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Article: G

Millett, Michael / Heuberger, Anika / Castosa, Elisabeth Martin / Comite, Allison / Wagner, Preston / Hall, Dominic / Gallardo, Ignacio / Chambers, Nicole E / Wagner, Lloyd / Moehle, Mark S

bioRxiv : the preprint server for biology

2024

Abstract: The heterotrimeric G-protein α subunit, Gα ...

Abstract	The heterotrimeric G-protein α subunit, Gα
Language	English
Publishing date	2024-04-05
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.04.03.587766
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: The Concise Guide to PHARMACOLOGY 2023/24: G protein-coupled receptors.

Alexander, Stephen P H / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair A / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Davies, Jamie A / Abbracchio, Maria Pia / Abraham, George / Agoulnik, Alexander / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Baker, Jillian G / Barnes, Nicholas M /

Bathgate, Ross / Beaulieu, Jean-Martin / Beck-Sickinger, Annette G / Behrens, Maik / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Cox, Helen M / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Garelja, Michael L / de Gasparo, Marc / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Grätz, Lukas / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Herr, Deron / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Larhammar, Dan / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Malfacini, Davide / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip M / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Singh, Khuraijam Dhanachandra / Smith, Craig M / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Toll, Lawrence / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Williams, Tom Lloyd / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

British journal of pharmacology

2023 Volume 180 Suppl 2, Page(s) S23–S144

Abstract: ... of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one ...

Abstract	The Concise Guide to PHARMACOLOGY 2023/24 is the sixth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of approximately 1800 drug targets, and about 6000 interactions with about 3900 ligands. There is an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (https://www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes almost 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.16177. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2023, and supersedes data presented in the 2021/22, 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
MeSH term(s)	Humans ; Databases, Pharmaceutical ; Receptors, G-Protein-Coupled ; Ligands ; Ion Channels/chemistry ; Receptors, Cytoplasmic and Nuclear
Chemical Substances	Receptors, G-Protein-Coupled ; Ligands ; Ion Channels ; Receptors, Cytoplasmic and Nuclear
Language	English
Publishing date	2023-12-18
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.16177
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Article ; Online: Regulation of the Hippo-YAP Pathway by G-Protein-Coupled Receptor Signaling.

Yu, Fa-Xing / Zhao, Bin / Panupinthu, Nattapon / Jewell, Jenna L / Lian, Ian / Wang, Lloyd H / Zhao, Jiagang / Yuan, Haixin / Tumaneng, Karen / Li, Hairi / Fu, Xiang-Dong / Mills, Gordon B / Guan, Kun-Liang

Cell

2024 Volume 187, Issue 6, Page(s) 1563–1564

Language	English
Publishing date	2024-03-15
Publishing country	United States
Document type	Published Erratum
ZDB-ID	187009-9
ISSN	1097-4172 ; 0092-8674
ISSN (online)	1097-4172
ISSN	0092-8674
DOI	10.1016/j.cell.2024.02.007
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Article ; Online: THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: G protein-coupled receptors.

Alexander, Stephen Ph / Christopoulos, Arthur / Davenport, Anthony P / Kelly, Eamonn / Mathie, Alistair / Peters, John A / Veale, Emma L / Armstrong, Jane F / Faccenda, Elena / Harding, Simon D / Pawson, Adam J / Southan, Christopher / Davies, Jamie A / Abbracchio, Maria Pia / Alexander, Wayne / Al-Hosaini, Khaled / Bäck, Magnus / Barnes, Nicholas M / Bathgate, Ross /

Beaulieu, Jean-Martin / Bernstein, Kenneth E / Bettler, Bernhard / Birdsall, Nigel J M / Blaho, Victoria / Boulay, Francois / Bousquet, Corinne / Bräuner-Osborne, Hans / Burnstock, Geoffrey / Caló, Girolamo / Castaño, Justo P / Catt, Kevin J / Ceruti, Stefania / Chazot, Paul / Chiang, Nan / Chini, Bice / Chun, Jerold / Cianciulli, Antonia / Civelli, Olivier / Clapp, Lucie H / Couture, Réjean / Csaba, Zsolt / Dahlgren, Claes / Dent, Gordon / Singh, Khuraijam Dhanachandra / Douglas, Steven D / Dournaud, Pascal / Eguchi, Satoru / Escher, Emanuel / Filardo, Edward J / Fong, Tung / Fumagalli, Marta / Gainetdinov, Raul R / Gasparo, Marc de / Gerard, Craig / Gershengorn, Marvin / Gobeil, Fernand / Goodfriend, Theodore L / Goudet, Cyril / Gregory, Karen J / Gundlach, Andrew L / Hamann, Jörg / Hanson, Julien / Hauger, Richard L / Hay, Debbie L / Heinemann, Akos / Hollenberg, Morley D / Holliday, Nicholas D / Horiuchi, Mastgugu / Hoyer, Daniel / Hunyady, László / Husain, Ahsan / IJzerman, Adriaan P / Inagami, Tadashi / Jacobson, Kenneth A / Jensen, Robert T / Jockers, Ralf / Jonnalagadda, Deepa / Karnik, Sadashiva / Kaupmann, Klemens / Kemp, Jacqueline / Kennedy, Charles / Kihara, Yasuyuki / Kitazawa, Takio / Kozielewicz, Pawel / Kreienkamp, Hans-Jürgen / Kukkonen, Jyrki P / Langenhan, Tobias / Leach, Katie / Lecca, Davide / Lee, John D / Leeman, Susan E / Leprince, Jérôme / Li, Xaria X / Williams, Tom Lloyd / Lolait, Stephen J / Lupp, Amelie / Macrae, Robyn / Maguire, Janet / Mazella, Jean / McArdle, Craig A / Melmed, Shlomo / Michel, Martin C / Miller, Laurence J / Mitolo, Vincenzo / Mouillac, Bernard / Müller, Christa E / Murphy, Philip / Nahon, Jean-Louis / Ngo, Tony / Norel, Xavier / Nyimanu, Duuamene / O'Carroll, Anne-Marie / Offermanns, Stefan / Panaro, Maria Antonietta / Parmentier, Marc / Pertwee, Roger G / Pin, Jean-Philippe / Prossnitz, Eric R / Quinn, Mark / Ramachandran, Rithwik / Ray, Manisha / Reinscheid, Rainer K / Rondard, Philippe / Rovati, G Enrico / Ruzza, Chiara / Sanger, Gareth J / Schöneberg, Torsten / Schulte, Gunnar / Schulz, Stefan / Segaloff, Deborah L / Serhan, Charles N / Stoddart, Leigh A / Sugimoto, Yukihiko / Summers, Roger / Tan, Valerie P / Thal, David / Thomas, Walter Wally / Timmermans, Pieter B M W M / Tirupula, Kalyan / Tulipano, Giovanni / Unal, Hamiyet / Unger, Thomas / Valant, Celine / Vanderheyden, Patrick / Vaudry, David / Vaudry, Hubert / Vilardaga, Jean-Pierre / Walker, Christopher S / Wang, Ji Ming / Ward, Donald T / Wester, Hans-Jürgen / Willars, Gary B / Woodruff, Trent M / Yao, Chengcan / Ye, Richard D

British journal of pharmacology

2021 Volume 178 Suppl 1, Page(s) S27–S156

Abstract: ... The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein ...

Abstract	The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key properties of nearly 1900 human drug targets with an emphasis on selective pharmacology (where available), plus links to the open access knowledgebase source of drug targets and their ligands (www.guidetopharmacology.org), which provides more detailed views of target and ligand properties. Although the Concise Guide constitutes over 500 pages, the material presented is substantially reduced compared to information and links presented on the website. It provides a permanent, citable, point-in-time record that will survive database updates. The full contents of this section can be found at http://onlinelibrary.wiley.com/doi/bph.15538. G protein-coupled receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: ion channels, nuclear hormone receptors, catalytic receptors, enzymes and transporters. These are presented with nomenclature guidance and summary information on the best available pharmacological tools, alongside key references and suggestions for further reading. The landscape format of the Concise Guide is designed to facilitate comparison of related targets from material contemporary to mid-2021, and supersedes data presented in the 2019/20, 2017/18, 2015/16 and 2013/14 Concise Guides and previous Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC-IUPHAR), therefore, providing official IUPHAR classification and nomenclature for human drug targets, where appropriate.
MeSH term(s)	Databases, Pharmaceutical ; Humans ; Ion Channels ; Ligands ; Pharmacology ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled
Chemical Substances	Ion Channels ; Ligands ; Receptors, Cytoplasmic and Nuclear ; Receptors, G-Protein-Coupled
Language	English
Publishing date	2021-09-22
Publishing country	England
Document type	Journal Article
ZDB-ID	80081-8
ISSN	1476-5381 ; 0007-1188
ISSN (online)	1476-5381
ISSN	0007-1188
DOI	10.1111/bph.15538
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Complete Genome Sequences of Cluster G Mycobacteriophage Darionha, Cluster A Mycobacteriophage Salz, and Cluster J Mycobacteriophage ThreeRngTarjay.

Sandoval, Andrea M / Abram, Amber M / Alhabib, Zahraa M / Antonyan, Angelina S / Brikho, Salar M / Buhay, Sarah I / Craig, Griffin E / Crile, Karen G / El Yaman, Nour / Garcia-Leon, Lizbeth / Hammoud, Zahraa B / Huffman, Anthony R / Issa, Ali H / Jackman, Alexander B / Krajcz, Victoria K / Lloyd, Yamiya J / Jones, Marcel L / McMahon, Diana L / Murdock, Briana A D /

Nelson, Jada J / Patel, Tulsi T / Patil, Yashodhara V / Ricketts, Sabriyyah A / Romero-Barajas, Leonardo S / Sareini, Laila H / Sesoko, Channing S / Shammami, Marcelio A / Sheardy, Erin E / Sherwood, John R / Simpson, Arren E / Tiba, Racha H / Conant, Stephanie B / Finkel, Jonathan S / Kagey, Jacob D

Microbiology resource announcements

2020 Volume 9, Issue 20

Abstract: Mycobacteriophages Darionha, Salz, and ThreeRngTarjay are mycobacteriophages isolated using the ... ...

Abstract	Mycobacteriophages Darionha, Salz, and ThreeRngTarjay are mycobacteriophages isolated using the host
Language	English
Publishing date	2020-05-14
Publishing country	United States
Document type	Journal Article
ISSN	2576-098X
ISSN (online)	2576-098X
DOI	10.1128/MRA.00160-20
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Article ; Online: Analyzing kinetic signaling data for G-protein-coupled receptors.

Hoare, Sam R J / Tewson, Paul H / Quinn, Anne Marie / Hughes, Thomas E / Bridge, Lloyd J

Scientific reports

2020 Volume 10, Issue 1, Page(s) 12263

Abstract: In classical pharmacology, bioassay data are fit to general equations (e.g. the dose response ... equation) to determine empirical drug parameters (e.g. EC ...

Abstract	In classical pharmacology, bioassay data are fit to general equations (e.g. the dose response equation) to determine empirical drug parameters (e.g. EC
MeSH term(s)	Dose-Response Relationship, Drug ; Drug Discovery ; Models, Biological ; Pharmacokinetics ; Receptors, G-Protein-Coupled/metabolism ; Signal Transduction/drug effects
Chemical Substances	Receptors, G-Protein-Coupled
Language	English
Publishing date	2020-07-23
Publishing country	England
Document type	Journal Article ; Research Support, N.I.H., Extramural
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/s41598-020-67844-3
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Conference proceedings ; Online: Piloting the G + Customer and Product Profile Tools for gender-responsive bean breeding in Zimbabwe

Nchanji, Eileen Bogweh / Lutomia, Cosmas Kweyu / Rubyogo, Jean-Claude / Chirwa, Rowland / Onyango, Patricia / Nyarai, Chisorochengwe / Tsekenedza, Shylet / Gutsa, Freeman / Lloyd, Sondayi

2023

Abstract: ... The tool; G+ product and customer profile recognizes changes in the modern agriculture as production and ...

Abstract	Gender is an integral part of bean breeding initiatives and provides the platform through which plant breeding should be implemented. Gender-sensitive breeding offers a clear focus on addressing gender gap in agriculture by considering different traits preferred by both men and women (Nchanji et al., 2021b). Through the gender lens, critical elements in women and men’s preferences are consulted even though such profiles do not necessarily have different traits for men and women (Nchanji et al., 2021b). Breeding teams are therefore capable of assessing gender-relevant differences in preferences, constraints, needs, and potential impact on women and men’s livelihood strategies. This observation is founded on the critical role women play in production of common beans in Zimbabwe. Therefore, their participation in bean breeding initiatives is considered essential because it is regarded as a women’s crop (PABRA 2015a). The CGIAR gender and breeding initiative has developed an important tool to guide breeders in identifying the gender gaps and preferences of customer to develop and prioritize new product that address persistent gender gaps in crop production. The tool; G+ product and customer profile recognizes changes in the modern agriculture as production and marketing systems transition towards more demand-driven business models for social inclusivity.
Keywords	gender ; gender analysis ; breeding ; product development ; value chains ; género ; análisis de género ; fitomejoramiento
Language	English
Publishing date	2023-01-04T08:59:02Z
Publishing country	fr
Document type	Conference proceedings ; Online
Database	BASE - Bielefeld Academic Search Engine (life sciences selection)

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Article ; Online: Sub-Femto-g Free Fall for Space-Based Gravitational Wave Observatories: LISA Pathfinder Results.

Armano, M / Audley, H / Auger, G / Baird, J T / Bassan, M / Binetruy, P / Born, M / Bortoluzzi, D / Brandt, N / Caleno, M / Carbone, L / Cavalleri, A / Cesarini, A / Ciani, G / Congedo, G / Cruise, A M / Danzmann, K / de Deus Silva, M / De Rosa, R /

Diaz-Aguiló, M / Di Fiore, L / Diepholz, I / Dixon, G / Dolesi, R / Dunbar, N / Ferraioli, L / Ferroni, V / Fichter, W / Fitzsimons, E D / Flatscher, R / Freschi, M / García Marín, A F / García Marirrodriga, C / Gerndt, R / Gesa, L / Gibert, F / Giardini, D / Giusteri, R / Guzmán, F / Grado, A / Grimani, C / Grynagier, A / Grzymisch, J / Harrison, I / Heinzel, G / Hewitson, M / Hollington, D / Hoyland, D / Hueller, M / Inchauspé, H / Jennrich, O / Jetzer, P / Johann, U / Johlander, B / Karnesis, N / Kaune, B / Korsakova, N / Killow, C J / Lobo, J A / Lloro, I / Liu, L / López-Zaragoza, J P / Maarschalkerweerd, R / Mance, D / Martín, V / Martin-Polo, L / Martino, J / Martin-Porqueras, F / Madden, S / Mateos, I / McNamara, P W / Mendes, J / Mendes, L / Monsky, A / Nicolodi, D / Nofrarias, M / Paczkowski, S / Perreur-Lloyd, M / Petiteau, A / Pivato, P / Plagnol, E / Prat, P / Ragnit, U / Raïs, B / Ramos-Castro, J / Reiche, J / Robertson, D I / Rozemeijer, H / Rivas, F / Russano, G / Sanjuán, J / Sarra, P / Schleicher, A / Shaul, D / Slutsky, J / Sopuerta, C F / Stanga, R / Steier, F / Sumner, T / Texier, D / Thorpe, J I / Trenkel, C / Tröbs, M / Tu, H B / Vetrugno, D / Vitale, S / Wand, V / Wanner, G / Ward, H / Warren, C / Wass, P J / Wealthy, D / Weber, W J / Wissel, L / Wittchen, A / Zambotti, A / Zanoni, C / Ziegler, T / Zweifel, P

Physical review letters

2016 Volume 116, Issue 23, Page(s) 231101

Abstract: ... of the power spectral density of 5.2±0.1 fm s^{-2}/sqrt[Hz], or (0.54±0.01)×10^{-15} g/sqrt[Hz], with g ...

Abstract	We report the first results of the LISA Pathfinder in-flight experiment. The results demonstrate that two free-falling reference test masses, such as those needed for a space-based gravitational wave observatory like LISA, can be put in free fall with a relative acceleration noise with a square root of the power spectral density of 5.2±0.1 fm s^{-2}/sqrt[Hz], or (0.54±0.01)×10^{-15} g/sqrt[Hz], with g the standard gravity, for frequencies between 0.7 and 20 mHz. This value is lower than the LISA Pathfinder requirement by more than a factor 5 and within a factor 1.25 of the requirement for the LISA mission, and is compatible with Brownian noise from viscous damping due to the residual gas surrounding the test masses. Above 60 mHz the acceleration noise is dominated by interferometer displacement readout noise at a level of (34.8±0.3) fm/sqrt[Hz], about 2 orders of magnitude better than requirements. At f≤0.5 mHz we observe a low-frequency tail that stays below 12 fm s^{-2}/sqrt[Hz] down to 0.1 mHz. This performance would allow for a space-based gravitational wave observatory with a sensitivity close to what was originally foreseen for LISA.
Language	English
Publishing date	2016-06-10
Publishing country	United States
Document type	Journal Article
ZDB-ID	208853-8
ISSN	1079-7114 ; 0031-9007
ISSN (online)	1079-7114
ISSN	0031-9007
DOI	10.1103/PhysRevLett.116.231101
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Article: Microscale thermophoresis analysis of the molecular interaction between small nuclear ribonucleoprotein polypeptide G and the RING finger domain of RBBP6 towards anti-cancer drug discovery.

Mabonga, Lloyd / Masamba, Priscilla / Basson, Albertus Kotze / Kappo, Abidemi Paul

American journal of translational research

2021 Volume 13, Issue 11, Page(s) 12775–12785

Abstract: Regulatory core-splicing proteins are now becoming highly promising therapeutic targets for the development of anti-cancer drugs. SNRPG and RBBP6 are two good examples of regulatory core-splicing proteins involved in tumorigenesis and tumor development ... ...

Abstract	Regulatory core-splicing proteins are now becoming highly promising therapeutic targets for the development of anti-cancer drugs. SNRPG and RBBP6 are two good examples of regulatory core-splicing proteins involved in tumorigenesis and tumor development whose multi-functional role is primarily mediated by protein-protein interactions. Over the years, skepticism abutting from the two onco-proteins has been mounting. Suggestive evidence using yeast 2-hybrid technique observed possible involvement between SNRPG and the RING finger domain of RBBP6. However, the putative interaction remains elusive and yet to be characterized. In this study, we developed the first MST-based assay to confirm the interaction between SNRPG and the RING finger domain of RBBP6. The results demonstrated a strong binding affinity between SNRPG and the RING finger domain of RBBP6 with a K
Language	English
Publishing date	2021-11-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Molecular interaction between small nuclear ribonucleoprotein polypeptide G and heat shock protein 70.14: a microscale thermophoresis exposition towards developing anti-cancer drugs.

Mabonga, Lloyd / Ikwegbue, Paul Chukwudi / Masamba, Priscilla / Kappo, Abidemi Paul

American journal of translational research

2022 Volume 14, Issue 9, Page(s) 6150–6162

Abstract: ... polypeptide G (SNRPG) and heat shock protein 70.14 (Hsp70.14) have attracted attention as potential smart ...

Abstract	Background: Targeting protein-protein interactions (PPIs) linked to protein quality control (PQC) pathways as potential anti-cancer drug targets have unanimously widened biological insights and the therapeutic potential of PPIs as smart-drug discovery tools in cancer. PPIs between disease-relevant proteins associated with protein homeostasis in PQC pathways have been linked to improved mechanistic understanding associated with conformational abnormalities and impairment, cellular proteotoxicity, induced apoptosis, and pathogenesis in different types of cancers. In this context, PPIs between small nuclear ribonucleoprotein polypeptide G (SNRPG) and heat shock protein 70.14 (Hsp70.14) have attracted attention as potential smart drug discovery tools in cancer diagnostics and therapeutics. Validated evidence of high-quality biological data has shown the presence of the two proteins in different types of cancers including breast cancer. The links between SNRPG and Hsp70.14 in cancer-cell networks remain elusive, overlooked, and uncharacterized. Methodology: In this study, we explored the interaction between the two oncogenic proteins using the MST-based assays. Results: The results revealed a low K Conclusions: The results suggest a possible involvement between the two proteins in hostile tumour microenvironments. Furthermore, these findings offer a different therapeutic perspective that could pave the way for the creation of novel small molecule inhibitors as drugs for the treatment of cancer.
Language	English
Publishing date	2022-09-15
Publishing country	United States
Document type	Journal Article
ZDB-ID	2471058-1
ISSN	1943-8141
ISSN	1943-8141
Database	MEDical Literature Analysis and Retrieval System OnLINE

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