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  1. Article ; Online: Utilisation des modèles murins pour l’étude du syndrome d’apnées obstructives du sommeil dans le syndrome de Down.

    Moreau, M / Madani, A / Dard, R / Bourgeois, T / d'Ortho, M-P / Delclaux, C / Janel, N / Matrot, B

    Revue des maladies respiratoires

    2024  Volume 41, Issue 4, Page(s) 279–282

    Abstract: Down syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) ... ...

    Title translation Use of murine models for the study of obstructive sleep apnea syndrome in Down syndrome.
    Abstract Down syndrome (DS), or trisomy 21, is a genetic disorder caused by the presence of an extra copy of chromosome 21, leading to various characteristic physical features as well as developmental and cognitive delays. Obstructive sleep apnea syndrome (OSAS) is a common disorder in both adult and pediatric patients with DS. Several characteristics of DS may contribute to the development or worsening of OSAS. Numerous murine models of DS exist. A number of studies have explored apneas and the risk of upper airway obstruction in these models, but up until now, only in adulthood.
    MeSH term(s) Adult ; Humans ; Animals ; Child ; Mice ; Down Syndrome/complications ; Disease Models, Animal ; Sleep Apnea, Obstructive/complications ; Sleep Apnea, Obstructive/epidemiology ; Continuous Positive Airway Pressure
    Language French
    Publishing date 2024-03-08
    Publishing country France
    Document type English Abstract ; Journal Article
    ZDB-ID 605743-3
    ISSN 1776-2588 ; 0301-0279 ; 0761-8425
    ISSN (online) 1776-2588
    ISSN 0301-0279 ; 0761-8425
    DOI 10.1016/j.rmr.2024.02.010
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Comment faire face à un événement inattendu pouvant modifier l’activité normale de thérapie cellulaire ? Recommandations de la Société Francophone de Greffe de Moelle et de Thérapie Cellulaire (SFGM-TC).

    Bay, Jacques Olivier / Beguin, Yves / Carpentier, Alexandre / Dard, Céline / Guillaume, Thierry / Labussiere-Wallet, Hélène / Lacassagne, Marie Noëlle / Sauze, Séverine / Yakoub-Agha, Ibrahim / Chalandon, Yves

    Bulletin du cancer

    2021  Volume 108, Issue 12S, Page(s) S20–S25

    Abstract: The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T ...

    Title translation How to deal with an unexpected event that could alter the normal activity of cellular therapy? Recommendations of the Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC).
    Abstract The SARS-CoV-2 (COVID-19) pandemic has rapidly impacted cell therapy activities across the globe. Not only was this, unexpected event, a threat to patients who had previously received hematopoietic cell transplantation or other cell therapy such as CAR-T cells, but also, it was responsible for a disruption of cell therapy activities due to the danger of the virus and to the lack of solid scientific data on the management of patients and donors. The Francophone Society of Bone Marrow Transplantation and Cellular Therapy (SFGM-TC) devoted a workshop to issue useful recommendations in such an unexpected event in order to harmonize the actions of all the actors involved in cellular therapy programs so that we can collectively face, in the future, the challenges that could threaten our patients. This work is not specifically dedicated to the SARS-CoV-2 outbreak, but the latter has been used as a concrete example of an unexpected event to build up our recommendations.
    MeSH term(s) Bone Marrow Transplantation/standards ; COVID-19/epidemiology ; Cell Transplantation/standards ; Cryopreservation ; Health Services Accessibility ; Hematopoietic Stem Cell Transplantation/standards ; Humans ; Immunotherapy, Adoptive/standards ; Pandemics ; Receptors, Chimeric Antigen/therapeutic use ; Societies, Medical ; Tissue Donors
    Chemical Substances Receptors, Chimeric Antigen
    Language French
    Publishing date 2021-06-30
    Publishing country France
    Document type Journal Article ; Practice Guideline ; Review
    ZDB-ID 213270-9
    ISSN 1769-6917 ; 0007-4551
    ISSN (online) 1769-6917
    ISSN 0007-4551
    DOI 10.1016/j.bulcan.2021.05.002
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Immediate Implant Placement in the Esthetic Zone Using a Novel Tapered Implant Design and a Digital Integrated Workflow: A Case Series.

    Pariente, Leon / Dada, Karim / Linder, Susy / Dard, Michel

    The International journal of periodontics & restorative dentistry

    2023  Volume 43, Issue 5, Page(s) 578–587

    Abstract: The purpose of this case series was to assess the application of a novel self-cutting, tapered implant (Straumann® BLX, Institut Straumann AG, Basel, Switzerland) in combination with a digital integrated prosthetic workflow for the immediate placement ... ...

    Abstract The purpose of this case series was to assess the application of a novel self-cutting, tapered implant (Straumann® BLX, Institut Straumann AG, Basel, Switzerland) in combination with a digital integrated prosthetic workflow for the immediate placement and restoration. Fourteen consecutive patients, requiring replacement of a single hopeless maxillary or mandibular tooth, meeting the clinical and radiographic indication criteria for immediate implant placement, were treated. All cases followed the same digitally-guided procedure of extraction and immediate implant placement. Immediate temporization with full contoured screw-retained provisionals was performed using an integrated digital workflow. After implant placement and dual-zone bone and soft tissue augmentation, connecting geometries and emergence profiles were finalized. The average implant insertion torque was 53.2 ± 14.9 Ncm and ranged between 35 and 80 Ncm, allowing immediate provisional restoration in all cases. Final restorations were delivered three months after implant placement. An implant survival rate of 100% was observed at the 1-year recall after loading. The results of this case series suggest that immediate placement of novel tapered implants and immediate provisionalization using an integrated digital workflow can result in predictable functional and esthetic results for the immediate transition of failing single teeth in the esthetic area.
    MeSH term(s) Humans ; Dental Implants ; Dental Implants, Single-Tooth ; Workflow ; Esthetics, Dental ; Dental Implantation, Endosseous/methods ; Immediate Dental Implant Loading/methods ; Maxilla/surgery ; Treatment Outcome
    Chemical Substances Dental Implants
    Language English
    Publishing date 2023-06-19
    Publishing country United States
    Document type Journal Article
    ISSN 1945-3388
    ISSN (online) 1945-3388
    DOI 10.11607/prd.5313
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: A Multicenter Cohort Study on 301 Tissue-Level Implants: Cumulative Implant Survival Rate and Marginal Bone Level Change up to 4.5 Years.

    Chacun, Doriane / Laforest, Laurent / Langlois-Jacques, Carole / Dard, Michel / Gritsch, Kerstin / Grosgogeat, Brigitte

    The International journal of oral & maxillofacial implants

    2024  Volume 39, Issue 2, Page(s) 224–234

    Abstract: Purpose: To retrospectively determine the cumulative survival rate (CSR) and marginal bone level change (ΔMBL) around novel hybrid design tissue-level (TL) dental implants that support multiple-screw-retained restorations.: Materials and methods: ... ...

    Abstract Purpose: To retrospectively determine the cumulative survival rate (CSR) and marginal bone level change (ΔMBL) around novel hybrid design tissue-level (TL) dental implants that support multiple-screw-retained restorations.
    Materials and methods: Implant CSRs were analyzed at the implant and patient level using Kaplan-Meier estimates. ΔMBL was measured by comparing the periapical loading and follow-up visit radiographs using an improved standardized digital methodology based on image gray levels. ΔMBL outcomes were subject to linear mixed regression to identify potential risk factors.
    Results: A total of 301 TL implants in 69 patients with an average age of 62.6 ± 11.7 years (range: 36 to 87 years) at the time of implant placement were considered for the analysis. All 301 implants were successfully restored and loaded. The 54-month CSRs at the implant and patient levels were 98.9% (95% CI: 96.7 to 99.6) and 95.3% (95% CI: 86.1 to 98.5), respectively. ΔMBL after a mean follow-up of 22 ± 10.7 months after loading was 0.00 ± 0.57 mm. None of the implant sites showed marginal bone loss exceeding 1.5 mm. Multivariate regression analysis revealed a significant association between ΔMBL and the loading protocol (P = .027) but not between ΔMBL and age or transgingival height.
    Conclusions: The high CSRs and stable peri-implant marginal bone levels support the use of recent TL implants, which have a hybrid design inherited from the bone-level implant-abutment connection, as a suitable treatment option for restoring partially or fully edentulous patients with a good mid-term prognosis. These results should be complemented by further prospective studies in a real-world multicenter private practice setup that represents the daily realities of implant treatment.
    MeSH term(s) Humans ; Middle Aged ; Aged ; Male ; Female ; Adult ; Aged, 80 and over ; Retrospective Studies ; Dental Implants ; Dental Restoration Failure ; Alveolar Bone Loss/diagnostic imaging ; Dental Prosthesis Design ; Dental Prosthesis, Implant-Supported ; Dental Implantation, Endosseous/methods ; Treatment Outcome
    Chemical Substances Dental Implants
    Language English
    Publishing date 2024-01-23
    Publishing country United States
    Document type Journal Article ; Multicenter Study
    ZDB-ID 632880-5
    ISSN 1942-4434 ; 0882-2786
    ISSN (online) 1942-4434
    ISSN 0882-2786
    DOI 10.11607/jomi.10141
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  5. Article ; Online: Incidental and secondary findings in trio exome sequencing.

    Cohen, Camille / Bellanger, Emeline / Mortreux, Jeremie / Raymond, Laure / Vialard, François / Dard, Rodolphe

    Genes & diseases

    2023  Volume 11, Issue 4, Page(s) 101137

    Language English
    Publishing date 2023-10-11
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 2821806-1
    ISSN 2352-3042 ; 2352-3042
    ISSN (online) 2352-3042
    ISSN 2352-3042
    DOI 10.1016/j.gendis.2023.101137
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Quality of life, patient preferences, and implant survival and success of tapered implant-retained mandibular overdentures as a function of the attachment system.

    Indriksone, Ilze / Vitols, Pauls / Avkstols, Viktors / Grieznis, Linards / Stamers, Kaspars / Linder, Susy / Dard, Michel

    Journal of periodontal & implant science

    2022  Volume 53, Issue 3, Page(s) 194–206

    Abstract: Purpose: A novel attachment system for implant-retained overdentures (IRODs) with novel material combinations for improved mechanical resilience and prosthodontic success (Novaloc) has been recently introduced as an alternative to an existing system ( ... ...

    Abstract Purpose: A novel attachment system for implant-retained overdentures (IRODs) with novel material combinations for improved mechanical resilience and prosthodontic success (Novaloc) has been recently introduced as an alternative to an existing system (Locator). This study investigated whether differences between the Novaloc and Locator attachment systems translate into differences in implant survival, implant success, and patient-centered outcomes when applied in a real-world in-practice comparative setting in patients restored with mandibular IRODs supported by 2 interforaminal implants (2-IRODs).
    Methods: This prospective, intra-subject crossover comparison compared 20 patients who received 2 intra-foraminal bone level tapered implants restored with full acrylic overdentures using either the Locator or Novaloc attachment system. After 6 months of function, the attachment in the corresponding dentures was switched, and the definitive attachment system type was delivered based on the patient's preference after 12 months. For the definitive attachment system, implant survival was evaluated after 24 months. The primary outcomes of this study were oral health-related quality of life and patient preferences related to prosthetic and implant survival. Secondary outcomes included implant survival rate and success, prosthetic survival, perceived general health, and patient satisfaction.
    Results: Patient-centered outcomes and patient preferences between attachment systems were comparable, with relatively high overall patient satisfaction levels for both attachment systems. No difference in the prosthetic survival rate between study groups was detected. The implant survival rate over the follow-up period after 24 months in both groups was 100%.
    Conclusions: The results of this in-practice comparison indicate that both attachment systems represent comparable candidates for the prosthodontic retention of 2-IRODs. Both systems showed high rates of patient satisfaction and implant survival. The influence of material combinations of the retentive system on treatment outcomes between the tested systems remains inconclusive and requires further investigations.
    Language English
    Publishing date 2022-11-08
    Publishing country Korea (South)
    Document type Journal Article
    ZDB-ID 2557339-1
    ISSN 2093-2286 ; 2093-2278
    ISSN (online) 2093-2286
    ISSN 2093-2278
    DOI 10.5051/jpis.2105840292
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  7. Article ; Online: Mitochondrial functions and rare diseases.

    Dard, L / Blanchard, W / Hubert, C / Lacombe, D / Rossignol, R

    Molecular aspects of medicine

    2020  Volume 71, Page(s) 100842

    Abstract: Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical processes as energy transduction, REDOX signaling, the biosynthesis of hormones and vitamins, inflammation or cell death execution. Cell biology studies ... ...

    Abstract Mitochondria are dynamic cellular organelles responsible for a large variety of biochemical processes as energy transduction, REDOX signaling, the biosynthesis of hormones and vitamins, inflammation or cell death execution. Cell biology studies established that 1158 human genes encode proteins localized to mitochondria, as registered in MITOCARTA. Clinical studies showed that a large number of these mitochondrial proteins can be altered in expression and function through genetic, epigenetic or biochemical mechanisms including the interaction with environmental toxics or iatrogenic medicine. As a result, pathogenic mitochondrial genetic and functional defects participate to the onset and the progression of a growing number of rare diseases. In this review we provide an exhaustive survey of the biochemical, genetic and clinical studies that demonstrated the implication of mitochondrial dysfunction in human rare diseases. We discuss the striking diversity of the symptoms caused by mitochondrial dysfunction and the strategies proposed for mitochondrial therapy, including a survey of ongoing clinical trials.
    MeSH term(s) Animals ; Disease Progression ; Gene Expression Regulation ; Genetic Predisposition to Disease ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Mitochondrial Proteins/genetics ; Mitochondrial Proteins/metabolism ; Mutation ; Oxidation-Reduction ; Rare Diseases/genetics ; Rare Diseases/metabolism
    Chemical Substances Mitochondrial Proteins
    Language English
    Publishing date 2020-02-03
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Review
    ZDB-ID 197640-0
    ISSN 1872-9452 ; 0098-2997
    ISSN (online) 1872-9452
    ISSN 0098-2997
    DOI 10.1016/j.mam.2019.100842
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  8. Article ; Online: Glutathione-mediated thermomorphogenesis and heat stress responses in Arabidopsis thaliana.

    Dard, Avilien / Weiss, Alizée / Bariat, Laetitia / Auverlot, Juline / Fontaine, Valentine / Picault, Nathalie / Pontvianne, Frédéric / Riondet, Christophe / Reichheld, Jean-Philippe

    Journal of experimental botany

    2023  Volume 74, Issue 8, Page(s) 2707–2725

    Abstract: In the context of climate change, the global rise of temperature and intense heat waves affect plant development and productivity. Among the molecular perturbations that high temperature induces in living cells is the accumulation of reactive oxygen ... ...

    Abstract In the context of climate change, the global rise of temperature and intense heat waves affect plant development and productivity. Among the molecular perturbations that high temperature induces in living cells is the accumulation of reactive oxygen species (ROS), which perturbs the cellular redox state. In plants, the dynamics of the cellular and subcellular redox state have been poorly investigated under high temperature. Glutathione plays a major role in maintaining the cellular redox state. We investigated its contribution in adaptation of Arabidopsis thaliana to contrasting high temperature regimes: high ambient temperature inducing thermomorphogenesis and heat stress affecting plant viability. Using the genetically encoded redox marker roGFP2, we show that high temperature regimes lead to cytoplasmic and nuclear oxidation and impact the glutathione pool. This pool is restored within a few hours, which probably contributes to plant adaptation to high temperatures. Moreover, low glutathione mutants fail to adapt to heat stress and to induce thermomorphogenesis, suggesting that glutathione is involved in both heat adaptation mechanisms. We also evaluate the transcriptomic signature in the two high temperature regimes and identified gene expression deviations in low glutathione mutants, which might contribute to their sensitivity to high temperature. Thus, we define glutathione as a major player in the adaptation of Arabidopsis to contrasting high temperature regimes.
    MeSH term(s) Arabidopsis/metabolism ; Glutathione/metabolism ; Arabidopsis Proteins/metabolism ; Oxidation-Reduction ; Heat-Shock Response ; Gene Expression Regulation, Plant
    Chemical Substances Glutathione (GAN16C9B8O) ; Arabidopsis Proteins
    Language English
    Publishing date 2023-02-20
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2976-2
    ISSN 1460-2431 ; 0022-0957
    ISSN (online) 1460-2431
    ISSN 0022-0957
    DOI 10.1093/jxb/erad042
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  9. Article ; Online: Antimicrobial and mechanical assessment of cellulose-based thermoformable material for invisible dental braces with natural essential oils protecting from biofilm formation.

    Astasov-Frauenhoffer, Monika / Göldi, Livia / Rohr, Nadja / Worreth, Sarah / Dard, Elise / Hünerfauth, Selina / Töpper, Tino / Zurflüh, Jonas / Braissant, Olivier

    Scientific reports

    2023  Volume 13, Issue 1, Page(s) 13428

    Abstract: Controlling biofilm formation in the oral cavity during orthodontic treatments is crucial. Therefore, antimicrobial surfaces for invisible dental appliances are of interest to both therapists and patients. Here we present a cellulose-based thermoformable ...

    Abstract Controlling biofilm formation in the oral cavity during orthodontic treatments is crucial. Therefore, antimicrobial surfaces for invisible dental appliances are of interest to both therapists and patients. Here we present a cellulose-based thermoformable material used for invisible braces that can be loaded with essential oils (EOs) having antibacterial and antifungal properties. We hypothesize that this material can absorb and release EOs, thus providing an antimicrobial effect without compromising the safety and mechanical properties necessary for dental invisible braces. Conventional microbiology and isothermal microcalorimetry analyses revealed that the thermoformable material loaded with essential oils significantly delayed the biofilm formation of oral streptococci (S. mutans and S. mitis) under static conditions (p < 0.05) and while simulating saliva flow (p < 0.05). In addition, cytotoxicity tests (ISO 10993-5), revealed that the loaded material is well tolerated by human gingival fibroblasts. Finally, the loading with antibacterial agents did not significantly alter the mechanical properties and stability of the material (initial force (p = 0.916); initial stress (p = 0.465)). Compared to gold-standard clear aligner materials, this material offers a reliable transmission of forces for orthodontic treatments. Moreover, this approach exhibits the potential for acting as an oral drug delivery platform for multiple compounds.
    MeSH term(s) Humans ; Orthodontic Brackets ; Anti-Infective Agents ; Anti-Bacterial Agents/pharmacology ; Cellulose ; Oils, Volatile/pharmacology ; Biofilms
    Chemical Substances Anti-Infective Agents ; Anti-Bacterial Agents ; Cellulose (9004-34-6) ; Oils, Volatile
    Language English
    Publishing date 2023-08-18
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 2615211-3
    ISSN 2045-2322 ; 2045-2322
    ISSN (online) 2045-2322
    ISSN 2045-2322
    DOI 10.1038/s41598-023-39320-1
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  10. Article: Tocilizumab Evaluation in HLA-Desensitization before Kidney Transplantation as an Add-On Therapy to Apheresis: The TETRA Study.

    Jouve, Thomas / Daligault, Mélanie / Noble, Johan / Terrec, Florian / Imerzoukene, Farida / Dard, Céline / Bardy, Béatrice / Malvezzi, Paolo / Rostaing, Lionel

    Journal of clinical medicine

    2023  Volume 12, Issue 2

    Abstract: Background: Desensitization strategies improve access to transplantation in highly sensitized kidney transplant candidates. Tocilizumab could be a valuable addition to more traditional desensitization regimens. We investigated the effect of tocilizumab ... ...

    Abstract Background: Desensitization strategies improve access to transplantation in highly sensitized kidney transplant candidates. Tocilizumab could be a valuable addition to more traditional desensitization regimens. We investigated the effect of tocilizumab as an add-on therapy to our standard of care (SoC) desensitization strategy based on rituximab and apheresis.
    Methods: In this study, we prospectively included highly sensitized patients to receive monthly tocilizumab infusions for 6 months before our SoC regimen (Toci + SoC group). We compared the reductions in the mean fluorescent intensity (MFI) rebound at post-transplantation and kidney function at 1-year post-transplantation to patients treated by SoC (based on apheresis and two doses of rituximab).
    Results: Twenty-six patients were included in the SoC group; seven in the Toci + SoC group. Reductions in pre-transplantation MFI were similar between groups. At 1-year post-transplantation, there was no absolute difference in overall MFI rebounds, including donor-specific antibodies. Toci + SoC helped lower the rebound of antibodies with more elevated baseline MFIs. Graft function and survival rates were similar at one-year post-transplantation (median eGFR 62.8 vs. 65.6 mL/min/1.73 m
    Conclusions: Tocilizumab as an add-on to SoC desensitization may help control the post-transplantation rebound of antibodies with elevated baseline MFIs. However, reductions in pre-transplantation MFIs were similar with or without tocilizumab. Further studies are needed to validate this pilot study.
    Language English
    Publishing date 2023-01-04
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2662592-1
    ISSN 2077-0383
    ISSN 2077-0383
    DOI 10.3390/jcm12020424
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