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Book ; Online: F-PKI

Chuat, Laurent / Krähenbühl, Cyrill / Mittal, Prateek / Perrig, Adrian

Enabling Innovation and Trust Flexibility in the HTTPS Public-Key Infrastructure

2021

Abstract: We present F-PKI, an enhancement to the HTTPS public-key infrastructure (or web PKI) that gives ... with F-PKI, each domain owner can define a domain policy (specifying, for example, which CAs are ... based on trust levels. F-PKI thus supports a property that is sorely needed in today's Internet: trust ...

Abstract	We present F-PKI, an enhancement to the HTTPS public-key infrastructure (or web PKI) that gives trust flexibility to both clients and domain owners, and enables certification authorities (CAs) to enforce stronger security measures. In today's web PKI, all CAs are equally trusted, and security is defined by the weakest link. We address this problem by introducing trust flexibility in two dimensions: with F-PKI, each domain owner can define a domain policy (specifying, for example, which CAs are authorized to issue certificates for their domain name) and each client can set or choose a validation policy based on trust levels. F-PKI thus supports a property that is sorely needed in today's Internet: trust heterogeneity. Different parties can express different trust preferences while still being able to verify all certificates. In contrast, today's web PKI only allows clients to fully distrust suspicious/misbehaving CAs, which is likely to cause collateral damage in the form of legitimate certificates being rejected. Our contribution is to present a system that is backward compatible, provides sensible security properties to both clients and domain owners, ensures the verifiability of all certificates, and prevents downgrade attacks. Furthermore, F-PKI provides a ground for innovation, as it gives CAs an incentive to deploy new security measures to attract more customers, without having these measures undercut by vulnerable CAs. Comment: Network and Distributed System Security Symposium (NDSS) 2022
Keywords	Computer Science - Cryptography and Security
Subject code	303
Publishing date	2021-08-19
Publishing country	us
Document type	Book ; Online
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Article ; Online: Ancistrosecolines A-F, Unprecedented

Fayez, Shaimaa / Bruhn, Torsten / Feineis, Doris / Assi, Laurent Aké / Awale, Suresh / Bringmann, Gerhard

Journal of natural products

2020 Volume 83, Issue 4, Page(s) 1139–1151

Abstract: Ancistrosecolines A-F ( ...

Abstract	Ancistrosecolines A-F (
MeSH term(s)	Alkaloids/chemistry ; Alkaloids/isolation & purification ; Alkaloids/pharmacology ; Antineoplastic Agents, Phytogenic/chemistry ; Antineoplastic Agents, Phytogenic/isolation & purification ; Antineoplastic Agents, Phytogenic/pharmacology ; Apoptosis/drug effects ; Caryophyllales/chemistry ; Cell Line, Tumor ; HeLa Cells ; Humans ; Isoquinolines/chemistry ; Isoquinolines/isolation & purification ; Isoquinolines/pharmacology ; Magnoliopsida/chemistry ; Molecular Structure ; Plant Roots/chemistry
Chemical Substances	Alkaloids ; Antineoplastic Agents, Phytogenic ; Isoquinolines
Language	English
Publishing date	2020-03-03
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	304325-3
ISSN	1520-6025 ; 0163-3864
ISSN (online)	1520-6025
ISSN	0163-3864
DOI	10.1021/acs.jnatprod.9b01168
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Article ; Online: Amphidinolides F and C2: An Odyssey in Total Synthesis.

Ferrié, Laurent / Ciss, Ismaila / Fenneteau, Johan / Vallerotto, Sara / Seck, Matar / Figadère, Bruno

The Journal of organic chemistry

2022 Volume 87, Issue 2, Page(s) 1110–1123

Abstract: Amphidinolides F, C, C2, and C3 are marine natural products isolated from dinoflagellates ...

Abstract	Amphidinolides F, C, C2, and C3 are marine natural products isolated from dinoflagellates
MeSH term(s)	Biological Products ; Dinoflagellida ; Macrolides ; Molecular Structure ; Stereoisomerism
Chemical Substances	Biological Products ; Macrolides ; amphidinolide F (139594-87-9)
Language	English
Publishing date	2022-01-07
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02458
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Article ; Online: Advances Toward Amphidinolides C, F and U: Isolations, Synthetic Studies and Total Syntheses.

Ciss, Ismaila / Seck, Matar / Figadère, Bruno / Ferrié, Laurent

Chemistry (Weinheim an der Bergstrasse, Germany)

2024 , Page(s) e202400471

Abstract: Amphidinolides C, F, and U, including C2-C4 analogs, are highly cytotoxic marine macrolides, mainly ... of these compounds. The various synthetic approaches to the total synthesis of C, F, and U amphidinolides are ...

Abstract	Amphidinolides C, F, and U, including C2-C4 analogs, are highly cytotoxic marine macrolides, mainly isolated from dinoflagellates of the genus Amphidinium. All these polyketides share a 75 % or more similar structure, highlighted by a macrolactone ring, at least one trans-2,5-substituted-THF motif and a characteristic polyenic side chain. From their isolation and absolute configurational assignment, the total synthesis of these marine macrolides represented an intense challenge to the organic synthesis community over the last 15 years, with around 14 research groups engaged in this inspiring task. In the first part of this review, we present the different approaches to the isolation and characterization of these natural products, including the most recent analogs, which may cast doubt on the biogenetic origin of these compounds. The various synthetic approaches to the total synthesis of C, F, and U amphidinolides are presented in a second part, focusing on key reactions and/or innovative strategies. The review concludes in a third section summarizing the successful approaches leading to the total synthesis of one of the members of this amphidinolide subfamily.
Language	English
Publishing date	2024-02-26
Publishing country	Germany
Document type	Journal Article ; Review
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202400471
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Article ; Online: High efficacy of the F-ATP synthase inhibitor TBAJ-5307 against nontuberculous mycobacteria in vitro and in vivo.

Ragunathan, Priya / Sae-Lao, Patcharaporn / Hamela, Claire / Alcaraz, Matthéo / Krah, Alexander / Poh, Wee Han / Ern Pee, Carmen Jia / Hou Lim, Albert Yick / Rice, Scott A / Pethe, Kevin / Bond, Peter J / Dick, Thomas / Kremer, Laurent / Bates, Roderick W / Grüber, Gerhard

The Journal of biological chemistry

2024 Volume 300, Issue 2, Page(s) 105618

Abstract: The F ...

Abstract	The F
MeSH term(s)	Humans ; Adenosine Triphosphate ; Anti-Bacterial Agents/pharmacology ; Anti-Bacterial Agents/therapeutic use ; Azabicyclo Compounds ; Carbapenems ; Enzyme Inhibitors/pharmacology ; Microbial Sensitivity Tests ; Mycobacterium Infections, Nontuberculous/drug therapy ; Mycobacterium Infections, Nontuberculous/microbiology ; Nontuberculous Mycobacteria ; Diarylquinolines/pharmacology
Chemical Substances	Adenosine Triphosphate (8L70Q75FXE) ; Anti-Bacterial Agents ; avibactam (7352665165) ; Azabicyclo Compounds ; Carbapenems ; Enzyme Inhibitors ; tebipenem (Q2TWQ1I31U) ; Diarylquinolines
Language	English
Publishing date	2024-01-03
Publishing country	United States
Document type	Journal Article
ZDB-ID	2997-x
ISSN	1083-351X ; 0021-9258
ISSN (online)	1083-351X
ISSN	0021-9258
DOI	10.1016/j.jbc.2023.105618
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Article ; Online: Pharmacological inhibition of the F

Cabou, Cendrine / Honorato, Paula / Briceño, Luis / Ghezali, Lamia / Duparc, Thibaut / León, Marcelo / Combes, Guillaume / Frayssinhes, Laure / Fournel, Audren / Abot, Anne / Masri, Bernard / Parada, Nicol / Aguilera, Valeria / Aguayo, Claudio / Knauf, Claude / González, Marcelo / Radojkovic, Claudia / Martinez, Laurent O

Acta physiologica (Oxford, England)

2019 Volume 226, Issue 3, Page(s) e13268

Abstract: ... regarding endothelial receptors involved in this effect. Ecto-F: Method: Nitric oxide synthesis was ... of endothelial nitric oxide synthase (eNOS) and of the ecto-F: Conclusions: Using a pharmacological approach, we thus found ... activation of the ecto-F ...

Abstract	Aim: The contribution of apolipoprotein A1 (APOA1), the major apolipoprotein of high-density lipoprotein (HDL), to endothelium-dependent vasodilatation is unclear, and there is little information regarding endothelial receptors involved in this effect. Ecto-F Method: Nitric oxide synthesis was assessed in human endothelial cells from umbilical veins (HUVECs) and isolated mouse aortas. Changes in vascular tone were evaluated by isometric force measurements in isolated human umbilical and placental veins and by assessing femoral artery blood flow in conscious mice. Results: Physiological concentrations of lipid-free APOA1 enhanced endothelial NO synthesis, which was abolished by inhibitors of endothelial nitric oxide synthase (eNOS) and of the ecto-F Conclusions: Using a pharmacological approach, we thus found that APOA1 promotes endothelial NO production and thereby controls vascular tone in a process that requires activation of the ecto-F
MeSH term(s)	Adenosine Diphosphate/metabolism ; Animals ; Apolipoprotein A-I/metabolism ; Endothelium/metabolism ; Female ; Human Umbilical Vein Endothelial Cells/metabolism ; Humans ; Male ; Mice ; Mice, Inbred C57BL ; Nitric Oxide/metabolism ; Nitric Oxide Synthase Type III/metabolism ; Pregnancy ; Proton-Translocating ATPases/metabolism ; Receptors, Purinergic P2Y1/metabolism ; Signal Transduction/physiology ; Vasodilation/drug effects
Chemical Substances	APOA1 protein, human ; Apoa1 protein, mouse ; Apolipoprotein A-I ; Receptors, Purinergic P2Y1 ; Nitric Oxide (31C4KY9ESH) ; Adenosine Diphosphate (61D2G4IYVH) ; Nitric Oxide Synthase Type III (EC 1.14.13.39) ; Proton-Translocating ATPases (EC 3.6.3.14)
Language	English
Publishing date	2019-04-04
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2218636-0
ISSN	1748-1716 ; 1748-1708
ISSN (online)	1748-1716
ISSN	1748-1708
DOI	10.1111/apha.13268
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Article ; Online: [ 18 F]fluoride Activation and 18 F-Labelling in Hydrous Conditions—Towards a Microfluidic Synthesis of PET Radiopharmaceuticals

Olga Ovdiichuk / Salla Lahdenpohja / Quentin Béen / Laurent Tanguy / Bertrand Kuhnast / Charlotte Collet-Defossez

Molecules, Vol 29, Iss 1, p

2023 Volume 147

Abstract: 18 F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical ... step in the preparation of 18 F-labelled tracers is the anhydrous F-18 nucleophilic substitution ... reaction, which involves [ 18 F]F − anions generated in aqueous media by the cyclotron ...

Abstract	18 F-labelled radiopharmaceuticals are indispensable in positron emission tomography. The critical step in the preparation of 18 F-labelled tracers is the anhydrous F-18 nucleophilic substitution reaction, which involves [ 18 F]F − anions generated in aqueous media by the cyclotron. For this, azeotropic drying by distillation is widely used in standard synthesisers, but microfluidic systems are often not compatible with such a process. To avoid this step, several methods compatible with aqueous media have been developed. We summarised the existing approaches and two of them have been studied in detail. [ 18 F]fluoride elution efficiencies have been investigated under different conditions showing high 18 F-recovery. Finally, a large scope of precursors has been assessed for radiochemical conversion, and these hydrous labelling techniques have shown their potential for tracer production using a microfluidic approach, more particularly compatible with iMiDEV™ cassette volumes.
Keywords	18 F-radiolabelling ; radiopharmaceuticals ; 18 F-activation ; hydrous radiofluorination ; microfluidics ; Organic chemistry ; QD241-441
Subject code	333
Language	English
Publishing date	2023-12-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article ; Online: Tuning the Regioselective Functionalization of Trifluoromethylated Dienes via Lanthanum-Mediated Single C-F Bond Activation.

Kumar, Tarun / Yang, Yan / Sghaier, Sirine / Zaid, Yassir / Le Goff, Xavier F / Rousset, Elodie / Massicot, Fabien / Harakat, Dominique / Martinez, Agathe / Taillefer, Marc / Maron, Laurent / Behr, Jean-Bernard / Jaroschik, Florian

Chemistry (Weinheim an der Bergstrasse, Germany)

2021 Volume 27, Issue 12, Page(s) 4016–4021

Abstract: The development of new fluorine-containing building blocks and their efficient synthetic access is currently a challenging research field. Herein, the highly regio- and stereoselective addition of a large range of aldehydes onto trifluoromethylated ... ...

Abstract	The development of new fluorine-containing building blocks and their efficient synthetic access is currently a challenging research field. Herein, the highly regio- and stereoselective addition of a large range of aldehydes onto trifluoromethylated benzofulvenes was achieved using a simple La/I
Language	English
Publishing date	2021-02-01
Publishing country	Germany
Document type	Journal Article
ZDB-ID	1478547-X
ISSN	1521-3765 ; 0947-6539
ISSN (online)	1521-3765
ISSN	0947-6539
DOI	10.1002/chem.202005239
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Article: Amphidinolides F and C2: An Odyssey in Total Synthesis

Ferrié, Laurent / Ciss, Ismaila / Fenneteau, Johan / Vallerotto, Sara / Seck, Matar / Figadère, Bruno

Journal of organic chemistry. 2022 Jan. 07, v. 87, no. 2

2022

Abstract: Amphidinolides F, C, C2, and C3 are marine natural products isolated from dinoflagellates ... a desulfonylation sequence. Our convergent strategy allowed the total synthesis of amphidinolide F and enabled a new ...

Abstract	Amphidinolides F, C, C2, and C3 are marine natural products isolated from dinoflagellates Amphidinium species. They share the same macrolactone core, with the difference between them residing at the side chain level. A predominant feature of these amphidinolides is the presence of two trans-THF rings inside the macrolactone core, which is thought to be built by C-glycosylation with titanium enolate of N-acetyl oxazolinethiones. Thus, the original strategy for their total synthesis was based on the assembly of three main fragments corresponding to C₁–C₉, C₁₀–C₁₉, and C₂₀–C₂₉ or C₂₀–C₃₄ disconnections. Whereas synthesis of all fragments was successful, the C-glycosylation reaction between C₁₉ and C₂₀ turned out to be an issue. Therefore, a second route was designed. The new disconnection between C₁₇ and C₁₈ was based on a sulfone addition and a desulfonylation sequence. Our convergent strategy allowed the total synthesis of amphidinolide F and enabled a new unifying route toward the synthesis of amphidinolides C, C2, and C3 using a late-stage divergent approach. Although there were unsatisfying yields at some critical steps, our work culminated into the first total synthesis of amphidinolide C2.
Keywords	Amphidinium ; organic chemistry ; titanium
Language	English
Dates of publication	2022-0107
Size	p. 1110-1123.
Publishing place	American Chemical Society
Document type	Article
ZDB-ID	123490-0
ISSN	1520-6904 ; 0022-3263
ISSN (online)	1520-6904
ISSN	0022-3263
DOI	10.1021/acs.joc.1c02458
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Article: Extended ECG Improves Classification of Paroxysmal and Persistent Atrial Fibrillation Based on P- and f-Waves.

Zink, Matthias Daniel / Laureanti, Rita / Hermans, Ben J M / Pison, Laurent / Verheule, Sander / Philippens, Suzanne / Pluymaekers, Nikki / Vroomen, Mindy / Hermans, Astrid / van Hunnik, Arne / Crijns, Harry J G M / Vernooy, Kevin / Linz, Dominik / Mainardi, Luca / Auricchio, Angelo / Zeemering, Stef / Schotten, Ulrich

Frontiers in physiology

2022 Volume 13, Page(s) 779826

Abstract: ... presenting in AF, f-wave properties in the QRST (the amplitude complex of the ventricular electrical activity ... paroxysmal (: Conclusion: The P- and f-wave analysis of extended ECG configurations identified specific ...

Abstract	Background: The standard 12-lead ECG has been shown to be of value in characterizing atrial conduction properties. The added value of extended ECG recordings (longer recordings from more sites) has not been systematically explored yet. Objective: The aim of this study is to employ an extended ECG to identify characteristics of atrial electrical activity related to paroxysmal vs. persistent atrial fibrillation (AF). Methods: In 247 participants scheduled for AF ablation, an extended ECG was recorded (12 standard plus 3 additional leads, 5 min recording, no filtering). For patients presenting in sinus rhythm (SR), the signal-averaged P-wave and the spatiotemporal P-wave variability was analyzed. For patients presenting in AF, f-wave properties in the QRST (the amplitude complex of the ventricular electrical activity: Q-, R-, S-, and T-wave)-canceled ECG were determined. Results: Significant differences between paroxysmal ( Conclusion: The P- and f-wave analysis of extended ECG configurations identified specific ECG features allowing improved classification of paroxysmal vs. persistent AF. The extended ECG significantly improved AF-type classification in our analyzed data as compared to a standard 10-s 12-lead ECG. Whether this can result in a better clinical AF type classification warrants further prospective study.
Language	English
Publishing date	2022-03-04
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2564217-0
ISSN	1664-042X
ISSN	1664-042X
DOI	10.3389/fphys.2022.779826
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