Article: [Effect of Xinling Wan in treatment of stable angina pectoris: a randomized, double-blinded, placebo parallel-controlled, multicenter trial].
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica
2018 Volume 43, Issue 6, Page(s) 1268–1275
Abstract: To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris ... The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and ... the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan ...
| Abstract | To evaluate the effectiveness and safety of Xinling Wan on patients with stable angina pectoris, a randomized, double-blinded, placebo parallel-controlled, multicenter clinical trial was conducted. A total of 232 subjects were enrolled and randomly divided into experiment group and placebo group. The experiment group was treated with Xinling Wan (two pills each time, three times daily) for 4 weeks, and the placebo group was treated with placebo. The effectiveness evaluation showed that Xinling Wan could significantly increase the total duration of treadmill exercise among patients with stable angina pectoris. FAS analysis showed that the difference value of the total exercise duration was between experiment group (72.11±139.32) s and placebo group (31.25±108.32) s. Xinling Wan could remarkably increase the total effective rate of angina pectoris symptom score, and the analysis showed that the total effective rate was 78.95% in experiment group and 42.61% in placebo group. The reduction of nitroglycerin dose was (2.45±2.41) tablets in experiment group and (0.50±2.24) tablets in placebo group on the basis of FAS analysis. The decrease of symptom integral was (4.68±3.49) in experiment group and (3.19±3.31) in placebo group based on FAS analysis. Besides, Xinling Wan could decrease the weekly attack time and the duration of angina pectoris. PPS analysis results were similar to those of FAS analysis. In conclusion, Xinling Wan has an obvious therapeutic effect in treating stable angina pectoris, with a good safety and a low incidence of adverse event and adverse reaction in experiment group. |
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| MeSH term(s) | Angina Pectoris/drug therapy ; Angina, Stable/drug therapy ; Double-Blind Method ; Drugs, Chinese Herbal/therapeutic use ; Exercise Test ; Humans ; Nitroglycerin |
| Chemical Substances | Drugs, Chinese Herbal ; Nitroglycerin (G59M7S0WS3) |
| Language | Chinese |
| Publishing date | 2018-04-16 |
| Publishing country | China |
| Document type | Journal Article ; Multicenter Study ; Randomized Controlled Trial |
| ZDB-ID | 1004649-5 |
| ISSN | 1001-5302 ; 0254-0029 |
| ISSN | 1001-5302 ; 0254-0029 |
| DOI | 10.19540/j.cnki.cjcmm.20171226.002 |
| Database | MEDical Literature Analysis and Retrieval System OnLINE |
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