LIVIVO - Search results -

Search results

Result 1 - 10 of total 8319

Search options

Article ; Online: Structural insights into functional properties of the oxidized form of cytochrome c oxidase.

Ishigami, Izumi / Sierra, Raymond G / Su, Zhen / Peck, Ariana / Wang, Cong / Poitevin, Frederic / Lisova, Stella / Hayes, Brandon / Moss, Frank R / Boutet, Sébastien / Sublett, Robert E / Yoon, Chun Hong / Yeh, Syun-Ru / Rousseau, Denis L

Nature communications

2023 Volume 14, Issue 1, Page(s) 5752

Abstract: Cytochrome c oxidase (CcO) is an essential enzyme in mitochondrial and bacterial respiration ...

Abstract	Cytochrome c oxidase (CcO) is an essential enzyme in mitochondrial and bacterial respiration. It catalyzes the four-electron reduction of molecular oxygen to water and harnesses the chemical energy to translocate four protons across biological membranes. The turnover of the CcO reaction involves an oxidative phase, in which the reduced enzyme (R) is oxidized to the metastable O
MeSH term(s)	Electron Transport Complex IV ; Protons ; Cell Membrane ; Crystallography, X-Ray ; Oxygen
Chemical Substances	Electron Transport Complex IV (EC 1.9.3.1) ; Protons ; Oxygen (S88TT14065)
Language	English
Publishing date	2023-09-16
Publishing country	England
Document type	Journal Article ; Research Support, U.S. Gov't, Non-P.H.S. ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	2553671-0
ISSN	2041-1723 ; 2041-1723
ISSN (online)	2041-1723
ISSN	2041-1723
DOI	10.1038/s41467-023-41533-x
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

This service is chargeable due to the Delivery terms set by subito. Orders including an article and supplementary material will be classified as separate orders. In these cases, fees will be demanded for each order.

Article ; Online: cMyBP-C ablation in human engineered cardiac tissue causes progressive Ca2+-handling abnormalities.

De Lange, Willem J / Farrell, Emily T / Hernandez, Jonathan J / Stempien, Alana / Kreitzer, Caroline R / Jacobs, Derek R / Petty, Dominique L / Moss, Richard L / Crone, Wendy C / Ralphe, J Carter

The Journal of general physiology

2023 Volume 155, Issue 4

Abstract: Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes ... cMyBP-C+/-) and homozygous (cMyBP-C-/-) frame-shift mutations into MYBPC3 in human iPSCs. Cardiomyocytes ... sensitivity. While heterozygous frame shifts did not alter cMyBP-C protein levels in 2-D cardiomyocytes, cMyBP ...

Abstract	Truncation mutations in cardiac myosin binding protein C (cMyBP-C) are common causes of hypertrophic cardiomyopathy (HCM). Heterozygous carriers present with classical HCM, while homozygous carriers present with early onset HCM that rapidly progress to heart failure. We used CRISPR-Cas9 to introduce heterozygous (cMyBP-C+/-) and homozygous (cMyBP-C-/-) frame-shift mutations into MYBPC3 in human iPSCs. Cardiomyocytes derived from these isogenic lines were used to generate cardiac micropatterns and engineered cardiac tissue constructs (ECTs) that were characterized for contractile function, Ca2+-handling, and Ca2+-sensitivity. While heterozygous frame shifts did not alter cMyBP-C protein levels in 2-D cardiomyocytes, cMyBP-C+/- ECTs were haploinsufficient. cMyBP-C-/- cardiac micropatterns produced increased strain with normal Ca2+-handling. After 2 wk of culture in ECT, contractile function was similar between the three genotypes; however, Ca2+-release was slower in the setting of reduced or absent cMyBP-C. At 6 wk in ECT culture, the Ca2+-handling abnormalities became more pronounced in both cMyBP-C+/- and cMyBP-C-/- ECTs, and force production became severely depressed in cMyBP-C-/- ECTs. RNA-seq analysis revealed enrichment of differentially expressed hypertrophic, sarcomeric, Ca2+-handling, and metabolic genes in cMyBP-C+/- and cMyBP-C-/- ECTs. Our data suggest a progressive phenotype caused by cMyBP-C haploinsufficiency and ablation that initially is hypercontractile, but progresses to hypocontractility with impaired relaxation. The severity of the phenotype correlates with the amount of cMyBP-C present, with more severe earlier phenotypes observed in cMyBP-C-/- than cMyBP-C+/- ECTs. We propose that while the primary effect of cMyBP-C haploinsufficiency or ablation may relate to myosin crossbridge orientation, the observed contractile phenotype is Ca2+-mediated.
MeSH term(s)	Humans ; Calcium/metabolism ; Tissue Engineering ; Myocardial Contraction ; Carrier Proteins/genetics ; Carrier Proteins/metabolism ; Myocytes, Cardiac/metabolism ; Cardiomyopathy, Hypertrophic ; Mutation
Chemical Substances	Calcium (SY7Q814VUP) ; Carrier Proteins
Language	English
Publishing date	2023-03-09
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov't
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202213204
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Discovery and Optimization of the First ATP Competitive Type-III c-MET Inhibitor.

Michaelides, Iacovos N / Collie, Gavin W / Börjesson, Ulf / Vasalou, Christina / Alkhatib, Omar / Barlind, Louise / Cheung, Tony / Dale, Ian L / Embrey, Kevin J / Hennessy, Edward J / Khurana, Puneet / Koh, Cheryl M / Lamb, Michelle L / Liu, Jianming / Moss, Thomas A / O'Neill, Daniel J / Phillips, Christopher / Shaw, Joseph / Snijder, Arjan /

Storer, R Ian / Stubbs, Christopher J / Han, Fujin / Li, Chengzhi / Qiao, Jingchuan / Sun, Dong-Qing / Wang, Jingwen / Wang, Peng / Yang, Wenzhen

Journal of medicinal chemistry

2023 Volume 66, Issue 13, Page(s) 8782–8807

Abstract: ... of c-MET kinase for the treatment of cancer. We report herein a novel chemical series of ATP ... competitive type-III inhibitors of WT and D1228V mutant c-MET. Using a combination of structure-based ...

Abstract	Recent clinical reports have highlighted the need for wild-type (WT) and mutant dual inhibitors of c-MET kinase for the treatment of cancer. We report herein a novel chemical series of ATP competitive type-III inhibitors of WT and D1228V mutant c-MET. Using a combination of structure-based drug design and computational analyses, ligand
MeSH term(s)	Rats ; Animals ; Protein Kinase Inhibitors/pharmacology ; Proto-Oncogene Proteins c-met ; Neoplasms ; Drug Design ; Adenosine Triphosphate ; Antineoplastic Agents/pharmacology
Chemical Substances	Protein Kinase Inhibitors ; Proto-Oncogene Proteins c-met (EC 2.7.10.1) ; Adenosine Triphosphate (8L70Q75FXE) ; Antineoplastic Agents
Language	English
Publishing date	2023-06-21
Publishing country	United States
Document type	Journal Article
ZDB-ID	218133-2
ISSN	1520-4804 ; 0022-2623
ISSN (online)	1520-4804
ISSN	0022-2623
DOI	10.1021/acs.jmedchem.3c00401
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.B 151: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular ab Jg. 2022: Lesesaal (EG)
Zs.MB 1: Show issues

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Computational, Mechanistic, and Experimental Insights into Regioselective Catalytic C-C Bond Activation in Linear 1-Aza-[3]triphenylene.

Ulč, Jan / Asanuma, Yuya / Moss, Robert / Manca, Gabriele / Císařová, Ivana / Kotora, Martin

ACS omega

2022 Volume 7, Issue 10, Page(s) 8665–8674

Abstract: C-C bond activation by transition metal complexes in ring-strained compounds followed by annulation ... However, the site of catalytic C-C bond activation is difficult to predict in unsymmetrically substituted polycyclic systems ... Here, we report a study on the (regio)selective catalytic cleavage of selected C-C bonds in 1-aza-[3 ...

Abstract	C-C bond activation by transition metal complexes in ring-strained compounds followed by annulation with unsaturated compounds is an efficient approach to generate structurally more complex compounds. However, the site of catalytic C-C bond activation is difficult to predict in unsymmetrically substituted polycyclic systems. Here, we report a study on the (regio)selective catalytic cleavage of selected C-C bonds in 1-aza-[3]triphenylene, followed by annulation with alkynes, forming products with extended π-conjugated frameworks. Based on density functional theory (DFT) calculations, we established the stability of possible transition metal intermediates formed by oxidative addition to the C-C bond and thus identified the likely site of C-C bond activation. The computationally predicted selectivity was confirmed by the following experimental tests for the corresponding Ir-catalyzed C-C cleavage reaction followed by an alkyne insertion that yielded mixtures of two mono-insertion products isolated with yields of 34-36%, due to the close reactivity of two bonds during the first C-C bond activation. Similar results were obtained for twofold Ir- or Rh-catalyzed insertion reactions, with higher yields of 72-77%. In a broader context, by combining DFT calculations, which provided insights into the relative reactivity of individual C-C bonds, with experimental results, our approach allows us to synthesize previously unknown pentacyclic azaaromatic compounds.
Language	English
Publishing date	2022-03-04
Publishing country	United States
Document type	Journal Article
ISSN	2470-1343
ISSN (online)	2470-1343
DOI	10.1021/acsomega.1c06664
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Lung Protection by Cathepsin C Inhibition

Korkmaz, Brice / Lesner, Adam / Marchand-Adam, Sylvain / Moss, Celia / Jenne, Dieter E.

Journal of Medicinal Chemistry ; ISSN 0022-2623 1520-4804

A New Hope for COVID-19 and ARDS? ; Miniperspective

2020

Keywords	Molecular Medicine ; Drug Discovery ; covid19
Language	English
Publisher	American Chemical Society (ACS)
Publishing country	us
Document type	Article ; Online
DOI	10.1021/acs.jmedchem.0c00776
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

Full text online

Full text

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Seasonality, C:N ratio and plant species influence on denitrification and plant nitrogen uptake in treatment wetlands

Allen, C.R. / Burr, M.D. / Camper, A.K. / Moss, J.J. / Stein, O.R.

Ecological Engineering. , p.106946-

2023 , Page(s) 106946–

Abstract: ... NH₄-N and 54 NO₃-N) and three organic carbon‑nitrogen (C:N) ratios (0, 1.2, 2.4) was batch-loaded ... and C:N ratio. Strong interactions between independent variables influence interpretation. At a C:N ... microcosms. However, unplanted microcosms showed nearly complete TDN removal at the highest C:N ratio and ...

Abstract	Synthetic wastewater with an average total dissolved nitrogen (TDN) concentration of 72 mg l⁻¹ (18 NH₄-N and 54 NO₃-N) and three organic carbon‑nitrogen (C:N) ratios (0, 1.2, 2.4) was batch-loaded to 72 microcosms planted in monocultures of five plant species or left unplanted. Water quality was measured at 0, 1, 3, 6, 9, and 15 days during 15-day incubations at eight temperature settings ranging from 4 to 24 °C. This allowed for comparisons of TDN removal as influenced by plant species, temperature, and C:N ratio. Strong interactions between independent variables influence interpretation. At a C:N ratio of zero, all plant species significantly increased TDN removal compared to the unplanted microcosms. However, unplanted microcosms showed nearly complete TDN removal at the highest C:N ratio and warm temperatures; removal decreased with decreasing temperature and C:N ratio. TDN removal in Deschampsia cespitosa and Typha latifolia was better but responded similarly to unplanted with respect to temperature and C:N ratio. Conversely, microcosms of Phragmites australis and Schoneoplectus acutus had complete and rapid removal of all applied TDN (177 g N m⁻² yr⁻¹) under all C:N ratios and temperatures. Complete TDN removal was observed in Carex utriculata for all C:N ratios and temperatures except for the coldest temperature (4 °C). However, increasing the C:N ratio at this temperature increased TDN removal. Higher C:N ratios increase TDN removal, likely by increased denitrification, but simultaneously reduce plant biomass and plant uptake of nitrogen. Overall, removal of nitrate was enhanced with organic carbon addition and warm temperature, but specific plant species promoted complete removal even without organic carbon and in winter.
Keywords	Carex utriculata ; Deschampsia cespitosa ; Phragmites australis ; Typha latifolia ; carbon nitrogen ratio ; denitrification ; nitrates ; nitrogen ; organic carbon ; phytomass ; plant nitrogen content ; temperature ; wastewater ; water quality ; winter ; Ammonium ; Carex ; Constructed wetland ; Deschampsia ; Nitrate ; Nitrification ; Phragmites ; Schoenoplectus ; Typha
Language	English
Publishing place	Elsevier B.V.
Document type	Article ; Online
Note	Pre-press version
ZDB-ID	1127407-4
ISSN	0925-8574
ISSN	0925-8574
DOI	10.1016/j.ecoleng.2023.106946
Database	NAL-Catalogue (AGRICOLA)

In stock of ZB MED Bonn / Germany

Z 5865: Show issues

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: cMyBP-C phosphorylation modulates the time-dependent slowing of unloaded shortening in murine skinned myocardium.

Giles, Jasmine / Fitzsimons, Daniel P / Patel, Jitandrakumar R / Knudtsen, Chloe / Neuville, Alexander / Moss, Richard L

The Journal of general physiology

2021 Volume 153, Issue 3

Abstract: In myocardium, phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) is thought to modulate ... Vmax) at saturating Ca2+. To test the idea that cMyBP-C phosphorylation contributes to the activation ... trabecula isolated from mice expressing either wild-type cMyBP-C (tWT), nonphosphorylatable cMyBP-C (t3SA ...

Abstract	In myocardium, phosphorylation of cardiac myosin-binding protein-C (cMyBP-C) is thought to modulate the cooperative activation of the thin filament by binding to myosin and/or actin, thereby regulating the probability of cross-bridge binding to actin. At low levels of Ca2+ activation, unloaded shortening velocity (Vo) in permeabilized cardiac muscle is comprised of an initial high-velocity phase and a subsequent low-velocity phase. The velocities in these phases scale with the level of activation, culminating in a single high-velocity phase (Vmax) at saturating Ca2+. To test the idea that cMyBP-C phosphorylation contributes to the activation dependence of Vo, we measured Vo before and following treatment with protein kinase A (PKA) in skinned trabecula isolated from mice expressing either wild-type cMyBP-C (tWT), nonphosphorylatable cMyBP-C (t3SA), or phosphomimetic cMyBP-C (t3SD). During maximal Ca2+ activation, Vmax was monophasic and not significantly different between the three groups. Although biphasic shortening was observed in all three groups at half-maximal activation under control conditions, the high- and low-velocity phases were faster in the t3SD myocardium compared with values obtained in either tWT or t3SA myocardium. Treatment with PKA significantly accelerated both the high- and low-velocity phases in tWT myocardium but had no effect on Vo in either the t3SD or t3SA myocardium. These results can be explained in terms of a model in which the level of cMyBP-C phosphorylation modulates the extent and rate of cooperative spread of myosin binding to actin.
MeSH term(s)	Animals ; Carrier Proteins/metabolism ; Mice ; Mice, Knockout ; Myocardial Contraction ; Myocardium/metabolism ; Phosphorylation
Chemical Substances	Carrier Proteins
Language	English
Publishing date	2021-02-18
Publishing country	United States
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	3118-5
ISSN	1540-7748 ; 0022-1295
ISSN (online)	1540-7748
ISSN	0022-1295
DOI	10.1085/jgp.202012782
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Uc I Zs.150: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: Highly Coupled Heterobicycle-Fused Porphyrin Dimers: Excitonic Coupling and Charge Separation with Coordinated Fullerene, C

Moss, Austen / Jang, Youngwoo / Arvidson, Jacob / Wang, Hong / D'Souza, Francis

ChemSusChem

2023 Volume 16, Issue 8, Page(s) e202202289

Abstract: Porphyrin dimers have been widely explored and studied owing to their importance in photosynthetic systems. A vast variety of dimers linked by different groups and at different angles have been synthesized and studied; however, the means by which to ... ...

Abstract	Porphyrin dimers have been widely explored and studied owing to their importance in photosynthetic systems. A vast variety of dimers linked by different groups and at different angles have been synthesized and studied; however, the means by which to synthesize rigidly fused porphyrins with direct conjugation of the chromophores remains limited. Such a class of porphyrins may possess interesting properties that unconjugated or stacked dimers may not exhibit. In this study, bisbenzimidazole-fused porphyrin dimers and their mono- and bis-zinc derivatives are synthesized and characterized. As a consequence of excitonic coupling, these dimers exhibit a split Soret band irrespective of the metal ion in the porphyrin cavity. Steady-state fluorescence and excitation spectra followed by femtosecond transient absorption spectral studies of the heterometallated dimer, (free-base and zinc porphyrin) reveals the occurrence of efficient singlet-singlet energy transfer (>95 % efficiency and rate constant >10
Language	English
Publishing date	2023-03-13
Publishing country	Germany
Document type	Journal Article
ISSN	1864-564X
ISSN (online)	1864-564X
DOI	10.1002/cssc.202202289
Database	MEDical Literature Analysis and Retrieval System OnLINE

Order via subito

Inter-library loan at ZB MED

Your chosen title can be delivered directly to ZB MED Cologne location if you are registered as a user at ZB MED Cologne.

Article ; Online: Therapeutic targeting of cathepsin C: from pathophysiology to treatment.

Pharmacology & therapeutics

2018 Volume 190, Page(s) 202–236

Abstract: Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase ...

Abstract	Cathepsin C (CatC) is a highly conserved tetrameric lysosomal cysteine dipeptidyl aminopeptidase. The best characterized physiological function of CatC is the activation of pro-inflammatory granule-associated serine proteases. These proteases are synthesized as inactive zymogens containing an N-terminal pro-dipeptide, which maintains the zymogen in its inactive conformation and prevents premature activation, which is potentially toxic to the cell. The activation of serine protease zymogens occurs through cleavage of the N-terminal dipeptide by CatC during cell maturation in the bone marrow. In vivo data suggest that pharmacological inhibition of pro-inflammatory serine proteases would suppress or attenuate deleterious effects mediated by these proteases in inflammatory/auto-immune disorders. The pathological deficiency in CatC is associated with Papillon-Lefèvre syndrome (PLS). The patients however do not present marked immunodeficiency despite the absence of active serine proteases in immune defense cells. Hence, the transitory pharmacological blockade of CatC activity in the precursor cells of the bone marrow may represent an attractive therapeutic strategy to regulate activity of serine proteases in inflammatory and immunologic conditions. A variety of CatC inhibitors have been developed both by pharmaceutical companies and academic investigators, some of which are currently being employed and evaluated in preclinical/clinical trials.
MeSH term(s)	Animals ; Autoimmune Diseases/drug therapy ; Autoimmune Diseases/physiopathology ; Cathepsin C/antagonists & inhibitors ; Cathepsin C/metabolism ; Drug Development/methods ; Humans ; Inflammation/drug therapy ; Inflammation/physiopathology ; Papillon-Lefevre Disease/drug therapy ; Papillon-Lefevre Disease/physiopathology ; Serine Proteases/metabolism
Chemical Substances	Serine Proteases (EC 3.4.-) ; Cathepsin C (EC 3.4.14.1)
Language	English
Publishing date	2018-05-26
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	194735-7
ISSN	1879-016X ; 0163-7258
ISSN (online)	1879-016X
ISSN	0163-7258
DOI	10.1016/j.pharmthera.2018.05.011
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Zs.A 1183: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular
Jg. 1995 - 2021: Lesesall (1.OG)
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

Article ; Online: α-synuclein aggregates induce c-Abl activation and dopaminergic neuronal loss by a feed-forward redox stress mechanism.

Ghosh, Soumitra / Won, Seok Joon / Wang, Jiejie / Fong, Rebecca / Butler, Nicholas J M / Moss, Arianna / Wong, Candance / Pan, June / Sanchez, Jennifer / Huynh, Annie / Wu, Long / Manfredsson, Fredric P / Swanson, Raymond A

Progress in neurobiology

2021 Volume 202, Page(s) 102070

Abstract: ... and the protein kinase c-Abl provides a potential amplifying link between these pathogenic factors ... aggregation in neuronal cultures. Exposure to PFFs induced oxidative stress and c-Abl activation in wild-type ... to exhibit either oxidative stress or c-Abl activation. N-acetyl cysteine, a thiol repletion agent ...

Abstract	Oxidative stress and α-synuclein aggregation both drive neurodegeneration in Parkinson's disease, and the protein kinase c-Abl provides a potential amplifying link between these pathogenic factors. Suppressing interactions between these factors may thus be a viable therapeutic approach for this disorder. To evaluate this possibility, pre-formed α-synuclein fibrils (PFFs) were used to induce α-synuclein aggregation in neuronal cultures. Exposure to PFFs induced oxidative stress and c-Abl activation in wild-type neurons. By contrast, α-synuclein - deficient neurons, which cannot form α-synuclein aggregates, failed to exhibit either oxidative stress or c-Abl activation. N-acetyl cysteine, a thiol repletion agent that supports neuronal glutathione metabolism, suppressed the PFF - induced redox stress and c-Abl activation in the wild-type neurons, and likewise suppressed α-synuclein aggregation. Parallel findings were observed in mouse brain: PFF-induced α-synuclein aggregation in the substantia nigra was associated with redox stress, c-Abl activation, and dopaminergic neuronal loss, along with microglial activation and motor impairment, all of which were attenuated with oral N-acetyl cysteine. Similar results were obtained using AAV-mediated α-synuclein overexpression as an alternative means of driving α-synuclein aggregation in vivo. These findings show that α-synuclein aggregates induce c-Abl activation by a redox stress mechanism. c-Abl activation in turn promotes α-synuclein aggregation, in a feed-forward interaction. The capacity of N-acetyl cysteine to interrupt this interaction adds mechanistic support its consideration as a therapeutic in Parkinson's disease.
MeSH term(s)	Animals ; Cysteine ; Dopamine ; Dopaminergic Neurons/metabolism ; Mice ; Oxidation-Reduction ; Parkinson Disease/drug therapy ; Substantia Nigra/metabolism ; alpha-Synuclein/metabolism
Chemical Substances	alpha-Synuclein ; Cysteine (K848JZ4886) ; Dopamine (VTD58H1Z2X)
Language	English
Publishing date	2021-05-02
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, Non-P.H.S.
ZDB-ID	185535-9
ISSN	1873-5118 ; 0301-0082
ISSN (online)	1873-5118
ISSN	0301-0082
DOI	10.1016/j.pneurobio.2021.102070
Database	MEDical Literature Analysis and Retrieval System OnLINE

In stock of ZB MED Cologne/Königswinter

Se 205: Show issues

Location:
Je nach Verfügbarkeit (siehe Angabe bei Bestand)
bis Jg. 2021: Bestellungen von Artikeln über das Online-Bestellformular
ab Jg. 2022: Lesesaal (EG)

Order via subito

Details ▾
- See ZB MED holdings
- Order with fees

To top

More links

Kategorien

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

Full text online

More links

Kategorien

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Bonn / Germany

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

Order via subito

Inter-library loan at ZB MED

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito

More links

Kategorien

In stock of ZB MED Cologne/Königswinter

Order via subito