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Article ; Online: Geng et al. reply.

Wang, Xinyi / Sun, Guangqiang / Feng, Teng / Zhang, Jing / Huang, Xun / Wang, Tao / Xie, Zuoquan / Chu, Xingkun / Yang, Jun / Wang, Huan / Chang, Shuaishuai / Gong, Yanxue / Ruan, Lingfei / Zhang, Guanqun / Yan, Siyuan / Lian, Wen / Du, Chen / Yang, Dabing / Zhang, Qingli /

Lin, Feifei / Liu, Jia / Zhang, Haiyan / Ge, Changrong / Xiao, Shifu / Ding, Jian / Geng, Meiyu

Cell research

2020 Volume 30, Issue 9, Page(s) 820

MeSH term(s)	Alzheimer Disease ; Amino Acids ; Disease Progression ; Gastrointestinal Microbiome ; Humans ; Sodium
Chemical Substances	Amino Acids ; Sodium (9NEZ333N27)
Keywords	covid19
Language	English
Publishing date	2020-07-13
Publishing country	England
Document type	Journal Article ; Comment
ZDB-ID	1319303-x
ISSN	1748-7838 ; 1001-0602
ISSN (online)	1748-7838
ISSN	1001-0602
DOI	10.1038/s41422-020-0377-7
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Zs.A 5283: Show issues

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Article ; Online: Jie Geng Tang reverses cisplatin resistance through the Nrf2 pathway in lung cancer.

Zhao, Jing / Hou, Manting / Ding, Kaixin / Li, Shixiong / Li, Hui / Zhang, Xili / Bai, Zhaofang / Liu, Wenlong

The Journal of pharmacy and pharmacology

2023 Volume 75, Issue 6, Page(s) 784–805

Abstract: Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits ...

Abstract	Objectives: Jie Geng Tang (JGT) is an ancient traditional Chinese herbal decoction that exhibits various pharmacological activities, however, is poorly understood in the sensitivity of lung cancer to chemotherapy. Here, we explored the effect of JGT on sensitizing cisplatin (DDP)-resistant A549 cells (A549/DDP). Methods: Cell viability was assessed using cell counting kit-8 assay. Flow cytometry was applied to detected cell apoptosis, mitochondrial membrane potential (MMP) and reactive oxygen species (ROS) levels. Western blotting and qRT-PCR were performed to determine protein and mRNA levels. Key findings: The results demonstrated that DDP co-treatment with JGT significantly increased the cytotoxicity of A549/DDP cells and exhibited efficacy in suppressing the migration and proliferation. The rate of apoptosis was increased by co-treatment with DDP and JGT, along with a higher rate of Bax/Bcl-2, and increased loss of MMP. Furthermore, the combination promoted ROS accumulation and increased γ-H2AX levels. Moreover, Nrf2 levels were suppressed in a dose- and time-dependent manner, Nrf2 stability was reduced following treatment with JGT. Notably, the combination induced inhibition of the Nrf2/ARE pathway at the mRNA and protein levels. Conclusions: Collectively, these results indicate that co-treatment with JGT and DDP can be considered a combinational approach to treating DDP resistance.
MeSH term(s)	Humans ; Cisplatin/pharmacology ; NF-E2-Related Factor 2/metabolism ; Reactive Oxygen Species/metabolism ; Drug Resistance, Neoplasm ; Lung Neoplasms/drug therapy ; Lung Neoplasms/metabolism ; Apoptosis ; Cell Proliferation ; Antineoplastic Agents/pharmacology ; Antineoplastic Agents/therapeutic use ; Cell Line, Tumor
Chemical Substances	Cisplatin (Q20Q21Q62J) ; NF-E2-Related Factor 2 ; Reactive Oxygen Species ; Antineoplastic Agents
Language	English
Publishing date	2023-03-28
Publishing country	England
Document type	Journal Article
ZDB-ID	3107-0
ISSN	2042-7158 ; 0022-3573 ; 0373-1022
ISSN (online)	2042-7158
ISSN	0022-3573 ; 0373-1022
DOI	10.1093/jpp/rgad018
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Article ; Online: Pedigree genome data of an early-matured Geng/japonica glutinous rice mega variety Longgeng 57.

Lei, Yuanbao / Zhang, Yunjiang / Xu, Linyun / Ma, Wendong / Zhou, Ziqi / Li, Jie / Quan, Pengyu / Faruquee, Muhiuddin / Yang, Dechen / Zhang, Fan / Zhou, Yongli / Quan, Guangjun / Zhao, Xiuqin / Wang, Wensheng / Liu, Bailong / Li, Zhikang / Xu, Jianlong / Zheng, Tianqing

Scientific data

2024 Volume 11, Issue 1, Page(s) 230

Abstract: ... a set of annotation data for an early-matured Geng/japonica glutinous rice mega variety genome, Longgeng ...

Abstract	By using PacBio HiFi technology, we produced over 700 Gb of long-read sequencing (LRS) raw data; and by using Illumina paired-end whole-genome shotgun (WGS) sequencing technology, we generated more than 70 Gb of short-read sequencing (SRS) data. With LRS data, we assembled one genome and then generate a set of annotation data for an early-matured Geng/japonica glutinous rice mega variety genome, Longgeng 57 (LG57), which carries multiple elite traits including good grain quality and wide adaptability. Together with the SRS data from three parents of LG57, pedigree genome variations were called for three representative types of genes. These data sets can be used for deep variation mining, aid in the discovery of new insights into genome structure, function, and evolution, and help to provide essential support to biological research in general.
MeSH term(s)	Oryza/genetics ; Phenotype ; Sequence Analysis, DNA ; Whole Genome Sequencing ; Genome, Plant
Language	English
Publishing date	2024-02-22
Publishing country	England
Document type	Dataset ; Journal Article
ZDB-ID	2775191-0
ISSN	2052-4463 ; 2052-4463
ISSN (online)	2052-4463
ISSN	2052-4463
DOI	10.1038/s41597-024-03057-x
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Article ; Online: Genomic insights on the contribution of introgressions from Xian/Indica to the genetic improvement of Geng/Japonica rice cultivars.

Cui, Di / Zhou, Han / Ma, Xiaoding / Lin, Zechuan / Sun, Linhua / Han, Bing / Li, Maomao / Sun, Jianchang / Liu, Jin / Jin, Guixiu / Wang, Xianju / Cao, Guilan / Deng, Xing Wang / He, Hang / Han, Longzhi

Plant communications

2022 Volume 3, Issue 3, Page(s) 100325

Abstract: Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization ...

Abstract	Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization of plant ideotypes has greatly contributed to yield improvements in modern GJ rice in China over the past 50 years. To explore the genomic basis of improved yield and disease resistance in GJ rice, we conducted a large-scale genomic landscape analysis of 816 elite GJ cultivars representing multiple eras of germplasm from China. We detected consistently increasing introgressions from three XI subpopulations into GJ cultivars since the 1980s and found that the XI genome introgressions significantly increased the grain number per panicle (GN) and decreased the panicle number per plant. This contributed to the improvement of plant type during modern breeding, changing multi-tiller plants to moderate tiller plants with a large panicle size and increasing the blast resistance. Notably, we found that key gene haplotypes controlling plant architecture, yield components, and pest and disease resistance, including IPA1, SMG1, DEP3, Pib, Pi-d2, and Bph3, were introduced from XI rice by introgression. By GWAS analysis, we detected a GN-related gene Gnd5, which had been consistently introgressed from XI into GJ cultivars since the 1980s. Gnd5 is a GRAS transcription factor gene, and Gnd5 knockout mutants showed a significant reduction in GN. The estimated genetic effects of genes varied among different breeding locations, which explained the distinct introgression levels of XI gene haplotypes, including Gnd5, DEP3, etc., to these GJ breeding pedigrees. These findings reveal the genomic contributions of introgressions from XI to the trait improvements of GJ rice cultivars and provide new insights for future rice genomic breeding.
MeSH term(s)	Alleles ; Disease Resistance/genetics ; Genomics ; Oryza/genetics ; Plant Breeding
Language	English
Publishing date	2022-04-13
Publishing country	China
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ISSN	2590-3462
ISSN (online)	2590-3462
DOI	10.1016/j.xplc.2022.100325
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Article ; Online: Genetic Dissection of Salt Tolerance and Yield Traits of Geng ( japonica ) Rice by Selective Subspecific Introgression

Simin Li / Ting Feng / Chenyang Zhang / Fanlin Zhang / Hua Li / Yanjun Chen / Lunping Liang / Chaopu Zhang / Wei Zeng / Erbao Liu / Yingyao Shi / Min Li / Lijun Meng

Current Issues in Molecular Biology, Vol 45, Iss 305, Pp 4796-

2023 Volume 4813

Abstract: ... from inter-subspecific crosses between an elite Geng ( japonica ) recipient and four Xian ( indica ) donors ... Thirty-four are Xian-Geng differentiated ones with the donor ( Xian ) alleles associated with ST ... genetic variation for developing superior Geng varieties with improved ST and YP, which could be efficiently ...

Abstract	Salinity is a major factor limiting rice productivity, and developing salt-tolerant (ST) varieties is the most efficient approach. Seventy-eight ST introgression lines (ILs), including nine promising lines with improved ST and yield potential (YP), were developed from four BC 2 F 4 populations from inter-subspecific crosses between an elite Geng ( japonica ) recipient and four Xian ( indica ) donors at the Institute of Crop Sciences, Chinese Academy of Agricultural Sciences. Genome-wide characterization of donor introgression identified 35 ST QTLs, 25 of which harbor 38 cloned ST genes as the most likely QTL candidates. Thirty-four are Xian-Geng differentiated ones with the donor ( Xian ) alleles associated with ST, suggesting differentiated responses to salt stress were one of the major phenotypic differences between the two subspecies. At least eight ST QTLs and many others affecting yield traits were identified under salt/non-stress conditions. Our results indicated that the Xian gene pool contains rich ‘hidden’ genetic variation for developing superior Geng varieties with improved ST and YP, which could be efficiently exploited by selective introgression. The developed ST ILs and their genetic information on the donor alleles for ST and yield traits would provide a useful platform for developing superior ST and high-yield Geng varieties through breeding by design in the future.
Keywords	salt tolerance ; selection ; correlated phenotypic responses ; QTL clusters ; rice ; Biology (General) ; QH301-705.5
Subject code	580
Language	English
Publishing date	2023-05-01T00:00:00Z
Publisher	MDPI AG
Document type	Article ; Online
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Article: Genomic insights on the contribution of introgressions from Xian/indica to the genetic improvement of Geng/japonica rice cultivars

Plant communications. 2022 Apr. 09,

2022

Abstract: Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization ...

Abstract	Hybridization between Xian/indica (XI) and Geng/japonica (GJ) rice combined with utilization of plant ideotypes has greatly contributed to yield improvements of modern GJ rice in China over the past 50 years. To explore the genomic basis of improving yield and disease resistance in GJ rice, we conducted a large-scale genomic landscape analysis of 816 elite GJ cultivars representing multiple eras of germplasm from China. We detected consistently increasing introgressions from three XI subpopulations into GJ cultivars since 1980s, and found the XI genome introgressions significantly increased the grain number per panicle (GN) and decreased the panicle number per plant, which contributed to the improvement of plant type during modern breeding, changing plant type from multi-tiller plants to moderate tillers and large panicle size and increased the blast resistance. Notably, we found key gene haplotypes controlling plant architecture, yield components, and pest and disease resistance, including IPA1, SMG1, DEP3, Pib, Pi-d2, and Bph3, were introduced from XI rice by introgression. By GWAS analysis, we detected a GN related gene Gnd5, which had been consistently introgressed from XI into GJ cultivars since 1980s. Gnd5 is a GRAS transcription factor gene, and Gnd5 knockout mutants showed a significant reduction in GN. Genetic effect of genes we estimated varied among different breeding locations, which explained distinct introgression level of XI gene haplotypes including Gnd5 and DEP3, etc. to these GJ breeding pedigrees. These findings reveal the genomic contributions of introgressions from XI to the trait improvements of GJ rice cultivars and provide new insight for future rice genomic breeding.
Keywords	cultivars ; disease resistance ; genes ; genetic improvement ; genomics ; germplasm ; haplotypes ; ideotypes ; introgression ; panicles ; pests ; plant architecture ; rice ; transcription factors ; China
Language	English
Dates of publication	2022-0409
Publishing place	Elsevier Inc.
Document type	Article
Note	Pre-press version
ISSN	2590-3462
DOI	10.1016/j.xplc.2022.100325
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Article ; Online: Tiao Geng decoction inhibits tributyltin chloride-induced GT1-7 neuronal apoptosis through ASK1/MKK7/JNK signaling pathway.

Li, Shengnan / Cong, Chao / Liu, Yang / Liu, Xiaofei / Liu, Huicong / Zhao, Li / Gao, Xianwei / Gui, Wenjia / Xu, Lianwei

Journal of ethnopharmacology

2020 Volume 269, Page(s) 113669

Abstract: Ethnopharmacological relevance: Tiao Geng (TG) decoction is a Chinese herbal medicine extract ...

Abstract	Ethnopharmacological relevance: Tiao Geng (TG) decoction is a Chinese herbal medicine extract that has been utilized for the treatment of menopausal symptoms for a history of over 30 years. In our previous study, we suggest that TG decoction possibly exerts an anti-apoptotic effect on hypothalamic neurons of ovariectomized rats via the ASK1/MKK7/JNK pathway. Tributyltin chloride (TBTC) causes oxidative damage and induces apoptosis of primary hypothalamic neurons in rats. Aim of the study: The present work aimed to explore the inhibition of TG decoction on TBTC-induced GT1-7 cell apoptosis and its possible molecular mechanism. Materials and methods: The GT1-7 cell line was exposed to TG decoction at diverse doses (31.25, 62.5, 125 μg/mL) for 24 h and later with TBTC (1 mg/L) for 1 h, with 17β-E Results: Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway. Moreover, Bcl-2/Bax ratio became higher, and the MKK7, ASK1, Casp3 and c-Jun levels were inhibited. Besides, TG decoction combined with SP600125 (the JNK inhibitor) more significantly inhibited GT1-7 cell apoptosis caused by TBTC. Conclusion: As discovered from the experiment in this study, TG decoction has a neuroprotective effect, which is achieved through inhibiting the ASK1/MKK7/JNK signal transduction pathway to reduce GT1-7 cell apoptosis.
MeSH term(s)	Animals ; Apoptosis/drug effects ; Apoptosis/physiology ; Cell Line ; Cell Survival/drug effects ; Cell Survival/physiology ; Dose-Response Relationship, Drug ; Drugs, Chinese Herbal/pharmacology ; MAP Kinase Kinase Kinase 5/antagonists & inhibitors ; MAP Kinase Kinase Kinase 5/metabolism ; MAP Kinase Signaling System/drug effects ; MAP Kinase Signaling System/physiology ; Mitogen-Activated Protein Kinases/antagonists & inhibitors ; Mitogen-Activated Protein Kinases/metabolism ; Neurons/drug effects ; Neurons/metabolism ; Rats ; Trialkyltin Compounds/antagonists & inhibitors ; Trialkyltin Compounds/toxicity
Chemical Substances	Drugs, Chinese Herbal ; Trialkyltin Compounds ; tributyltin (4XDX163P3D) ; Map2k7 protein, rat (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase Kinase 5 (EC 2.7.11.25)
Language	English
Publishing date	2020-12-15
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113669
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Article ; Online: Characterization of the chemical constituents of Jie-Geng-Tang and the metabolites in the serums and lungs of mice after oral administration by LC-Q-TOF-MS.

Liu, Yin-Ning / Hu, Meng-Ting / Qian, Jing / Wang, Yi / Wang, Shu-Fang

Chinese journal of natural medicines

2021 Volume 19, Issue 4, Page(s) 284–294

Abstract: Jie-Geng-Tang (JGT), a traditional formula, is employed in the treatment of sore throat and cough ...

Abstract	Jie-Geng-Tang (JGT), a traditional formula, is employed in the treatment of sore throat and cough and comprises Platycodonis Radix and Glycyrrhizae Radix et Rhizoma in the ratio 1 : 2. Our previous study demonstrated that JGT protected mice from S. aureus-induced acute lung injury (ALI). Five constituents of JGT showed antibacterial activities against S. aureus in vitro. However, the potential effective constituents of JGT in vivo were still unclear. In this study, the chemical constituents of JGT were identified by liquid chromatography with quadrupole time-of-flight spectrometry (LC-Q-TOF-MS). A total of 96 constituents were identified or assumed, including seven organic acids, 45 flavonoids, 36 triterpene saponins, and eight compounds of other types. The structures of 31 of the constituents were confirmed by comparing them with corresponding authentic standards. Moreover, 15 prototypes and 49 metabolites were deduced in the serums of mice, 24 prototypes and 47 metabolites were deduced in the lungs of mice after the oral administration of JGT. Three types of constituents, namely organic acids, flavonoids, and triterpene saponins, could be absorbed into the blood. Moreover, flavonoids and triterpene saponins were more likely distributed in the lung than in the blood. To the best of our knowledge, this is the first report on the systematic metabolites profile of JGT in vivo. The results reported were beneficial to the elucidation of the effective material basis of JGT.
MeSH term(s)	Administration, Oral ; Animals ; Chromatography, High Pressure Liquid ; Chromatography, Liquid ; Drugs, Chinese Herbal/chemistry ; Drugs, Chinese Herbal/pharmacokinetics ; Lung ; Mice ; Spectrum Analysis ; Staphylococcus aureus
Chemical Substances	Drugs, Chinese Herbal ; jie-geng-tang
Language	English
Publishing date	2021-05-04
Publishing country	China
Document type	Journal Article
ZDB-ID	2192577-X
ISSN	1875-5364 ; 2095-6975 ; 1672-3651
ISSN (online)	1875-5364
ISSN	2095-6975 ; 1672-3651
DOI	10.1016/S1875-5364(21)60028-6
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Article: Tiao Geng decoction inhibits tributyltin chloride-induced GT1-7 neuronal apoptosis through ASK1/MKK7/JNK signaling pathway

Li, Shengnan / Cong, Chao / Liu, Yang / Liu, Xiaofei / Liu, Huicong / Zhao, Li / Gao, Xianwei / Gui, Wenjia / Xu, Lianwei

Journal of ethnopharmacology. 2021 Apr. 06, v. 269

2021

Abstract: Tiao Geng (TG) decoction is a Chinese herbal medicine extract that has been utilized ...

Abstract	Tiao Geng (TG) decoction is a Chinese herbal medicine extract that has been utilized for the treatment of menopausal symptoms for a history of over 30 years. In our previous study, we suggest that TG decoction possibly exerts an anti-apoptotic effect on hypothalamic neurons of ovariectomized rats via the ASK1/MKK7/JNK pathway. Tributyltin chloride (TBTC) causes oxidative damage and induces apoptosis of primary hypothalamic neurons in rats.The present work aimed to explore the inhibition of TG decoction on TBTC-induced GT1-7 cell apoptosis and its possible molecular mechanism.The GT1-7 cell line was exposed to TG decoction at diverse doses (31.25, 62.5, 125 μg/mL) for 24 h and later with TBTC (1 mg/L) for 1 h, with 17β-E₂ (100 nM) treatment being the positive control. Then, CCK8 assay was conducted to evaluate cell viability, while flow cytometric analysis was conducted to examine the apoptosis level. Related pathways and differentially expressed proteins were identified by tandem mass tag (TMT)-based quantitative phosphoproteomics. qRT-PCR was carried out to examine mRNA levels of Bax and B-cell lymphoma-2 (Bcl-2). Western blotting was performed to detect the levels of Bax, Bcl-2, c-Jun, c-Jun N-terminal kinase (JNK), Caspase-3 (Casp3), Mitogen-activated protein kinase kinase 7 (MKK7), and apoptosis signal-regulating kinase 1 (ASK1) .Finally, cells were pretreated with SP600125, an inhibitor of JNK, later the expression of JNK and Casp3 was measured.Application of TG decoction mitigated the GT1-7 cell apoptosis and injury caused by TBTC; besides, it inhibited the activation of the ASK1/MKK7/JNK pathway. Moreover, Bcl-2/Bax ratio became higher, and the MKK7, ASK1, Casp3 and c-Jun levels were inhibited. Besides, TG decoction combined with SP600125 (the JNK inhibitor) more significantly inhibited GT1-7 cell apoptosis caused by TBTC.As discovered from the experiment in this study, TG decoction has a neuroprotective effect, which is achieved through inhibiting the ASK1/MKK7/JNK signal transduction pathway to reduce GT1-7 cell apoptosis.
Keywords	B-lymphocytes ; apoptosis ; caspase-3 ; cell lines ; cell viability ; flow cytometry ; gene expression regulation ; herbal medicines ; menopause ; mitogen-activated protein kinase ; mitogen-activated protein kinase kinase ; neurons ; neuroprotective effect ; ovariectomy ; proteomics ; signal transduction ; traditional medicine ; tri-n-butyltin hydride ; tributyltin
Language	English
Dates of publication	2021-0406
Publishing place	Elsevier B.V.
Document type	Article
Note	NAL-AP-2-clean
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113669
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Article ; Online: Tiao Geng decoction for treating menopausal syndrome exhibits anti-aging effects likely via suppressing ASK1/MKK7/JNK mediated apoptosis in ovariectomized rats.

Li, Shengnan / Cong, Chao / Liu, Yang / Liu, Xiaofei / Kluwe, Lan / Shan, Xin / Liu, Huicong / Gao, Min / Zhao, Li / Gao, Xianwei / Xu, Lianwei

Journal of ethnopharmacology

2020 Volume 261, Page(s) 113061

Abstract: Ethnopharmacological relevance: TG-decoction (Tiao Geng decoction) is the extract of a Chinese ...

Abstract	Ethnopharmacological relevance: TG-decoction (Tiao Geng decoction) is the extract of a Chinese herb mixture that has been used for treating menopausal symptoms for over 30 years. We have previously reported anti-aging and anti-oxidative effects of the TG-decoction on hypothalamic neurons in ovariectomized (OVX) rats. Aim of the study: The present study further investigates the effects of TG-decoction on the prevention of aging-related ultrastructural changes in menopausal hypothalamic neurons and the likely molecular mechanism. Materials and methods: A total of 120 four-month-old female SPF Sprague Dawley rats were divided into six groups. Five groups were ovariectomized (OVX) and one group served as a sham control. Three OVX groups received TG-decoction at three different doses. The remaining two OVX groups served as positive and negative controls by receiving estradiol valerate and saline solution. The sham group received saline. After one month, aging-related ultrastructural alterations in hypothalamic neurons were evaluated using transmission electron microscopy. Nissl staining was used to assess the pathomorphological changes of the hypothalamic neurons. Cell apoptosis was evaluated by TUNEL. Expression of Bcl-2 family genes was studied using qRT-PCR. Expression of the apoptosis-related proteins ASK1, MKK7, JNK, c-Jun, Bax, Casp3 and Bcl-2 was studied using western blotting. Results: Ovariectomy of female rats led to visible damage and aging-like alterations in the mitochondria and endoplasmic reticulum as well as large deposits of lipofuscin in hypothalamic tissue. TG-decoction treatment prevented this visible damage and lipofuscin deposition, increased the number of nerve cells and normally-shaped Nissl bodies, and reduced the number of TUNEL-positive cells. Expression of Bcl-2 gene was increased, while Bax gene reduced. Expression of the proteins ASK1, MKK7, JNK, c-Jun, Bax and Casp3 was reduced, while that of Bcl-2 was increased. Conclusion: TG-decoction reduces aging-related ultrastructural changes in hypothalamic neurons, likely by suppressing ASK1/MKK7/JNK-mediated apoptosis in neuronal mitochondria or nuclei.
MeSH term(s)	Age Factors ; Animals ; Apoptosis/drug effects ; Apoptosis Regulatory Proteins/genetics ; Apoptosis Regulatory Proteins/metabolism ; Drugs, Chinese Herbal/pharmacology ; Endoplasmic Reticulum/drug effects ; Endoplasmic Reticulum/enzymology ; Endoplasmic Reticulum/ultrastructure ; Female ; Hypothalamus/drug effects ; Hypothalamus/enzymology ; Hypothalamus/pathology ; JNK Mitogen-Activated Protein Kinases/metabolism ; MAP Kinase Kinase Kinase 5/metabolism ; Menopause/drug effects ; Menopause/metabolism ; Mitochondria/drug effects ; Mitochondria/enzymology ; Mitochondria/ultrastructure ; Mitogen-Activated Protein Kinases/metabolism ; Neurons/drug effects ; Neurons/enzymology ; Neurons/ultrastructure ; Ovariectomy ; Rats, Sprague-Dawley ; Signal Transduction ; Syndrome
Chemical Substances	Apoptosis Regulatory Proteins ; Drugs, Chinese Herbal ; tiao geng decoction ; JNK Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; Map2k7 protein, rat (EC 2.7.11.24) ; Mitogen-Activated Protein Kinases (EC 2.7.11.24) ; MAP Kinase Kinase Kinase 5 (EC 2.7.11.25)
Language	English
Publishing date	2020-06-07
Publishing country	Ireland
Document type	Journal Article
ZDB-ID	134511-4
ISSN	1872-7573 ; 0378-8741
ISSN (online)	1872-7573
ISSN	0378-8741
DOI	10.1016/j.jep.2020.113061
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