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  1. Article ; Online: Feasibility and performance of catheter ablation with zero-fluoroscopy approach for regular supraventricular tachycardia in patients with structural and/or congenital heart disease.

    Morka, Aleksandra / Śledź, Janusz / Deutsch, Karol / Ludwik, Bartosz / Zagrodzka, Magdalena / Szydłowski, Lesław / Stec, Sebastian

    Medicine

    2019  Volume 98, Issue 41, Page(s) e17333

    Abstract: Patients with structural heart disease (SHD) are more difficult to ablate than those with a structurally healthy heart. The reason may be technical problems. We compared periprocedural data in unselected patients (including SHD group) recruited for zero- ... ...

    Abstract Patients with structural heart disease (SHD) are more difficult to ablate than those with a structurally healthy heart. The reason may be technical problems. We compared periprocedural data in unselected patients (including SHD group) recruited for zero-fluoroscopy catheter ablation (ZF-CA) of supraventricular arrhythmias (SVTs).Consecutive adult patients with atrioventricular nodal reentry tachycardia (AVNRT), accessory pathways (AP), atrial flutter (AFL), and atrial tachycardia (AT) were recruited. A 3-dimensional electroanatomical mapping system (Ensite Velocity, NavX, St Jude Medical, Lake Bluff, Illinois) was used to create electroanatomical maps and navigate catheters. Fluoroscopy was used on the decision of the first operator after 5 minutes of unresolved problems.Of the 1280 patients ablated with the intention to be treated with ZF approach, 174 (13.6%) patients with SHD (age: 58.2 ± 13.6; AVNRT: 23.9%; AP: 8.5%; AFL: 61.4%; and AT: 6.2%) were recruited. These patients were compared with the 1106 patients with nonstructural heart disease (NSHD) (age: 51.4 ± 16.4; AVNRT: 58.0%; AP: 17.6%; AFL: 20.7%; and AT: 3.7% P ≤ .001). Procedural time (49.9 ± 24.6 vs 49.1 ± 23.9 minutes, P = .55) and number of applications were similar between groups (P = 0.08). The rate of conversion from ZF-CA to fluoroscopy was slightly higher in SHD as compared to NSHD (13.2% vs 7.8%, P = .02) while the total time of fluoroscopy and radiation doses were comparable in the group of SHD and NSHD (P = .55; P = .48).ZF-CA is feasible and safe in majority of patients with SHD and should be incorporated into a standard approach for SHD; however, the procedure requires sufficient experience.
    MeSH term(s) Adult ; Aged ; Arrhythmias, Cardiac/congenital ; Arrhythmias, Cardiac/surgery ; Catheter Ablation/methods ; Feasibility Studies ; Female ; Fluoroscopy/methods ; Heart Defects, Congenital/complications ; Heart Defects, Congenital/surgery ; Humans ; Male ; Middle Aged ; Prospective Studies ; Tachycardia, Supraventricular/congenital ; Tachycardia, Supraventricular/surgery ; Treatment Outcome
    Language English
    Publishing date 2019-10-05
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Multicenter Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000017333
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  2. Article ; Online: Association between the geographic region and the risk of familial atrioventricular nodal reentrant tachycardia in the Polish population.

    Deutsch, Karol / Ciurzyński, Michał / Śledź, Janusz / Zienciuk-Krajka, Agnieszka / Mazij, Mariusz / Ludwik, Bartosz / Stec, Piotr / Wileczek, Antoni / Pruszczyk, Piotr / Stec, Sebastian

    Polish archives of internal medicine

    2021  Volume 131, Issue 11

    MeSH term(s) Arrhythmias, Cardiac/surgery ; Catheter Ablation/methods ; Europe ; Humans ; Poland/epidemiology ; Tachycardia, Atrioventricular Nodal Reentry/diagnosis ; Tachycardia, Atrioventricular Nodal Reentry/epidemiology ; Tachycardia, Atrioventricular Nodal Reentry/genetics
    Language English
    Publishing date 2021-09-28
    Publishing country Poland
    Document type Journal Article
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.16099
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  3. Article ; Online: Zero-fluoroscopy catheter ablation of symptomatic pre-excitation from non-coronary cusp during pregnancy.

    Karbarz, Dariusz / Stec, Piotr J / Deutsch, Karol / Śledź, Janusz / Stec, Sebastian

    Kardiologia polska

    2017  Volume 75, Issue 12, Page(s) 1351

    MeSH term(s) Arrhythmias, Cardiac/diagnostic imaging ; Arrhythmias, Cardiac/etiology ; Arrhythmias, Cardiac/surgery ; Catheter Ablation ; Female ; Humans ; Pregnancy ; Pregnancy Complications, Cardiovascular/diagnostic imaging ; Pregnancy Complications, Cardiovascular/etiology ; Pregnancy Complications, Cardiovascular/surgery ; Wolff-Parkinson-White Syndrome/complications ; Young Adult
    Language English
    Publishing date 2017-12-18
    Publishing country Poland
    Document type Case Reports ; Journal Article
    ZDB-ID 411492-9
    ISSN 1897-4279 ; 0022-9032
    ISSN (online) 1897-4279
    ISSN 0022-9032
    DOI 10.5603/KP.2017.0231
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  4. Article ; Online: Maximum voltage gradient technique for optimization of ablation for typical atrial flutter with zero-fluoroscopy approach.

    Deutsch, Karol / Śledź, Janusz / Mazij, Mariusz / Ludwik, Bartosz / Labus, Michał / Karbarz, Dariusz / Pasicka, Bernadetta / Chrabąszcz, Michał / Śledź, Arkadiusz / Klank-Szafran, Monika / Vitali-Sendoz, Laura / Kameczura, Tomasz / Śpikowski, Jerzy / Stec, Piotr / Ujda, Marek / Stec, Sebastian

    Medicine

    2017  Volume 96, Issue 25, Page(s) e6939

    Abstract: Radiofrequency catheter ablation (RFCA) is an established effective method for the treatment of typical cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). The introduction of 3-dimensional electro-anatomic systems enables RFCA without ... ...

    Abstract Radiofrequency catheter ablation (RFCA) is an established effective method for the treatment of typical cavo-tricuspid isthmus (CTI)-dependent atrial flutter (AFL). The introduction of 3-dimensional electro-anatomic systems enables RFCA without fluoroscopy (No-X-Ray [NXR]). The aim of this study was to evaluate the feasibility and effectiveness of CTI RFCA during implementation of the NXR approach and the maximum voltage-guided (MVG) technique for ablation of AFL.Data were obtained from prospective standardized multicenter ablation registry. Consecutive patients with the first RFCA for CTI-dependent AFL were recruited. Two navigation approaches (NXR and fluoroscopy based as low as reasonable achievable [ALARA]) and 2 mapping and ablation techniques (MVG and pull-back technique [PBT]) were assessed. NXR + MVG (n  =  164; age: 63.7 ± 9.5; 30% women), NXR + PBT (n  =  55; age: 63.9 ± 10.7; 39% women); ALARA + MVG (n  =  36; age: 64.2 ± 9.6; 39% women); and ALARA + PBT (n  =  205; age: 64.7 ± 9.1; 30% women) were compared, respectively. All groups were simplified with a 2-catheter femoral approach using 8-mm gold tip catheters (Osypka AG, Germany or Biotronik, Germany) with 15 min of observation. The MVG technique was performed using step-by-step application by mapping the largest atrial signals within the CTI.Bidirectional block in CTI was achieved in 99% of all patients (P  =  NS, between groups). In NXR + MVG and NXR + PBT groups, the procedure time decreased (45.4 ± 17.6 and 47.2 ± 15.7 min vs. 52.6 ± 23.7 and 59.8 ± 24.0 min, P < .01) as compared to ALARA + MVG and ALARA + PBT subgroups. In NXR + MVG and NXR + PBT groups, 91% and 98% of the procedures were performed with complete elimination of fluoroscopy. The NXR approach was associated with a significant reduction in fluoroscopy exposure (from 0.2 ± 1.1 [NXR + PBT] and 0.3 ± 1.6 [NXR + MVG] to 7.7 ± 6.0 min [ALARA + MVG] and 9.1 ± 7.2 min [ALARA + PBT], P < .001). The total application time significantly decreased in the MVG technique subgroup both in NXR and ALARA (P < .01). No major complications were observed in either groups.Complete elimination of fluoroscopy is feasible, safe, and effective during RFCA of CTI in almost all AFL patients without cardiac implanted electronic devices. The most optimal method for RFCA of CTI-dependent AFL seems to be MVG; however, it required validation of optimal RFCA's parameters with clinical follow-up.
    MeSH term(s) Adult ; Aged ; Aged, 80 and over ; Atrial Flutter/surgery ; Catheter Ablation/methods ; Feasibility Studies ; Female ; Fluoroscopy ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Prospective Studies ; Quality Improvement ; Registries ; Treatment Outcome
    Language English
    Publishing date 2017-06-22
    Publishing country United States
    Document type Evaluation Study ; Journal Article ; Multicenter Study
    ZDB-ID 80184-7
    ISSN 1536-5964 ; 0025-7974
    ISSN (online) 1536-5964
    ISSN 0025-7974
    DOI 10.1097/MD.0000000000006939
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  5. Article ; Online: Long-term follow-up and comparison of techniques in radiofrequency ablation of ventricular arrhythmias originating from the aortic cusps (AVATAR Registry).

    Styczkiewicz, Katarzyna / Ludwik, Bartosz / Śledź, Janusz / Lipczyńska, Magdalena / Zaborska, Beata / Kryński, Tomasz / Deutsch, Karol / Morka, Aleksandra / Kukla, Piotr / Styczkiewicz, Marek / Kułakowski, Piotr / Stec, Sebastian M

    Polish archives of internal medicine

    2019  Volume 129, Issue 6, Page(s) 399–407

    Abstract: Introduction: Radiofrequency ablation (RFA) of outflow tract ventricular arrhythmia (VA) that originates from the aortic cusps can be challenging. Data on long‑ term efficacy and safety as well as optimal technique after aortic cusp ablation have not ... ...

    Abstract Introduction: Radiofrequency ablation (RFA) of outflow tract ventricular arrhythmia (VA) that originates from the aortic cusps can be challenging. Data on long‑ term efficacy and safety as well as optimal technique after aortic cusp ablation have not previously been reported.
    Objectives: This aim of the study was to determine the short- and long‑ term outcomes after RFA of aortic cusp VA, and to evaluate aortic valve injuries according to echocardiographic screening.
    Patients and methods: This was a prospective multicenter registry (AVATAR, Aortic Cusp Ventricular Arrhythmias: Long Term Safety and Outcome from a Multicenter Prospective Ablation Registry) study. A total of 103 patients at a mean age of 56 years (34-64) from the "Electra" Registry (2005-2017) undergoing RFA of aortic cusps VA were enrolled. The following 3 ablation techniques were used: zero‑fluoroscopy (ZF; electroanatomical mapping [EAM] without fluoroscopy), EAM with fluoroscopy, and conventional fluoroscopy‑ based RFA. Data on clinical history, complications after RFA, echocardiography, and 24‑ hour Holter monitoring were collected. The follow up was 12 months or longer.
    Results: There were no major acute cardiac complications after RFA. In one case, a vascular access complication required surgery. The median (interquartile range [IQR]) procedure time was 75 minutes (IQR, 58-95), median follow‑ up, 32 months (IQR, 12-70). Acute and long term procedural success rates were 93% and 86%, respectively. The long‑ term RFA outcomes were observed in ZF technique (88%), EAM with fluoroscopy (86%), and conventional RFA (82%), without differences. During long‑ term follow‑up, no abnormalities were found within the aortic root.
    Conclusions: Ablation of VA within the aortic cusps is safe and effective in long‑ term follow up. The ZF approach is feasible, although it requires greater expertise and more imaging modalities.
    MeSH term(s) Adult ; Aged ; Arrhythmias, Cardiac/surgery ; Catheter Ablation/methods ; Catheter Ablation/standards ; Female ; Fluoroscopy/methods ; Fluoroscopy/standards ; Follow-Up Studies ; Heart Ventricles/physiopathology ; Humans ; Male ; Middle Aged ; Practice Guidelines as Topic ; Prospective Studies ; Radiofrequency Ablation/methods ; Radiofrequency Ablation/standards ; Registries ; Treatment Outcome
    Language English
    Publishing date 2019-06-06
    Publishing country Poland
    Document type Comparative Study ; Journal Article ; Multicenter Study
    ZDB-ID 123500-x
    ISSN 1897-9483 ; 0032-3772
    ISSN (online) 1897-9483
    ISSN 0032-3772
    DOI 10.20452/pamw.14861
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  6. Article: Olefin metathesis in ionic liquids.

    Sledź, Paweł / Mauduit, Marc / Grela, Karol

    Chemical Society reviews

    2008  Volume 37, Issue 11, Page(s) 2433–2442

    Abstract: This tutorial review covers the use of ionic liquids as (co)solvents for the olefin metathesis reaction. Olefin metathesis is a simple and effective synthetic tool used to create many compounds which otherwise would require complex multistep syntheses. ... ...

    Abstract This tutorial review covers the use of ionic liquids as (co)solvents for the olefin metathesis reaction. Olefin metathesis is a simple and effective synthetic tool used to create many compounds which otherwise would require complex multistep syntheses. It is expected that the application of ionic liquids (IL) as well as the development of IL-enabled catalysts and separation techniques will create a green aspect to this important methodology.
    Language English
    Publishing date 2008-11
    Publishing country England
    Document type Journal Article
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/b711482f
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  7. Article ; Online: Feasibility of implementation of a "simplified, No-X-Ray, no-lead apron, two-catheter approach" for ablation of supraventricular arrhythmias in children and adults.

    Stec, Sebastian / Sledź, Janusz / Mazij, Mariusz / Raś, Małgorzata / Ludwik, Bartosz / Chrabąszcz, Michał / Sledź, Arkadiusz / Banasik, Małgorzata / Bzymek, Magdalena / Młynarczyk, Krzysztof / Deutsch, Karol / Labus, Michał / Spikowski, Jerzy / Szydłowski, Lesław

    Journal of cardiovascular electrophysiology

    2014  Volume 25, Issue 8, Page(s) 866–874

    Abstract: Introduction: Although the "near-zero-X-Ray" or "No-X-Ray" catheter ablation (CA) approach has been reported for treatment of various arrhythmias, few prospective studies have strictly used "No-X-Ray," simplified 2-catheter approaches for CA in patients ...

    Abstract Introduction: Although the "near-zero-X-Ray" or "No-X-Ray" catheter ablation (CA) approach has been reported for treatment of various arrhythmias, few prospective studies have strictly used "No-X-Ray," simplified 2-catheter approaches for CA in patients with supraventricular tachycardia (SVT). We assessed the feasibility of a minimally invasive, nonfluoroscopic (MINI) CA approach in such patients.
    Methods: Data were obtained from a prospective multicenter CA registry of patients with regular SVTs. After femoral access, 2 catheters were used to create simple, 3D electroanatomic maps and to perform electrophysiologic studies. Medical staff did not use lead aprons after the first 10 MINI CA cases.
    Results: A total of 188 patients (age, 45 ± 21 years; 17% <19 years; 55% women) referred for the No-X-Ray approach were included. They were compared to 714 consecutive patients referred for a simplified approach using X-rays (age, 52 ± 18 years; 7% <19 years; 55% women). There were 9 protocol exceptions that necessitated the use of X-rays. Ultimately, 179/188 patients underwent the procedure without fluoroscopy, with an acute success rate of 98%. The procedure times (63 ± 26 vs. 63 ± 29 minutes, P > 0.05), major complications (0% vs. 0%, P > 0.05) and acute (98% vs. 98%, P > 0.05) and long-term (93% vs. 94%, P > 0.05) success rates were similar in the "No-X-Ray" and control groups.
    Conclusions: Implementation of a strict "No-X-Ray, simplified 2-catheter" CA approach is safe and effective in majority of the patients with SVT. This modified approach for SVTs should be prospectively validated in a multicenter study.
    MeSH term(s) Adolescent ; Adult ; Aged ; Aged, 80 and over ; Cardiac Catheters ; Catheter Ablation/adverse effects ; Catheter Ablation/instrumentation ; Catheter Ablation/methods ; Child ; Child, Preschool ; Electrophysiologic Techniques, Cardiac ; Equipment Design ; Feasibility Studies ; Female ; Fluoroscopy ; Humans ; Lead ; Male ; Middle Aged ; Operative Time ; Poland ; Predictive Value of Tests ; Prospective Studies ; Protective Clothing ; Radiation Dosage ; Radiation Protection/instrumentation ; Registries ; Tachycardia, Supraventricular/diagnostic imaging ; Tachycardia, Supraventricular/physiopathology ; Tachycardia, Supraventricular/surgery ; Time Factors ; Treatment Outcome ; Young Adult
    Chemical Substances Lead (2P299V784P)
    Language English
    Publishing date 2014-08
    Publishing country United States
    Document type Evaluation Studies ; Journal Article ; Multicenter Study ; Research Support, Non-U.S. Gov't
    ZDB-ID 1025989-2
    ISSN 1540-8167 ; 1045-3873
    ISSN (online) 1540-8167
    ISSN 1045-3873
    DOI 10.1111/jce.12414
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  8. Article: Olefin metathesis in ionic liquids

    Śledź, Paweł / Mauduit, Marc / Grela, Karol

    Chemical Society reviews. 2008 Nov. 1, v. 37, no. 11

    2008  

    Abstract: This tutorial review covers the use of ionic liquids as (co)solvents for the olefin metathesis reaction. Olefin metathesis is a simple and effective synthetic tool used to create many compounds which otherwise would require complex multistep syntheses. ... ...

    Abstract This tutorial review covers the use of ionic liquids as (co)solvents for the olefin metathesis reaction. Olefin metathesis is a simple and effective synthetic tool used to create many compounds which otherwise would require complex multistep syntheses. It is expected that the application of ionic liquids (IL) as well as the development of IL-enabled catalysts and separation techniques will create a green aspect to this important methodology.
    Keywords catalysts ; ionic liquids ; olefin ; wills
    Language English
    Dates of publication 2008-1101
    Size p. 2433-2442.
    Publishing place The Royal Society of Chemistry
    Document type Article
    ZDB-ID 1472875-8
    ISSN 1460-4744 ; 0306-0012
    ISSN (online) 1460-4744
    ISSN 0306-0012
    DOI 10.1039/b711482f
    Database NAL-Catalogue (AGRICOLA)

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  9. Article: RNA interference in biology and disease.

    Sledz, Carol A / Williams, Bryan R G

    Blood

    2005  Volume 106, Issue 3, Page(s) 787–794

    Abstract: RNA interference (RNAi) is a conserved biologic response to double-stranded RNA that results in the sequence-specific silencing of target gene expression. Over the past 5 years, an intensive research effort has facilitated the rapid movement of RNAi from ...

    Abstract RNA interference (RNAi) is a conserved biologic response to double-stranded RNA that results in the sequence-specific silencing of target gene expression. Over the past 5 years, an intensive research effort has facilitated the rapid movement of RNAi from a relatively obscure biologic phenomenon to a valuable tool used to silence target gene expression and perform large-scale functional genomic screens. In fact, recent studies reported in this journal and others have demonstrated success using RNAi to address the role of oncogene expression in leukemia cell lines and to validate the therapeutic potential of RNAi for treating these blood disorders. In order to advance these applications and gain an appreciation for the future of RNAi both in basic research and in the treatment of diseases caused by aberrant gene expression, it is important to have an understanding of the process of RNAi and its limitations.
    MeSH term(s) Gene Expression Regulation, Neoplastic/drug effects ; Hematologic Neoplasms/therapy ; Humans ; RNA Interference ; RNA, Small Interfering/therapeutic use
    Chemical Substances RNA, Small Interfering
    Language English
    Publishing date 2005-04-12
    Publishing country United States
    Document type Journal Article ; Research Support, N.I.H., Extramural ; Research Support, U.S. Gov't, P.H.S. ; Review
    ZDB-ID 80069-7
    ISSN 1528-0020 ; 0006-4971
    ISSN (online) 1528-0020
    ISSN 0006-4971
    DOI 10.1182/blood-2004-12-4643
    Database MEDical Literature Analysis and Retrieval System OnLINE

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  10. Article ; Online: RNA interference and interferon.

    Sledz, Carol A / Williams, Bryan R G

    Discovery medicine

    2003  Volume 3, Issue 18, Page(s) 30–31

    Abstract: Extract: Over the past 5 years, the phenomenon of RNA interference (RNAi) has progressed from being considered a mysterious response to double-stranded RNA (dsRNA) in the nematode C. elegans to the latest potential therapeutic tool to silence gene ... ...

    Abstract Extract: Over the past 5 years, the phenomenon of RNA interference (RNAi) has progressed from being considered a mysterious response to double-stranded RNA (dsRNA) in the nematode C. elegans to the latest potential therapeutic tool to silence gene expression in certain diseases such as cancer or viral infections. However, the application of this biological phenomenon as a powerful research tool is not as clear-cut as scientists had initially hoped. dsRNA, the initiator of RNAi, is not made as a result of normal cellular processes, but is considered a warning to the cell of potential danger. Foreign dsRNA molecules can be formed through the transcription of potentially harmful transposons that contain inverted repeat sequences, as well as through the replication process of the majority of viruses during an infection. In organisms, such as the aforementioned nematode C. elegans and Drosophila, that respond to dsRNA-containing challenges through RNAi, the foreign dsRNA is recognized and cleaved into 21-23 nucleotide short interfering (si) RNAs. The siRNA is then incorporated into the RNA Induced Silencing Complex, which targets the mRNA of homologous sequence for degradation.
    Language English
    Publishing date 2003-10
    Publishing country United States
    Document type Journal Article
    ISSN 1944-7930
    ISSN (online) 1944-7930
    Database MEDical Literature Analysis and Retrieval System OnLINE

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