Article: RHAMNETIN IS A BETTER INHIBITOR OF SARS-COV-2 2'-O-METHYLTRANSFERASE THAN DOLUTEGRAVIR: A COMPUTATIONAL PREDICTION.
African journal of infectious diseases
2022 Volume 16, Issue 2, Page(s) 80–96
Abstract: Background: The 2'-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host's immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2'O- ... ...
Abstract | Background: The 2'-O-methyltransferase is responsible for the capping of SARS-CoV-2 mRNA and consequently the evasion of the host's immune system. This study aims at identifying prospective natural inhibitors of the active site of SARS-CoV-2 2'O-methyltransferase (2'-OMT) through an in silico approach. Materials and methods: The target was docked against a library of natural compounds obtained from edible African plants using PyRx - virtual screening software. The antiviral agent, Dolutegravir which has a binding affinity score of -8.5 kcal mol Results: The Root-Mean-Square-Deviation (RMSD) induced by Rhamnetin is 1.656A Conclusion: Rhamnetin showed better inhibitory activity at the target's active site than Dolutegravir. |
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Language | English |
Publishing date | 2022-05-06 |
Publishing country | Nigeria |
Document type | Journal Article |
ISSN | 2006-0165 |
ISSN | 2006-0165 |
DOI | 10.21010/Ajid.v16i2.9 |
Database | MEDical Literature Analysis and Retrieval System OnLINE |
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