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  1. Article ; Online: Research on Hygiene Based on Fieldwork and Experimental Studies.

    Yajima, Ichiro

    Nihon eiseigaku zasshi. Japanese journal of hygiene

    2017  Volume 72, Issue 1, Page(s) 49–54

    Abstract: Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. ... ...

    Abstract Several experimental studies on hygiene have recently been performed and fieldwork studies are also important and essential tools. However, the implementation of experimental studies is insufficient compared with that of fieldwork studies on hygiene. Here, we show our well-balanced implementation of both fieldwork and experimental studies of toxic-element-mediated diseases including skin cancer and hearing loss. Since the pollution of drinking well water by toxic elements induces various diseases including skin cancer, we performed both fieldwork and experimental studies to determine the levels of toxic elements and the mechanisms behind the development of toxic-element-related diseases and to develop a novel remediation system. Our fieldwork studies in several countries including Bangladesh, Vietnam and Malaysia demonstrated that drinking well water was polluted with high concentrations of several toxic elements including arsenic, barium, iron and manganese. Our experimental studies using the data from our fieldwork studies demonstrated that these toxic elements caused skin cancer and hearing loss. Further experimental studies resulted in the development of a novel remediation system that adsorbs toxic elements from polluted drinking water. A well-balanced implementation of both fieldwork and experimental studies is important for the prediction, prevention and therapy of toxic-element-mediated diseases.
    MeSH term(s) Arsenic/adverse effects ; Arsenic/analysis ; Barium/adverse effects ; Barium/analysis ; Developing Countries ; Drinking Water/adverse effects ; Drinking Water/analysis ; Environmental Health ; Hearing Loss/etiology ; Hearing Loss/prevention & control ; Humans ; Iron/adverse effects ; Iron/analysis ; Manganese/adverse effects ; Manganese/analysis ; Research ; Research Design ; Skin Neoplasms/etiology ; Skin Neoplasms/prevention & control ; Water Pollutants/adverse effects ; Water Pollutants/analysis ; Water Purification/methods ; Water Wells
    Chemical Substances Drinking Water ; Water Pollutants ; Barium (24GP945V5T) ; Manganese (42Z2K6ZL8P) ; Iron (E1UOL152H7) ; Arsenic (N712M78A8G)
    Language Japanese
    Publishing date 2017
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 604089-5
    ISSN 1882-6482 ; 0021-5082
    ISSN (online) 1882-6482
    ISSN 0021-5082
    DOI 10.1265/jjh.72.49
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.B 578: Show issues Location:
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  2. Article: Simultaneous Content Determination of Mono-, Di-, and Fructo-oligosaccharides in Citrus Fruit Juices Using an FTIR-PLS Method Based on Selected Absorption Bands.

    Yajima, Yurika / Wakabayashi, Hideyuki / Suehara, Ken-Ichiro / Kameoka, Takaharu / Hashimoto, Atsushi

    International journal of food science

    2024  Volume 2024, Page(s) 9265590

    Abstract: A quantification method was developed to determine the sugar components, either following addition or enzymatic treatment, in citrus fruit juices containing additional fructo-oligosaccharides using midinfrared spectroscopy. For the quantification, we ... ...

    Abstract A quantification method was developed to determine the sugar components, either following addition or enzymatic treatment, in citrus fruit juices containing additional fructo-oligosaccharides using midinfrared spectroscopy. For the quantification, we compared the results obtained by applying the simultaneous equation method, which uses very little wavenumber information, and the partial least squares (PLS) regression method, which requires a lot of wavenumber information. In order to prevent overfitting in the PLS method, we concentrated on reducing the amount of spectral data used in the analysis. The corresponding FTIR-PLS method led to an accurate quantification of the sugar contents, even in enzymatically treated orange juices with complicated compositions. The spectral data used for model calibration were significantly reduced by focusing on the absorption and assignment information of the sugar components. The RMSEs of Glc, Fru, Suc, GF2, and GF3 in enzyme-treated orange juice before and after spectral data reduction were 0.50, 0.46, 0.61, 0.74, and 0.61 g/L and 0.51, 0.49, 0.73, 0.86, and 0.61 g/L, respectively. The developed method could be easily implemented for practical applications, using a simple measuring instrument since only absorption information at the limited absorption bands is required.
    Language English
    Publishing date 2024-01-10
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2760370-2
    ISSN 2314-5765
    ISSN 2314-5765
    DOI 10.1155/2024/9265590
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  3. Article: Calcitriol inhibits arsenic-promoted tumorigenesis through regulation of arsenic-uptake in a human keratinocyte cell line.

    Yajima, Ichiro / Tazaki, Akira / Ohgami, Nobutaka / Kato, Masashi

    American journal of cancer research

    2022  Volume 12, Issue 11, Page(s) 5019–5028

    Abstract: Chronic arsenic exposure from drinking water causes a variety of diseases and it is now recognized that at least 140 million people in 50 countries have been drinking water containing arsenic at levels above the WHO provisional guideline value of 10 μg/L. ...

    Abstract Chronic arsenic exposure from drinking water causes a variety of diseases and it is now recognized that at least 140 million people in 50 countries have been drinking water containing arsenic at levels above the WHO provisional guideline value of 10 μg/L. Long-term exposure to arsenic is associated with various types of cancers in humans including skin cancers. However, there is limited information on key molecules regulating arsenic-promoted carcinogenesis, and methods for the prevention and therapy of arsenic-promoted carcinogenesis have not yet been fully developed. Our
    Language English
    Publishing date 2022-11-15
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2589522-9
    ISSN 2156-6976
    ISSN 2156-6976
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  4. Article: Evaluation of Crude and Recombinant Antigens of

    Angeles, Jose Ma M / Wanlop, Atcharaphan / Dang-Trinh, Minh-Anh / Kirinoki, Masashi / Kawazu, Shin-Ichiro / Yajima, Aya

    Diagnostics (Basel, Switzerland)

    2023  Volume 13, Issue 2

    Abstract: Asian schistosomiasis caused by the blood ... ...

    Abstract Asian schistosomiasis caused by the blood fluke
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics13020184
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  5. Article ; Online: Photo-Cross-Linked Probe-Modified Magnetic Particles for the Selective and Reliable Recovery of Nucleic Acids.

    Yajima, Shuto / Koto, Ayako / Koda, Maho / Sakamoto, Hiroaki / Takamura, Eiichiro / Suye, Shin-Ichiro

    ACS omega

    2022  Volume 7, Issue 15, Page(s) 12701–12706

    Abstract: Polymerase chain reaction (PCR) assays are used to diagnose various infectious diseases such as Coronavirus disease 2019 by detecting the nucleic acids of the pathogen. However, in practice, the yield of the extraction process and the inhibition of the ... ...

    Abstract Polymerase chain reaction (PCR) assays are used to diagnose various infectious diseases such as Coronavirus disease 2019 by detecting the nucleic acids of the pathogen. However, in practice, the yield of the extraction process and the inhibition of the reverse transcription reaction and PCR by foreign substances reduce the sensitivity and may yield false negative results. The sensitivity of the PCR test can be improved by using technologies that can reliably capture the target nucleic acid and remove foreign substances. In this study, we developed photo-cross-linkable probe-modified magnetic particles (PPMPs) for the sequence-specific recovery of target nucleic acids using photo-cross-linkable artificial nucleic acid probes and magnetic particles. Nucleic acid probes modified with photo-cross-linkable artificial nucleic acids can hybridize with the target nucleic acids in a sequence-specific manner and then securely capture the target nucleic acids by UV irradiation-mediated covalent bonding. Then the target nucleic acid is detected by trapping the target-bound probe on the surface of the magnetic particles and subjecting these collected magnetic particles to PCR. Recovery of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) N gene pseudo-DNA (120 bp) was performed using PPMPs. We confirmed that the PPMPs captured the target consistently even after washes were done with denaturing agents and surfactants. Even in the presence of foreign DNA fragments, PPMPs were able to specifically recover the target DNA. This method allows for a more accurate detection by recovering only the target DNA for PCR. Hence, PPMPs can be successfully used for PCR-mediated detection of SARS-CoV-2 and other pathogens whose nucleic acid sequences are known.
    Language English
    Publishing date 2022-04-06
    Publishing country United States
    Document type Journal Article
    ISSN 2470-1343
    ISSN (online) 2470-1343
    DOI 10.1021/acsomega.1c07012
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  6. Article ; Online: Selective miR-21 detection technology based on photocrosslinkable artificial nucleic acid-modified magnetic particles and hybridization chain reaction.

    Watanabe, Yui / Yajima, Shuto / Koda, Maho / Kinjou, Ayumu / Koto, Ayako / Takamura, Eiichiro / Sakamoto, Hiroaki / Suye, Shin-Ichiro

    Biosensors & bioelectronics

    2023  Volume 247, Page(s) 115920

    Abstract: Recently, microRNA (miRNA) detection in blood has attracted attention as a new early detection technology for cancer. The extraction of target miRNA is a necessary preliminary step for detection; however, currently, most extraction methods extract all ... ...

    Abstract Recently, microRNA (miRNA) detection in blood has attracted attention as a new early detection technology for cancer. The extraction of target miRNA is a necessary preliminary step for detection; however, currently, most extraction methods extract all RNA from the blood, which limits the detection selectivity. Therefore, a method for the selective extraction and detection of target miRNA from blood is very important. In this study, we utilized photocrosslinkable artificial nucleic acids and the hybridization chain reaction (HCR) in an attempt to improve upon the current standard method RT-qPCR, which is hampered by problems with primer design and enzymatic amplification. By introducing photocrosslinkable artificial nucleic acids to oligonucleotide probes modified with magnetic particles with a sequence complementary to that of the target miRNA and irradiating them with light, covalent bonds were formed between the target miRNA and the oligonucleotide probes. These tight covalent bonds enabled the capture of miRNA in blood, and intensive washing ensured that only the target miRNA were extracted. After extraction, two types of DNA (H1 and H2) modified with fluorescent dyes were added and the fluorescence signals were amplified by the HCR in the presence of the target miRNA bound to the photocrosslinkable artificial nucleic acids, allowing for isothermal and enzyme-free miRNA detection. The novel method is suitable for selective miRNA detection in real blood samples. Because the reaction proceeds isothermally and no specialized equipment is used for washing, this detection technology is simple and selective and suitable for application to point-of-care technology using microfluidic devices.
    MeSH term(s) Nucleic Acids ; Oligonucleotide Probes ; Biosensing Techniques/methods ; Nucleic Acid Hybridization/methods ; MicroRNAs/genetics ; Magnetic Phenomena
    Chemical Substances Nucleic Acids ; Oligonucleotide Probes ; MicroRNAs
    Language English
    Publishing date 2023-12-09
    Publishing country England
    Document type Journal Article
    ZDB-ID 1011023-9
    ISSN 1873-4235 ; 0956-5663
    ISSN (online) 1873-4235
    ISSN 0956-5663
    DOI 10.1016/j.bios.2023.115920
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    In stock of ZB MED Cologne/Königswinter

    Zs.A 2275: Show issues Location:
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    bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
    Jg. 1995 - 2021: Lesesall (2.OG)
    ab Jg. 2022: Lesesaal (EG)

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  7. Article: Current advances in serological and molecular diagnosis of Schistosoma mekongi infection.

    Macalanda, Adrian Miki C / Wanlop, Atcharaphan / Ona, Kevin Austin L / Galon, Eloiza May S / Khieu, Virak / Sayasone, Somphou / Yajima, Aya / Angeles, Jose Ma M / Kawazu, Shin-Ichiro

    Tropical medicine and health

    2024  Volume 52, Issue 1, Page(s) 32

    Abstract: Schistosomiasis, a neglected tropical disease, caused by blood flukes belonging to the genus Schistosoma; it persists as a public health problem in selected regions throughout Africa, South America, and Asia. Schistosoma mekongi, a zoonotic schistosome ... ...

    Abstract Schistosomiasis, a neglected tropical disease, caused by blood flukes belonging to the genus Schistosoma; it persists as a public health problem in selected regions throughout Africa, South America, and Asia. Schistosoma mekongi, a zoonotic schistosome species endemic to the Mekong River in Laos and Cambodia, is one of the significant causes of human schistosomiasis along with S. japonicum, S. mansoni, S. haematobium and S. intercalatum. Since its discovery, S. mekongi infection has been highly prevalent in communities along the Mekong River. Although surveillance and control measures have shown success in recent years, more robust diagnostic tools are still needed to establish more efficient control and prevention strategies to achieve and sustain an elimination status. Diagnosis of S. mekongi infection still relies on copro-parasitological techniques, commonly made by Kato-Katz stool examination. Serological techniques such as enzyme-linked immunosorbent assay (ELISA) may also be applicable but in a limited setting. Targeted molecular and serological tools specific to the species, on the other hand, have been limited. This is due, in part, to the limited research and studies on the molecular biology of S. mekongi since genome information of this species has not yet been released. In this review, current advances, and gaps and limitations in the molecular and immunological diagnosis of S. mekongi are discussed.
    Language English
    Publishing date 2024-04-22
    Publishing country Japan
    Document type Journal Article ; Review
    ZDB-ID 2209835-5
    ISSN 1349-4147 ; 1348-8945
    ISSN (online) 1349-4147
    ISSN 1348-8945
    DOI 10.1186/s41182-024-00598-0
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  8. Article ; Online: Status and prognostic value of immunological biomarkers of breast cancer.

    Murazawa, Chisa / Hashimoto, Nozomi / Kuraishi, Kana / Motoyama, Mutsumi / Hashimoto, Shin-Ichiro / Ikeuchi, Mayumi / Norimura, Shoko / Matsunaga, Toru / Teramoto, Koji / Haba, Reiji / Abe, Noriko / Yajima, Toshiki / Kontani, Keiichi

    Oncology letters

    2023  Volume 25, Issue 4, Page(s) 164

    Abstract: The immune response to cancer serves an important role in disease progression and patient prognosis. For triple-negative breast cancer showing aggressive behavior, immunotherapy has a good efficacy because of the potent immunogenicity of this type of ... ...

    Abstract The immune response to cancer serves an important role in disease progression and patient prognosis. For triple-negative breast cancer showing aggressive behavior, immunotherapy has a good efficacy because of the potent immunogenicity of this type of cancer. However, the dominant subtype, luminal human epidermal growth factor receptor-2 (HER2)-negative breast cancer, is less immunogenic. To determine whether luminal HER2-negative cancer reacts to the anticancer immune response, the present study analyzed the status and prognostic value of the principal immunological biomarkers of breast cancer, including tumor-infiltrating lymphocytes (TILs), CD8
    Language English
    Publishing date 2023-03-08
    Publishing country Greece
    Document type Journal Article
    ZDB-ID 2573196-8
    ISSN 1792-1082 ; 1792-1074
    ISSN (online) 1792-1082
    ISSN 1792-1074
    DOI 10.3892/ol.2023.13750
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  9. Article ; Online: Elevated arsenic level in fasting serum via ingestion of fish meat increased the risk of hypertension in humans and mice.

    Kagawa, Takumi / Ohgami, Nobutaka / He, Tingchao / Tazaki, Akira / Ohnuma, Shoko / Naito, Hisao / Yajima, Ichiro / Chen, Dijie / Deng, Yuqi / Tamura, Takashi / Kondo, Takaaki / Wakai, Kenji / Kato, Masashi

    European heart journal open

    2023  Volume 3, Issue 5, Page(s) oead074

    Abstract: Aims: There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the ... ...

    Abstract Aims: There has been a shortage of human studies to elucidate the association between serum arsenic levels and the prevalence of hypertension. This study multidirectionally investigated associations among arsenic exposure, dietary ingestion, and the risk of hypertension by combined human epidemiological and mouse experimental studies.
    Methods and results: This study focused on the total arsenic level in fasting serum, a biomarker of arsenic exposure. Associations among ingestion frequencies of 54 diet items of Japanese food separated into six categories, total arsenic level in fasting serum, and the prevalence of hypertension were investigated in 2709 general people in Japan. Logistic regression analysis demonstrated a dose-dependent association between serum arsenic level and hypertension and a positive association between the ingestion of fish meat and hypertension. Further analysis showed that the latter association was fully mediated by increased fasting serum arsenic levels in humans. Similarly, oral exposure to the putative human-equivalent dose of arsenic species mixture with the same ratios in a common fish meat in Japan increased systolic blood pressure and arsenic levels in fasting serum in mice.
    Conclusion: This interdisciplinary approach suggests that fish-meat ingestion is a potential risk factor for arsenic-mediated hypertension. Because the increased consumption of fish meat is a recent global trend, health risks of the increased ingestion of arsenic via fish meat should be further investigated.
    Language English
    Publishing date 2023-09-04
    Publishing country England
    Document type Journal Article
    ISSN 2752-4191
    ISSN (online) 2752-4191
    DOI 10.1093/ehjopen/oead074
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  10. Article: Cloning, Expression and Evaluation of Thioredoxin Peroxidase-1 Antigen for the Serological Diagnosis of

    Wanlop, Atcharaphan / Angeles, Jose Ma M / Macalanda, Adrian Miki C / Kirinoki, Masashi / Ohari, Yuma / Yajima, Aya / Yamagishi, Junya / Ona, Kevin Austin L / Kawazu, Shin-Ichiro

    Diagnostics (Basel, Switzerland)

    2022  Volume 12, Issue 12

    Abstract: Schistosoma ... ...

    Abstract Schistosoma mekongi
    Language English
    Publishing date 2022-12-07
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662336-5
    ISSN 2075-4418
    ISSN 2075-4418
    DOI 10.3390/diagnostics12123077
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