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  1. Article ; Online: H

    Kaiser, Angelika / Torres Ceja, Erick / Liu, Yujia / Huber, Florian / Müller, Raphael / Herr, Ulrich / Thonke, Klaus

    Nanotechnology

    2021  Volume 32, Issue 20, Page(s) 205505

    Abstract: This work presents a H ...

    Abstract This work presents a H
    Language English
    Publishing date 2021-04-07
    Publishing country England
    Document type Journal Article
    ZDB-ID 1362365-5
    ISSN 1361-6528 ; 0957-4484
    ISSN (online) 1361-6528
    ISSN 0957-4484
    DOI 10.1088/1361-6528/abe004
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  2. Article ; Online: Ergometrine stimulates histamine H

    Jacob, Hannes / Braekow, Pauline / Hofmann, Britt / Kirchhefer, Uwe / Forster, Lisa / Mönnich, Denise / Humphrys, Laura J / Pockes, Steffen / Neumann, Joachim / Gergs, Ulrich

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 396, Issue 12, Page(s) 3809–3822

    Abstract: Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We ... ...

    Abstract Ergometrine (6aR,9R)-N-((S)-1-hydroxypropan-2-yl)-7-methyl-4,6,6a,7,8,9-hexa-hydro-indolo-[4,3-fg]chinolin-9-carboxamide or lysergide acid β-ethanolamide or ergonovine) activates several types of serotonin and histamine receptors in the animal heart. We thus examined whether ergometrine can activate human serotonin 5-HT
    MeSH term(s) Humans ; Mice ; Animals ; Serotonin/pharmacology ; Histamine ; Atrial Fibrillation ; Myocardial Contraction ; Heart Atria ; Mice, Transgenic ; Serine/pharmacology ; Receptors, Histamine H2
    Chemical Substances Serotonin (333DO1RDJY) ; Histamine (820484N8I3) ; Serine (452VLY9402) ; Receptors, Histamine H2
    Language English
    Publishing date 2023-06-24
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02573-8
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  3. Article ; Online: Initial Characterization of a Transgenic Mouse with Overexpression of the Human H

    Rayo Abella, Lina Maria / Jacob, Hannes / Keller, Max / Schindler, Lisa / Pockes, Steffen / Pitzl, Sebastian / Klimas, Jan / Hadova, Katarína / Schneider, Sarah / Buchwalow, Igor B / Jin, CongYu / Panula, Pertti / Kirchhefer, Uwe / Neumann, Joachim / Gergs, Ulrich

    The Journal of pharmacology and experimental therapeutics

    2024  Volume 389, Issue 2, Page(s) 174–185

    Abstract: There is a debate on whether H ...

    Abstract There is a debate on whether H
    MeSH term(s) Humans ; Mice ; Animals ; Mice, Transgenic ; Histamine/pharmacology ; Pyrilamine/pharmacology ; Myocardial Contraction ; Heart ; Receptors, Histamine ; Heart Atria ; Heart Rate ; Receptors, Histamine H1/genetics ; Mammals
    Chemical Substances Histamine (820484N8I3) ; Pyrilamine (HPE317O9TL) ; Receptors, Histamine ; Receptors, Histamine H1
    Language English
    Publishing date 2024-04-18
    Publishing country United States
    Document type Journal Article
    ZDB-ID 3106-9
    ISSN 1521-0103 ; 0022-3565
    ISSN (online) 1521-0103
    ISSN 0022-3565
    DOI 10.1124/jpet.123.002060
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  4. Article: Hypervalent hydridosilicate in the Na-Si-H system.

    Spektor, Kristina / Kohlmann, Holger / Druzhbin, Dmitrii / Crichton, Wilson A / Bhat, Shrikant / Simak, Sergei I / Vekilova, Olga Yu / Häussermann, Ulrich

    Frontiers in chemistry

    2023  Volume 11, Page(s) 1251774

    Abstract: ... Si-H system by computational structure prediction and ...

    Abstract Hydrogenation reactions at gigapascal pressures can yield hydrogen-rich materials with properties relating to superconductivity, ion conductivity, and hydrogen storage. Here, we investigated the ternary Na-Si-H system by computational structure prediction and
    Language English
    Publishing date 2023-09-08
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2711776-5
    ISSN 2296-2646
    ISSN 2296-2646
    DOI 10.3389/fchem.2023.1251774
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  5. Article ; Online: Lysergic acid diethylamide stimulates cardiac human H

    Gergs, Ulrich / Jacob, Hannes / Braekow, Pauline / Hofmann, Britt / Pockes, Steffen / Humphrys, Laura J / Kirchhefer, Uwe / Fehse, Charlotte / Neumann, Joachim

    Naunyn-Schmiedeberg's archives of pharmacology

    2023  Volume 397, Issue 1, Page(s) 221–236

    Abstract: Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5- ... ...

    Abstract Lysergic acid diethylamide (LSD) is an artificial hallucinogenic drug. Thus, we hypothesized that LSD might act 5-HT
    MeSH term(s) Humans ; Mice ; Animals ; Serotonin/pharmacology ; Lysergic Acid Diethylamide/pharmacology ; Histamine/pharmacology ; Receptors, Serotonin, 5-HT4/genetics ; Heart Atria ; Mice, Transgenic ; Receptors, Serotonin ; Receptors, Histamine ; Myocardial Contraction ; Receptors, Histamine H2/genetics
    Chemical Substances Serotonin (333DO1RDJY) ; Lysergic Acid Diethylamide (8NA5SWF92O) ; Histamine (820484N8I3) ; Receptors, Serotonin, 5-HT4 (158165-40-3) ; Receptors, Serotonin ; Receptors, Histamine ; Receptors, Histamine H2
    Language English
    Publishing date 2023-07-04
    Publishing country Germany
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ZDB-ID 121471-8
    ISSN 1432-1912 ; 0028-1298
    ISSN (online) 1432-1912
    ISSN 0028-1298
    DOI 10.1007/s00210-023-02591-6
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  6. Article ; Online: Inhalative as well as Intravenous Administration of H

    Scheid, Stefanie / Goeller, Max / Baar, Wolfgang / Wollborn, Jakob / Buerkle, Hartmut / Schlunck, Günther / Lagrèze, Wolf / Goebel, Ulrich / Ulbrich, Felix

    International journal of molecular sciences

    2022  Volume 23, Issue 10

    Abstract: ... Hydrogen sulfide (H: Methods: Ischemia-reperfusion injury was induced in rats by a temporary increase ... in intraocular pressure (1 h). H: Results: Both inhalative and intravenously delivered H: Conclusion ... and inflammation. Both inhalative H ...

    Abstract Background: Neuronal ischemia-reperfusion injury (IRI), such as it can occur in glaucoma or strokes, is associated with neuronal cell death and irreversible loss of function of the affected tissue. Hydrogen sulfide (H
    Methods: Ischemia-reperfusion injury was induced in rats by a temporary increase in intraocular pressure (1 h). H
    Results: Both inhalative and intravenously delivered H
    Conclusion: Hydrogen sulfide acts, at least in part, via the mitogen-activated protein kinase (MAPK) ERK1/2 to reduce apoptosis and inflammation. Both inhalative H
    MeSH term(s) Administration, Intravenous ; Animals ; Hydrogen Sulfide/metabolism ; Hydrogen Sulfide/pharmacology ; Hydrogen Sulfide/therapeutic use ; Ischemia/metabolism ; Neuroprotection ; Rats ; Rats, Sprague-Dawley ; Reperfusion Injury/metabolism ; Retina/metabolism ; Vascular Endothelial Growth Factor A/metabolism
    Chemical Substances Vascular Endothelial Growth Factor A ; Hydrogen Sulfide (YY9FVM7NSN)
    Language English
    Publishing date 2022-05-15
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2019364-6
    ISSN 1422-0067 ; 1422-0067 ; 1661-6596
    ISSN (online) 1422-0067
    ISSN 1422-0067 ; 1661-6596
    DOI 10.3390/ijms23105519
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  7. Article ; Online: Neutron scattering study of polyamorphic THF·17(H

    Brant Carvalho, Paulo H B / Ivanov, Mikhail / Andersson, Ove / Loerting, Thomas / Bauer, Marion / Tulk, Chris A / Haberl, Bianca / Daemen, Luke L / Molaison, Jamie J / Amann-Winkel, Katrin / Lyubartsev, Alexander P / Bull, Craig L / Funnell, Nicholas P / Häussermann, Ulrich

    Physical chemistry chemical physics : PCCP

    2023  Volume 25, Issue 21, Page(s) 14981–14991

    Abstract: From crystalline tetrahydrofuran clathrate hydrate, THF-CH (THF· ... ...

    Abstract From crystalline tetrahydrofuran clathrate hydrate, THF-CH (THF·17H
    Language English
    Publishing date 2023-05-31
    Publishing country England
    Document type Journal Article
    ZDB-ID 1476244-4
    ISSN 1463-9084 ; 1463-9076
    ISSN (online) 1463-9084
    ISSN 1463-9076
    DOI 10.1039/d3cp00539a
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  8. Article ; Online: Fabrication of ZnO Nanobrushes by H

    Kohlmann, Niklas / Hansen, Luka / Lupan, Cristian / Schürmann, Ulrich / Reimers, Armin / Schütt, Fabian / Adelung, Rainer / Kersten, Holger / Kienle, Lorenz

    ACS applied materials & interfaces

    2021  Volume 13, Issue 51, Page(s) 61758–61769

    Abstract: Zinc oxide has widespread use in diverse applications due to its distinct properties. Many of these applications benefit from controlling the morphology on the nanoscale, where for example gas sensing is strongly enhanced for high surface-to-volume ... ...

    Abstract Zinc oxide has widespread use in diverse applications due to its distinct properties. Many of these applications benefit from controlling the morphology on the nanoscale, where for example gas sensing is strongly enhanced for high surface-to-volume ratios. In this work the formation of novel ZnO nanobrushes by plasma etching treatment as a new approach is presented. The morphology and structure of the ZnO nanobrushes are studied in detail by transmission and scanning electron microscopy. It is revealed that ZnO nanobrush structures are fabricated by self-patterned preferential etching of ZnO microtetrapods in a hydrogen-acetylene plasma. The etching process was found to be most effective at 1% C
    Language English
    Publishing date 2021-12-15
    Publishing country United States
    Document type Journal Article
    ISSN 1944-8252
    ISSN (online) 1944-8252
    DOI 10.1021/acsami.1c18679
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  9. Article: Function and Role of Histamine H

    Neumann, Joachim / Hofmann, Britt / Kirchhefer, Uwe / Dhein, Stefan / Gergs, Ulrich

    Pharmaceuticals (Basel, Switzerland)

    2023  Volume 16, Issue 5

    Abstract: ... at least four heptahelical receptors: H ...

    Abstract Histamine can change the force of cardiac contraction and alter the beating rate in mammals, including humans. However, striking species and regional differences have been observed. Depending on the species and the cardiac region (atrium versus ventricle) studied, the contractile, chronotropic, dromotropic, and bathmotropic effects of histamine vary. Histamine is present and is produced in the mammalian heart. Thus, histamine may exert autocrine or paracrine effects in the mammalian heart. Histamine uses at least four heptahelical receptors: H
    Language English
    Publishing date 2023-05-11
    Publishing country Switzerland
    Document type Journal Article ; Review
    ZDB-ID 2193542-7
    ISSN 1424-8247
    ISSN 1424-8247
    DOI 10.3390/ph16050734
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  10. Article ; Online: Anticoagulation with edoxaban in patients with long atrial high-rate episodes ≥24 h.

    Becher, Nina / Toennis, Tobias / Bertaglia, Emanuele / Blomström-Lundqvist, Carina / Brandes, Axel / Cabanelas, Nuno / Calvert, Melanie / Camm, A John / Chlouverakis, Gregory / Dan, Gheorghe-Andrei / Dichtl, Wolfgang / Diener, Hans Christoph / Fierenz, Alexander / Goette, Andreas / de Groot, Joris R / Hermans, Astrid N L / Lip, Gregory Y H / Lubinski, Andrzej / Marijon, Eloi /
    Merkely, Béla / Mont, Lluís / Ozga, Ann-Kathrin / Rajappan, Kim / Sarkozy, Andrea / Scherr, Daniel / Schnabel, Renate B / Schotten, Ulrich / Sehner, Susanne / Simantirakis, Emmanuel / Vardas, Panos / Velchev, Vasil / Wichterle, Dan / Zapf, Antonia / Kirchhof, Paulus

    European heart journal

    2023  Volume 45, Issue 10, Page(s) 837–849

    Abstract: Background and aims: Patients with long atrial high-rate episodes (AHREs) ≥24 h and stroke ... was 1.8 years. AHRE ≥24 h were present at baseline in 259/2389 patients (11%, 78 ± 7 years old, 28 ... The primary outcome occurred in 9/132 patients with AHRE ≥24 h (4.3%/patient-year, 2 strokes) treated ...

    Abstract Background and aims: Patients with long atrial high-rate episodes (AHREs) ≥24 h and stroke risk factors are often treated with anticoagulation for stroke prevention. Anticoagulation has never been compared with no anticoagulation in these patients.
    Methods: This secondary pre-specified analysis of the Non-vitamin K antagonist Oral anticoagulants in patients with Atrial High-rate episodes (NOAH-AFNET 6) trial examined interactions between AHRE duration at baseline and anticoagulation with edoxaban compared with placebo in patients with AHRE and stroke risk factors. The primary efficacy outcome was a composite of stroke, systemic embolism, or cardiovascular death. The safety outcome was a composite of major bleeding and death. Key secondary outcomes were components of these outcomes and electrocardiogram (ECG)-diagnosed atrial fibrillation.
    Results: Median follow-up of 2389 patients with core lab-verified AHRE was 1.8 years. AHRE ≥24 h were present at baseline in 259/2389 patients (11%, 78 ± 7 years old, 28% women, CHA2DS2-VASc 4). Clinical characteristics were not different from patients with shorter AHRE. The primary outcome occurred in 9/132 patients with AHRE ≥24 h (4.3%/patient-year, 2 strokes) treated with anticoagulation and in 14/127 patients treated with placebo (6.9%/patient-year, 2 strokes). Atrial high-rate episode duration did not interact with the efficacy (P-interaction = .65) or safety (P-interaction = .98) of anticoagulation. Analyses including AHRE as a continuous parameter confirmed this. Patients with AHRE ≥24 h developed more ECG-diagnosed atrial fibrillation (17.0%/patient-year) than patients with shorter AHRE (8.2%/patient-year; P < .001).
    Conclusions: This hypothesis-generating analysis does not find an interaction between AHRE duration and anticoagulation therapy in patients with device-detected AHRE and stroke risk factors. Further research is needed to identify patients with long AHRE at high stroke risk.
    MeSH term(s) Humans ; Female ; Aged ; Aged, 80 and over ; Male ; Atrial Fibrillation/complications ; Atrial Fibrillation/drug therapy ; Atrial Fibrillation/diagnosis ; Heart Atria ; Risk Factors ; Stroke/etiology ; Stroke/prevention & control ; Stroke/diagnosis ; Anticoagulants/therapeutic use ; Pyridines ; Thiazoles
    Chemical Substances edoxaban (NDU3J18APO) ; Anticoagulants ; Pyridines ; Thiazoles
    Language English
    Publishing date 2023-11-13
    Publishing country England
    Document type Journal Article
    ZDB-ID 603098-1
    ISSN 1522-9645 ; 0195-668X
    ISSN (online) 1522-9645
    ISSN 0195-668X
    DOI 10.1093/eurheartj/ehad771
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