Adult
Language	English
Publishing date	2020-03-08
Publishing country	United States
Document type	Journal Article
ZDB-ID	3089-2
ISSN	1933-0693 ; 0022-3085
ISSN (online)	1933-0693
ISSN	0022-3085
DOI	10.3171/2018.11.JNS181609
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Article ; Online: Shoulder reconstruction following coracoid chondrosarcoma using liquid nitrogen-treated tumor-bearing bone combined with a vascularized iliac bone graft: A case report.

Takemura, Yoshinori / Kodama, Narihito / Ando, Kosei / Takada, Daisuke / Ueba, Hiroaki / Imai, Shinji

Journal of orthopaedic science : official journal of the Japanese Orthopaedic Association

2020 Volume 28, Issue 4, Page(s) 942–948

MeSH term(s)	Humans ; Shoulder ; Ilium ; Bone Neoplasms/diagnostic imaging ; Bone Neoplasms/surgery ; Chondrosarcoma/diagnostic imaging ; Chondrosarcoma/surgery ; Bone Transplantation ; Shoulder Joint/surgery
Language	English
Publishing date	2020-12-10
Publishing country	Japan
Document type	Case Reports
ZDB-ID	1314243-4
ISSN	1436-2023 ; 0949-2658
ISSN (online)	1436-2023
ISSN	0949-2658
DOI	10.1016/j.jos.2020.10.018
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Article: Dependence of Poisson’s ratio and Young’s modulus on microfibril angle (MFA) in wood

Ando, Kosei / Hiroyuki Yamamoto / Keisuke Toba / Mayu Mizutani

Holzforschung. 2018 Mar. 28, v. 72, no. 4

2018

Abstract: Microfibril angle (MFA) is a major structural variable that describes the fine structure of the cell wall in wood. In this study, the relationships between the MFA of the S2 layer and the Poisson’s ratios and Young’s moduli (modulus of elasticity, MOE) ... ...

Abstract	Microfibril angle (MFA) is a major structural variable that describes the fine structure of the cell wall in wood. In this study, the relationships between the MFA of the S2 layer and the Poisson’s ratios and Young’s moduli (modulus of elasticity, MOE) of five wood species (agathis, larch, Japanese cedar, Japanese cypress and ginkgo) were determined by analyzing both their normal and compression woods. It was found that both the longitudinal MOE (MOEL) and MOE of the cell-wall substance (MOEW) decreased with increasing MFA, while the peaks values of Poisson’s ratio (νLT) were obtained at MFAs of ≈25°. In particular, at MFAs lower than 25°, the νLT increased with increasing MFA, and the opposite relationship was observed at MFA values exceeding 25°. This trend is in good agreement with the estimates obtained based on the theory of orthotropic elasticity with the underlying assumption that the orthotropic elasticity of materials is MFA-dependent. Hence, the MFA parameter incorporated into the orthotropic elasticity theory is useful for determination of the Poisson’s ratio.
Keywords	Cryptomeria japonica ; Ginkgo ; modulus of elasticity ; wood
Language	English
Dates of publication	2018-0328
Size	p. 321-327.
Publishing place	De Gruyter
Document type	Article
ZDB-ID	1466072-6
ISSN	1437-434X ; 0018-3830
ISSN (online)	1437-434X
ISSN	0018-3830
DOI	10.1515/hf-2017-0091
Database	NAL-Catalogue (AGRICOLA)

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Article ; Online: The efficacy and safety of anamorelin among patients with diabetes.

International journal of clinical oncology

2024

Abstract: Background: Anamorelin is a selective ghrelin receptor agonist approved for cancer cachexia in Japan. Little is known about predictors of anamorelin efficacy. This study aimed to assess the effect of diabetes on the efficacy and safety of anamorelin in ... ...

Abstract	Background: Anamorelin is a selective ghrelin receptor agonist approved for cancer cachexia in Japan. Little is known about predictors of anamorelin efficacy. This study aimed to assess the effect of diabetes on the efficacy and safety of anamorelin in patients with cancer cachexia. Methods: Medical records of patients with advanced non-small-cell lung, gastric, pancreatic, or colorectal cancer who received anamorelin between January 2021 and March 2023 were retrospectively reviewed. The diabetic (DM) group included patients with a confirmed diagnosis of type 2 diabetes mellitus, random plasma glucose of ≥ 200 mg/dL, or hemoglobin A1c of ≥ 6.5%. The maximum body weight gain and adverse events during anamorelin administration were compared between the DM and non-DM groups. Patients with a maximum body weight gain ≥ 0 kg were classified as the responders. Results: Of 103 eligible patients, 31 (30.1%) were assigned to the DM group. The DM group gained less weight (median of -0.53% vs. + 3.00%, p < 0.01) and had fewer responders (45.2% vs. 81.9%, p < 0.01) than the non-DM group. The odds ratio for non-response in the DM group was 6.55 (95% confidential interval 2.37-18.06, p < 0.01), adjusted by age and performance status. The DM group had a higher cumulative incidence of hyperglycaemic adverse events (72.2% vs. 6.3%, p < 0.01) and more discontinuations due to hyperglycaemic adverse events (25.8% vs. 4.2%, p < 0.01) than the non-DM group. Conclusions: Patients with diabetes and cancer cachexia are less likely to gain weight with anamorelin despite a high risk of hyperglycaemic adverse events.
Language	English
Publishing date	2024-05-09
Publishing country	Japan
Document type	Journal Article
ZDB-ID	1400227-9
ISSN	1437-7772 ; 1341-9625
ISSN (online)	1437-7772
ISSN	1341-9625
DOI	10.1007/s10147-024-02546-8
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Article: Influence of a wide range of moisture contents on the Poisson’s ratio of wood

Mizutani, Mayu / Kosei Ando

Journal of wood science. 2015 Feb., v. 61, no. 1

2015

Abstract: This study investigates the effect of a wide range of moisture contents (0–177 %) on the Poisson’s ratio of wood taken from Japanese cypress and magnolia by conducting longitudinal compression tests. Through analysis of variance and multiple comparisons, ...

Abstract	This study investigates the effect of a wide range of moisture contents (0–177 %) on the Poisson’s ratio of wood taken from Japanese cypress and magnolia by conducting longitudinal compression tests. Through analysis of variance and multiple comparisons, it was found that when the moisture content is below the respective fiber saturation point Poisson’s ratio decreases with increasing moisture content. In contrast, at moisture contents above the fiber saturation point, the Poisson’s ratio increases with moisture content. The same tendency was observed in both wood species, but the effect was more pronounced in magnolia than Japanese cypress.
Keywords	analysis of variance ; fiber saturation ; Magnolia ; water content ; wood
Language	English
Dates of publication	2015-02
Size	p. 81-85.
Publishing place	Springer Japan
Document type	Article
ZDB-ID	1429032-7
ISSN	1435-0211
ISSN	1435-0211
DOI	10.1007/s10086-014-1438-7
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Article ; Online: The Diagnostic Utility of IDH2 R172 Immunohistochemistry in Tall Cell Carcinoma With Reversed Polarity of the Breast.

Sasaki, Eiichi / Iwakoshi, Akari / Satake, Tatsunari / Nakajima, Kosei / Kobayashi, Mizuho / Ando, Yoshiaki / Koshikawa, Takashi / Masago, Katsuhiro / Honma, Naoko / Nishimura, Rieko / Kato, Yukinari / Ichihara, Shu

Applied immunohistochemistry & molecular morphology : AIMM

2022 Volume 30, Issue 10, Page(s) 654–661

Abstract: Tall cell carcinoma with reversed polarity (TCCRP) is a rare histologic type of low-grade breast cancer, consisting of tall columnar cells with reversed nuclear polarity and characterized by frequent IDH2 mutations. We herein report 3 cases of TCCRP with ...

Abstract	Tall cell carcinoma with reversed polarity (TCCRP) is a rare histologic type of low-grade breast cancer, consisting of tall columnar cells with reversed nuclear polarity and characterized by frequent IDH2 mutations. We herein report 3 cases of TCCRP with sequencing analyses of the IDH2 gene and immunohistochemical examination using monoclonal antibodies (11C8B1) against IDH2 R172. IDH2 R172 mutations were detected in all 3 resected tumors (R172S in 2 tumors and R172T in 1 tumor), and the presence of these mutations was confirmed by IDH2 R172 immunohistochemistry. Tumor cells of TCCRP showed strong and diffuse staining for the antibody against IDH2 R172. In 1 case, tumor tissue from 2 core needle biopsy samples collected on different days were also immunohistochemically positive for IDH2 R172. These results indicate that IDH2 R172 immunohistochemistry is suitable for the detection of TCCRP in both resection and biopsy samples. In addition, a literature review revealed that R172S and R172T account for 76% of IDH2 mutations in TCCRP, suggesting that 11C8B1, which reacts with R172S and R172T, was likely most sensitive for IDH2 -mutated TCCRP among many available antibodies for IDH2 R172. Furthermore, the combination of 2 or more antibodies against IDH2 R172 could be more effective for detecting TCCRP mutation. However, it is important to note that IDH2 R172 immunohistochemistry is not absolute, because IDH2 wild type is found in a small proportion (10%) of cases, and a few cases of IDH2 -mutated TCCRP may harbor rare subtypes of R172 that are not covered by available antibodies.
MeSH term(s)	Humans ; Immunohistochemistry ; Isocitrate Dehydrogenase/genetics ; Isocitrate Dehydrogenase/metabolism ; Biomarkers, Tumor/genetics ; Carcinoma/genetics ; Mutation
Chemical Substances	Isocitrate Dehydrogenase (EC 1.1.1.41) ; Biomarkers, Tumor
Language	English
Publishing date	2022-10-12
Publishing country	United States
Document type	Review ; Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	1473273-7
ISSN	1533-4058 ; 1062-3345 ; 1541-2016
ISSN (online)	1533-4058
ISSN	1062-3345 ; 1541-2016
DOI	10.1097/PAI.0000000000001074
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