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  1. Article: Structure-based pharmacophore modeling, virtual screening, and molecular dynamics simulation studies for identification of

    Oduselu, Gbolahan O / Afolabi, Rufus / Ademuwagun, Ibitayo / Vaughan, Ashley / Adebiyi, Ezekiel

    Frontiers in medicine

    2023  Volume 9, Page(s) 1022429

    Abstract: Plasmodium ... ...

    Abstract Plasmodium falciparum
    Language English
    Publishing date 2023-01-12
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2775999-4
    ISSN 2296-858X
    ISSN 2296-858X
    DOI 10.3389/fmed.2022.1022429
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: RAPD Profiling, DNA Fragmentation, and Histomorphometric Examination in Brains of Wistar Rats Exposed to Indoor 2.5 Ghz Wi-Fi Devices Radiation.

    Ibitayo, A O / Afolabi, O B / Akinyemi, A J / Ojiezeh, T I / Adekoya, K O / Ojewunmi, O O

    BioMed research international

    2017  Volume 2017, Page(s) 8653286

    Abstract: The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate ...

    Abstract The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate the injurious effect of radiofrequency emissions from installed Wi-Fi devices in brains of young male rats. Animals were divided into four equal groups; group 1 served as control while groups 2, 3, and 4 were exposed to 2.5 Ghz at intervals of 30, 45, and 60 consecutive days with free access to food and water ad libitum. Alterations in harvested brain tissues were confirmed by histopathological analyses which showed vascular congestion and DNA damage in the brain was assayed using agarose gel electrophoresis. Histomorphometry analyses of their brain tissues showed perivascular congestion and tissue damage as well.
    Language English
    Publishing date 2017
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2698540-8
    ISSN 2314-6141 ; 2314-6133
    ISSN (online) 2314-6141
    ISSN 2314-6133
    DOI 10.1155/2017/8653286
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article: Aqueous extract of

    Ojo, Oluwafemi Adeleke / Ojo, Adebola Busola / Awoyinka, Olayinka / Ajiboye, Basiru Olaitan / Oyinloye, Babatunji Emmanuel / Osukoya, Olukemi Adetutu / Olayide, Israel Idowu / Ibitayo, Adejoke

    Journal of traditional and complementary medicine

    2017  Volume 8, Issue 2, Page(s) 324–334

    Abstract: In Africa, the fruit, leaf, seed and roots ... ...

    Abstract In Africa, the fruit, leaf, seed and roots of
    Language English
    Publishing date 2017-09-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2709698-1
    ISSN 2225-4110
    ISSN 2225-4110
    DOI 10.1016/j.jtcme.2017.08.001
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  4. Article ; Online: RAPD Profiling, DNA Fragmentation, and Histomorphometric Examination in Brains of Wistar Rats Exposed to Indoor 2.5 Ghz Wi-Fi Devices Radiation

    A. O. Ibitayo / O. B. Afolabi / A. J. Akinyemi / T. I. Ojiezeh / K. O. Adekoya / O. O. Ojewunmi

    BioMed Research International, Vol

    2017  Volume 2017

    Abstract: The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate ...

    Abstract The advent of Wi-Fi connected high technology devices in executing day-to-day activities is fast evolving especially in developing countries of the world and hence the need to assess its safety among others. The present study was conducted to investigate the injurious effect of radiofrequency emissions from installed Wi-Fi devices in brains of young male rats. Animals were divided into four equal groups; group 1 served as control while groups 2, 3, and 4 were exposed to 2.5 Ghz at intervals of 30, 45, and 60 consecutive days with free access to food and water ad libitum. Alterations in harvested brain tissues were confirmed by histopathological analyses which showed vascular congestion and DNA damage in the brain was assayed using agarose gel electrophoresis. Histomorphometry analyses of their brain tissues showed perivascular congestion and tissue damage as well.
    Keywords Medicine ; R
    Language English
    Publishing date 2017-01-01T00:00:00Z
    Publisher Hindawi Limited
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  5. Article: Social and political amplification of technological hazards. The case of the PEPCON explosion.

    Ibitayo, Olurominiyi O / Mushkatel, Alvin / Pijawka, K David

    Journal of hazardous materials

    2004  Volume 114, Issue 1-3, Page(s) 15–25

    Abstract: Using an industrial explosion in Henderson, Nevada, as a case study, this paper examines three main issues: the efficacy of a technological hazard event in amplifying otherwise latent issues, the extent to which the hazard event can serve as a focusing ... ...

    Abstract Using an industrial explosion in Henderson, Nevada, as a case study, this paper examines three main issues: the efficacy of a technological hazard event in amplifying otherwise latent issues, the extent to which the hazard event can serve as a focusing event for substantive local and state policy initiatives, and the effect of fragmentation of political authority in managing technological hazards. The findings indicate that the explosion amplified several public safety issues and galvanized the public into pressing for major policy initiatives. However, notwithstanding the amplification of several otherwise latent issues, and the flurry of activities by the state and local governments, the hazard event did not seem to be an effective focusing event or trigger mechanism for substantive state and local policy initiatives. In addition, the study provides evidence of the need for a stronger nexus between political authority, land-use planning and technological hazard management.
    MeSH term(s) Accidents, Occupational ; Behavior ; Data Collection ; Disclosure ; Explosions ; Government ; Humans ; Nevada ; Politics ; Public Opinion ; Public Policy ; Risk Assessment ; Safety Management ; Social Environment
    Language English
    Publishing date 2004-10-18
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1491302-1
    ISSN 1873-3336 ; 0304-3894
    ISSN (online) 1873-3336
    ISSN 0304-3894
    DOI 10.1016/j.jhazmat.2004.08.020
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: HSP27 in signal transduction and association with contractile proteins in smooth muscle cells.

    Ibitayo, A I / Sladick, J / Tuteja, S / Louis-Jacques, O / Yamada, H / Groblewski, G / Welsh, M / Bitar, K N

    The American journal of physiology

    1999  Volume 277, Issue 2, Page(s) G445–54

    Abstract: Sustained smooth muscle contraction is mediated by protein kinase C (PKC) through a signal transduction cascade leading to contraction. Heat-shock protein 27 (HSP27) appears to be the link between these two major events, i.e., signal transduction and ... ...

    Abstract Sustained smooth muscle contraction is mediated by protein kinase C (PKC) through a signal transduction cascade leading to contraction. Heat-shock protein 27 (HSP27) appears to be the link between these two major events, i.e., signal transduction and sustained smooth muscle contraction. We have investigated the involvement of HSP27 in signal transduction and HSP27 association with contractile proteins (e.g., actin, myosin, tropomyosin, and caldesmon) resulting in sustained smooth muscle contraction. We have carried out confocal microscopy to investigate the cellular reorganization and colocalization of proteins and immunoprecipitation of HSP27 with actin, myosin, tropomyosin, and caldesmon as detected by sequential immunoblotting. Our results indicate that 1) translocation of Raf-1 to the membrane when stimulated with ceramide is inhibited by vasoactive intestinal peptide (VIP), a relaxant neuropeptide; 2) PKC-alpha and mitogen-activated protein kinase translocate and colocalize on the membrane in response to ceramide, and PKC-alpha translocation is inhibited by VIP; 3) HSP27 colocalizes with actin when contraction occurs; and 4) HSP27 immunoprecipitates with actin and with the contractile proteins myosin, tropomyosin, and caldesmon. We propose a model in which HSP27 is involved in sustained smooth muscle contraction and modulates the interaction of actin, myosin, tropomyosin, and caldesmon.
    MeSH term(s) Actins/metabolism ; Animals ; Azepines/pharmacology ; Biological Transport ; Calcium-Calmodulin-Dependent Protein Kinases/metabolism ; Calmodulin-Binding Proteins/metabolism ; Ceramides/pharmacology ; Colon/cytology ; Colon/drug effects ; Colon/metabolism ; Contractile Proteins/metabolism ; Cytoskeleton/metabolism ; Heat-Shock Proteins/metabolism ; Heat-Shock Proteins/physiology ; Isoenzymes/metabolism ; Muscle Contraction/drug effects ; Muscle Contraction/physiology ; Muscle, Smooth/cytology ; Muscle, Smooth/drug effects ; Muscle, Smooth/metabolism ; Myosins/metabolism ; Naphthalenes/pharmacology ; Precipitin Tests ; Protein Kinase C/metabolism ; Protein Kinase C-alpha ; Proto-Oncogene Proteins c-raf/metabolism ; Rabbits ; Signal Transduction/physiology ; Tissue Distribution ; Tropomyosin/metabolism
    Chemical Substances Actins ; Azepines ; Calmodulin-Binding Proteins ; Ceramides ; Contractile Proteins ; Heat-Shock Proteins ; Isoenzymes ; Naphthalenes ; Tropomyosin ; ML 7 (109376-83-2) ; Proto-Oncogene Proteins c-raf (EC 2.7.11.1) ; Protein Kinase C (EC 2.7.11.13) ; Protein Kinase C-alpha (EC 2.7.11.13) ; Calcium-Calmodulin-Dependent Protein Kinases (EC 2.7.11.17) ; Myosins (EC 3.6.4.1)
    Language English
    Publishing date 1999
    Publishing country United States
    Document type Journal Article ; Research Support, U.S. Gov't, P.H.S.
    ZDB-ID 2948-8
    ISSN 0002-9513
    ISSN 0002-9513
    DOI 10.1152/ajpgi.1999.277.2.G445
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