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Article: Innate immune recognition against SARS-CoV-2.

Yamada, Taisho / Takaoka, Akinori

2023 Volume 43, Issue 1, Page(s) 7

Abstract: Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of the infected individuals have asymptomatic or mild symptoms, but some patients ... ...

Abstract	Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) is the causative virus of pandemic acute respiratory disease called coronavirus disease 2019 (COVID-19). Most of the infected individuals have asymptomatic or mild symptoms, but some patients show severe and critical systemic inflammation including tissue damage and multi-organ failures. Immune responses to the pathogen determine clinical course. In general, the activation of innate immune responses is mediated by host pattern-recognition receptors (PRRs) that recognize pathogen-associated molecular patterns (PAMPs) as well as host damage-associated molecular patterns (DAMPs), which results in the activation of the downstream gene induction programs of types I and III interferons (IFNs) and proinflammatory cytokines for inducing antiviral activity. However, the excessive activation of these responses may lead to deleterious inflammation. Here, we review the recent advances in our understanding of innate immune responses to SARS-CoV-2 infection, particularly in terms of innate recognition and the subsequent inflammation underlying COVID-19 immunopathology.
Language	English
Publishing date	2023-01-26
Publishing country	England
Document type	Journal Article ; Review
ZDB-ID	2051471-2
ISSN	1880-9693 ; 0389-4290
ISSN	1880-9693 ; 0389-4290
DOI	10.1186/s41232-023-00259-5
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Article: [The development of the Japanese pharmaceutical industry (part 7). Histories of medical advertisements from Taisho Era till Showa Era].

Takehara, J / Yamada, H

Yakushigaku zasshi

1999 Volume 34, Issue 2, Page(s) 77–82

Abstract: ... from the Taisho Era to early in the Showa Era. When World War II broke out, the quanity of advertisements ...

Abstract	Medical advertisements in newspapers have been used quite often as a means of sales promotion since the Meiji Era. Medical advertisements were quantitatively the leading advertisements in Japanese newspapers from the Taisho Era to early in the Showa Era. When World War II broke out, the quanity of advertisements in newspapers decreased markedly. After the war ended, the quantity of radio commercials for medicine increased quite rapidly. In the 1960s, however, pharmaceutical companies were criticized for over-promoting and improperly using medicines.
MeSH term(s)	Advertising as Topic/history ; Drug Industry/history ; History, 19th Century ; History, 20th Century ; Japan
Language	Japanese
Publishing date	1999
Publishing country	Japan
Document type	English Abstract ; Historical Article ; Journal Article
ISSN	0285-2314
ISSN	0285-2314
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: Regulation of signaling mediated by nucleic acid sensors for innate interferon-mediated responses during viral infection.

Takaoka, Akinori / Yamada, Taisho

International immunology

2019 Volume 31, Issue 8, Page(s) 477–488

Abstract: Type I and type III interferons are important anti-viral cytokines that are massively induced during viral infection. This dynamic process is regulated by many executors and regulators for efficient eradication of invading viruses and protection from ... ...

Abstract	Type I and type III interferons are important anti-viral cytokines that are massively induced during viral infection. This dynamic process is regulated by many executors and regulators for efficient eradication of invading viruses and protection from harmful, excessive responses. An array of innate sensors recognizes virus-derived nucleic acids to activate their downstream signaling to evoke cytokine responses including interferons. In particular, a cytoplasmic RNA sensor RIG-I (retinoic acid-inducible gene I) is involved in the detection of multiple types of not only RNA viruses but also DNA viruses. Accumulating findings have revealed that activation of nucleic acid sensors and the related signaling mediators is regulated on the basis of post-translational modification such as ubiquitination, phosphorylation and ADP-ribosylation. In addition, long non-coding RNAs (lncRNAs) have been implicated as a new class of regulators in innate signaling. A comprehensive understanding of the regulatory mechanisms of innate sensor activation and its signaling in host-virus interaction will provide a better therapeutic strategy to efficiently control viral infection and maintain immune homeostasis.
MeSH term(s)	Animals ; Humans ; Immunity, Innate/immunology ; Interferons/immunology ; Nucleic Acids/immunology ; Signal Transduction/immunology ; Virus Diseases/immunology
Chemical Substances	Nucleic Acids ; Interferons (9008-11-1)
Keywords	covid19
Language	English
Publishing date	2019-04-15
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ZDB-ID	1013745-2
ISSN	1460-2377 ; 0953-8178
ISSN (online)	1460-2377
ISSN	0953-8178
DOI	10.1093/intimm/dxz034
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Zs.A 2619: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 70: Show issues

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Article ; Online: FICZ Exposure and Viral Infection in Mice.

Yamada, Taisho / Takaoka, Akinori

Bio-protocol

2017 Volume 7, Issue 1, Page(s) e2096

Abstract: The aryl hydrocarbon receptor (AHR) is known as a sensor for dioxins that mediates their toxicity, and also has important biophysiological roles such as circadian rhythms, cell differentiation and immune responses. 6-formylindolo(3,2-b)carbazole (FICZ), ... ...

Abstract	The aryl hydrocarbon receptor (AHR) is known as a sensor for dioxins that mediates their toxicity, and also has important biophysiological roles such as circadian rhythms, cell differentiation and immune responses. 6-formylindolo(3,2-b)carbazole (FICZ), which is derived through the metabolism of L-tryptophan by ultraviolet B irradiation, is one of putative physiological ligands for AHR ( Smirnova
Language	English
Publishing date	2017-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.2096
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Article ; Online: In vitro

Yamada, Taisho / Takaoka, Akinori

Bio-protocol

2017 Volume 7, Issue 1, Page(s) e2097

Abstract: Activation of the aryl hydrocarbon receptor (AHR) by endogenous ligands has been implicated in a variety of physiological processes such as cell cycle regulation, cell differentiation and immune responses. It is reported that tryptophan metabolites, such ...

Abstract	Activation of the aryl hydrocarbon receptor (AHR) by endogenous ligands has been implicated in a variety of physiological processes such as cell cycle regulation, cell differentiation and immune responses. It is reported that tryptophan metabolites, such as kynurenine (Kyn) and 6-formylindolo(3,2-b)carbazole (FICZ), are endogenous ligands for AHR ( Stockinger
Language	English
Publishing date	2017-01-05
Publishing country	United States
Document type	Journal Article
ZDB-ID	2833269-6
ISSN	2331-8325 ; 2331-8325
ISSN (online)	2331-8325
ISSN	2331-8325
DOI	10.21769/BioProtoc.2097
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Article ; Online: Augmented interferon regulatory factor 7 axis in whole tumor cell vaccines prevents tumor recurrence by inducing interferon gamma-secreting B cells.

Kajihara, Nabeel / Tanaka, Yoshino / Takeuchi, Riko / Kobayashi, Takuto / Tanji, Masafumi / Ataka, Tsukasa / Nakano, Shiho / Yamada, Taisho / Takaoka, Akinori / Hasegawa, Yoshinori / Seino, Ken-Ichiro / Wada, Haruka

Oncoimmunology

2023 Volume 12, Issue 1, Page(s) 2213132

Abstract: Among cancer immunotherapy, which has received great attention in recent years, cancer vaccines can potentially prevent recurrent tumors by using the exquisite power and specificity of the immune system. Specifically, whole tumor cell vaccines (WTCVs) ... ...

Abstract	Among cancer immunotherapy, which has received great attention in recent years, cancer vaccines can potentially prevent recurrent tumors by using the exquisite power and specificity of the immune system. Specifically, whole tumor cell vaccines (WTCVs) based on surgically resected tumors have been considered to elicit robust anti-tumor immune responses by exposing various tumor-associated antigens to host immunity. However, most tumors have little immunogenicity because of immunoediting by continuous interactions with host immunity; thus, preparing WTCVs based on patient-derived non-modified tumors cannot prevent tumor onset. Hence, the immunogenicity of tumor cells must be improved for effective WTCVs. In this study, we indicate the importance of the interferon regulatory factor 7 (Irf7) axis, including Irf7 and its downstream factors, within tumor cells in regulating immunogenicity. Indeed, WTCVs that augmented the Irf7 axis have exerted remarkable recurrence-preventive effects when vaccinated after tumor inactivation by radiation. Most notably, vaccination with murine colon cancer cells that enhanced the Irf7 axis prevented the development of challenged tumors in all mice and resulted in a 100% survival rate during the observation period. Furthermore, the mechanism leading to vaccine effectiveness was mediated by interferon-gamma-producing B cells. This study provides novel insights into how to enhance tumor immunogenicity and use WTCVs as recurrence prophylaxis.
MeSH term(s)	Animals ; Mice ; Interferon-gamma ; Neoplasm Recurrence, Local/prevention & control ; Interferon Regulatory Factor-7/genetics ; Cancer Vaccines/pharmacology ; Antigens, Neoplasm
Chemical Substances	Interferon-gamma (82115-62-6) ; Interferon Regulatory Factor-7 ; Cancer Vaccines ; Antigens, Neoplasm
Language	English
Publishing date	2023-05-22
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2645309-5
ISSN	2162-402X ; 2162-402X
ISSN (online)	2162-402X
ISSN	2162-402X
DOI	10.1080/2162402X.2023.2213132
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article ; Online: RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells.

Yamada, Taisho / Sato, Seiichi / Sotoyama, Yuki / Orba, Yasuko / Sawa, Hirofumi / Yamauchi, Hajime / Sasaki, Michihito / Takaoka, Akinori

Nature immunology

2021 Volume 22, Issue 7, Page(s) 820–828

Abstract: Efficient immune responses against viral infection are determined by sufficient activation of nucleic acid sensor-mediated innate ... ...

Abstract	Efficient immune responses against viral infection are determined by sufficient activation of nucleic acid sensor-mediated innate immunity
MeSH term(s)	A549 Cells ; Animals ; COVID-19/immunology ; Cell Line ; Cell Line, Tumor ; Chlorocebus aethiops ; DEAD Box Protein 58/immunology ; Dogs ; HEK293 Cells ; Humans ; Interferon Type I/immunology ; Interferons/immunology ; Lung/immunology ; Lung/virology ; Madin Darby Canine Kidney Cells ; Pulmonary Disease, Chronic Obstructive/immunology ; RNA-Dependent RNA Polymerase/immunology ; Receptors, Immunologic/immunology ; SARS-CoV-2/immunology ; Sf9 Cells ; Signal Transduction/immunology ; Vero Cells ; Viral Proteins/immunology ; Interferon Lambda
Chemical Substances	Interferon Type I ; Receptors, Immunologic ; Viral Proteins ; Interferons (9008-11-1) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; RIGI protein, human (EC 3.6.1.-) ; DEAD Box Protein 58 (EC 3.6.4.13) ; Interferon Lambda
Language	English
Publishing date	2021-05-11
Publishing country	United States
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2016987-5
ISSN	1529-2916 ; 1529-2908
ISSN (online)	1529-2916
ISSN	1529-2908
DOI	10.1038/s41590-021-00942-0
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 5294: Show issues			Location: Je nach Verfügbarkeit (siehe Angabe bei Bestand) bis Jg. 1994: Bestellungen von Artikeln über das Online-Bestellformular Jg. 1995 - 2021: Lesesall (2.OG) ab Jg. 2022: Lesesaal (EG)
Zs.MG 42: Show issues

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Article: [NF-kappaB signaling pathway and inflammation].

Yamada, Taisho / Takaoka, Akinori

Nihon rinsho. Japanese journal of clinical medicine

2012 Volume 70 Suppl 8, Page(s) 225–230

MeSH term(s)	Humans ; Inflammation/metabolism ; Molecular Targeted Therapy ; NF-kappa B/antagonists & inhibitors ; NF-kappa B/physiology ; Signal Transduction/drug effects ; Signal Transduction/physiology
Chemical Substances	NF-kappa B
Language	Japanese
Publishing date	2012-11
Publishing country	Japan
Document type	Journal Article
ZDB-ID	390903-7
ISSN	0047-1852
ISSN	0047-1852
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Zs.A 429: Show issues

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Article ; Online: Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection.

Viruses

2021 Volume 13, Issue 9

Abstract: The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been ...

Abstract	The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been reported that a hydrolysate of Ge-132, 3-(trihydroxygermyl) propanoic acid (THGP), shows a modulatory effect on microbial infections, inflammation, and immune responses. However, the detailed mechanism by which THGP can modify these processes during viral infections remained unknown. Here, we show that THGP can specifically downregulate type I interferon (IFN) production in response to stimulation with a cytosolic RNA sensor RIG-I ligand 5'-triphosphate RNA (3pRNA) but not double-stranded RNA, DNA, or lipopolysaccharide. Consistently, treatment with THGP resulted in the dose-dependent suppression of type I IFN induction upon infections with influenza virus (IAV) and vesicular stomatitis virus, which are known to be mainly sensed by RIG-I. Mechanistically, THGP directly binds to the 5'-triphosphate moiety of viral RNA and competes with RIG-I-mediated recognition. Furthermore, we found that THGP can directly counteract the replication of IAV but not EMCV (encephalitismyocarditis virus), by inhibiting the interaction of viral polymerase with RNA genome. Finally, IAV RNA levels were significantly reduced in the lung tissues of THGP-treated mice when compared with untreated mice. These results suggest a possible therapeutic implication of THGP and show direct antiviral action, together with the suppressive activity of innate inflammation.
MeSH term(s)	A549 Cells ; Animals ; Antiviral Agents/metabolism ; Antiviral Agents/pharmacology ; Antiviral Agents/therapeutic use ; Host-Pathogen Interactions/drug effects ; Humans ; Immunity, Innate/drug effects ; Influenza A virus/immunology ; Influenza A virus/pathogenicity ; Influenza A virus/physiology ; Interferon Type I/immunology ; Interferon Type I/metabolism ; Mice ; Organometallic Compounds/metabolism ; Organometallic Compounds/pharmacology ; Organometallic Compounds/therapeutic use ; Orthomyxoviridae Infections/drug therapy ; Orthomyxoviridae Infections/immunology ; Orthomyxoviridae Infections/virology ; RAW 264.7 Cells ; RNA, Viral/genetics ; RNA, Viral/metabolism ; Receptors, Retinoic Acid/genetics ; Receptors, Retinoic Acid/immunology ; Viral Nonstructural Proteins/genetics ; Viral Nonstructural Proteins/metabolism ; Virus Replication/drug effects ; Virus Replication/genetics
Chemical Substances	3-(trihydroxygermyl)propanoic acid ; Antiviral Agents ; Interferon Type I ; Organometallic Compounds ; PLAAT4 protein, human ; RNA, Viral ; Receptors, Retinoic Acid ; Viral Nonstructural Proteins
Language	English
Publishing date	2021-08-24
Publishing country	Switzerland
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2516098-9
ISSN	1999-4915 ; 1999-4915
ISSN (online)	1999-4915
ISSN	1999-4915
DOI	10.3390/v13091674
Database	MEDical Literature Analysis and Retrieval System OnLINE

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Article: Dual Effect of Organogermanium Compound THGP on RIG-I-Mediated Viral Sensing and Viral Replication during Influenza a Virus Infection

Viruses. 2021 Aug. 24, v. 13, no. 9

2021

Abstract	The interaction of viral nucleic acid with protein factors is a crucial process for initiating viral polymerase-mediated viral genome replication while activating pattern recognition receptor (PRR)-mediated innate immune responses. It has previously been reported that a hydrolysate of Ge-132, 3-(trihydroxygermyl) propanoic acid (THGP), shows a modulatory effect on microbial infections, inflammation, and immune responses. However, the detailed mechanism by which THGP can modify these processes during viral infections remained unknown. Here, we show that THGP can specifically downregulate type I interferon (IFN) production in response to stimulation with a cytosolic RNA sensor RIG-I ligand 5′-triphosphate RNA (3pRNA) but not double-stranded RNA, DNA, or lipopolysaccharide. Consistently, treatment with THGP resulted in the dose-dependent suppression of type I IFN induction upon infections with influenza virus (IAV) and vesicular stomatitis virus, which are known to be mainly sensed by RIG-I. Mechanistically, THGP directly binds to the 5′-triphosphate moiety of viral RNA and competes with RIG-I-mediated recognition. Furthermore, we found that THGP can directly counteract the replication of IAV but not EMCV (encephalitismyocarditis virus), by inhibiting the interaction of viral polymerase with RNA genome. Finally, IAV RNA levels were significantly reduced in the lung tissues of THGP-treated mice when compared with untreated mice. These results suggest a possible therapeutic implication of THGP and show direct antiviral action, together with the suppressive activity of innate inflammation.
Keywords	DNA ; Influenza A virus ; Vesiculovirus ; antiviral properties ; dose response ; double-stranded RNA ; hydrolysates ; inflammation ; interferons ; ligands ; lipopolysaccharides ; lungs ; moieties ; propionic acid ; therapeutics ; viral genome ; virus replication ; viruses
Language	English
Dates of publication	2021-0824
Publishing place	Multidisciplinary Digital Publishing Institute
Document type	Article
ZDB-ID	2516098-9
ISSN	1999-4915
ISSN	1999-4915
DOI	10.3390/v13091674
Database	NAL-Catalogue (AGRICOLA)

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