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  1. Article ; Online: RE: ISTH interim guidance to recognition and management of coagulopathy in COVID-19.

    Akima, Satoshi / McLintock, Claire / Hunt, Beverley J

    Journal of thrombosis and haemostasis : JTH

    2020  Volume 18, Issue 8, Page(s) 2057–2058

    MeSH term(s) Betacoronavirus ; Blood Coagulation Disorders ; COVID-19 ; Coronavirus Infections ; Humans ; Pandemics ; Pneumonia, Viral ; SARS-CoV-2
    Keywords covid19
    Language English
    Publishing date 2020-07-15
    Publishing country England
    Document type Letter ; Comment
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14853
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  3. Article ; Online: RE

    Akima, Satoshi / McLintock, Claire / Hunt, Beverley J.

    Journal of Thrombosis and Haemostasis

    ISTH interim guidance to recognition and management of coagulopathy in COVID‐19

    2020  Volume 18, Issue 8, Page(s) 2057–2058

    Keywords Hematology ; covid19
    Language English
    Publisher Wiley
    Publishing country us
    Document type Article ; Online
    ZDB-ID 2112661-6
    ISSN 1538-7836 ; 1538-7933
    ISSN (online) 1538-7836
    ISSN 1538-7933
    DOI 10.1111/jth.14853
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  4. Article ; Online: Mean-field analysis of directed modular networks.

    Moriya, Satoshi / Yamamoto, Hideaki / Akima, Hisanao / Hirano-Iwata, Ayumi / Kubota, Shigeru / Sato, Shigeo

    Chaos (Woodbury, N.Y.)

    2019  Volume 29, Issue 1, Page(s) 13142

    Abstract: We considered a modular network with a binomial degree distribution and related the analytical relationships of the network properties (modularity, average clustering coefficient, and small-worldness) with structural parameters that define the network, i. ...

    Abstract We considered a modular network with a binomial degree distribution and related the analytical relationships of the network properties (modularity, average clustering coefficient, and small-worldness) with structural parameters that define the network, i.e., number of nodes, number of modules, average node degree, and ratio of intra-modular to total connections. Even though modular networks are universally found in real-world systems and are consequently of broad interest in complex network science, the relationship between network properties and structural parameters has not yet been formulated. Here, we show that a series of equations for predicting the network properties can be related using a mean-field connectivity matrix that is defined on the basis of the structural parameters in the network generation algorithm. The theoretical results are then compared with values calculated numerically using the original connectivity matrix and are found to agree well, except when the connections between modules are sparse. Representation of the structure of the network using simple parameters is expected to be conducive for elucidating the structure-dynamics relationship.
    Language English
    Publishing date 2019-01-31
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1472677-4
    ISSN 1089-7682 ; 1054-1500
    ISSN (online) 1089-7682
    ISSN 1054-1500
    DOI 10.1063/1.5044689
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  5. Book ; Online: Accuracy Improvement Technique of DNN for Accelerating CFD Simulator

    Tsunoda, Yukito / Mori, Toshihiko / Akima, Hisanao / Inano, Satoshi / Tabaru, Tsuguchika / Oyama, Akira

    2021  

    Abstract: There is a Computational fluid dynamics (CFD) method of incorporating the DNN inference to reduce the computational cost. The reduction is realized by replacing some calculations by DNN inference. The cost reduction depends on the implementation method ... ...

    Abstract There is a Computational fluid dynamics (CFD) method of incorporating the DNN inference to reduce the computational cost. The reduction is realized by replacing some calculations by DNN inference. The cost reduction depends on the implementation method of the DNN and the accuracy of the DNN inference. Thus, we propose two techniques suitable to infer flow field on the CFD grid. The first technique is to infer the flow field of the steady state from the airfoil shape. We use the position on the coordinates of the grid point and the distance from the surface of the airfoil as input information for the DNN. The second method uses the customized mean square error as a loss function. The size of the associated area for each grid point was multiplied by the square error. This method compensates for the effect caused by the size of the associated area of nonuniform allocation of grid points. The evaluation results show that the CFD incorporated first technique achieves 1.7x speedup against the CFD without DNN, while maintaining equivalent result quality. By implementing the second technique, the CFD realized further 2.3x speed up against the CFD with first technique only.
    Keywords Physics - Fluid Dynamics ; Physics - Computational Physics
    Subject code 621
    Publishing date 2021-06-03
    Publishing country us
    Document type Book ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  6. Article ; Online: Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants

    Kiyomi Shitaoka / Akifumi Higashiura / Yohei Kawano / Akima Yamamoto / Yoko Mizoguchi / Takao Hashiguchi / Norihisa Nishimichi / Shiyu Huang / Ayano Ito / Shun Ohki / Miyuki Kanda / Tomohiro Taniguchi / Rin Yoshizato / Hitoshi Azuma / Yasuo Kitajima / Yasuyuki Yokosaki / Satoshi Okada / Takemasa Sakaguchi / Tomoharu Yasuda

    Communications Biology, Vol 6, Iss 1, Pp 1-

    2023  Volume 14

    Abstract: Abstract The decrease of antibody efficacy to mutated SARS-CoV-2 spike RBD explains the breakthrough infections and reinfections by Omicron variants. Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent ... ...

    Abstract Abstract The decrease of antibody efficacy to mutated SARS-CoV-2 spike RBD explains the breakthrough infections and reinfections by Omicron variants. Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent patients of early SARS-CoV-2 strains. One of the antibodies named NCV2SG48 is highly potent to broad SARS-CoV-2 variants including Omicron BA.1, BA.2, and BA.4/5. To reveal the mode of action, we determined the sequence and crystal structure of the Fab fragment of NCV2SG48 in a complex with spike RBD from the original, Delta, and Omicron BA.1. NCV2SG48 is from a minor VH but the multiple somatic hypermutations contribute to a markedly extended binding interface and hydrogen bonds to interact with conserved residues at the core receptor-binding motif of RBD, which efficiently neutralizes a broad spectrum of variants. Thus, eliciting the RBD-specific B cells to the longitudinal germinal center reaction confers potent immunity to broad SARS-CoV-2 variants emerging one after another.
    Keywords Biology (General) ; QH301-705.5
    Language English
    Publishing date 2023-04-01T00:00:00Z
    Publisher Nature Portfolio
    Document type Article ; Online
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  7. Article ; Online: Structural basis of spike RBM-specific human antibodies counteracting broad SARS-CoV-2 variants.

    Shitaoka, Kiyomi / Higashiura, Akifumi / Kawano, Yohei / Yamamoto, Akima / Mizoguchi, Yoko / Hashiguchi, Takao / Nishimichi, Norihisa / Huang, Shiyu / Ito, Ayano / Ohki, Shun / Kanda, Miyuki / Taniguchi, Tomohiro / Yoshizato, Rin / Azuma, Hitoshi / Kitajima, Yasuo / Yokosaki, Yasuyuki / Okada, Satoshi / Sakaguchi, Takemasa / Yasuda, Tomoharu

    Communications biology

    2023  Volume 6, Issue 1, Page(s) 395

    Abstract: The decrease of antibody efficacy to mutated SARS-CoV-2 spike RBD explains the breakthrough infections and reinfections by Omicron variants. Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent patients of ... ...

    Abstract The decrease of antibody efficacy to mutated SARS-CoV-2 spike RBD explains the breakthrough infections and reinfections by Omicron variants. Here, we analyzed broadly neutralizing antibodies isolated from long-term hospitalized convalescent patients of early SARS-CoV-2 strains. One of the antibodies named NCV2SG48 is highly potent to broad SARS-CoV-2 variants including Omicron BA.1, BA.2, and BA.4/5. To reveal the mode of action, we determined the sequence and crystal structure of the Fab fragment of NCV2SG48 in a complex with spike RBD from the original, Delta, and Omicron BA.1. NCV2SG48 is from a minor V
    MeSH term(s) Humans ; SARS-CoV-2 ; COVID-19 ; Antibodies ; Immunoglobulin Fab Fragments
    Chemical Substances Antibodies ; Immunoglobulin Fab Fragments
    Language English
    Publishing date 2023-04-11
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 2399-3642
    ISSN (online) 2399-3642
    DOI 10.1038/s42003-023-04782-6
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  8. Article ; Online: Post-artesunate delayed haemolysis in severe imported Plasmodium falciparum malaria.

    Chavada, Ruchir / Hui, Siong H / O'Connor, Sean / Akima, Satoshi / Gosbell, Iain B

    The Medical journal of Australia

    2015  Volume 203, Issue 9, Page(s) 364

    MeSH term(s) Adult ; Antimalarials/adverse effects ; Artemisinins/adverse effects ; Artesunate ; Female ; Hemolysis/drug effects ; Humans ; Malaria, Falciparum/complications ; Malaria, Falciparum/drug therapy
    Chemical Substances Antimalarials ; Artemisinins ; Artesunate (60W3249T9M)
    Language English
    Publishing date 2015-08-13
    Publishing country Australia
    Document type Case Reports ; Journal Article
    ZDB-ID 186082-3
    ISSN 1326-5377 ; 0025-729X
    ISSN (online) 1326-5377
    ISSN 0025-729X
    DOI 10.5694/mja15.00565
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    Ua VI Zs.398: Show issues Location:
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  9. Article ; Online: Therapeutic efficacy of large aligned cardiac tissue derived from induced pluripotent stem cell in a porcine ischemic cardiomyopathy model.

    Suzuki, Kota / Miyagawa, Shigeru / Liu, Li / Kawamura, Takuji / Li, Junjun / Qu, Xiang / Harada, Akima / Toda, Koichi / Yoshioka, Daisuke / Kainuma, Satoshi / Kawamura, Ai / Sawa, Yoshiki

    The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation

    2021  Volume 40, Issue 8, Page(s) 767–777

    Abstract: Background: Although induced pluripotent stem (iPS) cell-derived cardiac constructs may have a potential in cardiomyogenesis of a distressed myocardium, obtaining polarity in cardiac constructs, such as via myocyte alignment, may be crucial to achieve a ...

    Abstract Background: Although induced pluripotent stem (iPS) cell-derived cardiac constructs may have a potential in cardiomyogenesis of a distressed myocardium, obtaining polarity in cardiac constructs, such as via myocyte alignment, may be crucial to achieve a maximum contractile force for better clinical outcomes. We herein hypothesized that transplantation of an aligned cardiac tissue derived from iPS cells has therapeutic effects in a porcine ischemic cardiomyopathy model as a preclinical trial.
    Methods: Aligned cardiac tissues were developed by culturing high-purity iPS cell-derived cardiomyocytes in xeno-free conditions and transplanting them into infarct porcine hearts (iPS-CM group, n = 7; control, n = 6). Three months after treatment, therapeutic efficacy was evaluated functionally and histologically.
    Results: In vitro assessment revealed that the aligned cardiac tissue containing high purity cardiomyocytes contracted homogeneously and had excellent mechanical properties. In the in vivo study, the left ventricular ejection fraction of the iPS-CM group was significantly greater than that of the control group, 3 months after transplantation (37.8% ± 2.3% vs 28.3% ± 2.5%, p < 0.05). Pathologically, attenuated interstitial fibrosis, attenuation of hypertrophied cardiomyocytes, and an increased capillary density were also prominent in the iPS-CM group. A limited amount of engraftment of the transplanted tissue maintaining tissue alignment was observed at 2 weeks after transplantation.
    Conclusions: The creation of large-scale functional aligned cardiac tissue was feasible, and the transplantation of the aligned tissue improved cardiac function with angiogenesis and antifibrotic effects in a porcine cardiomyopathy model.
    MeSH term(s) Animals ; Cardiomyopathies/diagnosis ; Cardiomyopathies/physiopathology ; Cardiomyopathies/therapy ; Cell Differentiation ; Cells, Cultured ; Disease Models, Animal ; Induced Pluripotent Stem Cells/transplantation ; Myocardial Ischemia/diagnosis ; Myocardial Ischemia/physiopathology ; Myocardial Ischemia/therapy ; Myocytes, Cardiac/transplantation ; Swine ; Tissue Engineering/methods ; Ventricular Remodeling/physiology
    Language English
    Publishing date 2021-05-08
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 1062522-7
    ISSN 1557-3117 ; 1053-2498
    ISSN (online) 1557-3117
    ISSN 1053-2498
    DOI 10.1016/j.healun.2021.04.010
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  10. Article ; Online: Germinal center-derived broadly neutralizing antibodies adapt to SARS-CoV-2 antigenic drift

    Shitaoka, Kiyomi / Kawano, Yohei / Higashiura, Akifumi / Mizoguchi, Yoko / Hashiguchi, Takao / Nishimichi, Norihisa / Huang, Shiyu / Ito, Ayano / Yamamoto, Akima / Ohki, Shun / Kanda, Miyuki / Taniguchi, Tomohiro / Yokosaki, Yasuyuki / Okada, Satoshi / Sakaguchi, Takemasa / Yasuda, Tomoharu

    bioRxiv

    Abstract: The outbreak of SARS-CoV-2 variant Omicron which harbors a striking number of mutations in the spike protein has been raising concerns about the effectiveness of vaccines and antibody treatment1. Here, we confirmed a substantial reduction in neutralizing ...

    Abstract The outbreak of SARS-CoV-2 variant Omicron which harbors a striking number of mutations in the spike protein has been raising concerns about the effectiveness of vaccines and antibody treatment1. Here, we confirmed a substantial reduction in neutralizing potency against Omicron in all convalescent and vaccinated sera. However, we found that some people infected by the early strain show relatively higher neutralization to Omicron. From those B cells, we developed neutralizing antibodies inhibiting broad variants including Delta and Omicron. Unlike reported antibodies, one had an extremely large interface and widely covered receptor binding motif of spike, thereby interfering with diversified variants. Somatic mutations introduced by long-term germinal center reaction contributed to the key structure of antibodies and the universal interaction with spike variants. Recalling such rare B cells may confer sustainable protection against SARS-CoV-2 variants emerging one after another.
    Keywords covid19
    Language English
    Publishing date 2022-01-27
    Publisher Cold Spring Harbor Laboratory
    Document type Article ; Online
    DOI 10.1101/2022.01.26.477937
    Database COVID19

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