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  1. Article ; Online: Correction for: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2023  Volume 15, Issue 6, Page(s) 2358–2360

    Language English
    Publishing date 2023-03-30
    Publishing country United States
    Document type Journal Article ; Published Erratum
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204637
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa: two case reports.

    Xiao, Yi-Shuang / He, Wen-Ji / Jiang, Hong-Chao / Tan, Li / Ma, Jing / Zhang, Zhen

    Journal of medical case reports

    2023  Volume 17, Issue 1, Page(s) 226

    Abstract: ... of cases.: Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4 ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

    Abstract Background: Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases.
    Case presentation: Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations.
    Conclusions: These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
    MeSH term(s) Male ; Humans ; Child ; Infant ; Exome Sequencing ; Ethnicity/genetics ; Exome/genetics ; DNA Mutational Analysis ; China ; Retinitis Pigmentosa/genetics ; Retinitis Pigmentosa/diagnosis ; Retinitis Pigmentosa/pathology ; Mutation ; Pedigree ; Alcohol Oxidoreductases/genetics
    Chemical Substances RDH12 protein, human (EC 1.1.1.105) ; Alcohol Oxidoreductases (EC 1.1.-)
    Language English
    Publishing date 2023-06-02
    Publishing country England
    Document type Case Reports ; Journal Article
    ZDB-ID 2269805-X
    ISSN 1752-1947 ; 1752-1947
    ISSN (online) 1752-1947
    ISSN 1752-1947
    DOI 10.1186/s13256-023-03830-3
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Yi Mai granule improve energy supply of endothelial cells in atherosclerosis via miRNA-125a-5p regulating mitochondrial autophagy through Pink1-Mfn2-Parkin pathway.

    Kong, De Zhao / Sun, Peng / Lu, Yi / Yang, Ye / Min, Dong Yu / Zheng, Si Cheng / Yang, Yi / Zhang, Zhe / Yang, Guan Lin / Jiang, Jun Wen

    Journal of ethnopharmacology

    2023  Volume 319, Issue Pt 1, Page(s) 117114

    Abstract: Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine ...

    Abstract Ethnopharmacological relevance: Yi Mai granule (YMG) consists of two classic Chinese medicine formulas used to treat cardiovascular disease for centuries. The Pink1-Mfn2-Parkin pathway, a well-recognized mechanism that mediates mitochondrial autophagy, plays a big part in mitochondrial quality control and the maintenance of heart function. However, the effects of YMG on endothelial dysfunction and mitochondrial autophagy remain unknown.
    Aim of the study: Here, we focused on the therapeutic effects of YMG in improving mitochondrial autophagy and the mechanism of YMG against cardiovascular disease.
    Materials and methods: In this study, rats were fed high-fat diet (HFD) for 21 weeks and were given high, medium, and low doses of YMG in stomach. The open field test was used to evaluate the rats' behavior. Atherosclerotic plaques, blood lipids, and cytokine levels were measured. Mitochondrial autophagy changes were observed by Transmission electron microscope (TEM). Human umbilical vein endothelial cells (HUVECs) were injured by angiotensinⅡ(AngⅡ) and were given high, medium, and low doses of YMG medicated serum in cell culture medium. Pink1-Mfn2-Parkin expression and miRNA 125a-5p expression were measured by RT-PCR and Western blot.
    Results: We demonstrated that the atherosclerosis model group tended to exhibit reduced vitality behaviors. We proved that the atherosclerosis model group showed obvious atherosclerotic plaques, endothelial cells destruction, and high level of blood lipid and cytokines (including hs-CRP, ET). Mitochondria were reduced, and mitophagy was inhibited in aortic cells of the model group. MiRNA-125a-5p was up-regulated; at the same time, Pink1-Mfn2-Parkin-mediated mitochondrial autophagy was prevented. We also proved that AngⅡinjured HUVEC showed obviously low mRNA levels of Pink1, Mfn2, and Parkin. Interestingly, we found that miRNA-125a-5p was significantly down regulated in Ang II-induced HUVECs. In addition, miRNA-125a-5p significantly reduced the protective effect of YiMai Granules against Ang II injury.
    Conclusion: Our finding indicated that Pink1-Mfn2-Parkin-mediated mitochondrial autophagy plays a crucial role in alleviating atherosclerosis. YMG alleviated atherosclerosis by potentially activating mitochondrial autophagy may via miRNA-125a-5p, regulating Pink1-Mfn2-Parkin pathway, and regulating proinflammatory factors, vasoconstriction cytokine, and blood lipids.
    MeSH term(s) Rats ; Humans ; Animals ; Endothelial Cells/metabolism ; Plaque, Atherosclerotic/metabolism ; Cardiovascular Diseases ; Protein Kinases/metabolism ; Autophagy ; Mitochondria ; Ubiquitin-Protein Ligases/genetics ; Ubiquitin-Protein Ligases/metabolism ; Atherosclerosis/drug therapy ; Atherosclerosis/genetics ; Atherosclerosis/metabolism ; Cytokines/metabolism ; Lipids/pharmacology ; MicroRNAs/genetics ; MicroRNAs/metabolism
    Chemical Substances Protein Kinases (EC 2.7.-) ; Ubiquitin-Protein Ligases (EC 2.3.2.27) ; Cytokines ; Lipids ; MicroRNAs
    Language English
    Publishing date 2023-09-09
    Publishing country Ireland
    Document type Journal Article
    ZDB-ID 134511-4
    ISSN 1872-7573 ; 0378-8741
    ISSN (online) 1872-7573
    ISSN 0378-8741
    DOI 10.1016/j.jep.2023.117114
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Potential efficacious materials investigation of Yi-Yi Mixture based on Metabolome-oriented network pharmacology strategy.

    Gong, Guan-Wen / Tang, Wei-Hong / Zhou, Zhuo / Jiang, Yan-Wen / Wang, Cui-Zhong / Cheng, Hui / Cao, Yuan / Jiang, Zhi-Wei

    Journal of chromatography. B, Analytical technologies in the biomedical and life sciences

    2022  Volume 1197, Page(s) 123199

    Abstract: Yi-Yi Mixture, an efficient Chinese medicine preparation composed of four herbal medicines, has ... constituents in Yi-Yi Mixture. Secondly, metabolic exposure of chemical constituents as well as their global ... metabolites produced in biological systems were profiled and defined as metabolome of Yi-Yi Mixture ...

    Abstract Yi-Yi Mixture, an efficient Chinese medicine preparation composed of four herbal medicines, has been used in clinical practice in China for the treatment of acute pancreatitis over twenty years. However, its functional materials against acute pancreatitis remains unclear, which is a huge obstacle for quality control. In this study, a metabolome-oriented network pharmacology strategy was proposed to clarify its potential substances and further screen out quality markers. Firstly, an Ultra-High performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was utilized to profile the chemical constituents in Yi-Yi Mixture. Secondly, metabolic exposure of chemical constituents as well as their global metabolites produced in biological systems were profiled and defined as metabolome of Yi-Yi Mixture. Then, the metabolome targets were predicted based on network analysis. As a result, a total of 66 chemical components were characterized, including 6 stilbenes, 21 anthraquinones, 7 phenols, 13 neolignans, 3 naphthalenes and 16 other types. Moreover, metabolic profiles of YYM (32 prototypes and 37 metabolites) were analyzed in rat bio-samples. Among them, resveratrol, emodin, chrysophanol, rhein and their derivatives were detected in multiple tissues/organs, revealing their potential as key pharmacodynamic substances. These were further confirmed by metabolome-oriented network analysis and molecular docking techniques. This is the first comprehensive investigation on chemical and metabolic profiles of Yi-Yi Mixture, and the results provided scientific foundation for further research on quality control and clinical-safe medication administration.
    MeSH term(s) Acute Disease ; Animals ; Chromatography, High Pressure Liquid/methods ; Drugs, Chinese Herbal/analysis ; Drugs, Chinese Herbal/pharmacology ; Metabolome ; Molecular Docking Simulation ; Network Pharmacology ; Pancreatitis ; Rats ; Rats, Sprague-Dawley
    Chemical Substances Drugs, Chinese Herbal
    Language English
    Publishing date 2022-02-28
    Publishing country Netherlands
    Document type Journal Article
    ZDB-ID 1180823-8
    ISSN 1873-376X ; 0378-4347 ; 1570-0232 ; 1387-2273
    ISSN (online) 1873-376X
    ISSN 0378-4347 ; 1570-0232 ; 1387-2273
    DOI 10.1016/j.jchromb.2022.123199
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Jian-Pi-Yi-Shen decoction inhibits mitochondria-dependent granulosa cell apoptosis in a rat model of POF.

    Jiang, Xiao-Lin / Tai, He / Kuang, Jin-Song / Zhang, Jing-Yi / Cui, Shi-Chao / Lu, Yu-Xuan / Qi, Shu-Bo / Zhang, Shi-Yu / Li, Shun-Min / Chen, Jian-Ping / Meng, Xian-Sheng

    Aging

    2022  Volume 14, Issue 20, Page(s) 8321–8345

    Abstract: As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe ...

    Abstract As a widely applied traditional Chinese medicine (TCM), Jian-Pi-Yi-Shen (JPYS) decoction maybe applied in curing premature ovarian failure (POF) besides chronic kidney disease (CKD).
    MeSH term(s) Rats ; Female ; Humans ; Animals ; Primary Ovarian Insufficiency/metabolism ; Triptorelin Pamoate/metabolism ; Triptorelin Pamoate/pharmacology ; Drugs, Chinese Herbal/pharmacology ; Drugs, Chinese Herbal/therapeutic use ; Apoptosis ; Granulosa Cells/metabolism ; Mitochondria/metabolism
    Chemical Substances Triptorelin Pamoate (08AN7WA2G0) ; Drugs, Chinese Herbal
    Language English
    Publishing date 2022-10-27
    Publishing country United States
    Document type Journal Article ; Research Support, Non-U.S. Gov't
    ISSN 1945-4589
    ISSN (online) 1945-4589
    DOI 10.18632/aging.204320
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article ; Online: Bu Shen Yi Sui Capsule Promotes Myelin Repair by Modulating the Transformation of A1/A2 Reactive Astrocytes

    Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

    Oxidative medicine and cellular longevity

    2022  Volume 2022, Page(s) 3800004

    Abstract: Background/ ... ...

    Abstract Background/Aims
    MeSH term(s) Animals ; Astrocytes/metabolism ; Central Nervous System ; Complement C1q/metabolism ; Complement C1q/pharmacology ; Mice ; Mice, Inbred C57BL ; MicroRNAs/metabolism ; Multiple Sclerosis/drug therapy ; Multiple Sclerosis/metabolism ; Myelin Sheath ; Tumor Necrosis Factor-alpha/metabolism
    Chemical Substances MicroRNAs ; Tumor Necrosis Factor-alpha ; Complement C1q (80295-33-6)
    Language English
    Publishing date 2022-09-01
    Publishing country United States
    Document type Journal Article
    ZDB-ID 2455981-7
    ISSN 1942-0994 ; 1942-0994
    ISSN (online) 1942-0994
    ISSN 1942-0994
    DOI 10.1155/2022/3800004
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Clinical and whole exome sequencing findings in children from Yunnan Yi minority ethnic group with retinitis pigmentosa

    Yi-shuang Xiao / Wen-Ji He / Hong-chao Jiang / Li Tan / Jing Ma / Zhen Zhang

    Journal of Medical Case Reports, Vol 17, Iss 1, Pp 1-

    two case reports

    2023  Volume 6

    Abstract: ... of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year ... retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise ...

    Abstract Abstract Background Retinitis pigmentosa is a group of rare hereditary retinal dystrophy diseases that lead to difficulty seeing at night, progressive loss of peripheral field vision (tunnel vision), and eventual loss of central vision. However, a genetic cause cannot be determined in approximately 60% of cases. Case presentation Two non-consanguineous Yi minority ethnic group families who have a 6.4-year-old boy and a 0.5-year-old boy, respectively, were recruited for genetic diagnosis. Here, we used whole-exome sequencing to detect mutations in the genes of the probands of the retinitis pigmentosa families, and Sanger sequencing to confirm the causal mutations identified by whole exome sequencing. In addition, we report two cases with retinitis pigmentosa caused by RDH12 (c.524C > T) and PRPF4 (c.1273G > A) pathogenic mutations. Conclusions These results might extend the mutation spectrum of known retinitis pigmentosa genes and give these two Yi minority ethnic group families from Yunnan more precise genetic counseling and more specific prognoses.
    Keywords Mutation ; Retinitis pigmentosa ; Pediatric population ; Yunnan ; Medicine ; R
    Subject code 360
    Language English
    Publishing date 2023-06-01T00:00:00Z
    Publisher BMC
    Document type Article ; Online
    Database BASE - Bielefeld Academic Search Engine (life sciences selection)

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  8. Article ; Online: Study on the Anti-demyelination Mechanism of Bu-Shen-Yi-Sui Capsule in the Central Nervous System Based on Network Pharmacology and Experimental Verification.

    Zha, Zheng / Liu, Yi-Jiang / Liu, Si-Si / Zhang, Nan / Li, Jun-Ling / Qi, Fang / Jin, Liang-Yun / Xue, Bing / Yang, Tao / Fan, Yong-Ping / Zhao, Hui / Wang, Lei

    Mediators of inflammation

    2022  Volume 2022, Page(s) 9241261

    Abstract: Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the ... ...

    Abstract Methods: The potential active ingredients and corresponding potential targets of BSYS Capsule were obtained from the TCMSP, BATMAN-TCM, Swiss Target Prediction platform, and literature research. Disease targets of CNSD were explored through the GeneCards and the DisGeNET databases. The matching targets of BSYS in CNSD were identified from a Venn diagram. The protein-protein interaction (PPI) network was constructed using bioinformatics methods. Gene Ontology (GO) function and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed to predict the mechanisms of BSYS. Furthermore, the neuroprotective effects of BSYS were evaluated using a cell model of hydrogen peroxide- (H
    Results: A total of 59 potential bioactive components of BSYS Capsule and 227 intersection targets were obtained. Topological analysis showed that AKT had the highest connectivity degrees in the PPI network. Enrichment analysis revealed that the targets of BSYS in the treatment of CNSD were the PI3K-Akt and MAPK signaling pathway, among other pathways. GO analysis results showed that the targets were associated with various biological processes, including apoptosis, reactive oxygen species metabolic process, and response to oxidative stress, among others. The experimental results demonstrated that BSYS drug-containing serum alleviated the H
    Conclusion: BSYS Capsule alleviated H
    MeSH term(s) Animals ; Central Nervous System ; Drugs, Chinese Herbal/therapeutic use ; Hydrogen Peroxide/pharmacology ; Medicine, Chinese Traditional/methods ; Network Pharmacology ; Phosphatidylinositol 3-Kinases ; Proto-Oncogene Proteins c-akt
    Chemical Substances Drugs, Chinese Herbal ; Hydrogen Peroxide (BBX060AN9V) ; Proto-Oncogene Proteins c-akt (EC 2.7.11.1)
    Language English
    Publishing date 2022-07-12
    Publishing country United States
    Document type Journal Article
    ZDB-ID 1137605-3
    ISSN 1466-1861 ; 0962-9351
    ISSN (online) 1466-1861
    ISSN 0962-9351
    DOI 10.1155/2022/9241261
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  9. Article ; Online: Medicinal dietary plants of the Yi in Mile, Yunnan, China.

    Sun, Jingxian / Xiong, Yong / Li, Yanhong / Yang, Qingsong / Chen, Yijian / Jiang, Mengyuan / Li, Yukui / Li, Hongrui / Bi, Zizhen / Huang, Xiangzhong / Lu, Shugang

    Journal of ethnobiology and ethnomedicine

    2020  Volume 16, Issue 1, Page(s) 48

    Abstract: Background: The Yi is the largest ethnic group in Yunnan Province (China), with a population ... of five million. The Yi people tend to live in mountainous areas, and their culture includes a unique ... place in the Yi diet because they play a key role in health and the prevention and treatment of diseases ...

    Abstract Background: The Yi is the largest ethnic group in Yunnan Province (China), with a population of five million. The Yi people tend to live in mountainous areas, and their culture includes a unique dietary system for treating and protecting people against illnesses. Medicinal plants occupy an essential place in the Yi diet because they play a key role in health and the prevention and treatment of diseases. However, few studies have addressed these medicinal dietary plants and their importance in the Yi's daily lives. The aim of this study was to (1) investigate the medicinal dietary plants used by the Yi in Mile City, (2) document the traditional knowledge held about these plants, (3) identify species with important cultural significance to the Yi in Mile City, and (4) analyze the special preparation methods and consumption habits of these plants.
    Methods: Field investigations were performed in six villages in Mile City, Honghe Hani and Yi Autonomous Prefecture, Yunnan, from July 2017 to May 2018. Information was collected using direct observation, semi-structured interviews, key informant interviews, individual discussions, and focus group discussions. The use value (UV) and frequency of utilization index (FUI) of these plants were analyzed. Plant samples and voucher specimens were collected for taxonomic identification.
    Results: This study documented 124 species belonging to 62 families and 102 genera. These plants included angiosperms (117 spp.), gymnosperms (3), pteridophytes (2), lichen (1), and fungus (1). The 20 species with the highest UV were noted as being particularly important to the Yi people's daily life in Mile City. The primary medicinal preparation method for plants recorded in the study was decoction. The most commonly used plant parts were fruits and roots. The most frequently used edible parts were fruits, and the most frequently used medicinal parts were roots. The medicinal parts were used to treat diseases such as rheumatism, edemas, kidney deficiency, spleen deficiency, gastritis, parasites, and so on.
    Conclusion: A wide variety of medicinal dietary plants are used by the Yi people in Mile City. Those plants, which have both rich nutritional and medicinal value, occupy an essential part of the Yi dietary and medicine culture. Ethnobotanical surveys of medicinal dietary plants provide a theoretical reference for the conservation and sustainable use of the plant resources and could contribute to the protection of the Yi food culture and traditional medicine in Mile City. In addition, this information provides a sound basis for developing and using Yi ethnic medicine and health products.
    MeSH term(s) China ; Ethnic Groups ; Ethnobotany ; Ethnopharmacology ; Humans ; Knowledge ; Plants, Edible/classification ; Plants, Medicinal/classification
    Language English
    Publishing date 2020-08-28
    Publishing country England
    Document type Journal Article
    ISSN 1746-4269
    ISSN (online) 1746-4269
    DOI 10.1186/s13002-020-00400-5
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article: Potential efficacious materials investigation of Yi-Yi Mixture based on Metabolome-oriented network pharmacology strategy

    Gong, Guan-wen / Tang, Wei-hong / Zhou, Zhuo / Jiang, Yan-wen / Wang, Cui-zhong / Cheng, Hui / Cao, Yuan / Jiang, Zhi-wei

    Journal of chromatography. 2022 May 01, v. 1197

    2022  

    Abstract: Yi-Yi Mixture, an efficient Chinese medicine preparation composed of four herbal medicines, has ... constituents in Yi-Yi Mixture. Secondly, metabolic exposure of chemical constituents as well as their global ... metabolites produced in biological systems were profiled and defined as metabolome of Yi-Yi Mixture ...

    Abstract Yi-Yi Mixture, an efficient Chinese medicine preparation composed of four herbal medicines, has been used in clinical practice in China for the treatment of acute pancreatitis over twenty years. However, its functional materials against acute pancreatitis remains unclear, which is a huge obstacle for quality control. In this study, a metabolome-oriented network pharmacology strategy was proposed to clarify its potential substances and further screen out quality markers. Firstly, an Ultra-High performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry method was utilized to profile the chemical constituents in Yi-Yi Mixture. Secondly, metabolic exposure of chemical constituents as well as their global metabolites produced in biological systems were profiled and defined as metabolome of Yi-Yi Mixture. Then, the metabolome targets were predicted based on network analysis. As a result, a total of 66 chemical components were characterized, including 6 stilbenes, 21 anthraquinones, 7 phenols, 13 neolignans, 3 naphthalenes and 16 other types. Moreover, metabolic profiles of YYM (32 prototypes and 37 metabolites) were analyzed in rat bio-samples. Among them, resveratrol, emodin, chrysophanol, rhein and their derivatives were detected in multiple tissues/organs, revealing their potential as key pharmacodynamic substances. These were further confirmed by metabolome-oriented network analysis and molecular docking techniques. This is the first comprehensive investigation on chemical and metabolic profiles of Yi-Yi Mixture, and the results provided scientific foundation for further research on quality control and clinical-safe medication administration.
    Keywords Oriental traditional medicine ; emodin ; lignans ; mass spectrometry ; metabolites ; metabolome ; pancreatitis ; pharmacodynamics ; quality control ; rats ; resveratrol ; ultra-performance liquid chromatography ; China
    Language English
    Dates of publication 2022-0501
    Publishing place Elsevier B.V.
    Document type Article
    ISSN 1570-0232
    DOI 10.1016/j.jchromb.2022.123199
    Database NAL-Catalogue (AGRICOLA)

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