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  1. Article ; Online: Benefit of Extracellular Vesicles at the Blood-Brain Barrier.

    Davidson, Sean M

    Arteriosclerosis, thrombosis, and vascular biology

    2021  Volume 41, Issue 3, Page(s) 1146–1148

    MeSH term(s) ATP-Binding Cassette Transporters ; Animals ; Blood-Brain Barrier ; Extracellular Vesicles ; Mice ; NF-kappa B ; Stem Cells ; Stroke
    Chemical Substances ATP-Binding Cassette Transporters ; NF-kappa B
    Language English
    Publishing date 2021-02-24
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 1221433-4
    ISSN 1524-4636 ; 1079-5642
    ISSN (online) 1524-4636
    ISSN 1079-5642
    DOI 10.1161/ATVBAHA.121.315833
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: FAM3A - A mitochondrial route to the stimulation of angiogenesis?

    Davidson, Sean M

    EBioMedicine

    2019  Volume 43, Page(s) 3–4

    MeSH term(s) Animals ; Cytokines/genetics ; Cytokines/metabolism ; Humans ; Mitochondria/genetics ; Mitochondria/metabolism ; Neovascularization, Physiologic/genetics ; Signal Transduction
    Chemical Substances Cytokines ; FAM3A protein, human
    Language English
    Publishing date 2019-04-24
    Publishing country Netherlands
    Document type Letter
    ZDB-ID 2851331-9
    ISSN 2352-3964
    ISSN (online) 2352-3964
    DOI 10.1016/j.ebiom.2019.04.033
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: The RISK pathway leading to mitochondria and cardioprotection: how everything started.

    Yellon, Derek M / Beikoghli Kalkhoran, Siavash / Davidson, Sean M

    Basic research in cardiology

    2023  Volume 118, Issue 1, Page(s) 22

    Abstract: Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI), remains a major cause of mortality worldwide. Despite the development of effective pre-clinical cardioprotective therapies, clinical translation has been ... ...

    Abstract Ischaemic heart disease, which often manifests clinically as myocardial infarction (MI), remains a major cause of mortality worldwide. Despite the development of effective pre-clinical cardioprotective therapies, clinical translation has been disappointing. Nevertheless, the 'reperfusion injury salvage kinase' (RISK) pathway appears to be a promising target for cardioprotection. This pathway is crucial for the induction of cardioprotection by numerous pharmacological and non-pharmacological interventions, such as ischaemic conditioning. An important component of the cardioprotective effects of the RISK pathway involves the prevention of mitochondrial permeability transition pore (MPTP) opening and subsequent cardiac cell death. Here, we will review the historical perspective of the RISK pathway and focus on its interaction with mitochondria in the setting of cardioprotection.
    MeSH term(s) Humans ; Mitochondrial Membrane Transport Proteins/metabolism ; Myocardial Reperfusion Injury/prevention & control ; Myocardial Reperfusion Injury/metabolism ; Mitochondrial Permeability Transition Pore/metabolism ; Mitochondrial Permeability Transition Pore/pharmacology ; Myocardial Ischemia/prevention & control ; Myocardial Ischemia/metabolism ; Mitochondria/metabolism ; Ischemic Preconditioning, Myocardial ; Mitochondria, Heart/metabolism
    Chemical Substances Mitochondrial Membrane Transport Proteins ; Mitochondrial Permeability Transition Pore
    Language English
    Publishing date 2023-05-26
    Publishing country Germany
    Document type Journal Article ; Review ; Research Support, Non-U.S. Gov't
    ZDB-ID 189755-x
    ISSN 1435-1803 ; 0300-8428 ; 0175-9418
    ISSN (online) 1435-1803
    ISSN 0300-8428 ; 0175-9418
    DOI 10.1007/s00395-023-00992-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Extracellular vesicles signal from bones to vessels: an answer to the 'calcification paradox'?

    Chiva-Blanch, Gemma / Davidson, Sean M

    Cardiovascular research

    2022  Volume 118, Issue 11, Page(s) e75–e77

    MeSH term(s) Calcinosis ; Extracellular Vesicles ; Humans ; MicroRNAs
    Chemical Substances MicroRNAs
    Language English
    Publishing date 2022-08-16
    Publishing country England
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 80340-6
    ISSN 1755-3245 ; 0008-6363
    ISSN (online) 1755-3245
    ISSN 0008-6363
    DOI 10.1093/cvr/cvac111
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Opioids in Acute Coronary Syndromes: Friend or Foe?

    Basalay, Maryna V / Yellon, Derek M / Davidson, Sean M

    Cardiovascular drugs and therapy

    2022  Volume 36, Issue 5, Page(s) 1001–1003

    MeSH term(s) Acute Coronary Syndrome/diagnosis ; Acute Coronary Syndrome/drug therapy ; Analgesics, Opioid/adverse effects ; Humans
    Chemical Substances Analgesics, Opioid
    Language English
    Publishing date 2022-07-06
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07364-6
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  6. Article ; Online: Editorial to: "Building a Bridge to the Future of Cardiovascular Drugs and Therapy".

    Davidson, Sean M

    Cardiovascular drugs and therapy

    2017  Volume 31, Issue 1, Page(s) 51–52

    Language English
    Publishing date 2017-02
    Publishing country United States
    Document type Editorial
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-017-6715-4
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  7. Article ; Online: Nicorandil - an Effective Multitarget Drug for Cardioprotection?

    Pearce, Lucie / Carr, Richard D / Yellon, Derek M / Davidson, Sean M

    Cardiovascular drugs and therapy

    2022  Volume 37, Issue 1, Page(s) 5–8

    MeSH term(s) Humans ; Nicorandil/therapeutic use ; Nicorandil/pharmacology ; Myocardial Reperfusion Injury/prevention & control ; Oxidative Stress ; Vasodilator Agents/pharmacology
    Chemical Substances Nicorandil (260456HAM0) ; Vasodilator Agents
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Editorial ; Comment
    ZDB-ID 639068-7
    ISSN 1573-7241 ; 0920-3206
    ISSN (online) 1573-7241
    ISSN 0920-3206
    DOI 10.1007/s10557-022-07397-x
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  8. Article ; Online: Metabolic Considerations in Direct Procurement and Perfusion Protocols with DCD Heart Transplantation.

    Arnold, Maria / Do, Peter / Davidson, Sean M / Large, Stephen R / Helmer, Anja / Beer, Georgia / Siepe, Matthias / Longnus, Sarah L

    International journal of molecular sciences

    2024  Volume 25, Issue 8

    Abstract: Heart transplantation with donation after circulatory death (DCD) provides excellent patient outcomes and increases donor heart availability. However, unlike conventional grafts obtained through donation after brain death, DCD cardiac grafts are not only ...

    Abstract Heart transplantation with donation after circulatory death (DCD) provides excellent patient outcomes and increases donor heart availability. However, unlike conventional grafts obtained through donation after brain death, DCD cardiac grafts are not only exposed to warm, unprotected ischemia, but also to a potentially damaging pre-ischemic phase after withdrawal of life-sustaining therapy (WLST). In this review, we aim to bring together knowledge about changes in cardiac energy metabolism and its regulation that occur in DCD donors during WLST, circulatory arrest, and following the onset of warm ischemia. Acute metabolic, hemodynamic, and biochemical changes in the DCD donor expose hearts to high circulating catecholamines, hypoxia, and warm ischemia, all of which can negatively impact the heart. Further metabolic changes and cellular damage occur with reperfusion. The altered energy substrate availability prior to organ procurement likely plays an important role in graft quality and post-ischemic cardiac recovery. These aspects should, therefore, be considered in clinical protocols, as well as in pre-clinical DCD models. Notably, interventions prior to graft procurement are limited for ethical reasons in DCD donors; thus, it is important to understand these mechanisms to optimize conditions during initial reperfusion in concert with graft evaluation and re-evaluation for the purpose of tailoring and adjusting therapies and ensuring optimal graft quality for transplantation.
    MeSH term(s) Humans ; Heart Transplantation/methods ; Organ Preservation/methods ; Tissue and Organ Procurement/methods ; Animals ; Perfusion/methods ; Tissue Donors ; Energy Metabolism
    Language English
    Publishing date 2024-04-09
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms25084153
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  9. Article: Can glucagon-like peptide-1 (GLP-1) analogues make neuroprotection a reality?

    Basalay, Maryna V / Davidson, Sean M / Yellon, Derek M

    Neural regeneration research

    2020  Volume 15, Issue 10, Page(s) 1852–1853

    Language English
    Publishing date 2020-04-03
    Publishing country India
    Document type Journal Article
    ZDB-ID 2388460-5
    ISSN 1876-7958 ; 1673-5374
    ISSN (online) 1876-7958
    ISSN 1673-5374
    DOI 10.4103/1673-5374.280313
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  10. Article ; Online: Protection From Cardiac Ischemia-Reperfusion Injury by Epigenetic Regulation of NADPH Oxidase.

    Davidson, Sean M / Yellon, Derek M

    Circulation

    2019  Volume 138, Issue 24, Page(s) 2837–2840

    MeSH term(s) Epigenesis, Genetic ; Humans ; Leukemia, Megakaryoblastic, Acute ; Macrophages ; NADPH Oxidase 1 ; NADPH Oxidases ; Reactive Oxygen Species ; Reperfusion Injury
    Chemical Substances Reactive Oxygen Species ; NADPH Oxidase 1 (EC 1.6.3.-) ; NADPH Oxidases (EC 1.6.3.-)
    Language English
    Publishing date 2019-01-09
    Publishing country United States
    Document type Editorial ; Research Support, Non-U.S. Gov't ; Comment
    ZDB-ID 80099-5
    ISSN 1524-4539 ; 0009-7322 ; 0069-4193 ; 0065-8499
    ISSN (online) 1524-4539
    ISSN 0009-7322 ; 0069-4193 ; 0065-8499
    DOI 10.1161/CIRCULATIONAHA.118.036697
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