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  1. Article ; Online: A Randomized Controlled Trial Comparing Face-to-Face Versus Remote Delivery of Low-Tech Augmentative and Alternative Communication in Nonspeaking Children With Autism Spectrum Disorder.

    Mishra, Avinash

    Journal of speech, language, and hearing research : JSLHR

    2024  , Page(s) 1–12

    Abstract: Purpose: Thirty percent of children diagnosed with autism spectrum disorder (ASD) do not develop spoken language. To provide a means of communication for this subset of the population, augmentative and alternative communication (AAC) systems are often ... ...

    Abstract Purpose: Thirty percent of children diagnosed with autism spectrum disorder (ASD) do not develop spoken language. To provide a means of communication for this subset of the population, augmentative and alternative communication (AAC) systems are often utilized. Low-tech options have traditionally been delivered through the in-person modality. However, due to the COVID-19 pandemic, changes to service delivery models have been required. This randomized controlled trial was conducted in order to assess the efficacy of low-tech AAC delivered face-to-face versus remotely on communication outcomes in nonspeaking children with ASD.
    Conclusions: Both participant groups demonstrated similar gains in AAC proficiency, number and type of nonspeaking acts, and number of spoken communication acts. Remote delivery of low-tech AAC treatment is a viable alternative to face-to-face instruction.
    Language English
    Publishing date 2024-03-19
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1364086-0
    ISSN 1558-9102 ; 1092-4388
    ISSN (online) 1558-9102
    ISSN 1092-4388
    DOI 10.1044/2024_JSLHR-23-00390
    Database MEDical Literature Analysis and Retrieval System OnLINE

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    In stock of ZB MED Cologne/Königswinter

    Zs.A 606: Show issues Location:
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  2. Article ; Online: Universal slit-lamp mounted indentation gonioscopy tool for angle evaluation: An innovative device.

    Bhirud, Atul / Tripathi, Anchal / Agarwal, Mohini / Mishra, Avinash

    Indian journal of ophthalmology

    2024  

    Abstract: In the field of ophthalmology, slit-lamp gonioscopy has long been a cornerstone for examining anterior chamber angles and diagnosing conditions such as angle closure, secondary causes of raised intraocular pressure, neovascularization of angle, angle ... ...

    Abstract In the field of ophthalmology, slit-lamp gonioscopy has long been a cornerstone for examining anterior chamber angles and diagnosing conditions such as angle closure, secondary causes of raised intraocular pressure, neovascularization of angle, angle recession, angle tumors, and foreign bodies. However, the conventional approach for goniophotography is a demanding procedure requiring juggling a gonioscopy lens in one hand and a smartphone in the other. Balancing a gonioscopy lens with one hand makes it difficult to adjust and focus the image in busy clinical settings. This article introduces a groundbreaking solution to this problem - a universal slit-lamp-mounted gonioscope ingeniously repurposed from discarded materials, that is, indirect goniophotography (IndiGo). This novel system simplifies the process of both gonioscopy and goniophotography, allowing ophthalmologists to easily assess anterior chamber angles and capture high-quality images. These images can be swiftly shared with glaucoma specialists worldwide for digital analysis. Not only does this approach enhance examination efficiency, but also it fosters sustainability in ophthalmic diagnostics.
    Language English
    Publishing date 2024-04-16
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_3035_23
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    Zs.MO 598: Show issues

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  3. Article ; Online: Metabolite Profiling, Biological and Molecular Analyses Validate the Nutraceutical Potential of Green Seaweed

    Tanna, Bhakti / Yadav, Sonam / Patel, Manish Kumar / Mishra, Avinash

    Nutrients

    2024  Volume 16, Issue 8

    Abstract: Seaweeds have proven to be nutrient-dense and are rich in antioxidants, like phenolics, flavonoids, and other essential metabolites that help to provide their medicinal benefits. Non-targeted metabolite profiling of the tropical green ... ...

    Abstract Seaweeds have proven to be nutrient-dense and are rich in antioxidants, like phenolics, flavonoids, and other essential metabolites that help to provide their medicinal benefits. Non-targeted metabolite profiling of the tropical green seaweed
    MeSH term(s) Humans ; Dietary Supplements ; Seaweed/chemistry ; Antioxidants/pharmacology ; Plant Extracts/pharmacology ; HeLa Cells ; Metabolomics/methods ; Cell Proliferation/drug effects ; Cell Line, Tumor ; Flavonoids/pharmacology ; Flavonoids/analysis
    Chemical Substances Antioxidants ; Plant Extracts ; Flavonoids
    Language English
    Publishing date 2024-04-19
    Publishing country Switzerland
    Document type Journal Article
    ZDB-ID 2518386-2
    ISSN 2072-6643 ; 2072-6643
    ISSN (online) 2072-6643
    ISSN 2072-6643
    DOI 10.3390/nu16081222
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  4. Article ; Online: Differentiating stable and unstable protein using convolution neural network and molecular dynamics simulations.

    Suyash, Shreyansh / Jha, Akshat / Maitra, Priyasha / Punia, Parveen / Mishra, Avinash

    Computational biology and chemistry

    2024  Volume 110, Page(s) 108081

    Abstract: Protein stability is a critical aspect of molecular biology and biochemistry, hinges on an intricate balance of thermodynamic and structural factors. Determining protein stability is crucial for understanding and manipulating biological machineries, as ... ...

    Abstract Protein stability is a critical aspect of molecular biology and biochemistry, hinges on an intricate balance of thermodynamic and structural factors. Determining protein stability is crucial for understanding and manipulating biological machineries, as it directly correlated with the protein function. Thus, this study delves into the intricacies of protein stability, highlighting its dependence on various factors, including thermodynamics, thermal conditions, and structural properties. Moreover, a notable focus is placed on the free energy change of unfolding (ΔG
    Language English
    Publishing date 2024-04-20
    Publishing country England
    Document type Journal Article
    ISSN 1476-928X
    ISSN (online) 1476-928X
    DOI 10.1016/j.compbiolchem.2024.108081
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Intrastromal voriconazole as successful adjunctive approach for recalcitrant deep fungal keratitis.

    Bhirud, Atul / Mishra, Avinash / Agrawal, Mohini / Sharma, Jyoti

    Romanian journal of ophthalmology

    2023  Volume 67, Issue 1, Page(s) 7–13

    Abstract: Aim: ...

    Abstract Aim:
    MeSH term(s) Humans ; Adult ; Middle Aged ; Aged ; Voriconazole/therapeutic use ; Antifungal Agents/therapeutic use ; Ulcer/drug therapy ; Keratitis/diagnosis ; Keratitis/drug therapy ; Keratitis/microbiology ; Treatment Outcome ; Corneal Ulcer/diagnosis ; Corneal Ulcer/drug therapy ; Corneal Ulcer/microbiology ; Eye Infections, Fungal/diagnosis ; Eye Infections, Fungal/drug therapy ; Eye Infections, Fungal/microbiology
    Chemical Substances Voriconazole (JFU09I87TR) ; Antifungal Agents
    Language English
    Publishing date 2023-04-05
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2842202-8
    ISSN 2501-2533 ; 2457-4325
    ISSN (online) 2501-2533
    ISSN 2457-4325
    DOI 10.22336/rjo.2023.3
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  6. Article ; Online: Ophthalmic manifestations as the first presenting feature in dengue fever: a 10-year study.

    Mishra, Avinash / Tripathi, Anchal / Bhirud, Atul / Agrawal, Mohini / Gupta, Sandeep / Parihar, Jks

    Romanian journal of ophthalmology

    2024  Volume 68, Issue 1, Page(s) 31–36

    Abstract: Purpose: ...

    Abstract Purpose:
    MeSH term(s) Humans ; Vitreous Hemorrhage ; Pandemics ; Prospective Studies ; Uveitis, Anterior ; Abducens Nerve Diseases ; Eye Infections, Viral/diagnosis ; Eye Infections, Viral/epidemiology ; Keratitis ; Dengue/complications ; Dengue/diagnosis ; Dengue/epidemiology
    Language English
    Publishing date 2024-04-12
    Publishing country Romania
    Document type Journal Article
    ZDB-ID 2842202-8
    ISSN 2501-2533 ; 2457-4325
    ISSN (online) 2501-2533
    ISSN 2457-4325
    DOI 10.22336/rjo.2024.07
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  7. Article: Onychoscopic Analysis of Cyclophosphamide-Induced Polydactylic Bluish-Gray Discoloration in a Case of Pemphigus Foliaceus.

    Garg, Priya / Mundhe, Ashwini D / Jadhav, Avinash / Mishra, Nishtha / Deo, Kirti S

    Cureus

    2024  Volume 16, Issue 3, Page(s) e57233

    Abstract: Cyclophosphamide, an alkylating agent, has rarely been observed to cause a bluish discoloration of nails, an occurrence that is typically underreported. We describe the case of a middle-aged male undergoing dexamethasone-cyclophosphamide pulse therapy ... ...

    Abstract Cyclophosphamide, an alkylating agent, has rarely been observed to cause a bluish discoloration of nails, an occurrence that is typically underreported. We describe the case of a middle-aged male undergoing dexamethasone-cyclophosphamide pulse therapy for pemphigus foliaceus, who exhibited bluish-gray discoloration of the nails. It is crucial to differentiate this presentation from other conditions such as nail apparatus melanoma (NAM), which may manifest in a slightly different manner. We also report the onychoscopic findings observed in this case.
    Language English
    Publishing date 2024-03-30
    Publishing country United States
    Document type Case Reports
    ZDB-ID 2747273-5
    ISSN 2168-8184
    ISSN 2168-8184
    DOI 10.7759/cureus.57233
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  8. Article ; Online: Introgression of SbERD4 Gene Encodes an Early-Responsive Dehydration-Stress Protein That Confers Tolerance against Different Types of Abiotic Stresses in Transgenic Tobacco

    Rajesh Kumar Jha / Avinash Mishra

    Cells, Vol 11, Iss 62, p

    2022  Volume 62

    Abstract: Salicornia brachiata is an extreme halophyte that commonly grows on marsh conditions and is also considered a promising resource for drought and salt-responsive genes. To unveil a glimpse of stress endurance by plants, it is of the utmost importance to ... ...

    Abstract Salicornia brachiata is an extreme halophyte that commonly grows on marsh conditions and is also considered a promising resource for drought and salt-responsive genes. To unveil a glimpse of stress endurance by plants, it is of the utmost importance to develop an understanding of stress tolerance mechanisms. ‘Early Responsive to Dehydration’ (ERD) genes are defined as a group of genes involved in stress tolerance and the development of plants. To increase this understanding, parallel to this expedited thought, a novel SbERD4 gene was cloned from S. brachiata , characterized, and functionally validated in the model plant tobacco. The study showed that SbERD4 is a plasma-membrane bound protein, and its overexpression in tobacco plants improved salinity and osmotic stress tolerance. Transgenic plants showed high relative water, chlorophylls, sugars, starch, polyphenols, proline, free amino acids, and low electrolyte leakage and H 2 O 2 content compared to control plants (wild type and vector control) under different abiotic stress conditions. Furthermore, the transcript expression of antioxidant enzyme encoding genes NtCAT , NtSOD , NtGR , and NtAPX showed higher expression in transgenic compared to wild-type and vector controls under varying stress conditions. Overall, the overexpression of a novel early responsive to dehydration stress protein 4-encoding gene ( SbERD4 ) enhanced the tolerance of the plant against multiple abiotic stresses. In conclusion, the overexpression of the SbERD4 gene mitigates plant physiology by enduring stress tolerance and might be considered as a promising key gene for engineering salinity and drought stress tolerance in crops.
    Keywords abiotic stress ; drought ; genetic transformation ; halophyte ; salinity ; transgenic ; Biology (General) ; QH301-705.5
    Subject code 580
    Language English
    Publishing date 2022-12-01T00:00:00Z
    Publisher MDPI AG
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  9. Article ; Online: Universal slit-lamp-mounted mobile adapter with 20 D lens for fundus photography:

    Bhirud, Atul / Chandrakanth, Prithvi / Agrawal, Mohini / Mishra, Avinash

    Indian journal of ophthalmology

    2023  Volume 71, Issue 5, Page(s) 2222–2224

    Abstract: Fundus photography is an arduous task as it involves using 90 D in one hand and a smartphone attached on an eyepiece of a slit-lamp biomicroscope in the other hand. Similarly, with a 20 D lens, the filming distance is adjusted by moving the lens or ... ...

    Abstract Fundus photography is an arduous task as it involves using 90 D in one hand and a smartphone attached on an eyepiece of a slit-lamp biomicroscope in the other hand. Similarly, with a 20 D lens, the filming distance is adjusted by moving the lens or mobile forward or backward, which makes it difficult to adjust and focus the image in busy ophthalmology outpatient departments (OPDs). Moreover, fundus camera costs thousands of dollars. Authors describe a novel technique of performing fundus photography with a 20 D lens and a universal slit-lamp-mounted mobile adapter made from trash. By the use of this simple, yet frugal innovation, primary care physicians or ophthalmologists without a fundus camera can easily snap a fundus photo and subject it to digital analysis by retina specialists across the world. This will help in simultaneous ocular examination and fundus photos taken via mounted 20 D on a slit lamp itself and also reduce the need for unnecessary retina referrals to tertiary eye care centers.
    MeSH term(s) Humans ; Slit Lamp ; Diagnostic Techniques, Ophthalmological ; Eye Diseases/diagnosis ; Fundus Oculi ; Photography
    Language English
    Publishing date 2023-05-18
    Publishing country India
    Document type Journal Article
    ZDB-ID 187392-1
    ISSN 1998-3689 ; 0301-4738
    ISSN (online) 1998-3689
    ISSN 0301-4738
    DOI 10.4103/IJO.IJO_3226_22
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    In stock of ZB MED Cologne/Königswinter

    Zs.B 329: Show issues Location:
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    Zs.MO 598: Show issues

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  10. Article ; Online: Pharmacophore screening to identify natural origin compounds to target RNA-dependent RNA polymerase (RdRp) of SARS-CoV2.

    Mishra, Avinash / Rathore, Anurag S

    Molecular diversity

    2022  Volume 26, Issue 5, Page(s) 2613–2629

    Abstract: Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon ... ...

    Abstract Several existing drugs have gained initial consideration due to their therapeutic characteristics against COVID-19 (Corona Virus Disease 2019). Hydroxychloroquine (HCQ) was proposed as possible therapy for shortening the duration of COVID-19, but soon after this, it was discarded. Similarly, known antiviral compounds were also proposed and investigated to treat COVID-19. We report a pharmacophore screening using essential chemical groups derived from HCQ and known antivirals to search a natural compound chemical space. Molecular docking of HCQ under physiological condition with spike protein, 3C-like protease (3CLpro), and RNA-dependent RNA polymerase (RdRp) of SARS-CoV2 showed - 8.52 kcal/mole binding score with RdRp, while the other two proteins showed relatively weaker binding affinity. Docked complex of RdRp-HCQ is further examined using 100 ns molecular dynamic simulation. Docking and simulation study confirmed active chemical moieties of HCQ, treated as 6-point pharmacophore to screen ZINC natural compound database. Pharmacophore screening resulted in the identification of potent hit molecule [(3S,3aR,6R,6aS)-3-(5-phenylsulfanyltetrazol-1-yl)-2,3,3a,5,6,6a-hexahydrofuro[3,2-b]furan-6-yl]N-naphthalen-ylcarbamate from natural compound library. Additionally, a set of antiviral compounds with similar chemical scaffolds are also used to design a separate ligand-based pharmacophore screening. Antiviral pharmacophore screening produced a potent hit 4-[(1,5-dimethyl-3-oxo-2-phenylpyrazol-4-yl)-(2-hydroxyphenyl)methyl]-1,5-dimethyl-2-phenylpyrazol-3-one containing essential moieties that showed affinity towards RdRp. Further, both these screened compounds are docked (- 8.69 and - 8.86 kcal/mol) and simulated with RdRp protein for 100 ns in explicit solvent medium. They bind at the active site of RdRp and form direct/indirect interaction with ASP618, ASP760, and ASP761 catalytic residues of the protein. Successively, their molecular mechanics Poisson Boltzmann surface area (MMPBSA) binding energies are calculated over the simulation trajectory to determine the dynamic atomistic interaction details. Overall, this study proposes two key natural chemical moieties: (a) tetrazol and (b) phenylpyrazol that can be investigated as a potential chemical group to design inhibitors against SARS-CoV2 RdRp.
    MeSH term(s) Antiviral Agents/chemistry ; Antiviral Agents/pharmacology ; COVID-19 ; Furans ; Humans ; Hydroxychloroquine ; Ligands ; Molecular Docking Simulation ; Molecular Dynamics Simulation ; Peptide Hydrolases/metabolism ; RNA, Viral ; RNA-Dependent RNA Polymerase ; SARS-CoV-2 ; Solvents ; Spike Glycoprotein, Coronavirus ; Zinc
    Chemical Substances Antiviral Agents ; Furans ; Ligands ; RNA, Viral ; Solvents ; Spike Glycoprotein, Coronavirus ; spike protein, SARS-CoV-2 ; Hydroxychloroquine (4QWG6N8QKH) ; RNA-Dependent RNA Polymerase (EC 2.7.7.48) ; Peptide Hydrolases (EC 3.4.-) ; Zinc (J41CSQ7QDS)
    Language English
    Publishing date 2022-01-09
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1376507-3
    ISSN 1573-501X ; 1381-1991
    ISSN (online) 1573-501X
    ISSN 1381-1991
    DOI 10.1007/s11030-021-10358-5
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    Zs.A 4946: Show issues Location:
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