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Article ; Online: Manufacturing of primed mesenchymal stromal cells for therapy.

Yin, James Q / Zhu, Jun / Ankrum, James A

Nature biomedical engineering

2019 Volume 3, Issue 2, Page(s) 90–104

Abstract: Mesenchymal stromal cells (MSCs) for basic research and clinical applications are manufactured and developed as unique cell products by many different manufacturers and laboratories, often under different conditions. The lack of standardization of MSC ... ...

Abstract	Mesenchymal stromal cells (MSCs) for basic research and clinical applications are manufactured and developed as unique cell products by many different manufacturers and laboratories, often under different conditions. The lack of standardization of MSC identity has limited consensus around which MSC properties are relevant for specific outcomes. In this Review, we examine how the choice of media, cell source, culture environment and storage affects the phenotype and clinical utility of MSC-based products, and discuss the techniques better suited to prime MSCs with specific phenotypes of interest and the need for the continued development of standardized assays that provide quality assurance for clinical-grade MSCs. Bioequivalence between cell products and batches must be investigated rather than assumed, so that the diversity of phenotypes between differing MSC products can be accounted for to identify products with the highest therapeutic potential and to preserve their safety in clinical treatments.
MeSH term(s)	Animals ; Apoptosis ; Cell Differentiation ; Clinical Trials as Topic ; Cryopreservation ; Humans ; Mesenchymal Stem Cell Transplantation/adverse effects ; Mesenchymal Stem Cells/cytology
Language	English
Publishing date	2019-01-28
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't ; Review
ISSN	2157-846X
ISSN (online)	2157-846X
DOI	10.1038/s41551-018-0325-8
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Article: Enolase inhibitors as therapeutic leads for

Milanes, Jillian E / Yan, Victoria C / Pham, Cong-Dat / Muller, Florian / Kwain, Samuel / Rees, Kerrick C / Dominy, Brian N / Whitehead, Daniel C / Millward, Steven W / Bolejack, Madison / Abendroth, Jan / Phan, Isabelle Q / Staker, Bart / Moseman, E Ashley / Zhang, Xiang / Ma, Xipeng / Jebet, Audriy / Yin, Xinmin / Morris, James C

bioRxiv : the preprint server for biology

2024

Abstract: Infections with the pathogenic free-living ... ...

Abstract	Infections with the pathogenic free-living amoebae
Language	English
Publishing date	2024-01-17
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.16.575558
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Article: Network Proteomics of the Lewy Body Dementia Brain Reveals Presynaptic Signatures Distinct from Alzheimer's Disease.

Shantaraman, Anantharaman / Dammer, Eric B / Ugochukwu, Obiadada / Duong, Duc M / Yin, Luming / Carter, E Kathleen / Gearing, Marla / Chen-Plotkin, Alice / Lee, Edward B / Trojanowski, John Q / Bennett, David A / Lah, James J / Levey, Allan I / Seyfried, Nicholas T / Higginbotham, Lenora

bioRxiv : the preprint server for biology

2024

Abstract: Lewy body dementia (LBD), a class of disorders comprising Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer's disease (AD). The identification of biomarkers ... ...

Abstract	Lewy body dementia (LBD), a class of disorders comprising Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), features substantial clinical and pathological overlap with Alzheimer's disease (AD). The identification of biomarkers unique to LBD pathophysiology could meaningfully advance its diagnosis, monitoring, and treatment. Using quantitative mass spectrometry (MS), we measured over 9,000 proteins across 138 dorsolateral prefrontal cortex (DLPFC) tissues from a University of Pennsylvania autopsy collection comprising control, Parkinson's disease (PD), PDD, and DLB diagnoses. We then analyzed co-expression network protein alterations in those with LBD, validated these disease signatures in two independent LBD datasets, and compared these findings to those observed in network analyses of AD cases. The LBD network revealed numerous groups or "modules" of co-expressed proteins significantly altered in PDD and DLB, representing synaptic, metabolic, and inflammatory pathophysiology. A comparison of validated LBD signatures to those of AD identified distinct differences between the two diseases. Notably, synuclein-associated presynaptic modules were elevated in LBD but decreased in AD relative to controls. We also found that glial-associated matrisome signatures consistently elevated in AD were more variably altered in LBD, ultimately stratifying those LBD cases with low versus high burdens of concurrent beta-amyloid deposition. In conclusion, unbiased network proteomic analysis revealed diverse pathophysiological changes in the LBD frontal cortex distinct from alterations in AD. These results highlight the LBD brain network proteome as a promising source of biomarkers that could enhance clinical recognition and management.
Language	English
Publishing date	2024-01-24
Publishing country	United States
Document type	Preprint
DOI	10.1101/2024.01.23.576728
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Article: Molecular Mechanisms of Transdifferentiation of Adipose-Derived Stem Cells into Neural Cells: Current Status and Perspectives.

Luo, Liang / Hu, Da-Hai / Yin, James Q / Xu, Ru-Xiang

Stem cells international

2018 Volume 2018, Page(s) 5630802

Abstract: Neurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the ... ...

Abstract	Neurological diseases can severely compromise both physical and psychological health. Recently, adult mesenchymal stem cell- (MSC-) based cell transplantation has become a potential therapeutic strategy. However, most studies related to the transdifferentiation of MSCs into neural cells have had disappointing outcomes. Better understanding of the mechanisms underlying MSC transdifferentiation is necessary to make adult stem cells more applicable to treating neurological diseases. Several studies have focused on adipose-derived stromal/stem cell (ADSC) transdifferentiation. The purpose of this review is to outline the molecular characterization of ADSCs, to describe the methods for inducing ADSC transdifferentiation, and to examine factors influencing transdifferentiation, including transcription factors, epigenetics, and signaling pathways. Exploring and understanding the mechanisms are a precondition for developing and applying novel cell therapies.
Language	English
Publishing date	2018-09-13
Publishing country	United States
Document type	Journal Article ; Review
ZDB-ID	2573856-2
ISSN	1687-9678 ; 1687-966X
ISSN (online)	1687-9678
ISSN	1687-966X
DOI	10.1155/2018/5630802
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Article ; Online: Self-Assembling Anti-Freezing Lamellar Nanostructures in Subzero Temperatures.

Yin, Hongyao / Guo, Weiluo / Wang, Runxi / Doutch, James / Li, Peixun / Tian, Qiang / Zheng, Zhuo / Xie, Lingzhi / Feng, Yujun

Advanced science (Weinheim, Baden-Wurttemberg, Germany)

2024 , Page(s) e2309020

Abstract: The requirement for cryogenic supramolecular self-assembly of amphiphiles in subzero environments is a challenging topic. Here, the self-assembly of lamellar lyotropic liquid crystals (LLCs) are presented to a subzero temperature of -70 °C. These ... ...

Abstract	The requirement for cryogenic supramolecular self-assembly of amphiphiles in subzero environments is a challenging topic. Here, the self-assembly of lamellar lyotropic liquid crystals (LLCs) are presented to a subzero temperature of -70 °C. These lamellar nanostructures are assembled from specifically tailored ultra-long-chain surfactant stearyl diethanolamine (SDA) in water/glycerol binary solvent. As the temperature falls below zero, LLCs with a liquid-crystalline L
Language	English
Publishing date	2024-02-17
Publishing country	Germany
Document type	Journal Article
ZDB-ID	2808093-2
ISSN	2198-3844 ; 2198-3844
ISSN (online)	2198-3844
ISSN	2198-3844
DOI	10.1002/advs.202309020
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Article ; Online: High resolution spectroscopy of B0

Lin, Qinning / Ma, Jie / Coker, James / Pang, Renjun / Wang, Zesen / Furneaux, J E / Yin, Jianping / Yang, Tao

Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy

2024 Volume 311, Page(s) 123887

Abstract: Molecular tellurium ( ...

Abstract	Molecular tellurium (
Language	English
Publishing date	2024-01-14
Publishing country	England
Document type	Journal Article
ZDB-ID	210413-1
ISSN	1873-3557 ; 0370-8322 ; 0584-8539 ; 1386-1425
ISSN (online)	1873-3557
ISSN	0370-8322 ; 0584-8539 ; 1386-1425
DOI	10.1016/j.saa.2024.123887
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Article: Clinical Uncertainty Influences Antibiotic Prescribing for Upper Respiratory Tract Infections: A Qualitative Study of Township Hospital Physicians and Village Doctors in Rural Shandong Province, China.

Shen, Liyan / Wang, Ting / Yin, Jia / Sun, Qiang / Dyar, Oliver James

Antibiotics (Basel, Switzerland)

2023 Volume 12, Issue 6

Abstract: Objective: This study aimed to explore how clinical uncertainty influences antibiotic prescribing practices among township hospital physicians and village doctors in rural Shandong Province, China.: Methods: Qualitative semi-structured interviews ... ...

Abstract	Objective: This study aimed to explore how clinical uncertainty influences antibiotic prescribing practices among township hospital physicians and village doctors in rural Shandong Province, China. Methods: Qualitative semi-structured interviews were conducted with 30 township hospital physicians and 6 village doctors from rural Shandong Province, China. A multi-stage random sampling method was used to identify respondents. Conceptual content analysis together with Colaizzi's method were used to generate qualitative codes and identify themes. Results: Three final thematic categories emerged during the data analysis: (1) Incidence and treatment of Upper Respiratory Tract Infections (URTIs) in township hospitals and village clinics; (2) Antibiotic prescribing practices based on the clinical experience of clinicians; (3) Influence of clinical uncertainty on antibiotic prescribing. Respondents from both township hospitals and village clinics reported that URTIs were the most common reason for antibiotic prescriptions at their facilities and that clinical uncertainty appears to be an important driver for the overuse of antibiotics for URTIs. Clinical uncertainty was primarily due to: (1) Diagnostic uncertainty (establishing a relevant diagnosis is hindered by limited diagnostic resources and capacities, as well as limited willingness of patients to pay for investigations), and (2) Insufficient prognostic evidence. As a consequence of the clinical uncertainty caused by both diagnostic and prognostic uncertainty, respondents stated that antibiotics are frequently prescribed for URTIs to prevent both prolonged courses or recurrence of the disease, as well as clinical worsening, hospital admission, or complications. Conclusion: Our study suggests that clinical uncertainty is a key driver for the overuse and misuse of prescribing antibiotics for URTIs in both rural township hospitals and village clinics in Shandong province, China, and that interventions to reduce clinical uncertainty may help minimize the unnecessary use of antibiotics in these settings. Interventions that use clinical rules to identify patients at low risk of complications or hospitalization may be more feasible in the near-future than laboratory-based interventions aimed at reducing diagnostic uncertainty.
Language	English
Publishing date	2023-06-08
Publishing country	Switzerland
Document type	Journal Article
ZDB-ID	2681345-2
ISSN	2079-6382
ISSN	2079-6382
DOI	10.3390/antibiotics12061027
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Article ; Online: Incidence and risk factors for glaucoma development and progression after corneal transplantation.

Saini, Chhavi / Davies, Emma C / Ung, Lawson / Chodosh, James / Ciolino, Joseph B / Jurkunas, Ula V / Paschalis, Eleftherios I / Pineda, Roberto / Saeed, Hajirah N / Yin, Jia / Shen, Lucy Q

Eye (London, England)

2022 Volume 37, Issue 10, Page(s) 2117–2125

Abstract: Objective: To assess the cumulative incidence and risk factors for glaucoma development and progression within 1-2 years following corneal transplant surgery.: Design: Retrospective cohort study.: Methods: Patients undergoing penetrating ... ...

Abstract	Objective: To assess the cumulative incidence and risk factors for glaucoma development and progression within 1-2 years following corneal transplant surgery. Design: Retrospective cohort study. Methods: Patients undergoing penetrating keratoplasty (PK), deep anterior lamellar keratoplasty (DALK), Descemet stripping endothelial keratoplasty (DSEK), Descemet membrane endothelial keratoplasty (DMEK), Boston keratoprosthesis type I (KPro) implantation, or endothelial keratoplasty (DSEK or DMEK) under previous PK (EK under previous PK) at one academic institution with at least 1 year of follow-up were included. Primary outcome measures were cumulative incidence of glaucoma development and progression after corneal transplant, in patients without and with preoperative glaucoma, respectively. Risk factors for glaucoma development and progression were also assessed. Results: Four hundred and thirty-one eyes of 431 patients undergoing PK (113), DALK (17), DSEK (71), DMEK (168), KPro (35) and EK under previous PK (27) with a mean follow-up of 22.9 months were analyzed. The 1-year cumulative incidence for glaucoma development and progression was 28.0% and 17.8% in patients without and with preoperative glaucoma, respectively. In a Cox proportional hazards analysis, DSEK surgery, KPro implantation, average intraocular pressure (IOP) through follow-up and postoperative IOP spikes of ≥30 mmHg were each independently associated with glaucoma development or progression (p < 0.04 for all). Conclusions: A significant proportion of patients developed glaucoma or exhibited glaucoma progression within 1 year after corneal transplantation. Patient selection for DSEK may partly explain the higher risk for glaucoma in these patients. Postoperative IOP spikes should be minimized and may indicate the need for co-management with a glaucoma specialist.
MeSH term(s)	Humans ; Incidence ; Retrospective Studies ; Cornea ; Corneal Diseases/epidemiology ; Corneal Diseases/surgery ; Corneal Diseases/complications ; Descemet Stripping Endothelial Keratoplasty/adverse effects ; Prostheses and Implants/adverse effects ; Glaucoma/epidemiology ; Glaucoma/etiology ; Glaucoma/surgery ; Keratoplasty, Penetrating/adverse effects ; Risk Factors ; Follow-Up Studies
Language	English
Publishing date	2022-11-03
Publishing country	England
Document type	Journal Article
ZDB-ID	91001-6
ISSN	1476-5454 ; 0950-222X
ISSN (online)	1476-5454
ISSN	0950-222X
DOI	10.1038/s41433-022-02299-6
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Article ; Online: EID3 directly associates with DNMT3A during transdifferentiation of human umbilical cord mesenchymal stem cells to NPC-like cells.

Luo, Liang / Chen, Wen-Jin / Yin, James Q / Xu, Ru-Xiang

Scientific reports

2017 Volume 7, Page(s) 40463

Abstract: There has been recently been increased interest in the plasticity of human umbilical cord mesenchymal stem cells (UMSCs) and their potential in the treatment of neurological disorders. In this study, UMSCs were transdifferentiated into neural stem-like ... ...

Abstract	There has been recently been increased interest in the plasticity of human umbilical cord mesenchymal stem cells (UMSCs) and their potential in the treatment of neurological disorders. In this study, UMSCs were transdifferentiated into neural stem-like cells (uNSCL), these cells grow in neurosphere-like structures and express high levels of NSCs markers. Epigenetics-related gene screening was here used to assess the relationship between E1A-like inhibitor of differentiation 3 (EID3), a p300 inhibitor, and DNA methyltransferase 3 A (DNMT3A) during the transdifferentiation of UMSCs into uNSCL in vitro. Before transdifferentiation of UMSCs into uNSCLs, high levels of EID3 and low levels of DNMT3A were detected; after transdifferentiation, low levels of EID3 and high levels of DNMT3A were detected. The current work showed that EID3 and DNMT3A co-localized in cell nuclei and EID3 interacted directly with DNMT3A in uNSCL. In summary, these results suggest that DNMT3A is probably directly regulated by EID3 during UMSC transdifferentiation into uNSCLs. These findings indicated a novel mechanism by which EID3, a p300 acetyltransferase inhibitor, could directly affect DNMT3A, this enzyme possesses dual methylation and demethylation abilities. These studies may be helpful for understanding a complex regulation mode of DNMT3A, which is a unique member of the methyltransferase family.
MeSH term(s)	Biomarkers/metabolism ; Carrier Proteins/metabolism ; Cell Transdifferentiation ; DNA (Cytosine-5-)-Methyltransferases/metabolism ; HEK293 Cells ; Humans ; Mesenchymal Stromal Cells/cytology ; Mesenchymal Stromal Cells/metabolism ; Neural Stem Cells/cytology ; Neural Stem Cells/metabolism ; Protein Binding ; Umbilical Cord/cytology
Chemical Substances	Biomarkers ; Carrier Proteins ; EID3 protein, human ; DNA (Cytosine-5-)-Methyltransferases (EC 2.1.1.37) ; DNA methyltransferase 3A (EC 2.1.1.37)
Language	English
Publishing date	2017-01-11
Publishing country	England
Document type	Journal Article ; Research Support, Non-U.S. Gov't
ZDB-ID	2615211-3
ISSN	2045-2322 ; 2045-2322
ISSN (online)	2045-2322
ISSN	2045-2322
DOI	10.1038/srep40463
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Article ; Online: An insight into the thermo-thickening behavior of wormlike micellar solutions based on ultra-long-chain surfactants.

Yin, Quan / Tian, Qiang / Doutch, James / Frimpong, Asante O / Xu, Xiao / Yin, Hongyao / Li, Peixun / Feng, Yujun

Physical chemistry chemical physics : PCCP

2022 Volume 24, Issue 18, Page(s) 11112–11123

Abstract: Generally, the solution viscosity of wormlike micelles (WLMs) assembled from common surfactants decreases upon an increase in the temperature, following the Arrhenius law. However, abnormal thermo-thickening behavior has been repeatedly observed for WLMs ...

Abstract	Generally, the solution viscosity of wormlike micelles (WLMs) assembled from common surfactants decreases upon an increase in the temperature, following the Arrhenius law. However, abnormal thermo-thickening behavior has been repeatedly observed for WLMs formed by ultra-long-chain (≥C18) surfactants. It would be useful to unravel the mechanism behind this phenomenon. Here, three C
Language	English
Publishing date	2022-05-11
Publishing country	England
Document type	Journal Article
ZDB-ID	1476244-4
ISSN	1463-9084 ; 1463-9076
ISSN (online)	1463-9084
ISSN	1463-9076
DOI	10.1039/d2cp00687a
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